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Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.

Atukorale PU, Raghunathan SP, Raguveer V, Moon TJ, Zheng C, Bielecki PA, Wiese ML, Goldberg AL, Covarrubias G, Hoimes CJ, Karathanasis E.

Cancer Res. 2019 Oct 15;79(20):5394-5406. doi: 10.1158/0008-5472.CAN-19-0381. Epub 2019 Aug 20.


Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.

Sha Z, Blyszcz T, González-Prieto R, Vertegaal ACO, Goldberg AL.

J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.


SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.

Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13404-13413. doi: 10.1073/pnas.1901039116. Epub 2019 Jun 18.


PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.

Zhang H, Pan B, Wu P, Parajuli N, Rekhter MD, Goldberg AL, Wang X.

Sci Adv. 2019 May 22;5(5):eaaw5870. doi: 10.1126/sciadv.aaw5870. eCollection 2019 May.


26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.

VerPlank JJS, Lokireddy S, Zhao J, Goldberg AL.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4228-4237. doi: 10.1073/pnas.1809254116. Epub 2019 Feb 19.


UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells.

Kim HT, Goldberg AL.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11642-E11650. doi: 10.1073/pnas.1808731115. Epub 2018 Nov 28. Erratum in: Proc Natl Acad Sci U S A. 2019 Jan 14;:.


ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation.

Lee D, Takayama S, Goldberg AL.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9550-E9559. doi: 10.1073/pnas.1809934115. Epub 2018 Sep 25. Erratum in: Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1458.


Exploring the Regulation of Proteasome Function by Subunit Phosphorylation.

VerPlank JJS, Goldberg AL.

Methods Mol Biol. 2018;1844:309-319. doi: 10.1007/978-1-4939-8706-1_20.


Measurement of the Multiple Activities of 26S Proteasomes.

Kim HT, Collins GA, Goldberg AL.

Methods Mol Biol. 2018;1844:289-308. doi: 10.1007/978-1-4939-8706-1_19.


Methods to Rapidly Prepare Mammalian 26S Proteasomes for Biochemical Analysis.

Kuo CL, Collins GA, Goldberg AL.

Methods Mol Biol. 2018;1844:277-288. doi: 10.1007/978-1-4939-8706-1_18.


Impairment of protein degradation and proteasome function in hereditary neuropathies.

VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L.

Glia. 2018 Feb;66(2):379-395. doi: 10.1002/glia.23251. Epub 2017 Oct 27.


An open-label pilot study of an intervention using mobile phones to deliver contingency management of tobacco abstinence to high school students.

Kong G, Goldberg AL, Dallery J, Krishnan-Sarin S.

Exp Clin Psychopharmacol. 2017 Oct;25(5):333-337. doi: 10.1037/pha0000151.


Regulating protein breakdown through proteasome phosphorylation.

VerPlank JJS, Goldberg AL.

Biochem J. 2017 Sep 24;474(19):3355-3371. doi: 10.1042/BCJ20160809. Review.


The Logic of the 26S Proteasome.

Collins GA, Goldberg AL.

Cell. 2017 May 18;169(5):792-806. doi: 10.1016/j.cell.2017.04.023. Review.


The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

Kim HT, Goldberg AL.

J Biol Chem. 2017 Jun 9;292(23):9830-9839. doi: 10.1074/jbc.M116.763128. Epub 2017 Apr 17.


Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.

Kuo CL, Goldberg AL.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3404-E3413. doi: 10.1073/pnas.1701734114. Epub 2017 Apr 10.


Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.

Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF.

Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.


Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization.

Volodin A, Kosti I, Goldberg AL, Cohen S.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1375-E1384. doi: 10.1073/pnas.1612988114. Epub 2017 Jan 17.


Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation.

Sha Z, Goldberg AL.

Curr Biol. 2016 Sep 26;26(18):R836-R837. doi: 10.1016/j.cub.2016.08.030.


Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR.

Zhao J, Goldberg AL.

Autophagy. 2016 Oct 2;12(10):1967-1970. Epub 2016 Jul 26.


Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21.


The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins.

Lee do H, Sherman MY, Goldberg AL.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):100-6. doi: 10.1016/j.bbrc.2016.05.046. Epub 2016 May 10.


Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.

Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H.

Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1.


Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.

Li M, Kandror O, Akopian T, Dharkar P, Wlodawer A, Maurizi MR, Goldberg AL.

J Biol Chem. 2016 Apr 1;291(14):7465-76. doi: 10.1074/jbc.M115.700344. Epub 2016 Feb 8.


Control of proteasomal proteolysis by mTOR.

Zhao J, Garcia GA, Goldberg AL.

Nature. 2016 Jan 21;529(7586):E1-2. doi: 10.1038/nature16472. No abstract available.


Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE.

Nat Med. 2016 Jan;22(1):46-53. doi: 10.1038/nm.4011. Epub 2015 Dec 21.


cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

Lokireddy S, Kukushkin NV, Goldberg AL.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7176-85. doi: 10.1073/pnas.1522332112. Epub 2015 Dec 15.


mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.

Zhao J, Zhai B, Gygi SP, Goldberg AL.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15790-7. doi: 10.1073/pnas.1521919112. Epub 2015 Dec 15.


Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.

Lee D, Goldberg AL.

J Biol Chem. 2015 Dec 18;290(51):30269-79. doi: 10.1074/jbc.M115.685164. Epub 2015 Oct 29.


Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S.

Elife. 2015 Sep 1;4. doi: 10.7554/eLife.08467.


Blocking Cancer Growth with Less POMP or Proteasomes.

Goldberg AL, Zhao J, Collins GA.

Mol Cell. 2015 Jul 16;59(2):143-5. doi: 10.1016/j.molcel.2015.07.005.


Structural characterization of the interaction of Ubp6 with the 26S proteasome.

Aufderheide A, Beck F, Stengel F, Hartwig M, Schweitzer A, Pfeifer G, Goldberg AL, Sakata E, Baumeister W, Förster F.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8626-31. doi: 10.1073/pnas.1510449112. Epub 2015 Jun 30.


Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates.

Sandu C, Chandramouli N, Glickman JF, Molina H, Kuo CL, Kukushkin N, Goldberg AL, Steller H.

J Cell Mol Med. 2015 Sep;19(9):2181-92. doi: 10.1111/jcmm.12602. Epub 2015 May 30.


Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.

Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M.

Nat Commun. 2015 Apr 10;6:6670. doi: 10.1038/ncomms7670.


Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.

Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL.

J Biol Chem. 2015 Apr 24;290(17):11008-20. doi: 10.1074/jbc.M114.625640. Epub 2015 Mar 10.


Muscle wasting in disease: molecular mechanisms and promising therapies.

Cohen S, Nathan JA, Goldberg AL.

Nat Rev Drug Discov. 2015 Jan;14(1):58-74. doi: 10.1038/nrd4467. Review.


The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.

Gao W, Kim JY, Anderson JR, Akopian T, Hong S, Jin YY, Kandror O, Kim JW, Lee IA, Lee SY, McAlpine JB, Mulugeta S, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg AL, Pauli GF, Suh JW, Franzblau SG, Cho S.

Antimicrob Agents Chemother. 2015 Feb;59(2):880-9. doi: 10.1128/AAC.04054-14. Epub 2014 Nov 24.


Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.

Sha Z, Goldberg AL.

Curr Biol. 2014 Jul 21;24(14):1573-1583. doi: 10.1016/j.cub.2014.06.004. Epub 2014 Jul 3.


Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL.

EMBO J. 2014 May 16;33(10):1159-76. doi: 10.1002/embj.201386906. Epub 2014 May 8.


Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.

Cohen S, Lee D, Zhai B, Gygi SP, Goldberg AL.

J Cell Biol. 2014 Mar 3;204(5):747-58. doi: 10.1083/jcb.201304167. Epub 2014 Feb 24.


Re-examining class-I presentation and the DRiP hypothesis.

Rock KL, Farfán-Arribas DJ, Colbert JD, Goldberg AL.

Trends Immunol. 2014 Apr;35(4):144-52. doi: 10.1016/ Epub 2014 Feb 21. Review.


Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK.

Neurobiol Dis. 2014 Apr;64:79-87. doi: 10.1016/j.nbd.2013.12.011. Epub 2013 Dec 31.


Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N.

Dis Model Mech. 2013 Nov;6(6):1339-52. doi: 10.1242/dmm.012559. Epub 2013 Oct 2. Review.


BMP signaling controls muscle mass.

Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M.

Nat Genet. 2013 Nov;45(11):1309-18. doi: 10.1038/ng.2772. Epub 2013 Sep 29.


Mechanisms of muscle growth and atrophy in mammals and Drosophila.

Piccirillo R, Demontis F, Perrimon N, Goldberg AL.

Dev Dyn. 2014 Feb;243(2):201-15. doi: 10.1002/dvdy.24036. Epub 2013 Oct 24. Review.


SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.

Lee D, Goldberg AL.

J Biol Chem. 2013 Oct 18;288(42):30515-26. doi: 10.1074/jbc.M113.489716. Epub 2013 Sep 3.


The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

Peth A, Nathan JA, Goldberg AL.

J Biol Chem. 2013 Oct 4;288(40):29215-22. doi: 10.1074/jbc.M113.482570. Epub 2013 Aug 21.


The influence of skeletal muscle on systemic aging and lifespan.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N.

Aging Cell. 2013 Dec;12(6):943-9. doi: 10.1111/acel.12126. Epub 2013 Jul 17. Review.


Myostatin/activin pathway antagonism: molecular basis and therapeutic potential.

Han HQ, Zhou X, Mitch WE, Goldberg AL.

Int J Biochem Cell Biol. 2013 Oct;45(10):2333-47. doi: 10.1016/j.biocel.2013.05.019. Epub 2013 May 28. Review.


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