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Development and evaluation of a novel VHH-based immunocapture assay for high sensitivity detection of Shiga toxin type 2 (Stx2) in stool samples.

Melli LJ, Zylberman V, Hiriart Y, Lauche CE, Baschkier A, Pardo R, Miliwebsky E, Chinen I, Rivas M, Goldbaum FA, Ugalde JE, Comerci DJ, Ciocchini AE.

J Clin Microbiol. 2019 Dec 11. pii: JCM.01566-19. doi: 10.1128/JCM.01566-19. [Epub ahead of print]


An All-Inclusive and Straightway Laboratory Activity to Solve the Three-Dimensional Crystal Structure of a Protein.

Klinke S, Rinaldi J, Goldbaum FA, Suarez S, Otero LH.

Biochem Mol Biol Educ. 2019 Nov;47(6):700-707. doi: 10.1002/bmb.21296. Epub 2019 Aug 24.


A high-throughput screening for inhibitors of riboflavin synthase identifies novel antimicrobial compounds to treat brucellosis.

Serer MI, Carrica MDC, Trappe J, López Romero S, Bonomi HR, Klinke S, Cerutti ML, Goldbaum FA.

FEBS J. 2019 Jul;286(13):2522-2535. doi: 10.1111/febs.14829. Epub 2019 Apr 10.


Mucosal immunization with polymeric antigen BLSOmp31 using alternative delivery systems against Brucella ovis in rams.

Díaz AG, Quinteros DA, Paolicchi FA, Rivero MA, Palma SD, Pardo RP, Clausse M, Zylberman V, Goldbaum FA, Estein SM.

Vet Immunol Immunopathol. 2019 Mar;209:70-77. doi: 10.1016/j.vetimm.2019.02.005. Epub 2019 Mar 2.


Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens.

Alzogaray V, Urrutia M, Berguer P, Rossi A, Zylberman V, Pardo R, Bonomi HR, Goldbaum FA.

J Biotechnol. 2019 Mar 10;293:17-23. doi: 10.1016/j.jbiotec.2019.01.001. Epub 2019 Jan 26.


The Next Generation Scientist program: capacity-building for future scientific leaders in low- and middle-income countries.

Pillai G, Chibale K, Constable EC, Keller AN, Gutierrez MM, Mirza F, Sengstag C, Masimirembwa C, Denti P, Maartens G, Ramsay M, Ogutu B, Makonnen E, Gordon R, Ferreira CG, Goldbaum FA, Degrave WMS, Spector J, Tadmor B, Kaiser HJ.

BMC Med Educ. 2018 Oct 10;18(1):233. doi: 10.1186/s12909-018-1331-y.


Crystallization and initial X-ray diffraction analysis of the multi-domain Brucella blue light-activated histidine kinase LOV-HK in its illuminated state.

Rinaldi J, Fernández I, Poth LM, Shepard WE, Savko M, Goldbaum FA, Klinke S.

Biochem Biophys Rep. 2018 Sep 26;16:39-43. doi: 10.1016/j.bbrep.2018.09.005. eCollection 2018 Dec.


Acidic pH triggers the phosphorylation of the response regulator NtrX in alphaproteobacteria.

Fernández I, Sycz G, Goldbaum FA, Carrica MDC.

PLoS One. 2018 Apr 10;13(4):e0194486. doi: 10.1371/journal.pone.0194486. eCollection 2018.


Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok.

Sapp A, Huguet-Tapia JC, Sánchez-Lamas M, Antelo GT, Primo ED, Rinaldi J, Klinke S, Goldbaum FA, Bonomi HR, Christner BC, Otero LH.

Genome Announc. 2018 Mar 8;6(10). pii: e00145-18. doi: 10.1128/genomeA.00145-18.


The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists.

Balcazar DE, Vanrell MC, Romano PS, Pereira CA, Goldbaum FA, Bonomi HR, Carrillo C.

PLoS Negl Trop Dis. 2017 Apr 13;11(4):e0005513. doi: 10.1371/journal.pntd.0005513. eCollection 2017 Apr.


Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs.

Clausse M, Díaz AG, Pardo RP, Zylberman V, Goldbaum FA, Estein SM.

Vet Immunol Immunopathol. 2017 Feb;184:36-41. doi: 10.1016/j.vetimm.2016.11.004. Epub 2016 Dec 5.


Three-Dimensional Structure of Full-Length NtrX, an Unusual Member of the NtrC Family of Response Regulators.

Fernández I, Cornaciu I, Carrica MD, Uchikawa E, Hoffmann G, Sieira R, Márquez JA, Goldbaum FA.

J Mol Biol. 2017 Apr 21;429(8):1192-1212. doi: 10.1016/j.jmb.2016.12.022. Epub 2017 Jan 12.


Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity.

Cerutti ML, Otero LH, Smal C, Pellizza L, Goldbaum FA, Klinke S, Aran M.

J Struct Biol. 2017 Mar;197(3):201-209. doi: 10.1016/j.jsb.2016.10.010. Epub 2016 Nov 1.


Xanthomonas campestris attenuates virulence by sensing light through a bacteriophytochrome photoreceptor.

Bonomi HR, Toum L, Sycz G, Sieira R, Toscani AM, Gudesblat GE, Leskow FC, Goldbaum FA, Vojnov AA, Malamud F.

EMBO Rep. 2016 Nov;17(11):1565-1577. Epub 2016 Sep 12.


Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis.

Díaz AG, Quinteros DA, Gutiérrez SE, Rivero MA, Palma SD, Allemandi DA, Pardo RP, Zylberman V, Goldbaum FA, Estein SM.

Vet Immunol Immunopathol. 2016 Oct 1;178:50-6. doi: 10.1016/j.vetimm.2016.07.004. Epub 2016 Jul 5.


Development of camelid single chain antibodies against Shiga toxin type 2 (Stx2) with therapeutic potential against Hemolytic Uremic Syndrome (HUS).

Mejías MP, Hiriart Y, Lauché C, Fernández-Brando RJ, Pardo R, Bruballa A, Ramos MV, Goldbaum FA, Palermo MS, Zylberman V.

Sci Rep. 2016 Apr 27;6:24913. doi: 10.1038/srep24913.


Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism.

Otero LH, Klinke S, Rinaldi J, Velázquez-Escobar F, Mroginski MA, Fernández López M, Malamud F, Vojnov AA, Hildebrandt P, Goldbaum FA, Bonomi HR.

J Mol Biol. 2016 Sep 25;428(19):3702-20. doi: 10.1016/j.jmb.2016.04.012. Epub 2016 Apr 20.


Spray dried microspheres based on chitosan: A promising new carrier for intranasal administration of polymeric antigen BLSOmp31 for prevention of ovine brucellosis.

Díaz AG, Quinteros DA, Llabot JM, Palma SD, Allemandi DA, Ghersi G, Zylberman V, Goldbaum FA, Estein SM.

Mater Sci Eng C Mater Biol Appl. 2016 May;62:489-96. doi: 10.1016/j.msec.2016.01.084. Epub 2016 Feb 2.


Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain.

Rinaldi J, Arrar M, Sycz G, Cerutti ML, Berguer PM, Paris G, Estrín DA, Martí MA, Klinke S, Goldbaum FA.

J Mol Biol. 2016 Mar 27;428(6):1165-1179. doi: 10.1016/j.jmb.2016.01.026. Epub 2016 Feb 2.


Expression of the Multimeric and Highly Immunogenic Brucella spp. Lumazine Synthase Fused to Bovine Rotavirus VP8d as a Scaffold for Antigen Production in Tobacco Chloroplasts.

Alfano EF, Lentz EM, Bellido D, Dus Santos MJ, Goldbaum FA, Wigdorovitz A, Bravo-Almonacid FF.

Front Plant Sci. 2015 Dec 23;6:1170. doi: 10.3389/fpls.2015.01170. eCollection 2015.


A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses.

Ibañez AE, Coria LM, Carabajal MV, Delpino MV, Risso GS, Cobiello PG, Rinaldi J, Barrionuevo P, Bruno L, Frank F, Klinke S, Goldbaum FA, Briones G, Giambartolomei GH, Pasquevich KA, Cassataro J.

J Control Release. 2015 Dec 28;220(Pt A):18-28. doi: 10.1016/j.jconrel.2015.10.011. Epub 2015 Oct 9.


S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations.

Klinke S, Foos N, Rinaldi JJ, Paris G, Goldbaum FA, Legrand P, Guimarães BG, Thompson A.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1433-43. doi: 10.1107/S1399004715007622. Epub 2015 Jun 30.


Snapshots of Conformational Changes Shed Light into the NtrX Receiver Domain Signal Transduction Mechanism.

Fernández I, Otero LH, Klinke S, Carrica MDC, Goldbaum FA.

J Mol Biol. 2015 Oct 9;427(20):3258-3272. doi: 10.1016/j.jmb.2015.06.010. Epub 2015 Jun 23.


LOV Histidine Kinase Modulates the General Stress Response System and Affects the virB Operon Expression in Brucella abortus.

Sycz G, Carrica MC, Tseng TS, Bogomolni RA, Briggs WR, Goldbaum FA, Paris G.

PLoS One. 2015 May 19;10(5):e0124058. doi: 10.1371/journal.pone.0124058. eCollection 2015.


Brucella spp. Lumazine Synthase Induces a TLR4-Mediated Protective Response against B16 Melanoma in Mice.

Rossi AH, Farias A, Fernández JE, Bonomi HR, Goldbaum FA, Berguer PM.

PLoS One. 2015 May 14;10(5):e0126827. doi: 10.1371/journal.pone.0126827. eCollection 2015.


Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species.

Gutiérrez-Preciado A, Torres AG, Merino E, Bonomi HR, Goldbaum FA, García-Angulo VA.

PLoS One. 2015 May 4;10(5):e0126124. doi: 10.1371/journal.pone.0126124. eCollection 2015.


Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris.

Klinke S, Otero LH, Rinaldi J, Sosa S, Guimarães BG, Shepard WE, Goldbaum FA, Bonomi HR.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1636-9. doi: 10.1107/S2053230X14023243. Epub 2014 Nov 14.


Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand-alone TPM domain.

Aran M, Smal C, Pellizza L, Gallo M, Otero LH, Klinke S, Goldbaum FA, Ithurralde ER, Bercovich A, Mac Cormack WP, Turjanski AG, Cicero DO.

Proteins. 2014 Nov;82(11):3062-78. doi: 10.1002/prot.24667. Epub 2014 Sep 3.


Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility.

Serer MI, Bonomi HR, Guimarães BG, Rossi RC, Goldbaum FA, Klinke S.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1419-34. doi: 10.1107/S1399004714005161. Epub 2014 Apr 30.


Identification and characterization of RibN, a novel family of riboflavin transporters from Rhizobium leguminosarum and other proteobacteria.

García Angulo VA, Bonomi HR, Posadas DM, Serer MI, Torres AG, Zorreguieta Á, Goldbaum FA.

J Bacteriol. 2013 Oct;195(20):4611-9. doi: 10.1128/JB.00644-13. Epub 2013 Aug 9.


Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice.

Mejias MP, Ghersi G, Craig PO, Panek CA, Bentancor LV, Baschkier A, Goldbaum FA, Zylberman V, Palermo MS.

J Immunol. 2013 Sep 1;191(5):2403-11. doi: 10.4049/jimmunol.1300999. Epub 2013 Aug 5.


The vaccine candidate BLSOmp31 protects mice against Brucella canis infection.

Clausse M, Díaz AG, Ghersi G, Zylberman V, Cassataro J, Giambartolomei GH, Goldbaum FA, Estein SM.

Vaccine. 2013 Dec 9;31(51):6129-35. doi: 10.1016/j.vaccine.2013.07.041. Epub 2013 Jul 30.


Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.

Díaz AG, Clausse M, Paolicchi FA, Fiorentino MA, Ghersi G, Zylberman V, Goldbaum FA, Estein SM.

Vet Immunol Immunopathol. 2013 Jul 15;154(1-2):36-41. doi: 10.1016/j.vetimm.2013.04.003. Epub 2013 Apr 11.


The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs.

Menzel S, Rissiek B, Haag F, Goldbaum FA, Koch-Nolte F.

FEBS J. 2013 Aug;280(15):3543-50. doi: 10.1111/febs.12313. Epub 2013 Jun 14. Review.


The two-component systems PrrBA and NtrYX co-ordinately regulate the adaptation of Brucella abortus to an oxygen-limited environment.

Carrica Mdel C, Fernandez I, Sieira R, Paris G, Goldbaum FA.

Mol Microbiol. 2013 Apr;88(2):222-33. doi: 10.1111/mmi.12181. Epub 2013 Mar 26.


A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants.

Berguer PM, Alzogaray VA, Rossi AH, Mundiñano J, Piazzon I, Goldbaum FA.

PLoS One. 2012;7(9):e45705. doi: 10.1371/journal.pone.0045705. Epub 2012 Sep 24.


Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor.

Bonomi HR, Posadas DM, Paris G, Carrica Mdel C, Frederickson M, Pietrasanta LI, Bogomolni RA, Zorreguieta A, Goldbaum FA.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12135-40. doi: 10.1073/pnas.1121292109. Epub 2012 Jul 5.


The NtrY/X two-component system of Brucella spp. acts as a redox sensor and regulates the expression of nitrogen respiration enzymes.

Carrica Mdel C, Fernandez I, Martí MA, Paris G, Goldbaum FA.

Mol Microbiol. 2012 Jul;85(1):39-50. doi: 10.1111/j.1365-2958.2012.08095.x. Epub 2012 May 30.


The β-scaffold of the LOV domain of the Brucella light-activated histidine kinase is a key element for signal transduction.

Rinaldi J, Gallo M, Klinke S, Paris G, Bonomi HR, Bogomolni RA, Cicero DO, Goldbaum FA.

J Mol Biol. 2012 Jun 29;420(1-2):112-27. doi: 10.1016/j.jmb.2012.04.006. Epub 2012 Apr 11.


Polymeric Display of Proteins through High Affinity Leucine Zipper Peptide Adaptors.

Craig PO, Alzogaray V, Goldbaum FA.

Biomacromolecules. 2012 Apr 9;13(4):1112-21. doi: 10.1021/bm201875p. Epub 2012 Mar 20.


Heterologous prime-boost oral immunization with GK-1 peptide from Taenia crassiceps cysticerci induces protective immunity.

Fragoso G, Esquivel-Guadarrama F, Santana MA, Bobes RJ, Hernández B, Cervantes J, Segura R, Goldbaum FA, Sciutto E, Rosas G.

Clin Vaccine Immunol. 2011 Jul;18(7):1067-76. doi: 10.1128/CVI.05030-11. Epub 2011 May 18.


YqiC of Salmonella enterica serovar Typhimurium is a membrane fusogenic protein required for mice colonization.

Carrica MC, Craig PO, García-Angulo VA, Aguirre A, García-Véscovi E, Goldbaum FA, Cravero SL.

BMC Microbiol. 2011 May 9;11:95. doi: 10.1186/1471-2180-11-95.


Sensing the dissociation of a polymeric enzyme by means of an engineered intrinsic probe.

Ainciart N, Zylberman V, Craig PO, Nygaard D, Bonomi HR, Cauerhff AA, Goldbaum FA.

Proteins. 2011 Apr;79(4):1079-88. doi: 10.1002/prot.22945. Epub 2011 Jan 18.


Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium.

Alzogaray V, Danquah W, Aguirre A, Urrutia M, Berguer P, García Véscovi E, Haag F, Koch-Nolte F, Goldbaum FA.

FASEB J. 2011 Feb;25(2):526-34. doi: 10.1096/fj.10-162958. Epub 2010 Oct 12.


An atypical riboflavin pathway is essential for Brucella abortus virulence.

Bonomi HR, Marchesini MI, Klinke S, Ugalde JE, Zylberman V, Ugalde RA, Comerci DJ, Goldbaum FA.

PLoS One. 2010 Feb 25;5(2):e9435. doi: 10.1371/journal.pone.0009435.


Single domain antibodies are specially suited for quantitative determination of gliadins under denaturing conditions.

Doña V, Urrutia M, Bayardo M, Alzogaray V, Goldbaum FA, Chirdo FG.

J Agric Food Chem. 2010 Jan 27;58(2):918-26. doi: 10.1021/jf902973c.


The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams.

Estein SM, Fiorentino MA, Paolicchi FA, Clausse M, Manazza J, Cassataro J, Giambartolomei GH, Coria LM, Zylberman V, Fossati CA, Kjeken R, Goldbaum FA.

Vaccine. 2009 Nov 12;27(48):6704-11. doi: 10.1016/j.vaccine.2009.08.097. Epub 2009 Sep 11.


Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze DV, Goldbaum FA, Haag F, Koch-Nolte F.

Med Microbiol Immunol. 2009 Aug;198(3):157-74. doi: 10.1007/s00430-009-0116-7. Epub 2009 Jun 16. Review.


Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system.

Bellido D, Craig PO, Mozgovoj MV, Gonzalez DD, Wigdorovitz A, Goldbaum FA, Dus Santos MJ.

Vaccine. 2009 Jan 1;27(1):136-45. doi: 10.1016/j.vaccine.2008.10.018. Epub 2008 Oct 28.


Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies.

Ratier L, Urrutia M, Paris G, Zarebski L, Frasch AC, Goldbaum FA.

PLoS One. 2008;3(10):e3524. doi: 10.1371/journal.pone.0003524. Epub 2008 Oct 24.

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