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Items: 1 to 50 of 89

1.

Protective effect of a locked retinal chromophore analogue against light-induced retinal degeneration.

Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B.

Mol Pharmacol. 2018 Jul 17. pii: mol.118.112581. doi: 10.1124/mol.118.112581. [Epub ahead of print]

2.

The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin.

Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J.

ACS Chem Biol. 2018 Aug 17;13(8):2121-2129. doi: 10.1021/acschembio.8b00290. Epub 2018 Jun 15.

PMID:
29883100
3.

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K.

Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.

4.

Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor.

Gorelenkova Miller O, Cole KS, Emerson CC, Allimuthu D, Golczak M, Stewart PL, Weerapana E, Adams DJ, Mieyal JJ.

PLoS One. 2017 Nov 20;12(11):e0187991. doi: 10.1371/journal.pone.0187991. eCollection 2017.

5.

Transcription factor ISX mediates the cross talk between diet and immunity.

Widjaja-Adhi MAK, Palczewski G, Dale K, Knauss EA, Kelly ME, Golczak M, Levine AD, von Lintig J.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11530-11535. doi: 10.1073/pnas.1714963114. Epub 2017 Oct 9.

6.

Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis.

Chelstowska S, Widjaja-Adhi MAK, Silvaroli JA, Golczak M.

Biochemistry. 2017 Aug 29;56(34):4489-4499. doi: 10.1021/acs.biochem.7b00451. Epub 2017 Aug 15.

PMID:
28758396
7.

Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M.

ACS Chem Biol. 2017 Sep 15;12(9):2296-2304. doi: 10.1021/acschembio.7b00336. Epub 2017 Jul 26.

PMID:
28708375
8.

Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas.

Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K.

Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.

9.

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K.

J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.

10.

Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2.

Arne JM, Widjaja-Adhi MA, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S, Moiseenkova-Bell VY, Golczak M.

J Lipid Res. 2017 Apr;58(4):719-730. doi: 10.1194/jlr.M073692. Epub 2017 Jan 17.

11.

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.

Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K.

J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.

12.

Molecular Basis for Vitamin A Uptake and Storage in Vertebrates.

Chelstowska S, Widjaja-Adhi MA, Silvaroli JA, Golczak M.

Nutrients. 2016 Oct 26;8(11). pii: E676. Review.

13.

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD.

J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.

14.

Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism.

Palczewski G, Widjaja-Adhi MA, Amengual J, Golczak M, von Lintig J.

J Lipid Res. 2016 Sep;57(9):1684-95. doi: 10.1194/jlr.M069021. Epub 2016 Jul 7.

15.

Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures.

Silvaroli JA, Arne JM, Chelstowska S, Kiser PD, Banerjee S, Golczak M.

J Biol Chem. 2016 Apr 15;291(16):8528-40. doi: 10.1074/jbc.M116.714535. Epub 2016 Feb 21.

16.

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease.

Johnson WM, Golczak M, Choe K, Curran PL, Miller OG, Yao C, Wang W, Lin J, Milkovic NM, Ray A, Ravindranath V, Zhu X, Wilson MA, Wilson-Delfosse AL, Chen SG, Mieyal JJ.

Biochemistry. 2016 Aug 16;55(32):4519-32. doi: 10.1021/acs.biochem.5b01132. Epub 2016 Aug 1.

17.

The Biochemical Basis of Vitamin A3 Production in Arthropod Vision.

Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J.

ACS Chem Biol. 2016 Apr 15;11(4):1049-57. doi: 10.1021/acschembio.5b00967. Epub 2016 Feb 2.

18.

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases.

Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD.

J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23.

19.

Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.

Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J.

J Biol Chem. 2015 Oct 9;290(41):24844-57. doi: 10.1074/jbc.M115.668822. Epub 2015 Aug 25.

20.

Retinylamine Benefits Early Diabetic Retinopathy in Mice.

Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS.

J Biol Chem. 2015 Aug 28;290(35):21568-79. doi: 10.1074/jbc.M115.655555. Epub 2015 Jul 2.

21.

Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K.

J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun 15.

22.

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.

Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K.

Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr 20.

23.

A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption.

Widjaja-Adhi MA, Lobo GP, Golczak M, Von Lintig J.

Hum Mol Genet. 2015 Jun 1;24(11):3206-19. doi: 10.1093/hmg/ddv072. Epub 2015 Feb 20.

24.

Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.

Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR.

Biomaterials. 2015 Mar;44:103-10. doi: 10.1016/j.biomaterials.2014.12.019. Epub 2015 Jan 12.

25.

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.

Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M.

Mol Pharmacol. 2015;87(3):477-91. doi: 10.1124/mol.114.096560. Epub 2014 Dec 23.

26.

Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice.

Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR.

Biomacromolecules. 2014 Dec 8;15(12):4570-8. doi: 10.1021/bm501352s. Epub 2014 Nov 20.

27.

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.

Golczak M, Sears AE, Kiser PD, Palczewski K.

Nat Chem Biol. 2015 Jan;11(1):26-32. doi: 10.1038/nchembio.1687. Epub 2014 Nov 10.

28.

Endogenous fluorophores enable two-photon imaging of the primate eye.

Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4438-47. doi: 10.1167/iovs.14-14395.

29.

Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.

Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K.

Nat Med. 2014 Jul;20(7):785-9. doi: 10.1038/nm.3590. Epub 2014 Jun 22.

30.

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase.

Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD.

Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9.

31.

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K.

FASEB J. 2014 Aug;28(8):3780-91. doi: 10.1096/fj.14-254292. Epub 2014 May 8.

32.

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.

Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1428-37. doi: 10.1073/pnas.1317986111. Epub 2014 Mar 24.

33.

Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO).

Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K.

J Biol Chem. 2014 May 2;289(18):12286-99. doi: 10.1074/jbc.M114.552836. Epub 2014 Mar 19.

34.

Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity.

Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A.

J Am Chem Soc. 2014 Jan 8;136(1):137-46. doi: 10.1021/ja411366w. Epub 2013 Dec 20.

35.

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.

Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K.

J Clin Invest. 2013 Dec;123(12):5119-34. doi: 10.1172/JCI69076. Epub 2013 Nov 15.

36.

Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.

Amengual J, Widjaja-Adhi MA, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J.

J Biol Chem. 2013 Nov 22;288(47):34081-96. doi: 10.1074/jbc.M113.501049. Epub 2013 Oct 8.

37.

Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates.

Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M.

J Phys Chem B. 2013 Sep 19;117(37):10719-29. doi: 10.1021/jp405410t. Epub 2013 Sep 10.

PMID:
23964907
38.

Chemistry of the retinoid (visual) cycle.

Kiser PD, Golczak M, Palczewski K.

Chem Rev. 2014 Jan 8;114(1):194-232. doi: 10.1021/cr400107q. Epub 2013 Jul 11. Review. No abstract available.

39.

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection.

Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J.

J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. Epub 2013 Feb 20.

40.

Asymmetry of the rhodopsin dimer in complex with transducin.

Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K.

FASEB J. 2013 Apr;27(4):1572-84. doi: 10.1096/fj.12-225383. Epub 2013 Jan 9.

41.

Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein.

Amengual J, Golczak M, Palczewski K, von Lintig J.

J Biol Chem. 2012 Jul 13;287(29):24216-27. doi: 10.1074/jbc.M112.353979. Epub 2012 May 27.

42.

Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.

Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K.

J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.

43.

Melanopsin is highly resistant to light and chemical bleaching in vivo.

Sexton TJ, Golczak M, Palczewski K, Van Gelder RN.

J Biol Chem. 2012 Jun 15;287(25):20888-97. doi: 10.1074/jbc.M111.325969. Epub 2012 Apr 30.

44.

Retinal photodamage mediated by all-trans-retinal.

Maeda T, Golczak M, Maeda A.

Photochem Photobiol. 2012 Nov-Dec;88(6):1309-19. doi: 10.1111/j.1751-1097.2012.01143.x. Epub 2012 Apr 24. Review.

45.

Primary amines protect against retinal degeneration in mouse models of retinopathies.

Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K.

Nat Chem Biol. 2011 Dec 25;8(2):170-8. doi: 10.1038/nchembio.759.

46.

Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.

Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K.

J Biol Chem. 2012 Feb 10;287(7):5059-69. doi: 10.1074/jbc.M111.315432. Epub 2011 Dec 19.

47.

Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization.

Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.

J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.

48.

Role of bulk water in hydrolysis of the rhodopsin chromophore.

Jastrzebska B, Palczewski K, Golczak M.

J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.

49.

Key enzymes of the retinoid (visual) cycle in vertebrate retina.

Kiser PD, Golczak M, Maeda A, Palczewski K.

Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5. Review.

50.

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations.

Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K.

J Biol Chem. 2011 Mar 25;286(12):10551-67. doi: 10.1074/jbc.M110.209759. Epub 2011 Jan 11.

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