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Items: 1 to 50 of 202


Opportunities and challenges for transcriptome-wide association studies.

Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A.

Nat Genet. 2019 Apr;51(4):592-599. doi: 10.1038/s41588-019-0385-z. Epub 2019 Mar 29. Review.


Bayesian-based noninvasive prenatal diagnosis of single-gene disorders.

Rabinowitz T, Polsky A, Golan D, Danilevsky A, Shapira G, Raff C, Basel-Salmon L, Matar RT, Shomron N.

Genome Res. 2019 Mar;29(3):428-438. doi: 10.1101/gr.235796.118. Epub 2019 Feb 20.


Validity of a multi-domain computerized cognitive assessment battery for patients with multiple sclerosis.

Golan D, Wilken J, Doniger GM, Fratto T, Kane R, Srinivasan J, Zarif M, Bumstead B, Buhse M, Fafard L, Topalli I, Gudesblatt M.

Mult Scler Relat Disord. 2019 May;30:154-162. doi: 10.1016/j.msard.2019.01.051. Epub 2019 Jan 30.


Artificial intelligence, machine learning and the evolution of healthcare: A bright future or cause for concern?

Jones LD, Golan D, Hanna SA, Ramachandran M.

Bone Joint Res. 2018 May 5;7(3):223-225. doi: 10.1302/2046-3758.73.BJR-2017-0147.R1. eCollection 2018 Mar. No abstract available.


Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression.

Calderon D, Bhaskar A, Knowles DA, Golan D, Raj T, Fu AQ, Pritchard JK.

Am J Hum Genet. 2017 Nov 2;101(5):686-699. doi: 10.1016/j.ajhg.2017.09.009. Epub 2017 Oct 26.


NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L; NIH Centers for Accelerated Innovations.

Nat Rev Drug Discov. 2017 Oct;16(10):663-664. doi: 10.1038/nrd.2017.131. Epub 2017 Aug 4. No abstract available.


Building Workforce Capacity Abroad While Strengthening Global Health Programs at Home: Participation of Seven Harvard-Affiliated Institutions in a Health Professional Training Initiative in Rwanda.

Cancedda C, Riviello R, Wilson K, Scott KW, Tuteja M, Barrow JR, Hedt-Gauthier B, Bukhman G, Scott J, Milner D, Raviola G, Weissman B, Smith S, Nuthulaganti T, McClain CD, Bierer BE, Farmer PE, Becker AE, Binagwaho A, Rhatigan J, Golan DE.

Acad Med. 2017 May;92(5):649-658. doi: 10.1097/ACM.0000000000001638.


The impact of subjective cognitive fatigue and depression on cognitive function in patients with multiple sclerosis.

Golan D, Doniger GM, Wissemann K, Zarif M, Bumstead B, Buhse M, Fafard L, Lavi I, Wilken J, Gudesblatt M.

Mult Scler. 2018 Feb;24(2):196-204. doi: 10.1177/1352458517695470. Epub 2017 Feb 1.


Detection of human adaptation during the past 2000 years.

Field Y, Boyle EA, Telis N, Gao Z, Gaulton KJ, Golan D, Yengo L, Rocheleau G, Froguel P, McCarthy MI, Pritchard JK.

Science. 2016 Nov 11;354(6313):760-764. Epub 2016 Oct 13.


Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis.

Golan D, Miller A, Sotirchos ES, Bhargava P, Calabresi PA.

Neurology. 2016 Jul 26;87(4):446. doi: 10.1212/01.wnl.0000490142.79912.ff. No abstract available.


RNA splicing is a primary link between genetic variation and disease.

Li YI, van de Geijn B, Raj A, Knowles DA, Petti AA, Golan D, Gilad Y, Pritchard JK.

Science. 2016 Apr 29;352(6285):600-4. doi: 10.1126/science.aad9417. Epub 2016 Apr 28.


Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk.

Tehranchi AK, Myrthil M, Martin T, Hie BL, Golan D, Fraser HB.

Cell. 2016 Apr 21;165(3):730-41. doi: 10.1016/j.cell.2016.03.041. Epub 2016 Apr 14.


Shifting paradigms in multiple sclerosis: from disease-specific, through population-specific toward patient-specific.

Golan D, Staun-Ram E, Miller A.

Curr Opin Neurol. 2016 Jun;29(3):354-61. doi: 10.1097/WCO.0000000000000324. Review.


NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.

Chiasson-MacKenzie C, Morris ZS, Baca Q, Morris B, Coker JK, Mirchev R, Jensen AE, Carey T, Stott SL, Golan DE, McClatchey AI.

J Cell Biol. 2015 Oct 26;211(2):391-405. doi: 10.1083/jcb.201503081. Epub 2015 Oct 19.


Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation.

Golan D, Rosset S, Lander ES.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5452-3. doi: 10.1073/pnas.1511370112. Epub 2015 Sep 28. No abstract available.


Cognitive Function of Patients with Crohn's Disease is Associated with Intestinal Disease Activity.

Golan D, Gross B, Miller A, Klil-Drori S, Lavi I, Shiller M, Honigman S, Almog R, Segol O.

Inflamm Bowel Dis. 2016 Feb;22(2):364-71. doi: 10.1097/MIB.0000000000000594.


Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients.

Edvardson S, Gerhard F, Jalas C, Lachmann J, Golan D, Saada A, Shaag A, Ungermann C, Elpeleg O.

J Med Genet. 2015 Nov;52(11):749-53. doi: 10.1136/jmedgenet-2015-103239. Epub 2015 Aug 25.



Golan D, Linn S.

Harefuah. 2015 Jun;154(6):389-93, 403. Review. Hebrew.


Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum.

Isakov O, Bordería AV, Golan D, Hamenahem A, Celniker G, Yoffe L, Blanc H, Vignuzzi M, Shomron N.

Bioinformatics. 2015 Jul 1;31(13):2141-50. doi: 10.1093/bioinformatics/btv101. Epub 2015 Feb 19.


Late diagnosis of autism spectrum disorder after initial negative assessment by a multidisciplinary team.

Davidovitch M, Levit-Binnun N, Golan D, Manning-Courtney P.

J Dev Behav Pediatr. 2015 May;36(4):227-34. doi: 10.1097/DBP.0000000000000133.


Measuring missing heritability: inferring the contribution of common variants.

Golan D, Lander ES, Rosset S.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5272-81. doi: 10.1073/pnas.1419064111. Epub 2014 Nov 24.


Effective genetic-risk prediction using mixed models.

Golan D, Rosset S.

Am J Hum Genet. 2014 Oct 2;95(4):383-93. doi: 10.1016/j.ajhg.2014.09.007.


Membrane protein dynamics and functional implications in mammalian cells.

Alenghat FJ, Golan DE.

Curr Top Membr. 2013;72:89-120. doi: 10.1016/B978-0-12-417027-8.00003-9.


Statistical modeling of coverage in high-throughput data.

Golan D, Rosset S.

Methods Mol Biol. 2013;1038:61-79. doi: 10.1007/978-1-62703-514-9_4.


Using state machines to model the Ion Torrent sequencing process and to improve read error rates.

Golan D, Medvedev P.

Bioinformatics. 2013 Jul 1;29(13):i344-51. doi: 10.1093/bioinformatics/btt212.


Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta: a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties.

Golan D, Halhal B, Glass-Marmor L, Staun-Ram E, Rozenberg O, Lavi I, Dishon S, Barak M, Ish-Shalom S, Miller A.

BMC Neurol. 2013 Jun 14;13:60. doi: 10.1186/1471-2377-13-60.


The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis.

Golan D, Staun-Ram E, Glass-Marmor L, Lavi I, Rozenberg O, Dishon S, Barak M, Ish-Shalom S, Miller A.

Brain Behav Immun. 2013 Aug;32:180-5. doi: 10.1016/j.bbi.2013.04.010. Epub 2013 May 7.


Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers.

Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D, Laitman Y, Barshack I, Friedman E, Shomron N.

Breast Cancer Res Treat. 2013 Apr;138(3):753-60. doi: 10.1007/s10549-013-2502-5. Epub 2013 Apr 3.


Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.

Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM.

J Virol. 2013 May;87(9):5019-27. doi: 10.1128/JVI.00007-13. Epub 2013 Feb 20.


Identifying personal genomes by surname inference.

Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y.

Science. 2013 Jan 18;339(6117):321-4. doi: 10.1126/science.1229566.


Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD.

J Cell Sci. 2012 Nov 15;125(Pt 22):5535-45. doi: 10.1242/jcs.111260. Epub 2012 Sep 12.


MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability.

Jin BY, Lin AJ, Golan DE, Michel T.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14864-9. doi: 10.1073/pnas.1204974109. Epub 2012 Aug 27.


Weighted pooling--practical and cost-effective techniques for pooled high-throughput sequencing.

Golan D, Erlich Y, Rosset S.

Bioinformatics. 2012 Jun 15;28(12):i197-206. doi: 10.1093/bioinformatics/bts208.


Comment on "the predictive capacity of personal genome sequencing".

Golan D, Rosset S.

Sci Transl Med. 2012 May 23;4(135):135le4; author reply 135lr3. doi: 10.1126/scitranslmed.3004197. No abstract available.


lobSTR: A short tandem repeat profiler for personal genomes.

Gymrek M, Golan D, Rosset S, Erlich Y.

Genome Res. 2012 Jun;22(6):1154-62. doi: 10.1101/gr.135780.111. Epub 2012 Apr 20.


CD151 restricts the α6 integrin diffusion mode.

Yang XH, Mirchev R, Deng X, Yacono P, Yang HL, Golan DE, Hemler ME.

J Cell Sci. 2012 Mar 15;125(Pt 6):1478-87. doi: 10.1242/jcs.093963. Epub 2012 Feb 10.


Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis.

Melamud L, Golan D, Luboshitzky R, Lavi I, Miller A.

J Neurol Sci. 2012 Mar 15;314(1-2):37-40. doi: 10.1016/j.jns.2011.11.003. Epub 2011 Dec 1.


Feed-forward microprocessing and splicing activities at a microRNA-containing intron.

Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD.

PLoS Genet. 2011 Oct;7(10):e1002330. doi: 10.1371/journal.pgen.1002330. Epub 2011 Oct 20.


Membrane compartmentalization in Southeast Asian ovalocytosis red blood cells.

Mirchev R, Lam A, Golan DE.

Br J Haematol. 2011 Oct;155(1):111-21. doi: 10.1111/j.1365-2141.2011.08805.x. Epub 2011 Jul 27.


Accurate estimation of heritability in genome wide studies using random effects models.

Golan D, Rosset S.

Bioinformatics. 2011 Jul 1;27(13):i317-23. doi: 10.1093/bioinformatics/btr219.


Revisiting the statistical analysis of the Israeli-Palestinian conflict.

Golan D, Rosenblatt JD.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):E53-4; author reply E55-6. doi: 10.1073/pnas.1016378108. Epub 2011 Apr 4. No abstract available.


Israeli children with autism spectrum disorder are not macrocephalic.

Davidovitch M, Golan D, Vardi O, Lev D, Lerman-Sagie T.

J Child Neurol. 2011 May;26(5):580-5. doi: 10.1177/0883073810387666. Epub 2011 Apr 4.


Analysis of molecular diffusion by first-passage time variance identifies the size of confinement zones.

Rajani V, Carrero G, Golan DE, de Vries G, Cairo CW.

Biophys J. 2011 Mar 16;100(6):1463-72. doi: 10.1016/j.bpj.2011.01.064.


Ligation of complement receptor 1 increases erythrocyte membrane deformability.

Glodek AM, Mirchev R, Golan DE, Khoory JA, Burns JM, Shevkoplyas SS, Nicholson-Weller A, Ghiran IC.

Blood. 2010 Dec 23;116(26):6063-71. doi: 10.1182/blood-2010-04-273904. Epub 2010 Sep 22.


Biased hosting of intronic microRNA genes.

Golan D, Levy C, Friedman B, Shomron N.

Bioinformatics. 2010 Apr 15;26(8):992-5. doi: 10.1093/bioinformatics/btq077. Epub 2010 Feb 24.


Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells.

Cairo CW, Das R, Albohy A, Baca QJ, Pradhan D, Morrow JS, Coombs D, Golan DE.

J Biol Chem. 2010 Apr 9;285(15):11392-401. doi: 10.1074/jbc.M109.075648. Epub 2010 Feb 17.


Patients with multiple sclerosis in a war zone: coping strategies associated with reduced risk for relapse.

Somer E, Golan D, Dishon S, Cuzin-Disegni L, Lavi I, Miller A.

Mult Scler. 2010 Apr;16(4):463-71. doi: 10.1177/1352458509358714. Epub 2010 Jan 19.


An evolutionary perspective of animal microRNAs and their targets.

Shomron N, Golan D, Hornstein E.

J Biomed Biotechnol. 2009;2009:594738. doi: 10.1155/2009/594738. Epub 2009 Sep 14. Review.


Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.

Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE.

Am J Physiol Cell Physiol. 2009 Aug;297(2):C263-77. doi: 10.1152/ajpcell.00527.2008. Epub 2009 Apr 22.


C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex.

Karnchanaphanurach P, Mirchev R, Ghiran I, Asara JM, Papahadjopoulos-Sternberg B, Nicholson-Weller A, Golan DE.

J Clin Invest. 2009 Apr;119(4):788-801. doi: 10.1172/JCI36088. Epub 2009 Mar 2.

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