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Laser-free GHz stroboscopic transmission electron microscope: Components, system integration, and practical considerations for pump-probe measurements.

Lau JW, Schliep KB, Katz MB, Gokhale VJ, Gorman JJ, Jing C, Liu A, Zhao Y, Montgomery E, Choe H, Rush W, Kanareykin A, Fu X, Zhu Y.

Rev Sci Instrum. 2020 Feb 1;91(2):021301. doi: 10.1063/1.5131758.


In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.

Montoya JJ, Turnidge MA, Wai DH, Patel AR, Lee DW, Gokhale V, Hurley LH, Arceci RJ, Wetmore C, Azorsa DO.

BMC Cancer. 2019 Dec 27;19(1):1251. doi: 10.1186/s12885-019-6464-9.


Glucose Monitoring in Critically Ill: Is Absence of "Stress Hyperglycemia" a Cause for Concern?

Gokhale V, Batra T, Shinde SS, Gulati S, Kakrani AL.

J Assoc Physicians India. 2019 Apr;67(4):43-46.


Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).

François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M.

ACS Chem Biol. 2019 Sep 20;14(9):2006-2013. doi: 10.1021/acschembio.9b00481. Epub 2019 Aug 27.


Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.

Song JH, Kang HJ, Luevano LA, Gokhale V, Wu K, Pandey R, Sherry Chow HH, Hurley LH, Kraft AS.

Cell Chem Biol. 2019 Aug 15;26(8):1110-1121.e4. doi: 10.1016/j.chembiol.2019.04.009. Epub 2019 May 30.


Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA, Bellampalli SS, Luo S, François-Moutal L, Serafini MJ, Ha T, Perez-Miller S, Park KD, Patwardhan AM, Streicher JM, Colecraft HM, Khanna M.

Pain. 2019 Jul;160(7):1644-1661. doi: 10.1097/j.pain.0000000000001524.


A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M.

ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6.


Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.

François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R.

Channels (Austin). 2018;12(1):219-227. doi: 10.1080/19336950.2018.1491244. Epub 2018 Aug 6.


Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R.

Pain. 2018 Oct;159(10):2115-2127. doi: 10.1097/j.pain.0000000000001294.


Unusual Presentation of Injection Site Adverse Effect.

Sahasrabudhe R, Limaye T, Gokhale V.

J Assoc Physicians India. 2017 Nov;65(11):96-97.


Approaching the intrinsic quality factor limit for micromechanical bulk acoustic resonators using phononic crystal tethers.

Gokhale VJ, Gorman JJ.

Appl Phys Lett. 2017;111(1). pii: 013501. doi: 10.1063/1.4990960. Epub 2017 Jul 5.


Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.

Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC.

Nucleic Acids Res. 2018 Jan 25;46(2):886-896. doi: 10.1093/nar/gkx1122.


Insulin Injection Site Adverse Effect in a Type 1 Diabetes Patient: An Unusual Presentation.

Sahasrabudhe RA, Limaye TY, Gokhale VS.

J Clin Diagn Res. 2017 Aug;11(8):OD10-OD11. doi: 10.7860/JCDR/2017/28919.10433. Epub 2017 Aug 1.


Incidence, Risk Factors, and Outcomes of Retinal Detachment after Pediatric Cataract Surgery.

Agarkar S, Gokhale VV, Raman R, Bhende M, Swaminathan G, Jain M.

Ophthalmology. 2018 Jan;125(1):36-42. doi: 10.1016/j.ophtha.2017.07.003. Epub 2017 Aug 24.


Dyrk1 inhibition improves Alzheimer's disease-like pathology.

Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A, Oddo S.

Aging Cell. 2017 Oct;16(5):1146-1154. doi: 10.1111/acel.12648. Epub 2017 Aug 4.


A simple mathematical approach to the analysis of polypharmacology and polyspecificity data.

Maggiora G, Gokhale V.

F1000Res. 2017 Jun 6;6. pii: Chem Inf Sci-788. doi: 10.12688/f1000research.11517.1. eCollection 2017.


Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth.

Kendrick S, Muranyi A, Gokhale V, Hurley LH, Rimsza LM.

J Med Chem. 2017 Aug 10;60(15):6587-6597. doi: 10.1021/acs.jmedchem.7b00298. Epub 2017 Jul 25.


The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.

Brown RV, Wang T, Chappeta VR, Wu G, Onel B, Chawla R, Quijada H, Camp SM, Chiang ET, Lassiter QR, Lee C, Phanse S, Turnidge MA, Zhao P, Garcia JGN, Gokhale V, Yang D, Hurley LH.

J Am Chem Soc. 2017 Jun 7;139(22):7456-7475. doi: 10.1021/jacs.6b10028. Epub 2017 May 19.


Persistent Pupillary Membrane.

Gokhale V, Agarkar S.

N Engl J Med. 2017 Feb 9;376(6):561. doi: 10.1056/NEJMicm1507964. No abstract available.


Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R.

Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17.


Unexplained Persistent Hyperglycaemia in a Type I Diabetes Patient - Is Injection Site Lipohypertrophy the Cause?

Sahasrabudhe RA, Limaye TY, Gokhale VS.

J Clin Diagn Res. 2016 Sep;10(9):OD05-OD06. Epub 2016 Sep 1.


A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters.

Kang HJ, Cui Y, Yin H, Scheid A, Hendricks WPD, Schmidt J, Sekulic A, Kong D, Trent JM, Gokhale V, Mao H, Hurley LH.

J Am Chem Soc. 2016 Oct 19;138(41):13673-13692. doi: 10.1021/jacs.6b07598. Epub 2016 Oct 5.


Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure".

Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH.

J Am Chem Soc. 2016 Sep 7;138(35):11408. doi: 10.1021/jacs.6b07292. Epub 2016 Aug 29. No abstract available.


TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Amin AD, Li L, Rajan SS, Gokhale V, Groysman MJ, Pongtornpipat P, Tapia EO, Wang M, Schatz JH.

Oncotarget. 2016 Apr 26;7(17):23715-29. doi: 10.18632/oncotarget.8173.


Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

Shen K, Ramirez B, Mapes B, Shen GR, Gokhale V, Brown ME, Santarsiero B, Ishii Y, Dudek SM, Wang T, Garcia JG.

PLoS One. 2015 Jun 25;10(6):e0130515. doi: 10.1371/journal.pone.0130515. eCollection 2015.


The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Davis AL, Qiao S, Lesson JL, Rojo de la Vega M, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT.

J Biol Chem. 2015 Jan 16;290(3):1623-38. doi: 10.1074/jbc.M114.592626. Epub 2014 Dec 4.


Clinical and nerve conduction study correlation in patients of diabetic neuropathy.

Kakrani AL, Gokhale VS, Vohra KV, Chaudhary N.

J Assoc Physicians India. 2014 Jan;62(1):24-7.


An acute unusual presentation of hepatocellular carcinoma.

Sharma ZD, Gokhale VS, Chaudhari N, Kakrani AL.

J Cancer Res Ther. 2014 Apr-Jun;10(2):401-3. doi: 10.4103/0973-1482.136671.


Phonon-electron interactions in piezoelectric semiconductor bulk acoustic wave resonators.

Gokhale VJ, Rais-Zadeh M.

Sci Rep. 2014 Jul 8;4:5617. doi: 10.1038/srep05617.


Effect of Basti (oil enema) therapy for the management of cough in pertussis.

Gujarathi RH, Gokhale VM, Tongaonkar JN.

Ayu. 2013 Oct;34(4):397-400. doi: 10.4103/0974-8520.127722.


The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.

Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH.

J Am Chem Soc. 2014 Mar 19;136(11):4161-71. doi: 10.1021/ja410934b. Epub 2014 Mar 7. Erratum in: J Am Chem Soc. 2016 Sep 7;138(35):11408.


Detection of Escherichia fergusonii by PCR-based DNA sequencing in a case of delayed-onset chronic endophthalmitis after cataract surgery.

Gokhale VV, Therese KL, Bagyalakshmi R, Biswas J.

J Cataract Refract Surg. 2014 Feb;40(2):327-30. doi: 10.1016/j.jcrs.2013.12.006.


Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.

Medda F, Sells E, Chang HH, Dietrich J, Chappeta S, Smith B, Gokhale V, Meuillet EJ, Hulme C.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):528-31. doi: 10.1016/j.bmcl.2012.11.030. Epub 2012 Nov 21.


Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

Smith B, Medda F, Gokhale V, Dunckley T, Hulme C.

ACS Chem Neurosci. 2012 Nov 21;3(11):857-72. doi: 10.1021/cn300094k. Epub 2012 Aug 28. Review.


Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.

Jagadish B, Guntle GP, Zhao D, Gokhale V, Ozumerzifon TJ, Ahad AM, Mash EA, Raghunand N.

J Med Chem. 2012 Dec 13;55(23):10378-86. doi: 10.1021/jm300736f. Epub 2012 Nov 28.


Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

Boddupally PV, Hahn S, Beman C, De B, Brooks TA, Gokhale V, Hurley LH.

J Med Chem. 2012 Jul 12;55(13):6076-86. doi: 10.1021/jm300282c. Epub 2012 Jun 25.


Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Smith B, Chang HH, Medda F, Gokhale V, Dietrich J, Davis A, Meuillet EJ, Hulme C.

Bioorg Med Chem Lett. 2012 May 15;22(10):3567-70. doi: 10.1016/j.bmcl.2012.03.013. Epub 2012 Mar 28.


Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.

Yu Z, Gaerig V, Cui Y, Kang H, Gokhale V, Zhao Y, Hurley LH, Mao H.

J Am Chem Soc. 2012 Mar 21;134(11):5157-64. doi: 10.1021/ja210399h. Epub 2012 Mar 9.


Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.

Brown RV, Danford FL, Gokhale V, Hurley LH, Brooks TA.

J Biol Chem. 2011 Nov 25;286(47):41018-27. doi: 10.1074/jbc.M111.274720. Epub 2011 Sep 28.


Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.

Chang HH, Song Z, Wisner L, Tripp T, Gokhale V, Meuillet EJ.

Invest New Drugs. 2012 Oct;30(5):1865-77. doi: 10.1007/s10637-011-9748-8. Epub 2011 Sep 20.


Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging.

Raghunand N, Guntle GP, Gokhale V, Nichol GS, Mash EA, Jagadish B.

J Med Chem. 2010 Sep 23;53(18):6747-57. doi: 10.1021/jm100592u.


mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".

Nakanishi M, Gokhale V, Meuillet EJ, Rosenberg DW.

Biochimie. 2010 Jun;92(6):660-4. doi: 10.1016/j.biochi.2010.02.006. Epub 2010 Feb 13. Review.


Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.

Dietrich J, Gokhale V, Wang X, Hurley LH, Flynn GA.

Bioorg Med Chem. 2010 Jan 1;18(1):292-304. doi: 10.1016/j.bmc.2009.10.055. Epub 2009 Nov 11.


NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH.

Mol Cancer Ther. 2009 May;8(5):1363-77. doi: 10.1158/1535-7163.MCT-08-1093. Epub 2009 May 12.


Wound construction in manual small incision cataract surgery.

Haldipurkar SS, Shikari HT, Gokhale V.

Indian J Ophthalmol. 2009 Jan-Feb;57(1):9-13.


Psorospermin structural requirements for P-glycoprotein resistance reversal.

Carey SS, Gleason-Guzman M, Gokhale V, Hurley LH.

Mol Cancer Ther. 2008 Nov;7(11):3617-23. doi: 10.1158/1535-7163.MCT-08-0519.


Discovery of a novel class of AKT pleckstrin homology domain inhibitors.

Mahadevan D, Powis G, Mash EA, George B, Gokhale VM, Zhang S, Shakalya K, Du-Cuny L, Berggren M, Ali MA, Jana U, Ihle N, Moses S, Franklin C, Narayan S, Shirahatti N, Meuillet EJ.

Mol Cancer Ther. 2008 Sep;7(9):2621-32. doi: 10.1158/1535-7163.MCT-07-2276.


Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.

Guo K, Gokhale V, Hurley LH, Sun D.

Nucleic Acids Res. 2008 Aug;36(14):4598-608. doi: 10.1093/nar/gkn380. Epub 2008 Jul 9.


The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.

Sun D, Liu WJ, Guo K, Rusche JJ, Ebbinghaus S, Gokhale V, Hurley LH.

Mol Cancer Ther. 2008 Apr;7(4):880-9. doi: 10.1158/1535-7163.MCT-07-2119.

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