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Items: 1 to 50 of 69

1.

Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function.

Bothra A, Arumugam P, Panchal V, Menon D, Srivastava S, Shankaran D, Nandy A, Jaisinghani N, Singh A, Gokhale RS, Gandotra S, Rao V.

Sci Rep. 2018 May 29;8(1):8317. doi: 10.1038/s41598-018-26710-z.

2.

STIM1 activation of adenylyl cyclase 6 connects Ca2+ and cAMP signaling during melanogenesis.

Motiani RK, Tanwar J, Raja DA, Vashisht A, Khanna S, Sharma S, Srivastava S, Sivasubbu S, Natarajan VT, Gokhale RS.

EMBO J. 2018 Mar 1;37(5). pii: e97597. doi: 10.15252/embj.201797597. Epub 2018 Jan 8.

PMID:
29311116
3.

Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligo.

Singh A, Gotherwal V, Junni P, Vijayan V, Tiwari M, Ganju P, Kumar A, Sharma P, Fatima T, Gupta A, Holla A, Kar HK, Khanna S, Thukral L, Malik G, Natarajan K, Gadgil CJ, Lahesmaa R, Natarajan VT, Rani R, Gokhale RS.

Sci Rep. 2017 Aug 29;7(1):9860. doi: 10.1038/s41598-017-10253-w.

4.

Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks.

Ramkumar A, Murthy D, Raja DA, Singh A, Krishnan A, Khanna S, Vats A, Thukral L, Sharma P, Sivasubbu S, Rani R, Natarajan VT, Gokhale RS.

Autophagy. 2017 Aug 3;13(8):1331-1347. doi: 10.1080/15548627.2017.1327509. Epub 2017 Jun 9.

5.

Association and expression of the antigen-processing gene PSMB8, coding for low-molecular-mass protease 7, with vitiligo in North India: case-control study.

Dani P, Patnaik N, Singh A, Jaiswal A, Agrawal B, Kumar AA, Varkhande SR, Sharma A, Vaish U, Ghosh P, Sharma VK, Sharma P, Verma G, Kar HK, Gupta S, Natarajan VT, Gokhale RS, Rani R.

Br J Dermatol. 2018 Feb;178(2):482-491. doi: 10.1111/bjd.15391. Epub 2017 Oct 9.

PMID:
28207947
6.

Bioinspired Functionalized Melanin Nanovariants with a Range of Properties Provide Effective Color Matched Photoprotection in Skin.

Vij M, Grover R, Gotherwal V, Wani NA, Joshi P, Gautam H, Sharma K, Chandna S, Gokhale RS, Rai R, Ganguli M, Natarajan VT.

Biomacromolecules. 2016 Sep 12;17(9):2912-9. doi: 10.1021/acs.biomac.6b00740. Epub 2016 Aug 8.

PMID:
27477067
7.

Water Buffalo (Bubalus bubalis) as a spontaneous animal model of Vitiligo.

Singh VP, Motiani RK, Singh A, Malik G, Aggarwal R, Pratap K, Wani MR, Gokhale SB, Natarajan VT, Gokhale RS.

Pigment Cell Melanoma Res. 2016 Jul;29(4):465-9. doi: 10.1111/pcmr.12485.

PMID:
27124831
8.

Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model.

Kinatukara P, Patel KD, Haque AS, Singh R, Gokhale RS, Sankaranarayananan R.

J Struct Biol. 2016 Jun;194(3):368-74. doi: 10.1016/j.jsb.2016.03.014. Epub 2016 Mar 16.

PMID:
26993465
9.

Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects.

Ganju P, Nagpal S, Mohammed MH, Nishal Kumar P, Pandey R, Natarajan VT, Mande SS, Gokhale RS.

Sci Rep. 2016 Jan 13;6:18761. doi: 10.1038/srep18761.

10.

Non-invasive topical delivery of plasmid DNA to the skin using a peptide carrier.

Vij M, Natarajan P, Pattnaik BR, Alam S, Gupta N, Santhiya D, Sharma R, Singh A, Ansari KM, Gokhale RS, Natarajan VT, Ganguli M.

J Control Release. 2016 Jan 28;222:159-68. doi: 10.1016/j.jconrel.2015.12.017. Epub 2015 Dec 14.

PMID:
26699422
11.

Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.

Srivastava S, Chaudhary S, Thukral L, Shi C, Gupta RD, Gupta R, Priyadarshan K, Vats A, Haque AS, Sankaranarayanan R, Natarajan VT, Sharma R, Aldrich CC, Gokhale RS.

Chem Biol. 2015 Dec 17;22(12):1577-87. doi: 10.1016/j.chembiol.2015.10.009. Epub 2015 Nov 25.

12.

The Molecular Mechanism Underlying Recruitment and Insertion of Lipid-Anchored LC3 Protein into Membranes.

Thukral L, Sengupta D, Ramkumar A, Murthy D, Agrawal N, Gokhale RS.

Biophys J. 2015 Nov 17;109(10):2067-78. doi: 10.1016/j.bpj.2015.09.022.

13.

Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches.

Anand A, Verma P, Singh AK, Kaushik S, Pandey R, Shi C, Kaur H, Chawla M, Elechalawar CK, Kumar D, Yang Y, Bhavesh NS, Banerjee R, Dash D, Singh A, Natarajan VT, Ojha AK, Aldrich CC, Gokhale RS.

Mol Cell. 2015 Nov 19;60(4):637-50. doi: 10.1016/j.molcel.2015.10.016. Epub 2015 Nov 12.

14.

Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection.

Maji A, Misra R, Kumar Mondal A, Kumar D, Bajaj D, Singhal A, Arora G, Bhaduri A, Sajid A, Bhatia S, Singh S, Singh H, Rao V, Dash D, Baby Shalini E, Sarojini Michael J, Chaudhary A, Gokhale RS, Singh Y.

Sci Rep. 2015 Oct 15;5:15214. doi: 10.1038/srep15214.

15.

Delineating the reaction mechanism of reductase domains of Nonribosomal Peptide Synthetases from mycobacteria.

Haque AS, Patel KD, Deshmukh MV, Chhabra A, Gokhale RS, Sankaranarayanan R.

J Struct Biol. 2014 Sep;187(3):207-214. doi: 10.1016/j.jsb.2014.07.008. Epub 2014 Aug 7.

PMID:
25108240
16.

Multifaceted pathways protect human skin from UV radiation.

Natarajan VT, Ganju P, Ramkumar A, Grover R, Gokhale RS.

Nat Chem Biol. 2014 Jul;10(7):542-51. doi: 10.1038/nchembio.1548. Review.

PMID:
24937072
17.

IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation.

Natarajan VT, Ganju P, Singh A, Vijayan V, Kirty K, Yadav S, Puntambekar S, Bajaj S, Dani PP, Kar HK, Gadgil CJ, Natarajan K, Rani R, Gokhale RS.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2301-6. doi: 10.1073/pnas.1304988111. Epub 2014 Jan 28.

18.

Network, nodes and nexus: systems approach to multitarget therapeutics.

Murthy D, Attri KS, Gokhale RS.

Curr Opin Biotechnol. 2013 Dec;24(6):1129-36. doi: 10.1016/j.copbio.2013.02.009. Epub 2013 Feb 28. Review.

PMID:
23453398
19.

Identification and characterization of a type III polyketide synthase involved in quinolone alkaloid biosynthesis from Aegle marmelos Correa.

Resmi MS, Verma P, Gokhale RS, Soniya EV.

J Biol Chem. 2013 Mar 8;288(10):7271-81. doi: 10.1074/jbc.M112.429886. Epub 2013 Jan 17.

20.

Retrobiosynthetic approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids.

Vats A, Singh AK, Mukherjee R, Chopra T, Ravindran MS, Mohanty D, Chatterji D, Reyrat JM, Gokhale RS.

J Biol Chem. 2012 Aug 31;287(36):30677-87. doi: 10.1074/jbc.M112.384966. Epub 2012 Jul 13.

21.

Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues.

Swaroop PS, Raut GN, Gonnade RG, Verma P, Gokhale RS, Reddy DS.

Org Biomol Chem. 2012 Jul 28;10(28):5385-94. doi: 10.1039/c2ob25831e. Epub 2012 May 25.

PMID:
22627490
22.

Interleukin-4 genetic variants correlate with its transcript and protein levels in patients with vitiligo.

Imran M, Laddha NC, Dwivedi M, Mansuri MS, Singh J, Rani R, Gokhale RS, Sharma VK, Marfatia YS, Begum R.

Br J Dermatol. 2012 Aug;167(2):314-23. doi: 10.1111/j.1365-2133.2012.11000.x.

PMID:
22512783
23.

Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases.

Chhabra A, Haque AS, Pal RK, Goyal A, Rai R, Joshi S, Panjikar S, Pasha S, Sankaranarayanan R, Gokhale RS.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5681-6. doi: 10.1073/pnas.1118680109. Epub 2012 Mar 26.

24.

Protein model discrimination using mutational sensitivity derived from deep sequencing.

Adkar BV, Tripathi A, Sahoo A, Bajaj K, Goswami D, Chakrabarti P, Swarnkar MK, Gokhale RS, Varadarajan R.

Structure. 2012 Feb 8;20(2):371-81. doi: 10.1016/j.str.2011.11.021.

25.

Molecular basis of the functional divergence of fatty acyl-AMP ligase biosynthetic enzymes of Mycobacterium tuberculosis.

Goyal A, Verma P, Anandhakrishnan M, Gokhale RS, Sankaranarayanan R.

J Mol Biol. 2012 Feb 17;416(2):221-38. doi: 10.1016/j.jmb.2011.12.031. Epub 2011 Dec 21.

PMID:
22206988
26.

Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideum.

Nair DR, Ghosh R, Manocha A, Mohanty D, Saran S, Gokhale RS.

PLoS One. 2011;6(9):e24262. doi: 10.1371/journal.pone.0024262. Epub 2011 Sep 12.

27.

Tuberculosis research: staying ahead of the game.

Gokhale RS.

Tuberculosis (Edinb). 2011 Sep;91(5):406. doi: 10.1016/j.tube.2011.08.001. No abstract available.

PMID:
21911205
28.

HLA alleles and amino-acid signatures of the peptide-binding pockets of HLA molecules in vitiligo.

Singh A, Sharma P, Kar HK, Sharma VK, Tembhre MK, Gupta S, Laddha NC, Dwivedi M, Begum R; Indian Genome Variation Consortium, Gokhale RS, Rani R.

J Invest Dermatol. 2012 Jan;132(1):124-34. doi: 10.1038/jid.2011.240. Epub 2011 Aug 11.

29.

Fatty acyl-AMP ligases and polyketide synthases are unique enzymes of lipid biosynthetic machinery in Mycobacterium tuberculosis.

Mohanty D, Sankaranarayanan R, Gokhale RS.

Tuberculosis (Edinb). 2011 Sep;91(5):448-55. doi: 10.1016/j.tube.2011.04.006. Epub 2011 May 20. Review.

PMID:
21601529
30.

Transcriptional upregulation of Nrf2-dependent phase II detoxification genes in the involved epidermis of vitiligo vulgaris.

Natarajan VT, Singh A, Kumar AA, Sharma P, Kar HK, Marrot L, Meunier JR, Natarajan K, Rani R, Gokhale RS.

J Invest Dermatol. 2010 Dec;130(12):2781-9. doi: 10.1038/jid.2010.201. Epub 2010 Jul 22.

31.

Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles.

Khurana P, Gokhale RS, Mohanty D.

BMC Bioinformatics. 2010 Jan 27;11:57. doi: 10.1186/1471-2105-11-57.

32.

Polyketide versatility in the biosynthesis of complex mycobacterial cell wall lipids.

Chopra T, Gokhale RS.

Methods Enzymol. 2009;459:259-94. doi: 10.1016/S0076-6879(09)04612-6.

PMID:
19362644
33.

Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

Yadav G, Gokhale RS, Mohanty D.

PLoS Comput Biol. 2009 Apr;5(4):e1000351. doi: 10.1371/journal.pcbi.1000351. Epub 2009 Apr 10.

34.

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis.

Arora P, Goyal A, Natarajan VT, Rajakumara E, Verma P, Gupta R, Yousuf M, Trivedi OA, Mohanty D, Tyagi A, Sankaranarayanan R, Gokhale RS.

Nat Chem Biol. 2009 Mar;5(3):166-73. doi: 10.1038/nchembio.143. Epub 2009 Feb 1.

35.

In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.

Ansari MZ, Sharma J, Gokhale RS, Mohanty D.

BMC Bioinformatics. 2008 Oct 25;9:454. doi: 10.1186/1471-2105-9-454.

36.

Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase.

Chopra T, Banerjee S, Gupta S, Yadav G, Anand S, Surolia A, Roy RP, Mohanty D, Gokhale RS.

PLoS Biol. 2008 Jul 8;6(7):e163. doi: 10.1371/journal.pbio.0060163.

37.

Structural insights into biosynthesis of resorcinolic lipids by a type III polyketide synthase in Neurospora crassa.

Goyal A, Saxena P, Rahman A, Singh PK, Kasbekar DP, Gokhale RS, Sankaranarayanan R.

J Struct Biol. 2008 Jun;162(3):411-21. doi: 10.1016/j.jsb.2008.02.009. Epub 2008 Mar 30.

PMID:
18462950
38.

Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol.

Ghosh R, Chhabra A, Phatale PA, Samrat SK, Sharma J, Gosain A, Mohanty D, Saran S, Gokhale RS.

J Biol Chem. 2008 Apr 25;283(17):11348-54. doi: 10.1074/jbc.M709588200. Epub 2008 Feb 5.

39.

Versatility of polyketide synthases in generating metabolic diversity.

Gokhale RS, Sankaranarayanan R, Mohanty D.

Curr Opin Struct Biol. 2007 Dec;17(6):736-43. Epub 2007 Nov 1. Review.

PMID:
17935970
40.

Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.

Gokhale RS, Saxena P, Chopra T, Mohanty D.

Nat Prod Rep. 2007 Apr;24(2):267-77. Epub 2007 Feb 28. Review.

PMID:
17389997
41.

Identification of substrates of the Mycobacterium tuberculosis proteasome.

Pearce MJ, Arora P, Festa RA, Butler-Wu SM, Gokhale RS, Darwin KH.

EMBO J. 2006 Nov 15;25(22):5423-32. Epub 2006 Nov 2.

42.

Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis.

Goyal A, Yousuf M, Rajakumara E, Arora P, Gokhale RS, Sankaranarayanan R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):350-2. Epub 2006 Mar 10.

43.

A genetic locus required for iron acquisition in Mycobacterium tuberculosis.

Krithika R, Marathe U, Saxena P, Ansari MZ, Mohanty D, Gokhale RS.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2069-74. Epub 2006 Feb 3.

44.

Bioscience in India: times are changing.

Dhawan J, Gokhale RS, Verma IM.

Cell. 2005 Dec 2;123(5):743-5.

45.

Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis.

Arora P, Vats A, Saxena P, Mohanty D, Gokhale RS.

J Am Chem Soc. 2005 Jul 6;127(26):9388-9.

PMID:
15984864
46.

SEARCHGTr: a program for analysis of glycosyltransferases involved in glycosylation of secondary metabolites.

Kamra P, Gokhale RS, Mohanty D.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W220-5.

47.

Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.

Trivedi OA, Arora P, Vats A, Ansari MZ, Tickoo R, Sridharan V, Mohanty D, Gokhale RS.

Mol Cell. 2005 Mar 4;17(5):631-43.

48.

A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.

Sankaranarayanan R, Saxena P, Marathe UB, Gokhale RS, Shanmugam VM, Rukmini R.

Nat Struct Mol Biol. 2004 Sep;11(9):894-900. Epub 2004 Aug 1.

PMID:
15286723
49.

NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases.

Ansari MZ, Yadav G, Gokhale RS, Mohanty D.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W405-13.

50.

Novel label-free DNA sensors based on poly(3,4-ethylenedioxythiophene).

Krishnamoorthy K, Gokhale RS, Contractor AQ, Kumar A.

Chem Commun (Camb). 2004 Apr 7;(7):820-1. Epub 2004 Feb 24.

PMID:
15045080

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