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Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells.

Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M, Plath K, Coca D, Barbaric I, Gokhale P, Andrews PW.

Stem Cell Reports. 2018 Jun 5;10(6):1895-1907. doi: 10.1016/j.stemcr.2018.04.015. Epub 2018 May 17.


Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.

Kedves AT, Gleim S, Liang X, Bonal DM, Sigoillot F, Harbinski F, Sanghavi S, Benander C, George E, Gokhale PC, Nguyen QD, Kirschmeier PT, Distel RJ, Jenkins J, Goldberg MS, Forrester WC.

J Clin Invest. 2017 Dec 1;127(12):4554-4568. doi: 10.1172/JCI92914. Epub 2017 Nov 13.


Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.


Controlling the crack formation in inkjet-printed silver nanoparticle thin-films for high resolution patterning using intense pulsed light treatment.

Gokhale P, Mitra D, Sowade E, Mitra KY, Gomes HL, Ramon E, Al-Hamry A, Kanoun O, Baumann RR.

Nanotechnology. 2017 Dec 8;28(49):495301. doi: 10.1088/1361-6528/aa9238.


Inhibition of USP10 induces degradation of oncogenic FLT3.

Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ.

Nat Chem Biol. 2017 Dec;13(12):1207-1215. doi: 10.1038/nchembio.2486. Epub 2017 Oct 2.


QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors.

Solanki JD, Gadhavi BP, Makwana AH, Mehta HB, Shah CJ, Gokhale PA.

J Pharmacol Pharmacother. 2016 Oct-Dec;7(4):165-170. doi: 10.4103/0976-500X.195900.


Maternal outcomes following the initiation of an institutional delayed cord clamping protocol: an observational case-control study.

Kuo K, Gokhale P, Hackney DN, Ruangkit C, Bhola M, March M.

J Matern Fetal Neonatal Med. 2018 Jan;31(2):197-201. doi: 10.1080/14767058.2017.1280018. Epub 2017 Feb 14.


Extracting information from imaging cytometry: a review.

Gokhale PJ.

Biotech Histochem. 2016 Nov;91(8):540-548. Review.


Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells.

Baker D, Hirst AJ, Gokhale PJ, Juarez MA, Williams S, Wheeler M, Bean K, Allison TF, Moore HD, Andrews PW, Barbaric I.

Stem Cell Reports. 2016 Nov 8;7(5):998-1012. doi: 10.1016/j.stemcr.2016.10.003.


Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB.

Rolando C, Erni A, Grison A, Beattie R, Engler A, Gokhale PJ, Milo M, Wegleiter T, Jessberger S, Taylor V.

Cell Stem Cell. 2016 Nov 3;19(5):653-662. doi: 10.1016/j.stem.2016.07.003. Epub 2016 Aug 18.


Is the peripheral arterial disease in low risk type 2 diabetic patients influenced by body mass index, lipidemic control, and statins?

Solanki JD, Makwana AH, Mehta HB, Gokhale PA, Shah CJ.

J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):87-92. doi: 10.4103/0976-500X.184772.


Effect of current glycemic control on qualitative body composition in sedentary ambulatory Type 2 diabetics.

Solanki JD, Makwana AH, Mehta HB, Kamdar P, Gokhale PA, Shah CJ.

Niger Med J. 2016 Jan-Feb;57(1):5-9. doi: 10.4103/0300-1652.180562.


Intravenous Sedation Without Intubation and the Risk of Anesthesia Complications for Obese and Non-Obese Women Undergoing Surgical Abortion: A Retrospective Cohort Study.

Gokhale P, Lappen JR, Waters JH, Perriera LK.

Anesth Analg. 2016 Jun;122(6):1957-62. doi: 10.1213/ANE.0000000000001335.


Lung Transfer Factor in Middle Aged Asymptomatic Male Smokers of a City from West India: A Cross-Sectional Study.

Gadhavi BP, Solanki JD, Mehta HB, Shah CJ, Gokhale PA, Makwana AH.

J Clin Diagn Res. 2016 Mar;10(3):CC07-10. doi: 10.7860/JCDR/2016/18662.7443. Epub 2016 Mar 1.


Obstetrician Attitudes, Experience, and Knowledge of Planned Home Birth: An Exploratory Study.

Leone J, Mostow J, Hackney D, Gokhale P, Janata J, Greenfield M.

Birth. 2016 Sep;43(3):220-5. doi: 10.1111/birt.12232. Epub 2016 Mar 23.


Body Composition in Type 2 Diabetes: Change in Quality and not Just Quantity that Matters.

Solanki JD, Makwana AH, Mehta HB, Gokhale PA, Shah CJ.

Int J Prev Med. 2015 Dec 21;6:122. doi: 10.4103/2008-7802.172376. eCollection 2015.


Study of computerized spirometric parameters of traffic police personnel of Saurashtra region, Gujarat, India.

Makwana AH, Solanki JD, Gokhale PA, Mehta HB, Shah CJ, Gadhavi BP.

Lung India. 2015 Sep-Oct;32(5):457-61. doi: 10.4103/0970-2113.164177.


Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model.

Reardon DA, Gokhale PC, Klein SR, Ligon KL, Rodig SJ, Ramkissoon SH, Jones KL, Conway AS, Liao X, Zhou J, Wen PY, Van Den Abbeele AD, Hodi FS, Qin L, Kohl NE, Sharpe AH, Dranoff G, Freeman GJ.

Cancer Immunol Res. 2016 Feb;4(2):124-35. doi: 10.1158/2326-6066.CIR-15-0151. Epub 2015 Nov 6.


Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells.

Jones AJ, Gokhale PJ, Allison TF, Sampson B, Athwal S, Grant S, Andrews PW, Allen ND, Case CP.

Sci Rep. 2015 Jul 14;5:11694. doi: 10.1038/srep11694.


Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation.

Gokhale PJ, Au-Young JK, Dadi S, Keys DN, Harrison NJ, Jones M, Soneji S, Enver T, Sherlock JK, Andrews PW.

PLoS One. 2015 Apr 14;10(4):e0123467. doi: 10.1371/journal.pone.0123467. eCollection 2015.


Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang SM, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q.

Regen Med. 2015;10(2 Suppl):1-44. doi: 10.2217/rme.14.93. No abstract available.


Variations in immunogenetics, human papillomavirus (HPV) infection & predisposition to cervical cancer in Indian women.

Gokhale P, Kerkar S, Tongaonkar H, Chaudhari H, Warke H, Salvi V, Mania-Pramanik J.

Indian J Med Res. 2014 Nov;140 Suppl:S36-43.


Practical challenges in conducting respiratory studies.

Hake SD, Patil ML, Shah TM, Gokhale PM, Suvarna V.

Perspect Clin Res. 2015 Jan-Mar;6(1):15-9. doi: 10.4103/2229-3485.148798. Review.


Evaluation of imprecision, bias and total error of clinical chemistry analysers.

Biswas SS, Bindra M, Jain V, Gokhale P.

Indian J Clin Biochem. 2015 Jan;30(1):104-8. doi: 10.1007/s12291-014-0448-y. Epub 2014 Jun 22.


Cervical cancer in Indian women reveals contrasting association among common sub-family of HLA class I alleles.

Gokhale P, Mania-Pramanik J, Sonawani A, Idicula-Thomas S, Kerkar S, Tongaonkar H, Chaudhari H, Warke H, Salvi V.

Immunogenetics. 2014 Dec;66(12):683-91. doi: 10.1007/s00251-014-0805-2. Epub 2014 Sep 30.


Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation.

Barbaric I, Biga V, Gokhale PJ, Jones M, Stavish D, Glen A, Coca D, Andrews PW.

Stem Cell Reports. 2014 Jun 12;3(1):142-55. doi: 10.1016/j.stemcr.2014.05.006. eCollection 2014 Jul 8.


Chemical protein polyubiquitination reveals the role of a noncanonical polyubiquitin chain in DNA damage tolerance.

Yang K, Gong P, Gokhale P, Zhuang Z.

ACS Chem Biol. 2014 Aug 15;9(8):1685-91. doi: 10.1021/cb500133k. Epub 2014 Jun 11.


Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics.

Jin M, Petronella BA, Cooke A, Kadalbajoo M, Siu KW, Kleinberg A, May EW, Gokhale PC, Schulz R, Kahler J, Bittner MA, Foreman K, Pachter JA, Wild R, Epstein D, Mulvihill MJ.

ACS Med Chem Lett. 2013 May 23;4(7):627-31. doi: 10.1021/ml400160a. eCollection 2013 Jul 11.


A recipe for pluripotency: the correct sp(l)ices make all the difference. Focus on "Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency".

Gokhale PJ.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1106-7. doi: 10.1152/ajpcell.00116.2014. Epub 2014 Apr 16. No abstract available.


HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants.

Gokhale PS, Sonawani A, Idicula-Thomas S, Kerkar S, Tongaonkar H, Mania-Pramanik J.

J Med Virol. 2014 Jun;86(6):968-74. doi: 10.1002/jmv.23924. Epub 2014 Mar 7.


A comparative study of simple auditory reaction time in blind (congenitally) and sighted subjects.

Gandhi PH, Gokhale PA, Mehta HB, Shah CJ.

Indian J Psychol Med. 2013 Jul;35(3):273-7. doi: 10.4103/0253-7176.119486.


Characterization of human pluripotent stem cells.

Gokhale PJ, Andrews PW.

Neuroreport. 2013 Dec 18;24(18):1031-4. doi: 10.1097/WNR.0000000000000040.


A Study of Prevalence and Association of Risk Factors for Diabetic Vasculopathy in an Urban Area of Gujarat.

Solanki JD, Makwana AH, Mehta HB, Gokhale PA, Shah CJ.

J Family Med Prim Care. 2013 Oct-Dec;2(4):360-4. doi: 10.4103/2249-4863.123906.


ESTOOLS Data@Hand: human stem cell gene expression resource.

Kong L, Aho KL, Granberg K, Lund R, Järvenpää L, Seppälä J, Gokhale P, Leinonen K, Hahne L, Mäkelä J, Laurila K, Pukkila H, Närvä E, Yli-Harja O, Andrews PW, Nykter M, Lahesmaa R, Roos C, Autio R.

Nat Methods. 2013 Sep;10(9):814-5. doi: 10.1038/nmeth.2576. No abstract available.


Karyotypically abnormal human ESCs are sensitive to HDAC inhibitors and show altered regulation of genes linked to cancers and neurological diseases.

Lund RJ, Emani MR, Barbaric I, Kivinen V, Jones M, Baker D, Gokhale P, Nykter M, Lahesmaa R, Andrews PW.

Stem Cell Res. 2013 Nov;11(3):1022-36. doi: 10.1016/j.scr.2013.07.002. Epub 2013 Jul 18.


CTLA-4 gene polymorphism at position +49 A>G in exon 1: a risk factor for cervical cancer in Indian women.

Gokhale P, Kerkar S, Tongaonkar H, Salvi V, Mania-Pramanik J.

Cancer Genet. 2013 May;206(5):154-61. doi: 10.1016/j.cancergen.2013.04.003. Epub 2013 Jul 5.


Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.

Steinig AG, Li AH, Wang J, Chen X, Dong H, Ferraro C, Jin M, Kadalbajoo M, Kleinberg A, Stolz KM, Tavares-Greco PA, Wang T, Albertella MR, Peng Y, Crew L, Kahler J, Kan J, Schulz R, Cooke A, Bittner M, Turton RW, Franklin M, Gokhale P, Landfair D, Mantis C, Workman J, Wild R, Pachter J, Epstein D, Mulvihill MJ.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4381-7. doi: 10.1016/j.bmcl.2013.05.074. Epub 2013 May 30.


STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells.

Wongtrakoongate P, Jones M, Gokhale PJ, Andrews PW.

PLoS One. 2013;8(2):e56893. doi: 10.1371/journal.pone.0056893. Epub 2013 Feb 14.


The development of pluripotent stem cells.

Gokhale PJ, Andrews PW.

Curr Opin Genet Dev. 2012 Oct;22(5):403-8. doi: 10.1016/j.gde.2012.07.006. Epub 2012 Aug 3. Review.


Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells.

Hyka-Nouspikel N, Desmarais J, Gokhale PJ, Jones M, Meuth M, Andrews PW, Nouspikel T.

Stem Cells. 2012 Sep;30(9):1901-10. doi: 10.1002/stem.1177.


Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.

Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.


Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman MS, Evans WH, Newson R, Case CP.

Nat Nanotechnol. 2011 Nov 6;6(12):824-33. doi: 10.1038/nnano.2011.188.


Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells.

Patacsil D, Osayi S, Tran AT, Saenz F, Yimer L, Shajahan AN, Gokhale PC, Verma M, Clarke R, Chauhan SC, Kumar D.

Genes Nutr. 2012 Jan;7(1):83-9. doi: 10.1007/s12263-011-0242-x. Epub 2011 Aug 13.


Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.

Bhagwat SV, Gokhale PC, Crew AP, Cooke A, Yao Y, Mantis C, Kahler J, Workman J, Bittner M, Dudkin L, Epstein DM, Gibson NW, Wild R, Arnold LD, Houghton PJ, Pachter JA.

Mol Cancer Ther. 2011 Aug;10(8):1394-406. doi: 10.1158/1535-7163.MCT-10-1099. Epub 2011 Jun 14.


Mapping the stem cell state: eight novel human embryonic stem and embryonal carcinoma cell antibodies.

Wright A, Andrews N, Bardsley K, Nielsen JE, Avery K, Pewsey E, Jones M, Harley D, Nielsen AR, Moore H, Gokhale P, Rajpert-De Meyts E, Andrews PW, Walsh J, Harrison NJ.

Int J Androl. 2011 Aug;34(4 Pt 2):e175-87; discussion e187-8. doi: 10.1111/j.1365-2605.2011.01185.x. Epub 2011 Jun 9.


High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.

Barbaric I, Jones M, Harley DJ, Gokhale PJ, Andrews PW.

J Biomol Screen. 2011 Jul;16(6):603-17. doi: 10.1177/1087057111406547. Epub 2011 May 18.


Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.

Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM.

Cancer Res. 2011 Mar 1;71(5):1573-83. doi: 10.1158/0008-5472.CAN-10-3126.


Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

Crew AP, Bhagwat SV, Dong H, Bittner MA, Chan A, Chen X, Coate H, Cooke A, Gokhale PC, Honda A, Jin M, Kahler J, Mantis C, Mulvihill MJ, Tavares-Greco PA, Volk B, Wang J, Werner DS, Arnold LD, Pachter JA, Wild R, Gibson NW.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2092-7. doi: 10.1016/j.bmcl.2011.01.139. Epub 2011 Feb 3.


18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer.

McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC.

Clin Cancer Res. 2011 May 15;17(10):3332-40. doi: 10.1158/1078-0432.CCR-10-2274. Epub 2011 Jan 21.

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