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The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate.

Lis P, Dyląg M, Niedźwiecka K, Ko YH, Pedersen PL, Goffeau A, Ułaszewski S.

Molecules. 2016 Dec 15;21(12). pii: E1730. Review.


Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma.

Niedźwiecka K, Dyląg M, Augustyniak D, Majkowska-Skrobek G, Cal-Bąkowska M, Ko YH, Pedersen PL, Goffeau A, Ułaszewski S.

Oncotarget. 2016 Oct 4;7(40):65614-65626. doi: 10.18632/oncotarget.11592.


The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside.

Azevedo-Silva J, Queirós O, Baltazar F, Ułaszewski S, Goffeau A, Ko YH, Pedersen PL, Preto A, Casal M.

J Bioenerg Biomembr. 2016 Aug;48(4):349-62. doi: 10.1007/s10863-016-9670-z. Epub 2016 Jul 25. Review.


Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate.

Lis P, Jurkiewicz P, Cal-Bąkowska M, Ko YH, Pedersen PL, Goffeau A, Ułaszewski S.

Oncotarget. 2016 Mar 1;7(9):10153-73. doi: 10.18632/oncotarget.7174.


The complete genome of Blastobotrys (Arxula) adeninivorans LS3 - a yeast of biotechnological interest.

Kunze G, Gaillardin C, Czernicka M, Durrens P, Martin T, Böer E, Gabaldón T, Cruz JA, Talla E, Marck C, Goffeau A, Barbe V, Baret P, Baronian K, Beier S, Bleykasten C, Bode R, Casaregola S, Despons L, Fairhead C, Giersberg M, Gierski PP, Hähnel U, Hartmann A, Jankowska D, Jubin C, Jung P, Lafontaine I, Leh-Louis V, Lemaire M, Marcet-Houben M, Mascher M, Morel G, Richard GF, Riechen J, Sacerdot C, Sarkar A, Savel G, Schacherer J, Sherman DJ, Stein N, Straub ML, Thierry A, Trautwein-Schult A, Vacherie B, Westhof E, Worch S, Dujon B, Souciet JL, Wincker P, Scholz U, Neuvéglise C.

Biotechnol Biofuels. 2014 Apr 24;7:66. doi: 10.1186/1754-6834-7-66. eCollection 2014.


Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy.

Majkowska-Skrobek G, Augustyniak D, Lis P, Bartkowiak A, Gonchar M, Ko YH, Pedersen PL, Goffeau A, Ułaszewski S.

Anticancer Drugs. 2014 Jul;25(6):673-82. doi: 10.1097/CAD.0000000000000094.


3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans.

Dyląg M, Lis P, Niedźwiecka K, Ko YH, Pedersen PL, Goffeau A, Ułaszewski S.

Biochem Biophys Res Commun. 2013 May 3;434(2):322-7. doi: 10.1016/j.bbrc.2013.02.125. Epub 2013 Mar 26.


Yeast ATP-binding cassette transporters conferring multidrug resistance.

Prasad R, Goffeau A.

Annu Rev Microbiol. 2012;66:39-63. doi: 10.1146/annurev-micro-092611-150111. Epub 2012 Jun 11. Review.


Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae.

Lis P, Zarzycki M, Ko YH, Casal M, Pedersen PL, Goffeau A, Ułaszewski S.

J Bioenerg Biomembr. 2012 Feb;44(1):155-61. doi: 10.1007/s10863-012-9421-8. Epub 2012 Feb 23.


The mammalian ABC transporter ABCA1 induces lipid-dependent drug sensitivity in yeast.

Bocer T, Zarubica A, Roussel A, Flis K, Trombik T, Goffeau A, Ulaszewski S, Chimini G.

Biochim Biophys Acta. 2012 Mar;1821(3):373-80. doi: 10.1016/j.bbalip.2011.07.005. Epub 2011 Jul 20.


Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycetous yeasts.

Dias PJ, Seret ML, Goffeau A, Correia IS, Baret PV.

OMICS. 2010 Dec;14(6):701-10. doi: 10.1089/omi.2010.0104.


Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae.

Wawrzycka D, Sobczak I, Bartosz G, Bocer T, Ułaszewski S, Goffeau A.

FEMS Yeast Res. 2010 Nov;10(7):828-38. doi: 10.1111/j.1567-1364.2010.00673.x. Epub 2010 Sep 15.


Fungal PDR transporters: Phylogeny, topology, motifs and function.

Lamping E, Baret PV, Holmes AR, Monk BC, Goffeau A, Cannon RD.

Fungal Genet Biol. 2010 Feb;47(2):127-42. doi: 10.1016/j.fgb.2009.10.007. Epub 2009 Oct 24. Review.


Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts.

Seret ML, Diffels JF, Goffeau A, Baret PV.

BMC Genomics. 2009 Oct 1;10:459. doi: 10.1186/1471-2164-10-459.


Efflux-mediated antifungal drug resistance.

Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, Keniya MV, Tanabe K, Niimi M, Goffeau A, Monk BC.

Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents. doi: 10.1128/CMR.00051-08. Review.


Outwitting multidrug resistance to antifungals.

Monk BC, Goffeau A.

Science. 2008 Jul 18;321(5887):367-9. doi: 10.1126/science.1159746.


Drug resistance: the fight against fungi.

Goffeau A.

Nature. 2008 Apr 3;452(7187):541-2. doi: 10.1038/452541a. No abstract available.


Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae.

Kolaczkowska A, Kolaczkowski M, Goffeau A, Moye-Rowley WS.

FEBS Lett. 2008 Mar 19;582(6):977-83. doi: 10.1016/j.febslet.2008.02.045. Epub 2008 Feb 26.


A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts.

Palma M, Goffeau A, Spencer-Martins I, Baret PV.

J Mol Microbiol Biotechnol. 2007;12(3-4):241-8.


Evolution of the carboxylate Jen transporters in fungi.

Lodi T, Diffels J, Goffeau A, Baret PV.

FEMS Yeast Res. 2007 Aug;7(5):646-56. Epub 2007 May 10.


Heavy metal transporters in Hemiascomycete yeasts.

Diffels JF, Seret ML, Goffeau A, Baret PV.

Biochimie. 2006 Nov;88(11):1639-49. Epub 2006 Sep 12.


Role of the yeast ABC transporter Yor1p in cadmium detoxification.

Nagy Z, Montigny C, Leverrier P, Yeh S, Goffeau A, Garrigos M, Falson P.

Biochimie. 2006 Nov;88(11):1665-71. Epub 2006 Jun 21.


Genomics: multiple moulds.

Goffeau A.

Nature. 2005 Dec 22;438(7071):1092-3. No abstract available.


Emergence of species-specific transporters during evolution of the hemiascomycete phylum.

De Hertogh B, Hancy F, Goffeau A, Baret PV.

Genetics. 2006 Feb;172(2):771-81. Epub 2005 Aug 22.


The genome of the kinetoplastid parasite, Leishmania major.

Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Müller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schäfer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ.

Science. 2005 Jul 15;309(5733):436-42.


Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus.

Bolotin A, Quinquis B, Renault P, Sorokin A, Ehrlich SD, Kulakauskas S, Lapidus A, Goltsman E, Mazur M, Pusch GD, Fonstein M, Overbeek R, Kyprides N, Purnelle B, Prozzi D, Ngui K, Masuy D, Hancy F, Burteau S, Boutry M, Delcour J, Goffeau A, Hols P.

Nat Biotechnol. 2004 Dec;22(12):1554-8. Epub 2004 Nov 14.


Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.

Falson P, Goffeau A, Boutry M, Jault JM.

Biochim Biophys Acta. 2004 Jul 23;1658(1-2):133-40. Review.


The uses of genome-wide yeast mutant collections.

Scherens B, Goffeau A.

Genome Biol. 2004;5(7):229. Epub 2004 Jun 25. Review.


Evolutionary genomics: seeing double.

Goffeau A.

Nature. 2004 Jul 1;430(6995):25-6. No abstract available.


The archaeal P-type ATPases.

De Hertogh B, Lantin AC, Baret PV, Goffeau A.

J Bioenerg Biomembr. 2004 Feb;36(1):135-42. Review.


Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.

Niimi K, Harding DR, Parshot R, King A, Lun DJ, Decottignies A, Niimi M, Lin S, Cannon RD, Goffeau A, Monk BC.

Antimicrob Agents Chemother. 2004 Apr;48(4):1256-71.


Novel transporters from hemiascomycete yeasts.

De Hertogh B, Talla E, Tekaia F, Beyne E, Sherman D, Baret PV, Dujon B, Goffeau A.

J Mol Microbiol Biotechnol. 2003;6(1):19-28.


Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.

Conseil G, Perez-Victoria JM, Renoir JM, Goffeau A, Di Pietro A.

Biochim Biophys Acta. 2003 Aug 7;1614(2):131-4.


Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p.

Ferreira-Pereira A, Marco S, Decottignies A, Nader J, Goffeau A, Rigaud JL.

J Biol Chem. 2003 Apr 4;278(14):11995-9. Epub 2003 Jan 27.


Greed takes over "our" yeast genome sequence.

Goffeau A.

Biochem Biophys Res Commun. 2002 Sep 20;297(2):161-2. No abstract available.


Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae.

De Hertogh B, Carvajal E, Talla E, Dujon B, Baret P, Goffeau A.

Funct Integr Genomics. 2002 Sep;2(4-5):154-70. Epub 2002 Jun 5. Review.


Characterization of a hyperthermophilic P-type ATPase from Methanococcus jannaschii expressed in yeast.

Morsomme P, Chami M, Marco S, Nader J, Ketchum KA, Goffeau A, Rigaud JL.

J Biol Chem. 2002 Aug 16;277(33):29608-16. Epub 2002 Jun 4.


Functional dissection of Pdr1p, a regulator of multidrug resistance in Saccharomyces cerevisiae.

Kolaczkowska A, Kolaczkowski M, Delahodde A, Goffeau A.

Mol Genet Genomics. 2002 Mar;267(1):96-106. Epub 2002 Feb 20.


Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Di Pietro A, Conseil G, Pérez-Victoria JM, Dayan G, Baubichon-Cortay H, Trompier D, Steinfels E, Jault JM, de Wet H, Maitrejean M, Comte G, Boumendjel A, Mariotte AM, Dumontet C, McIntosh DB, Goffeau A, Castanys S, Gamarro F, Barron D.

Cell Mol Life Sci. 2002 Feb;59(2):307-22. Review.


The genome sequence of Schizosaccharomyces pombe.

Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schäfer M, Müller-Auer S, Gabel C, Fuchs M, Düsterhöft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dréano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sánchez M, del Rey F, Benito J, Domínguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P.

Nature. 2002 Feb 21;415(6874):871-80. Erratum in: Nature 2003 Jan 2;421(6918):94. Cerrutti L [corrected to Cerutti L].


Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.

Nakamura K, Niimi M, Niimi K, Holmes AR, Yates JE, Decottignies A, Monk BC, Goffeau A, Cannon RD.

Antimicrob Agents Chemother. 2001 Dec;45(12):3366-74.


The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance.

Nawrocki A, Fey SJ, Goffeau A, Roepstorff P, Larsen PM.

Proteomics. 2001 Aug;1(8):1022-32. Erratum in: Proteomics 2001 Oct;1(10):1340-1.


Regulation of pleiotropic drug resistance in yeast.

Kolaczkowska A, Goffeau A.

Drug Resist Updat. 1999 Dec;2(6):403-414.


Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.

Capela D, Barloy-Hubler F, Gouzy J, Bothe G, Ampe F, Batut J, Boistard P, Becker A, Boutry M, Cadieu E, Dréano S, Gloux S, Godrie T, Goffeau A, Kahn D, Kiss E, Lelaure V, Masuy D, Pohl T, Portetelle D, Pühler A, Purnelle B, Ramsperger U, Renard C, Thébault P, Vandenbol M, Weidner S, Galibert F.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9877-82. Epub 2001 Jul 31.


The composite genome of the legume symbiont Sinorhizobium meliloti.

Galibert F, Finan TM, Long SR, Puhler A, Abola P, Ampe F, Barloy-Hubler F, Barnett MJ, Becker A, Boistard P, Bothe G, Boutry M, Bowser L, Buhrmester J, Cadieu E, Capela D, Chain P, Cowie A, Davis RW, Dreano S, Federspiel NA, Fisher RF, Gloux S, Godrie T, Goffeau A, Golding B, Gouzy J, Gurjal M, Hernandez-Lucas I, Hong A, Huizar L, Hyman RW, Jones T, Kahn D, Kahn ML, Kalman S, Keating DH, Kiss E, Komp C, Lelaure V, Masuy D, Palm C, Peck MC, Pohl TM, Portetelle D, Purnelle B, Ramsperger U, Surzycki R, Thebault P, Vandenbol M, Vorholter FJ, Weidner S, Wells DH, Wong K, Yeh KC, Batut J.

Science. 2001 Jul 27;293(5530):668-72.


Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs.

do Valle Matta MA, Jonniaux JL, Balzi E, Goffeau A, van den Hazel B.

Gene. 2001 Jul 11;272(1-2):111-9.


Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae.

Kiser GL, Gentzsch M, Kloser AK, Balzi E, Wolf DH, Goffeau A, Riordan JR.

Arch Biochem Biophys. 2001 Jun 15;390(2):195-205.


Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.

Conseil G, Perez-Victoria JM, Jault JM, Gamarro F, Goffeau A, Hofmann J, Di Pietro A.

Biochemistry. 2001 Feb 27;40(8):2564-71.


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