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Items: 39

1.

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.

Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S.

J Am Soc Nephrol. 2019 Oct 1. pii: ASN.2019020163. doi: 10.1681/ASN.2019020163. [Epub ahead of print]

PMID:
31575700
2.

Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance.

Gong Z, Zhang X, Su K, Jiang R, Sun Z, Chen W, Forno E, Goetzman ES, Wang J, Dong HH, Dutta P, Muzumdar R.

Diabetologia. 2019 Sep 11. doi: 10.1007/s00125-019-04983-x. [Epub ahead of print]

PMID:
31511929
3.

The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide.

Zhang Y, Bharathi SS, Beck ME, Goetzman ES.

Redox Biol. 2019 Sep;26:101253. doi: 10.1016/j.redox.2019.101253. Epub 2019 Jun 15.

4.

An acyl-CoA dehydrogenase microplate activity assay using recombinant porcine electron transfer flavoprotein.

Zhang Y, Mohsen AW, Kochersperger C, Solo K, Schmidt AV, Vockley J, Goetzman ES.

Anal Biochem. 2019 Sep 15;581:113332. doi: 10.1016/j.ab.2019.06.003. Epub 2019 Jun 10.

PMID:
31194945
5.

Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.

Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S.

J Am Soc Nephrol. 2019 Jul;30(7):1192-1205. doi: 10.1681/ASN.2018111170. Epub 2019 May 29.

PMID:
31142573
6.

Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.

Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV.

J Biol Chem. 2019 Apr 5;294(14):5466-5486. doi: 10.1074/jbc.RA118.005200. Epub 2019 Feb 12.

PMID:
30755479
7.

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.

Goetzman ES, Prochownik EV.

Front Endocrinol (Lausanne). 2018 Apr 12;9:129. doi: 10.3389/fendo.2018.00129. eCollection 2018. Review.

8.

Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice.

Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):700-704. doi: 10.1016/j.bbrc.2018.02.135. Epub 2018 Feb 16.

9.

Advances in the Understanding and Treatment of Mitochondrial Fatty Acid Oxidation Disorders.

Goetzman ES.

Curr Genet Med Rep. 2017 Sep;5(3):132-142. doi: 10.1007/s40142-017-0125-6. Epub 2017 Jul 25.

10.

Metabolic pathways at the crossroads of diabetes and inborn errors.

Goetzman ES, Gong Z, Schiff M, Wang Y, Muzumdar RH.

J Inherit Metab Dis. 2018 Jan;41(1):5-17. doi: 10.1007/s10545-017-0091-x. Epub 2017 Sep 26. Review.

11.

Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation.

Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV.

Cancer Res. 2017 Nov 1;77(21):5795-5807. doi: 10.1158/0008-5472.CAN-17-1325. Epub 2017 Sep 7.

12.

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.

Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES.

J Biol Chem. 2017 Jun 16;292(24):10239-10249. doi: 10.1074/jbc.M117.785022. Epub 2017 Apr 30.

13.

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma.

Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV.

J Biol Chem. 2017 Jun 16;292(24):10068-10086. doi: 10.1074/jbc.M117.782052. Epub 2017 Apr 21.

14.

Aspirin increases mitochondrial fatty acid oxidation.

Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):346-351. doi: 10.1016/j.bbrc.2016.11.066. Epub 2016 Nov 14.

15.

Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma.

Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Beer-Stolz D, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV.

J Biol Chem. 2016 Dec 16;291(51):26241-26251. Epub 2016 Oct 13.

16.

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease.

Guarani V, Jardel C, Chrétien D, Lombès A, Bénit P, Labasse C, Lacène E, Bourillon A, Imbard A, Benoist JF, Dorboz I, Gilleron M, Goetzman ES, Gaignard P, Slama A, Elmaleh-Bergès M, Romero NB, Rustin P, Ogier de Baulny H, Paulo JA, Harper JW, Schiff M.

Elife. 2016 Sep 13;5. pii: e17163. doi: 10.7554/eLife.17163.

17.

c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.

J Biol Chem. 2015 Aug 14;290(33):20100. doi: 10.1074/jbc.A114.580662. No abstract available.

18.

Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.

Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES.

J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3.

19.

Nickel inhibits mitochondrial fatty acid oxidation.

Uppala R, McKinney RW, Brant KA, Fabisiak JP, Goetzman ES.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):806-10. doi: 10.1016/j.bbrc.2015.06.017. Epub 2015 Jun 5.

20.

SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase.

Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES.

PLoS One. 2015 Mar 26;10(3):e0122297. doi: 10.1371/journal.pone.0122297. eCollection 2015.

21.

Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.

Schiff M, Haberberger B, Xia C, Mohsen AW, Goetzman ES, Wang Y, Uppala R, Zhang Y, Karunanidhi A, Prabhu D, Alharbi H, Prochownik EV, Haack T, Häberle J, Munnich A, Rötig A, Taylor RW, Nicholls RD, Kim JJ, Prokisch H, Vockley J.

Hum Mol Genet. 2015 Jun 1;24(11):3238-47. doi: 10.1093/hmg/ddv074. Epub 2015 Feb 26.

22.

Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.

de Moura MB, Uppala R, Zhang Y, Van Houten B, Goetzman ES.

PLoS One. 2014 Aug 28;9(8):e106028. doi: 10.1371/journal.pone.0106028. eCollection 2014.

23.

c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.

J Biol Chem. 2014 Sep 5;289(36):25382-92. doi: 10.1074/jbc.M114.580662. Epub 2014 Jul 22. Erratum in: J Biol Chem. 2015 Aug 14;290(33):20100.

24.

Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosmider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J.

J Biol Chem. 2014 Apr 11;289(15):10668-79. doi: 10.1074/jbc.M113.540260. Epub 2014 Mar 3.

25.

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E.

Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013.

26.

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.

Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES.

J Biol Chem. 2013 Nov 22;288(47):33837-47. doi: 10.1074/jbc.M113.510354. Epub 2013 Oct 11.

27.

Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.

Sarin M, Wang Y, Zhang F, Rothermund K, Zhang Y, Lu J, Sims-Lucas S, Beer-Stolz D, Van Houten BE, Vockley J, Goetzman ES, Graves JA, Prochownik EV.

Cell Death Dis. 2013 Jun 13;4:e670. doi: 10.1038/cddis.2013.201.

28.

Long chain fatty acid (Lcfa) abnormalities in hyper Igd syndrome (Hids) and Familial Mediterranean Fever (Fmf): new insight into heritable periodic fevers.

Simon A, Drenth JP, Matern D, Goetzman ES, Hager EJ, Gibson KM.

Mol Genet Metab. 2013 Mar;108(3):166-71. doi: 10.1016/j.ymgme.2013.01.004. Epub 2013 Jan 15.

29.

Modeling disorders of fatty acid metabolism in the mouse.

Goetzman ES.

Prog Mol Biol Transl Sci. 2011;100:389-417. doi: 10.1016/B978-0-12-384878-9.00010-8. Review.

PMID:
21377632
30.

Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice.

Skilling H, Coen PM, Fairfull L, Ferrell RE, Goodpaster BH, Vockley J, Goetzman ES.

Biochem Biophys Res Commun. 2010 Sep 24;400(3):318-22. doi: 10.1016/j.bbrc.2010.08.053. Epub 2010 Aug 19.

31.

Evidence for physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes.

Wang Y, Mohsen AW, Mihalik SJ, Goetzman ES, Vockley J.

J Biol Chem. 2010 Sep 24;285(39):29834-41. doi: 10.1074/jbc.M110.139493. Epub 2010 Jul 27.

32.

The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone.

Goetzman ES.

Obesity (Silver Spring). 2009 Jan;17(1):196-8. doi: 10.1038/oby.2008.467. Epub 2008 Oct 23.

33.

Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system.

Goetzman ES, Wang Y, He M, Mohsen AW, Ninness BK, Vockley J.

Mol Genet Metab. 2007 Jun;91(2):138-47. Epub 2007 Mar 19.

34.

Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion protein.

Rapaka RR, Goetzman ES, Zheng M, Vockley J, McKinley L, Kolls JK, Steele C.

J Immunol. 2007 Mar 15;178(6):3702-12. Erratum in: J Immunol. 2007 May 15;178(10):6653.

35.

Functional analysis of acyl-CoA dehydrogenase catalytic residue mutants using surface plasmon resonance and circular dichroism.

Goetzman ES, He M, Nguyen TV, Vockley J.

Mol Genet Metab. 2006 Mar;87(3):233-42. Epub 2005 Dec 22.

PMID:
16376132
36.

Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids.

Ensenauer R, He M, Willard JM, Goetzman ES, Corydon TJ, Vandahl BB, Mohsen AW, Isaya G, Vockley J.

J Biol Chem. 2005 Sep 16;280(37):32309-16. Epub 2005 Jul 14.

38.

Convergent evolution of a 2-methylbutyryl-CoA dehydrogenase from isovaleryl-CoA dehydrogenase in Solanum tuberosum.

Goetzman ES, Mohsen AW, Prasad K, Vockley J.

J Biol Chem. 2005 Feb 11;280(6):4873-9. Epub 2004 Dec 1.

39.

HIV protease inhibitor ritonavir induces lipoatrophy in male mice.

Goetzman ES, Tian L, Nagy TR, Gower BA, Schoeb TR, Elgavish A, Acosta EP, Saag MS, Wood PA.

AIDS Res Hum Retroviruses. 2003 Dec;19(12):1141-50.

PMID:
14709251

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