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Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain Injury.

Goetzl EJ, Peltz CB, Mustapic M, Kapogiannis D, Yaffe K.

J Neurotrauma. 2019 Oct 11. doi: 10.1089/neu.2019.6711. [Epub ahead of print]


Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging.

Kapogiannis D, Mustapic M, Shardell MD, Berkowitz ST, Diehl TC, Spangler RD, Tran J, Lazaropoulos MP, Chawla S, Gulyani S, Eitan E, An Y, Huang CW, Oh ES, Lyketsos CG, Resnick SM, Goetzl EJ, Ferrucci L.

JAMA Neurol. 2019 Jul 15. doi: 10.1001/jamaneurol.2019.2462. [Epub ahead of print]


Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy.

Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D.

Front Neurosci. 2019 May 8;13:452. doi: 10.3389/fnins.2019.00452. eCollection 2019.


Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia.

Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA.

Alzheimers Dement (Amst). 2019 Jan 9;11:61-66. doi: 10.1016/j.dadm.2018.11.002. eCollection 2019 Dec.


Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology.

Hampel H, Goetzl EJ, Kapogiannis D, Lista S, Vergallo A.

Front Pharmacol. 2019 Mar 29;10:310. doi: 10.3389/fphar.2019.00310. eCollection 2019.


Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury.

Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A.

FASEB J. 2019 Apr;33(4):5082-5088. doi: 10.1096/fj.201802319R. Epub 2019 Jan 3.


"Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders.

Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH.

Front Aging Neurosci. 2018 Nov 9;10:343. doi: 10.3389/fnagi.2018.00343. eCollection 2018.


Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment.

Winston CN, Goetzl EJ, Baker LD, Vitiello MV, Rissman RA.

J Alzheimers Dis. 2018;66(3):971-981. doi: 10.3233/JAD-180302.


Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease.

Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D.

FASEB J. 2019 Jan;33(1):231-238. doi: 10.1096/fj.201801001. Epub 2018 Jun 20.


High complement levels in astrocyte-derived exosomes of Alzheimer disease.

Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D.

Ann Neurol. 2018 Mar;83(3):544-552. doi: 10.1002/ana.25172. Epub 2018 Mar 10.


Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease.

Goetzl EJ, Abner EL, Jicha GA, Kapogiannis D, Schwartz JB.

FASEB J. 2018 Feb;32(2):888-893. doi: 10.1096/fj.201700731R. Epub 2018 Jan 4.


Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

Mustapic M, Eitan E, Werner JK Jr, Berkowitz ST, Lazaropoulos MP, Tran J, Goetzl EJ, Kapogiannis D.

Front Neurosci. 2017 May 22;11:278. doi: 10.3389/fnins.2017.00278. eCollection 2017.


Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.

Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA.

FASEB J. 2017 Aug;31(8):3689-3694. doi: 10.1096/fj.201700149. Epub 2017 May 5.


Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease.

Mullins RJ, Mustapic M, Goetzl EJ, Kapogiannis D.

Hum Brain Mapp. 2017 Apr;38(4):1933-1940. doi: 10.1002/hbm.23494. Epub 2017 Jan 20.


Multicellular hypothesis for the pathogenesis of Alzheimer's disease.

Goetzl EJ, Miller BL.

FASEB J. 2017 May;31(5):1792-1795. doi: 10.1096/fj.201601221R. Epub 2017 Jan 18. Review.


Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease.

Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL.

FASEB J. 2016 Nov;30(11):3853-3859. Epub 2016 Aug 10.


Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.

Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC.

Alzheimers Dement. 2017 May;13(5):541-549. doi: 10.1016/j.jalz.2016.08.012. Epub 2016 Oct 15.


Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease.

Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL.

FASEB J. 2016 Dec;30(12):4141-4148. Epub 2016 Sep 6.


Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile.

Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, Masliah E, Rissman RA.

Alzheimers Dement (Amst). 2016 May 7;3:63-72. doi: 10.1016/j.dadm.2016.04.001. eCollection 2016.


Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging.

Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ.

Ann Clin Transl Neurol. 2016 Apr 13;3(5):399-403. doi: 10.1002/acn3.309. eCollection 2016 May.


Novel window on early human neurodevelopment via fetal exosomes in maternal blood.

Goetzl L, Darbinian N, Goetzl EJ.

Ann Clin Transl Neurol. 2016 Feb 25;3(5):381-5. doi: 10.1002/acn3.296. eCollection 2016 May.


Human plasma platelet-derived exosomes: effects of aspirin.

Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L.

FASEB J. 2016 May;30(5):2058-63. doi: 10.1096/fj.201500150R. Epub 2016 Feb 12.


Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D.

Ann Clin Transl Neurol. 2015 Jul;2(7):769-73. doi: 10.1002/acn3.211. Epub 2015 May 13.


Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.

Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D.

Neurology. 2015 Jul 7;85(1):40-7. doi: 10.1212/WNL.0000000000001702. Epub 2015 Jun 10.


Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.

Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ.

FASEB J. 2015 Feb;29(2):589-96. doi: 10.1096/fj.14-262048. Epub 2014 Oct 23.


Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study.

Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ.

Alzheimers Dement. 2015 Jun;11(6):600-7.e1. doi: 10.1016/j.jalz.2014.06.008. Epub 2014 Aug 15.


Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages.

Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ.

FASEB J. 2013 Dec;27(12):5141-50. doi: 10.1096/fj.13-238980. Epub 2013 Sep 6.


Distinct energy requirements for human memory CD4 T-cell homeostatic functions.

Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ.

FASEB J. 2013 Jan;27(1):342-9. doi: 10.1096/fj.12-217620. Epub 2012 Sep 12.


Lenalidomide enhancement of human T cell functions in human immunodeficiency virus (HIV)-infected and HIV-negative CD4 T lymphocytopenic patients.

Lim H, Kane L, Schwartz JB, Hesdorffer CS, Deeks SG, Greig N, Ferrucci L, Goetzl EJ.

Clin Exp Immunol. 2012 Aug;169(2):182-9. doi: 10.1111/j.1365-2249.2012.04603.x.


Distinctive immunoregulatory effects of adenosine on T cells of older humans.

Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ.

FASEB J. 2012 Mar;26(3):1301-10. doi: 10.1096/fj.11-197046. Epub 2011 Nov 25.


Is aging a drug target?

Goetzl EJ.

FASEB J. 2011 Aug;25(8):2509-11. doi: 10.1096/fj.11-0801ufm. No abstract available.


Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia.

Goetzl EJ, Schwartz JB, Huang MC.

J Clin Immunol. 2011 Oct;31(5):744-51. doi: 10.1007/s10875-011-9554-2. Epub 2011 Jun 14.


VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis.

Yadav M, Huang MC, Goetzl EJ.

Cell Immunol. 2011;267(2):124-32. doi: 10.1016/j.cellimm.2011.01.001. Epub 2011 Jan 7.


Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide.

Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ.

Clin Immunol. 2011 Feb;138(2):201-11. doi: 10.1016/j.clim.2010.11.002. Epub 2010 Dec 3.


Gender specificity of altered human immune cytokine profiles in aging.

Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL.

FASEB J. 2010 Sep;24(9):3580-9. doi: 10.1096/fj.10-160911. Epub 2010 May 7.


Human CD4- 8- T cells are a distinctive immunoregulatory subset.

Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ.

FASEB J. 2010 Jul;24(7):2558-66. doi: 10.1096/fj.09-153148. Epub 2010 Feb 12.


Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.

Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ.

Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1193-9. doi: 10.1152/ajpheart.01032.2008. Epub 2009 Feb 20.


Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor.

Liao JJ, Huang MC, Fast K, Gundling K, Yadav M, Van Brocklyn JR, Wabl MR, Goetzl EJ.

FASEB J. 2009 Jun;23(6):1786-96. doi: 10.1096/fj.08-124891. Epub 2009 Jan 21.


Diverse mechanisms and consequences of immunoadoption of neuromediator systems.

Goetzl EJ, Chan RC, Yadav M.

Ann N Y Acad Sci. 2008 Nov;1144:56-60. doi: 10.1196/annals.1418.008. Review.


Neural signaling opportunities for novel diagnostic approaches and therapies. Preface.

Goetzl EJ.

Ann N Y Acad Sci. 2008 Nov;1144:xi-xiii. doi: 10.1196/annals.1418.030. No abstract available.


Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity.

Goetzl EJ, Liao JJ, Huang MC.

Biochim Biophys Acta. 2008 Sep;1781(9):503-7. doi: 10.1016/j.bbalip.2008.03.001. Epub 2008 Mar 12. Review.


Changing paradigms in the immunological science of allergy: 2008.

Goetzl EJ.

Curr Allergy Asthma Rep. 2008 Mar;8(1):28-31. Review.


Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines.

Huang MC, Liao JJ, Bonasera S, Longo DL, Goetzl EJ.

FASEB J. 2008 Jul;22(7):2142-50. doi: 10.1096/fj.07-103721. Epub 2008 Feb 11.


Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia.

Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3150-8. Epub 2007 Aug 31.


Changing paradigms in the immunological science of allergy.

Goetzl EJ.

Curr Allergy Asthma Rep. 2007 Apr;7(1):7-10. Review.


Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

Liao JJ, Huang MC, Goetzl EJ.

J Immunol. 2007 May 1;178(9):5425-8.

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