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Items: 34

1.

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation.

Reiff SD, Mantel R, Smith LL, Greene JT, Muhowski EM, Fabian CA, Goettl VM, Tran M, Harrington BK, Rogers KA, Awan FT, Maddocks K, Andritsos L, Lehman AM, Sampath D, Lapalombella R, Eathiraj S, Abbadessa G, Schwartz B, Johnson AJ, Byrd JC, Woyach JA.

Cancer Discov. 2018 Oct;8(10):1300-1315. doi: 10.1158/2159-8290.CD-17-1409. Epub 2018 Aug 9.

PMID:
30093506
2.

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.

Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, Beaver L, Goettl VM, Lucas DM, Woyach JA, Sampath D, Lehman AM, Yu L, Zhang J, Ma Y, Zhang Y, Spevak W, Shi S, Severson P, Shellooe R, Carias H, Tsang G, Dong K, Ewing T, Marimuthu A, Tantoy C, Walters J, Sanftner L, Rezaei H, Nespi M, Matusow B, Habets G, Ibrahim P, Zhang C, Mathé EA, Bollag G, Byrd JC, Lapalombella R.

Cancer Discov. 2018 Apr;8(4):458-477. doi: 10.1158/2159-8290.CD-17-0902. Epub 2018 Jan 31.

PMID:
29386193
3.

NF-κB p50 (nfkb1) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia.

Chen TL, Tran M, Lakshmanan A, Harrington BK, Gupta N, Goettl VM, Lehman AM, Trudeau S, Lucas DM, Johnson AJ, Byrd JC, Hertlein E.

Blood. 2017 Jul 20;130(3):376-379. doi: 10.1182/blood-2017-01-761130. Epub 2017 May 17. No abstract available.

4.

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.

Hing ZA, Fung HY, Ranganathan P, Mitchell S, El-Gamal D, Woyach JA, Williams K, Goettl VM, Smith J, Yu X, Meng X, Sun Q, Cagatay T, Lehman AM, Lucas DM, Baloglu E, Shacham S, Kauffman MG, Byrd JC, Chook YM, Garzon R, Lapalombella R.

Leukemia. 2016 Dec;30(12):2364-2372. doi: 10.1038/leu.2016.136. Epub 2016 May 20.

5.

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

Zhong Y, El-Gamal D, Dubovsky JA, Beckwith KA, Harrington BK, Williams KE, Goettl VM, Jha S, Mo X, Jones JA, Flynn JM, Maddocks KJ, Andritsos LA, McCauley D, Shacham S, Kauffman M, Byrd JC, Lapalombella R.

Leukemia. 2014 May;28(5):1158-63. doi: 10.1038/leu.2014.9. Epub 2014 Jan 13. No abstract available.

6.

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).

Woyach JA, Bojnik E, Ruppert AS, Stefanovski MR, Goettl VM, Smucker KA, Smith LL, Dubovsky JA, Towns WH, MacMurray J, Harrington BK, Davis ME, Gobessi S, Laurenti L, Chang BY, Buggy JJ, Efremov DG, Byrd JC, Johnson AJ.

Blood. 2014 Feb 20;123(8):1207-13. doi: 10.1182/blood-2013-07-515361. Epub 2013 Dec 5.

7.

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.

J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

8.

17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.

Hertlein E, Wagner AJ, Jones J, Lin TS, Maddocks KJ, Towns WH 3rd, Goettl VM, Zhang X, Jarjoura D, Raymond CA, West DA, Croce CM, Byrd JC, Johnson AJ.

Blood. 2010 Jul 8;116(1):45-53. doi: 10.1182/blood-2010-01-263756. Epub 2010 Mar 29.

9.

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

Lucas DM, Edwards RB, Lozanski G, West DA, Shin JD, Vargo MA, Davis ME, Rozewski DM, Johnson AJ, Su BN, Goettl VM, Heerema NA, Lin TS, Lehman A, Zhang X, Jarjoura D, Newman DJ, Byrd JC, Kinghorn AD, Grever MR.

Blood. 2009 May 7;113(19):4656-66. doi: 10.1182/blood-2008-09-175430. Epub 2009 Feb 3.

10.

Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice.

Hacimuftuoglu A, Handy CR, Goettl VM, Lin CG, Dane S, Stephens RL Jr.

Behav Brain Res. 2006 Oct 16;173(2):211-6. Epub 2006 Aug 17.

PMID:
16919817
11.

Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.

Wu LC, Goettl VM, Madiai F, Hackshaw KV, Hussain SR.

BMC Neurosci. 2006 Jan 12;7:4.

12.

Anti-fibroblast growth factor-2 antibodies attenuate mechanical allodynia in a rat model of neuropathic pain.

Madiai F, Goettl VM, Hussain SR, Clairmont AR, Stephens RL Jr, Hackshaw KV.

J Mol Neurosci. 2005;27(3):315-24.

PMID:
16280602
13.

Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model.

Binns BC, Huang Y, Goettl VM, Hackshaw KV, Stephens RL Jr.

Brain Res. 2005 Apr 11;1041(1):38-47.

PMID:
15804498
14.

Proteomic identification of brainstem cytosolic proteins in a neuropathic pain model.

Alzate O, Hussain SR, Goettl VM, Tewari AK, Madiai F, Stephens RL Jr, Hackshaw KV.

Brain Res Mol Brain Res. 2004 Sep 28;128(2):193-200.

PMID:
15363894
15.

Differential change in mRNA expression of p75 and Trk neurotrophin receptors in nucleus gracilis after spinal nerve ligation in the rat.

Goettl VM, Hussain SR, Alzate O, Wirtz DJ, Stephens RL Jr, Hackshaw KV.

Exp Neurol. 2004 Jun;187(2):533-6.

PMID:
15144880
16.

GM1 enhances dopaminergic markers in the brain of aged rats.

Goettl VM, Zhang H, Burrows AC, Wemlinger TA, Neff NH, Hadjiconstantinou M.

Exp Neurol. 2003 Oct;183(2):665-72.

PMID:
14552908
17.

Sciatic nerve axotomy in aged rats: response of motoneurons and the effect of GM1 ganglioside treatment.

Goettl VM, Neff NH, Hadjiconstantinou M.

Brain Res. 2003 Apr 4;968(1):44-53.

PMID:
12644263
18.

Upregulation of FGF-2 in reactive spinal cord astrocytes following unilateral lumbar spinal nerve ligation.

Madiai F, Hussain SR, Goettl VM, Burry RW, Stephens RL Jr, Hackshaw KV.

Exp Brain Res. 2003 Feb;148(3):366-76. Epub 2002 Nov 26.

PMID:
12541147
19.

Reduced basal release of serotonin from the ventrobasal thalamus of the rat in a model of neuropathic pain.

Goettl VM, Huang Y, Hackshaw KV, Stephens RL Jr.

Pain. 2002 Sep;99(1-2):359-66.

PMID:
12237215
20.

Motoric behavior in aged rats treated with GM1.

Goettl VM, Wemlinger TA, Colvin AE, Neff NH, Hadjiconstantinou M.

Brain Res. 2001 Jul 6;906(1-2):92-100.

PMID:
11430865
21.

Boron neutron capture therapy of brain tumors: functional and neuropathologic effects of blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.

Yang W, Barth RF, Rotaru JH, Boesel CP, Wilkie DA, Bresnahan JC, Hadjiconstantinou M, Goettl VM, Joel DD, Nawrocky MM.

J Neurooncol. 2000 Jul;48(3):179-90.

PMID:
11100816
22.

Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside.

Goettl VM, Wemlinger TA, Fong TG, Neff NH, Hadjiconstantinou M.

Brain Res. 2000 Sep 15;877(1):1-6.

PMID:
10980236
23.

GM1 ganglioside restores abnormal responses to acute thermal and mechanical stimuli in aged rats.

Goettl VM, Lindsey AE, Neff NH, Hadjiconstantinou M.

Brain Res. 2000 Mar 10;858(2):380-5.

PMID:
10708690
24.

GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats.

Goettl VM, Wemlinger TA, Duchemin AM, Neff NH, Hadjiconstantinou M.

Neuroscience. 1999;92(3):991-1000.

PMID:
10426539
25.

Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside.

Goettl VM, Tejwani GA, Neff NH, Hadjiconstantinou M.

Neuroreport. 1999 Feb 25;10(3):513-6.

PMID:
10208581
29.

Substance P N-terminus inhibits C-fiber-dependent facilitation of the rat flexor reflex.

Goettl VM, Xu XJ, Larson AA, Wiesenfeld-Hallin Z.

Eur J Pharmacol. 1994 Jun 23;259(1):83-6.

PMID:
7525313
32.

Porcine malignant hyperthermia: halothane effects on force generation in skeletal muscles.

Gallant EM, Goettl VM.

Muscle Nerve. 1989 Jan;12(1):56-63.

PMID:
2747737
33.

Porcine malignant hyperthermia: cell injury enhances halothane sensitivity of biopsies.

Gallant EM, Fletcher TF, Goettl VM, Rempel WE.

Muscle Nerve. 1986 Feb;9(2):174-84. Erratum in: Muscle Nerve 1986 Sep;9(7):648-9.

PMID:
3951491
34.

Effects of calcium antagonists on mechanical responses of mammalian skeletal muscles.

Gallant EM, Goettl VM.

Eur J Pharmacol. 1985 Nov 5;117(2):259-65.

PMID:
2416576

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