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Items: 41


CD44 splice isoform switching determines breast cancer stem cell state.

Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C.

Genes Dev. 2019 Feb 1;33(3-4):166-179. doi: 10.1101/gad.319889.118. Epub 2019 Jan 28.


αvβ3 Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin.

Wang T, Huang J, Vue M, Alavian MR, Goel HL, Altieri DC, Languino LR, FitzGerald TJ.

Mol Cancer Res. 2019 Feb;17(2):398-408. doi: 10.1158/1541-7786.MCR-18-0544. Epub 2018 Sep 28.


Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays.

Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM.

Nanomedicine. 2018 Aug;14(6):1931-1939. doi: 10.1016/j.nano.2018.05.009. Epub 2018 May 17.


VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin.

Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM.

Sci Signal. 2018 May 1;11(528). pii: eaao6897. doi: 10.1126/scisignal.aao6897.


The α6β4 integrin promotes resistance to ferroptosis.

Brown CW, Amante JJ, Goel HL, Mercurio AM.

J Cell Biol. 2017 Dec 4;216(12):4287-4297. doi: 10.1083/jcb.201701136. Epub 2017 Sep 28.


P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM.

Cell Rep. 2016 Mar 8;14(9):2193-2208. doi: 10.1016/j.celrep.2016.02.016. Epub 2016 Feb 25.


Tead and AP1 Coordinate Transcription and Motility.

Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J.

Cell Rep. 2016 Feb 9;14(5):1169-1180. doi: 10.1016/j.celrep.2015.12.104. Epub 2016 Jan 28.


Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells.

Yoshii T, Geng Y, Le ND, Goel HL, Mercurio AM, Rotello VM.

Nanomedicine (Lond). 2015;10(23):3427-9. doi: 10.2217/nnm.15.179. Epub 2015 Nov 26. No abstract available.


IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.

Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM.

Oncogene. 2016 Mar 3;35(9):1111-21. doi: 10.1038/onc.2015.164. Epub 2015 May 18.


Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.

Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW.

Structure. 2015 Apr 7;23(4):677-87. doi: 10.1016/j.str.2015.01.018. Epub 2015 Mar 5.


A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells.

Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM.

Genes Dev. 2015 Jan 1;29(1):1-6. doi: 10.1101/gad.253682.114.


Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.

Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM.

Cell Rep. 2014 May 8;7(3):747-61. doi: 10.1016/j.celrep.2014.03.059. Epub 2014 Apr 24.


VEGF targets the tumour cell.

Goel HL, Mercurio AM.

Nat Rev Cancer. 2013 Dec;13(12):871-82. doi: 10.1038/nrc3627. Review.


GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.

Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM.

EMBO Mol Med. 2013 Apr;5(4):488-508. doi: 10.1002/emmm.201202078. Epub 2013 Feb 21.


β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.

Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR.

J Cell Physiol. 2013 Jul;228(7):1601-9. doi: 10.1002/jcp.24323.


Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology.

Goel HL, Mercurio AM.

Cell Adh Migr. 2012 Nov-Dec;6(6):554-60. doi: 10.4161/cam.22419. Epub 2012 Oct 17. Review.


VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.

Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM.

Cancer Discov. 2012 Oct;2(10):906-21. doi: 10.1158/2159-8290.CD-12-0085. Epub 2012 Jul 9.


Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling.

Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM.

J Cell Sci. 2012 Jan 15;125(Pt 2):497-506. doi: 10.1242/jcs.094433. Epub 2012 Feb 2.


Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.

Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM.

Development. 2011 Jul;138(14):2969-76. doi: 10.1242/dev.051318.


Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.

Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC.

Br J Cancer. 2011 Feb 15;104(4):629-34. doi: 10.1038/bjc.2011.9. Epub 2011 Feb 1.


CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells.

Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR.

Am J Transl Res. 2010 Mar 15;2(2):135-44.


Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.

Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR.

J Cell Physiol. 2010 Jul;224(1):210-7. doi: 10.1002/jcp.22116.


Integrin signaling aberrations in prostate cancer.

Goel HL, Alam N, Johnson IN, Languino LR.

Am J Transl Res. 2009 Apr 20;1(3):211-20.


Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.

Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC.

Am J Pathol. 2010 Jan;176(1):393-401. doi: 10.2353/ajpath.2010.090521. Epub 2009 Nov 30.


Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.

Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR.

Cancer Res. 2009 Jul 1;69(13):5374-82. doi: 10.1158/0008-5472.CAN-09-0186. Epub 2009 Jun 23.


Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation.

Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ.

Prostate. 2008 Dec 1;68(16):1734-42. doi: 10.1002/pros.20838.


Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention.

Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR.

Expert Rev Anticancer Ther. 2008 Jun;8(6):967-74. doi: 10.1586/14737140.8.6.967. Review.


Integrins in prostate cancer progression.

Goel HL, Li J, Kogan S, Languino LR.

Endocr Relat Cancer. 2008 Sep;15(3):657-64. doi: 10.1677/ERC-08-0019. Epub 2008 Jun 4. Review.


The integrin-growth factor receptor duet.

Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, Languino LR.

J Cell Physiol. 2007 Dec;213(3):649-53. Review.


Focal adhesion kinase regulates insulin resistance in skeletal muscle.

Bisht B, Goel HL, Dey CS.

Diabetologia. 2007 May;50(5):1058-69. Epub 2007 Feb 28.


Regulation of survivin expression by IGF-1/mTOR signaling.

Vaira V, Lee CW, Goel HL, Bosari S, Languino LR, Altieri DC.

Oncogene. 2007 Apr 26;26(19):2678-84. Epub 2006 Oct 30.


Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment.

Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR.

Cancer Res. 2006 Jan 1;66(1):331-42.


beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts.

Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR.

Cancer Res. 2005 Aug 1;65(15):6692-700.


High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression.

Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ.

Prostate. 2005 Jun 15;64(1):83-91.


Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.

Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR.

J Cell Biol. 2004 Aug 2;166(3):407-18.


Integrin signaling in cancer.

Goel HL, Languino LR.

Cancer Treat Res. 2004;119:15-31. Review. No abstract available.


Role of protein kinase C during insulin mediated skeletal muscle cell spreading.

Goel HL, Dey CS.

J Muscle Res Cell Motil. 2002;23(4):269-77.


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