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Coencapsulation of ISCs and MSCs Enhances Viability and Function of both Cell Types for Improved Wound Healing.

Aijaz A, Teryek M, Goedken M, Polunas M, Olabisi RM.

Cell Mol Bioeng. 2019 Jul 1;12(5):481-493. doi: 10.1007/s12195-019-00582-3. eCollection 2019 Oct.


Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard.

Sunil VR, Vayas KN, Abramova EV, Rancourt R, Cervelli JA, Malaviya R, Goedken M, Venosa A, Gow AJ, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2019 Oct 30:114798. doi: 10.1016/j.taap.2019.114798. [Epub ahead of print]


Bioengineered adipose-derived stem cells for targeted enzyme-prodrug therapy of ovarian cancer intraperitoneal metastasis.

Malekshah OM, Sarkar S, Nomani A, Patel N, Javidian P, Goedken M, Polunas M, Louro P, Hatefi A.

J Control Release. 2019 Sep 6;311-312:273-287. doi: 10.1016/j.jconrel.2019.09.006. [Epub ahead of print]


Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity.

Donepudi AC, Goedken MJ, Schuetz JD, E Manautou J.

Toxicol Rep. 2019 Aug 7;6:841-849. doi: 10.1016/j.toxrep.2019.08.005. eCollection 2019.


Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion.

D'Errico JN, Doherty C, Fournier SB, Renkel N, Kallontzi S, Goedken M, Fabris L, Buckley B, Stapleton PA.

Biomed Pharmacother. 2019 Sep;117:109148. doi: 10.1016/j.biopha.2019.109148. Epub 2019 Jul 4.


Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats.

Arman T, Lynch KD, Montonye ML, Goedken M, Clarke JD.

Toxins (Basel). 2019 Jul 9;11(7). pii: E398. doi: 10.3390/toxins11070398.


Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development.

Schumacher JD, Kong B, Wu J, Rizzolo D, Armstrong LE, Chow MD, Goedken M, Lee YH, Guo GL.

Hepatology. 2019 Jun 17. doi: 10.1002/hep.30810. [Epub ahead of print]


Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model.

Rizzolo D, Buckley K, Kong B, Zhan L, Shen J, Stofan M, Brinker A, Goedken M, Buckley B, Guo GL.

Hepatology. 2019 Jul;70(1):389-402. doi: 10.1002/hep.30612. Epub 2019 Apr 25.


Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.

Clarke JD, Dzierlenga A, Arman T, Toth E, Li H, Lynch KD, Tian DD, Goedken M, Paine MF, Cherrington N.

Toxicon. 2019 Apr 15;162:1-8. doi: 10.1016/j.toxicon.2019.03.002. Epub 2019 Mar 5.


Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition.

Toth EL, Li H, Dzierlenga AL, Clarke JD, Vildhede A, Goedken M, Cherrington NJ.

Drug Metab Dispos. 2018 Nov;46(11):1478-1486. doi: 10.1124/dmd.118.082081. Epub 2018 Aug 30.


Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard.

Sunil VR, Vayas KN, Cervelli JA, Ebramova EV, Gow AJ, Goedken M, Malaviya R, Laskin JD, Laskin DL.

Toxicol Sci. 2018 Nov 1;166(1):108-122. doi: 10.1093/toxsci/kfy188.


Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer.

Newman JH, Augeri DJ, NeMoyer R, Malhotra J, Langenfeld E, Chesson CB, Dobias NS, Lee MJ, Tarabichi S, Jhawar SR, Bommareddy PK, Marshall S, Sadimin ET, Kerrigan JE, Goedken M, Minerowicz C, Jabbour SK, Li S, Carayannopolous MO, Zloza A, Langenfeld J.

Oncogene. 2018 Jul;37(27):3672-3685. doi: 10.1038/s41388-018-0156-9. Epub 2018 Apr 6.


The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.

Schumacher JD, Kong B, Pan Y, Zhan L, Sun R, Aa J, Rizzolo D, Richardson JR, Chen A, Goedken M, Aleksunes LM, Laskin DL, Guo GL.

Toxicol Appl Pharmacol. 2017 Sep 1;330:1-8. doi: 10.1016/j.taap.2017.06.023. Epub 2017 Jul 1.


In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.

Li H, Clarke JD, Dzierlenga AL, Bear J, Goedken MJ, Cherrington NJ.

J Biochem Mol Toxicol. 2017 Feb;31(2). doi: 10.1002/jbt.21840. Epub 2016 Oct 6.


Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.

Laho T, Clarke JD, Dzierlenga AL, Li H, Klein DM, Goedken M, Micuda S, Cherrington NJ.

Biochem Pharmacol. 2016 Sep 1;115:144-51. doi: 10.1016/j.bcp.2016.07.001. Epub 2016 Jul 2.


Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.

Ferreira DW, Goedken MJ, Rommelaere S, Chasson L, Galland F, Naquet P, Manautou JE.

Biochim Biophys Acta. 2016 Apr;1862(4):662-669. doi: 10.1016/j.bbadis.2016.02.001. Epub 2016 Feb 2.


Update: Do probiotics prevent or treat pediatric atopic dermatitis?

Blattner CM, Crosby MS, Goedken M, Murase JE.

Pediatr Allergy Immunol. 2016 Jun;27(4):425-8. doi: 10.1111/pai.12539. Epub 2016 Feb 26. No abstract available.


Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.

Clarke JD, Dzierlenga AL, Nelson NR, Li H, Werts S, Goedken MJ, Cherrington NJ.

Diabetes. 2015 Sep;64(9):3305-13. doi: 10.2337/db14-1947. Epub 2015 May 27.


Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.

Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2015 Jul;43(7):944-50. doi: 10.1124/dmd.114.061705. Epub 2015 Apr 20.


Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.

Tsuchiya H, da Costa KA, Lee S, Renga B, Jaeschke H, Yang Z, Orena SJ, Goedken MJ, Zhang Y, Kong B, Lebofsky M, Rudraiah S, Smalling R, Guo G, Fiorucci S, Zeisel SH, Wang L.

Gastroenterology. 2015 May;148(5):1012-1023.e14. doi: 10.1053/j.gastro.2015.01.045. Epub 2015 Feb 19.


Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice.

Ghanem CI, Rudraiah S, Bataille AM, Vigo MB, Goedken MJ, Manautou JE.

Biochem Pharmacol. 2015 Apr 1;94(3):203-11. doi: 10.1016/j.bcp.2015.01.013. Epub 2015 Feb 7.


Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis.

Canet MJ, Hardwick RN, Lake AD, Dzierlenga AL, Clarke JD, Goedken MJ, Cherrington NJ.

Drug Metab Dispos. 2015 Feb;43(2):266-72. doi: 10.1124/dmd.114.060574. Epub 2014 Dec 8.


Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.

Kyriakides M, Hardwick RN, Jin Z, Goedken MJ, Holmes E, Cherrington NJ, Coen M.

Toxicol Sci. 2014 Nov;142(1):105-16. doi: 10.1093/toxsci/kfu160. Epub 2014 Aug 21.


Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?

Rohrer PR, Rudraiah S, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2014 Oct;42(10):1663-74. doi: 10.1124/dmd.114.059006. Epub 2014 Aug 4.


Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.

Hardwick RN, Clarke JD, Lake AD, Canet MJ, Anumol T, Street SM, Merrell MD, Goedken MJ, Snyder SA, Cherrington NJ.

Toxicol Sci. 2014 Nov;142(1):45-55. doi: 10.1093/toxsci/kfu156. Epub 2014 Jul 31.


MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells.

Wen X, Gibson CJ, Yang I, Buckley B, Goedken MJ, Richardson JR, Aleksunes LM.

Toxicol Sci. 2014 Oct;141(2):475-83. doi: 10.1093/toxsci/kfu141. Epub 2014 Jul 11.


Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.

Rudraiah S, Rohrer PR, Gurevich I, Goedken MJ, Rasmussen T, Hines RN, Manautou JE.

Toxicol Sci. 2014 Sep;141(1):263-77. doi: 10.1093/toxsci/kfu124. Epub 2014 Jun 27.


Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.

Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM.

Am J Pathol. 2014 May;184(5):1299-308. doi: 10.1016/j.ajpath.2014.01.025. Epub 2014 Mar 15.


Synergistic interaction between genetics and disease on pravastatin disposition.

Clarke JD, Hardwick RN, Lake AD, Lickteig AJ, Goedken MJ, Klaassen CD, Cherrington NJ.

J Hepatol. 2014 Jul;61(1):139-47. doi: 10.1016/j.jhep.2014.02.021. Epub 2014 Mar 5.


Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.

Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, Saldutti LP.

Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):41-53. doi: 10.1002/bdrb.21035. Epub 2013 Jan 24.


Pregnancy represses induction of efflux transporters in livers of type I diabetic mice.

Aleksunes LM, Xu J, Lin E, Wen X, Goedken MJ, Slitt AL.

Pharm Res. 2013 Sep;30(9):2209-20. doi: 10.1007/s11095-013-0981-z. Epub 2013 Jan 15.


Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD.

J Pharmacol Exp Ther. 2010 Oct;335(1):2-12. doi: 10.1124/jpet.110.170084. Epub 2010 Jul 6.


Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, Klaassen CD.

J Pharmacol Exp Ther. 2010 Apr;333(1):140-51. doi: 10.1124/jpet.109.162271. Epub 2010 Jan 19.


Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD.

Toxicol Sci. 2009 Jul;110(1):47-60. doi: 10.1093/toxsci/kfp094. Epub 2009 Apr 30.


Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function.

Campion SN, Tatis-Rios C, Augustine LM, Goedken MJ, van Rooijen N, Cherrington NJ, Manautou JE.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):49-58. doi: 10.1016/j.taap.2009.01.007. Epub 2009 Jan 24.


Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

Tanaka Y, Aleksunes LM, Goedken MJ, Chen C, Reisman SA, Manautou JE, Klaassen CD.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):364-73. doi: 10.1016/j.taap.2008.05.022. Epub 2008 Jul 9.


Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.

Campion SN, Johnson R, Aleksunes LM, Goedken MJ, van Rooijen N, Scheffer GL, Cherrington NJ, Manautou JE.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G294-304. doi: 10.1152/ajpgi.00541.2007. Epub 2008 Jun 12.


Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes.

Aleksunes LM, Campion SN, Goedken MJ, Manautou JE.

Toxicol Sci. 2008 Aug;104(2):261-73. doi: 10.1093/toxsci/kfn093. Epub 2008 May 8.


Spontaneous and age-related testicular findings in beagle dogs.

Goedken MJ, Kerlin RL, Morton D.

Toxicol Pathol. 2008 Apr;36(3):465-71. doi: 10.1177/0192623308315670. Epub 2008 May 8.


Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE.

Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83. Epub 2007 Aug 31.


Impact of two novel mutations on the structure and function of human myeloperoxidase.

Goedken M, McCormick S, Leidal KG, Suzuki K, Kameoka Y, Astern JM, Huang M, Cherkasov A, Nauseef WM.

J Biol Chem. 2007 Sep 21;282(38):27994-8003. Epub 2007 Jul 24.


Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases.

Barnes SN, Aleksunes LM, Augustine L, Scheffer GL, Goedken MJ, Jakowski AB, Pruimboom-Brees IM, Cherrington NJ, Manautou JE.

Drug Metab Dispos. 2007 Oct;35(10):1963-9. Epub 2007 Jul 12.


Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

Aleksunes LM, Slitt AL, Maher JM, Dieter MZ, Knight TR, Goedken M, Cherrington NJ, Chan JY, Klaassen CD, Manautou JE.

Cell Stress Chaperones. 2006 Winter;11(4):356-63.


Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.

Aleksunes LM, Goedken M, Manautou JE.

World J Gastroenterol. 2006 Mar 28;12(12):1937-40.


Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene.

Manautou JE, de Waart DR, Kunne C, Zelcer N, Goedken M, Borst P, Elferink RO.

Hepatology. 2005 Nov;42(5):1091-8.


Flow cytometry as a tool to quantify oyster defence mechanisms.

Goedken M, De Guise S.

Fish Shellfish Immunol. 2004 Apr;16(4):539-52.


Sorting for storage in myeloid cells of nonmyeloid proteins and chimeras with the propeptide of myeloperoxidase precursor.

Bülow E, Nauseef WM, Goedken M, McCormick S, Calafat J, Gullberg U, Olsson I.

J Leukoc Biol. 2002 Feb;71(2):279-88.


Identification and cloning of the SNARE proteins VAMP-2 and syntaxin-4 from HL-60 cells and human neutrophils.

Smolen JE, Hessler RJ, Nauseef WM, Goedken M, Joe Y.

Inflammation. 2001 Aug;25(4):255-65.


Impact of missense mutations on biosynthesis of myeloperoxidase.

Nauseef WM, McCormick S, Goedken M.

Redox Rep. 2000;5(4):197-206. Review. Erratum in: Redox Rep 2001;6(2):76.


A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.

DeLeo FR, Goedken M, McCormick SJ, Nauseef WM.

J Clin Invest. 1998 Jun 15;101(12):2900-9.

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