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Items: 1 to 50 of 77

1.

Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).

Chavez-Abiega S, Mos I, Centeno PP, Elajnaf T, Schlattl W, Ward DT, Goedhart J, Kallay E.

Adv Exp Med Biol. 2020;1131:1031-1063. doi: 10.1007/978-3-030-12457-1_41. Review.

PMID:
31646544
2.

Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells.

Reinhard NR, Van Der Niet S, Chertkova A, Postma M, Hordijk PL, Gadella TWJ Jr, Goedhart J.

Small GTPases. 2019 Aug 30:1-15. doi: 10.1080/21541248.2019.1658509. [Epub ahead of print]

PMID:
31469028
3.

Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging.

Chavez-Abiega S, Goedhart J, Bruggeman FJ.

Curr Opin Struct Biol. 2019 Apr;55:204-211. doi: 10.1016/j.sbi.2019.05.007. Epub 2019 Jul 15. Review.

PMID:
31319372
4.

PlotsOfData-A web app for visualizing data together with their summaries.

Postma M, Goedhart J.

PLoS Biol. 2019 Mar 27;17(3):e3000202. doi: 10.1371/journal.pbio.3000202. eCollection 2019 Mar.

5.

In vivo characterisation of fluorescent proteins in budding yeast.

Botman D, de Groot DH, Schmidt P, Goedhart J, Teusink B.

Sci Rep. 2019 Feb 19;9(1):2234. doi: 10.1038/s41598-019-38913-z.

6.

Superfolder mTurquoise2ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets.

Meiresonne NY, Consoli E, Mertens LMY, Chertkova AO, Goedhart J, den Blaauwen T.

Mol Microbiol. 2019 Apr;111(4):1025-1038. doi: 10.1111/mmi.14206. Epub 2019 Feb 28.

7.

The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling.

van Unen J, Botman D, Yin T, Wu YI, Hink MA, Gadella TWJ Jr, Postma M, Goedhart J.

BMC Cell Biol. 2018 Jun 7;19(1):6. doi: 10.1186/s12860-018-0155-2.

8.

Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots.

Long Y, Stahl Y, Weidtkamp-Peters S, Smet W, Du Y, Gadella TWJ Jr, Goedhart J, Scheres B, Blilou I.

Front Plant Sci. 2018 May 15;9:639. doi: 10.3389/fpls.2018.00639. eCollection 2018.

9.

Correction: A FRET-based biosensor for measuring Gα13 activation in single cells.

Mastop M, Reinhard NR, Zuconelli CR, Terwey F, Gadella TWJ Jr, van Unen J, Adjobo-Hermans MJW, Goedhart J.

PLoS One. 2018 Apr 4;13(4):e0195649. doi: 10.1371/journal.pone.0195649. eCollection 2018.

10.

A FRET-based biosensor for measuring Gα13 activation in single cells.

Mastop M, Reinhard NR, Zuconelli CR, Terwey F, Gadella TWJ Jr, van Unen J, Adjobo-Hermans MJW, Goedhart J.

PLoS One. 2018 Mar 5;13(3):e0193705. doi: 10.1371/journal.pone.0193705. eCollection 2018. Erratum in: PLoS One. 2018 Apr 4;13(4):e0195649.

11.

Dispense with redundant P values.

Goedhart J.

Nature. 2018 Feb 1;554(7690):31. doi: 10.1038/d41586-018-01314-9. No abstract available.

PMID:
29388982
12.

The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate.

Reinhard NR, Mastop M, Yin T, Wu Y, Bosma EK, Gadella TWJ Jr, Goedhart J, Hordijk PL.

Mol Biol Cell. 2017 Nov 7;28(23):3371-3382. doi: 10.1091/mbc.E17-03-0136. Epub 2017 Sep 27.

13.

Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2.

Mastop M, Bindels DS, Shaner NC, Postma M, Gadella TWJ Jr, Goedhart J.

Sci Rep. 2017 Sep 20;7(1):11999. doi: 10.1038/s41598-017-12212-x.

14.

Forward genetic screens identify a role for the mitochondrial HER2 in E-2-hexenal responsiveness.

Scala A, Mirabella R, Goedhart J, de Vries M, Haring MA, Schuurink RC.

Plant Mol Biol. 2017 Nov;95(4-5):399-409. doi: 10.1007/s11103-017-0659-8. Epub 2017 Sep 16.

15.

In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots.

Long Y, Stahl Y, Weidtkamp-Peters S, Postma M, Zhou W, Goedhart J, Sánchez-Pérez MI, Gadella TWJ, Simon R, Scheres B, Blilou I.

Nature. 2017 Aug 3;548(7665):97-102. doi: 10.1038/nature23317. Epub 2017 Jul 26.

PMID:
28746306
16.

Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.

Goedhart J, van Unen J.

Small GTPases. 2019 May;10(3):178-186. doi: 10.1080/21541248.2017.1302551. Epub 2017 May 19.

17.

Tetraspanin microdomains control localized protein kinase C signaling in B cells.

Zuidscherwoude M, Dunlock VE, van den Bogaart G, van Deventer SJ, van der Schaaf A, van Oostrum J, Goedhart J, In 't Hout J, Hämmerling GJ, Tanaka S, Nadler A, Schultz C, Wright MD, Adjobo-Hermans MJW, van Spriel AB.

Sci Signal. 2017 May 9;10(478). pii: eaag2755. doi: 10.1126/scisignal.aag2755.

PMID:
28487417
18.

In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes.

Vermeer JEM, van Wijk R, Goedhart J, Geldner N, Chory J, Gadella TWJ Jr, Munnik T.

Plant Cell Physiol. 2017 Jul 1;58(7):1196-1207. doi: 10.1093/pcp/pcx012.

19.

Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq.

van Unen J, Yin T, Wu YI, Mastop M, Gadella TW Jr, Goedhart J.

Sci Rep. 2016 Nov 11;6:36825. doi: 10.1038/srep36825.

20.

Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.

van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella TW Jr, Goedhart J.

Mol Pharmacol. 2016 Sep;90(3):162-76. doi: 10.1124/mol.116.104505. Epub 2016 Jun 29. Erratum in: Mol Pharmacol. 2016 Sep;90(3):413.

PMID:
27358232
21.

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells.

Reinhard NR, van Helden SF, Anthony EC, Yin T, Wu YI, Goedhart J, Gadella TW, Hordijk PL.

Sci Rep. 2016 May 5;6:25502. doi: 10.1038/srep25502.

22.

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

Raspe M, Kedziora KM, van den Broek B, Zhao Q, de Jong S, Herz J, Mastop M, Goedhart J, Gadella TW, Young IT, Jalink K.

Nat Methods. 2016 Jun;13(6):501-4. doi: 10.1038/nmeth.3836. Epub 2016 Apr 18.

PMID:
27088314
23.

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.

Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD.

Nat Commun. 2016 Jan 27;7:10493. doi: 10.1038/ncomms10493.

24.

A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells.

van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW Jr, Goedhart J.

PLoS One. 2016 Jan 22;11(1):e0146789. doi: 10.1371/journal.pone.0146789. eCollection 2016.

25.

Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.

van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J.

Sci Rep. 2015 Oct 5;5:14693. doi: 10.1038/srep14693.

26.

SCARECROW-LIKE23 and SCARECROW jointly specify endodermal cell fate but distinctly control SHORT-ROOT movement.

Long Y, Goedhart J, Schneijderberg M, Terpstra I, Shimotohno A, Bouchet BP, Akhmanova A, Gadella TW Jr, Heidstra R, Scheres B, Blilou I.

Plant J. 2015 Nov;84(4):773-84. doi: 10.1111/tpj.13038.

27.

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.

J Cell Sci. 2015 Sep 15;128(18):3514. doi: 10.1242/jcs.179424. No abstract available.

28.

Domain analysis of the Nematostella vectensis SNAIL ortholog reveals unique nucleolar localization that depends on the zinc-finger domains.

Dattoli AA, Hink MA, DuBuc TQ, Teunisse BJ, Goedhart J, Röttinger E, Postma M.

Sci Rep. 2015 Jul 20;5:12147. doi: 10.1038/srep12147.

29.

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.

J Cell Sci. 2015 Aug 15;128(16):3041-54. doi: 10.1242/jcs.168674. Epub 2015 Jun 26. Erratum in: J Cell Sci. 2015 Sep 15;128(18):3514.

30.

A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.

van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ.

Mol Pharmacol. 2015 Sep;88(3):589-95. doi: 10.1124/mol.115.098897. Epub 2015 May 13. Review.

31.

Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity.

Klarenbeek J, Goedhart J, van Batenburg A, Groenewald D, Jalink K.

PLoS One. 2015 Apr 14;10(4):e0122513. doi: 10.1371/journal.pone.0122513. eCollection 2015.

32.

Effect of fixation procedures on the fluorescence lifetimes of Aequorea victoria derived fluorescent proteins.

Joosen L, Hink MA, Gadella TW Jr, Goedhart J.

J Microsc. 2014 Dec;256(3):166-76. doi: 10.1111/jmi.12168. Epub 2014 Sep 1.

33.

Development of FRET biosensors for mammalian and plant systems.

Hamers D, van Voorst Vader L, Borst JW, Goedhart J.

Protoplasma. 2014 Mar;251(2):333-47. doi: 10.1007/s00709-013-0590-z. Epub 2013 Dec 12. Review.

PMID:
24337770
34.

SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.

Jezierska J, Goedhart J, Kampinga HH, Reits EA, Verbeek DS.

J Neurochem. 2014 Mar;128(5):741-51. doi: 10.1111/jnc.12491. Epub 2013 Nov 13.

35.

Optimization of fluorescent proteins.

Bindels DS, Goedhart J, Hink MA, van Weeren L, Joosen L, Gadella TW Jr.

Methods Mol Biol. 2014;1076:371-417. doi: 10.1007/978-1-62703-649-8_16.

PMID:
24108635
36.

An introduction to fluorescence imaging techniques geared towards biosensor applications.

Goedhart J, Hink MA, Jalink K.

Methods Mol Biol. 2014;1071:17-28. doi: 10.1007/978-1-62703-622-1_2. Review.

PMID:
24052377
37.

Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location.

Goedhart J, van Unen J, Adjobo-Hermans MJ, Gadella TW Jr.

Sci Rep. 2013;3:2284. doi: 10.1038/srep02284.

38.

The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides.

Gillis J, Schipper-Krom S, Juenemann K, Gruber A, Coolen S, van den Nieuwendijk R, van Veen H, Overkleeft H, Goedhart J, Kampinga HH, Reits EA.

J Biol Chem. 2013 Jun 14;288(24):17225-37. doi: 10.1074/jbc.M112.421685. Epub 2013 Apr 23.

39.

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

Adjobo-Hermans MJ, Crosby KC, Putyrski M, Bhageloe A, van Weeren L, Schultz C, Goedhart J, Gadella TW Jr.

Cell Signal. 2013 Jan;25(1):255-63. doi: 10.1016/j.cellsig.2012.09.022. Epub 2012 Sep 21.

PMID:
23006664
40.

Structure of a fluorescent protein from Aequorea victoria bearing the obligate-monomer mutation A206K.

von Stetten D, Noirclerc-Savoye M, Goedhart J, Gadella TW Jr, Royant A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):878-82. doi: 10.1107/S1744309112028667. Epub 2012 Jul 26.

41.

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%.

Goedhart J, von Stetten D, Noirclerc-Savoye M, Lelimousin M, Joosen L, Hink MA, van Weeren L, Gadella TW Jr, Royant A.

Nat Commun. 2012 Mar 20;3:751. doi: 10.1038/ncomms1738.

42.

Quantitative co-expression of proteins at the single cell level--application to a multimeric FRET sensor.

Goedhart J, van Weeren L, Adjobo-Hermans MJ, Elzenaar I, Hink MA, Gadella TW Jr.

PLoS One. 2011;6(11):e27321. doi: 10.1371/journal.pone.0027321. Epub 2011 Nov 17.

43.

Bypassing GPCRs with chemical dimerizers.

Goedhart J, Gadella TW Jr.

Chem Biol. 2011 Sep 23;18(9):1067-8. doi: 10.1016/j.chembiol.2011.09.004. No abstract available.

44.

Understanding why older people develop a wish to die: a qualitative interview study.

Rurup ML, Pasman HR, Goedhart J, Deeg DJ, Kerkhof AJ, Onwuteaka-Philipsen BD.

Crisis. 2011;32(4):204-16. doi: 10.1027/0227-5910/a000078.

PMID:
21940258
45.

Recruiting end-of-life cancer patients in the Netherlands for a study on suffering and euthanasia requests.

Ruijs CD, Goedhart J, Kerkhof AJ, van der Wal G, Onwuteaka-Philipsen BD.

Fam Pract. 2011 Dec;28(6):689-95. doi: 10.1093/fampra/cmr035. Epub 2011 Jun 15.

PMID:
21677047
46.

Real-time visualization of heterotrimeric G protein Gq activation in living cells.

Adjobo-Hermans MJ, Goedhart J, van Weeren L, Nijmeijer S, Manders EM, Offermanns S, Gadella TW Jr.

BMC Biol. 2011 May 27;9:32. doi: 10.1186/1741-7007-9-32.

47.

A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range.

Klarenbeek JB, Goedhart J, Hink MA, Gadella TW, Jalink K.

PLoS One. 2011 Apr 29;6(4):e19170. doi: 10.1371/journal.pone.0019170.

48.

Imaging lipids in living cells.

Schultz C, Neef AB, Gadella TW Jr, Goedhart J.

Cold Spring Harb Protoc. 2010 Jul 1;2010(7):pdb.top83. doi: 10.1101/pdb.top83.

PMID:
20647368
49.

Labeling lipids for imaging in live cells.

Schultz C, Neef AB, Gadella TW Jr, Goedhart J.

Cold Spring Harb Protoc. 2010 Jul 1;2010(7):pdb.prot5459. doi: 10.1101/pdb.prot5459.

PMID:
20647363
50.

Labeling lipids for imaging in fixed cells.

Schultz C, Neef AB, Gadella TW Jr, Goedhart J.

Cold Spring Harb Protoc. 2010 Jul 1;2010(7):pdb.prot5458. doi: 10.1101/pdb.prot5458.

PMID:
20647362

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