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Items: 1 to 50 of 349

1.

Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice.

Skachokova Z, Martinisi A, Flach M, Sprenger F, Naegelin Y, Steiner-Monard V, Sollberger M, Monsch AU, Goedert M, Tolnay M, Winkler DT.

Acta Neuropathol Commun. 2019 May 7;7(1):72. doi: 10.1186/s40478-019-0725-3.

2.

Aaron Klug and the study of Alzheimer's disease.

Goedert M.

Alzheimers Dement. 2019 Jun;15(6):859-861. doi: 10.1016/j.jalz.2019.03.001. Epub 2019 Apr 19. No abstract available.

PMID:
31010788
3.

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy.

Malcolm JC, Breuillaud L, Do Carmo S, Hall H, Welikovitch LA, Macdonald JA, Goedert M, Cuello AC.

Neurobiol Dis. 2019 Jul;127:323-338. doi: 10.1016/j.nbd.2019.03.018. Epub 2019 Mar 21.

4.

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.

Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW.

Nature. 2019 Apr;568(7752):420-423. doi: 10.1038/s41586-019-1026-5. Epub 2019 Mar 20.

PMID:
30894745
5.

Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.

Goedert M, Falcon B, Zhang W, Ghetti B, Scheres SHW.

Cold Spring Harb Symp Quant Biol. 2019 Mar 18. pii: 037580. doi: 10.1101/sqb.2018.83.037580. [Epub ahead of print]

PMID:
30886056
6.

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord.

Macdonald JA, Bronner IF, Drynan L, Fan J, Curry A, Fraser G, Lavenir I, Goedert M.

Acta Neuropathol Commun. 2019 Mar 18;7(1):44. doi: 10.1186/s40478-019-0695-5.

7.

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.

Zhang W, Falcon B, Murzin AG, Fan J, Crowther RA, Goedert M, Scheres SH.

Elife. 2019 Feb 5;8. pii: e43584. doi: 10.7554/eLife.43584.

8.

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.

Falcon B, Zhang W, Schweighauser M, Murzin AG, Vidal R, Garringer HJ, Ghetti B, Scheres SHW, Goedert M.

Acta Neuropathol. 2018 Nov;136(5):699-708. doi: 10.1007/s00401-018-1914-z. Epub 2018 Oct 1.

9.

Beta-sheet assembly of Tau and neurodegeneration in Drosophila melanogaster.

Passarella D, Goedert M.

Neurobiol Aging. 2018 Dec;72:98-105. doi: 10.1016/j.neurobiolaging.2018.07.022. Epub 2018 Aug 3.

10.

Rodent models for Alzheimer disease.

Götz J, Bodea LG, Goedert M.

Nat Rev Neurosci. 2018 Oct;19(10):583-598. doi: 10.1038/s41583-018-0054-8. Review.

PMID:
30194347
11.

Structures of filaments from Pick's disease reveal a novel tau protein fold.

Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R, Crowther RA, Ghetti B, Scheres SHW, Goedert M.

Nature. 2018 Sep;561(7721):137-140. doi: 10.1038/s41586-018-0454-y. Epub 2018 Aug 29.

12.

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia.

Brelstaff J, Tolkovsky AM, Ghetti B, Goedert M, Spillantini MG.

Cell Rep. 2018 Aug 21;24(8):1939-1948.e4. doi: 10.1016/j.celrep.2018.07.072.

13.

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases.

Mund T, Masuda-Suzukake M, Goedert M, Pelham HR.

PLoS One. 2018 Jul 18;13(7):e0200763. doi: 10.1371/journal.pone.0200763. eCollection 2018. Erratum in: PLoS One. 2018 Aug 7;13(8):e0202158.

14.

Tau filaments in neurodegenerative diseases.

Goedert M.

FEBS Lett. 2018 Jul;592(14):2383-2391. doi: 10.1002/1873-3468.13108. Epub 2018 Jul 6. Review.

PMID:
29790176
15.

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.

16.

Tau Filaments and the Development of Positron Emission Tomography Tracers.

Goedert M, Yamaguchi Y, Mishra SK, Higuchi M, Sahara N.

Front Neurol. 2018 Feb 15;9:70. doi: 10.3389/fneur.2018.00070. eCollection 2018. Review.

17.

Galectin-8-mediated selective autophagy protects against seeded tau aggregation.

Falcon B, Noad J, McMahon H, Randow F, Goedert M.

J Biol Chem. 2018 Feb 16;293(7):2438-2451. doi: 10.1074/jbc.M117.809293. Epub 2017 Dec 27.

18.

What is the evidence that tau pathology spreads through prion-like propagation?

Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP.

Acta Neuropathol Commun. 2017 Dec 19;5(1):99. doi: 10.1186/s40478-017-0488-7. Review.

19.

Parkinson's disease - the story of an eponym.

Goedert M, Compston A.

Nat Rev Neurol. 2018 Jan;14(1):57-62. doi: 10.1038/nrneurol.2017.165. Epub 2017 Dec 8. Review.

PMID:
29217826
20.

Neurodegeneration and the ordered assembly of α-synuclein.

Spillantini MG, Goedert M.

Cell Tissue Res. 2018 Jul;373(1):137-148. doi: 10.1007/s00441-017-2706-9. Epub 2017 Nov 8. Review.

21.

Propagation of Tau Aggregates and Neurodegeneration.

Goedert M, Eisenberg DS, Crowther RA.

Annu Rev Neurosci. 2017 Jul 25;40:189-210. doi: 10.1146/annurev-neuro-072116-031153. Review.

PMID:
28772101
22.

Cryo-EM structures of tau filaments from Alzheimer's disease.

Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW.

Nature. 2017 Jul 13;547(7662):185-190. doi: 10.1038/nature23002. Epub 2017 Jul 5.

23.

Propagation of Tau aggregates.

Goedert M, Spillantini MG.

Mol Brain. 2017 May 30;10(1):18. doi: 10.1186/s13041-017-0298-7. Review.

24.

The Synucleinopathies: Twenty Years On.

Goedert M, Jakes R, Spillantini MG.

J Parkinsons Dis. 2017;7(s1):S51-S69. doi: 10.3233/JPD-179005. Review.

25.

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3.

26.

The Prion-Like Behavior of Assembled Tau in Transgenic Mice.

Clavaguera F, Tolnay M, Goedert M.

Cold Spring Harb Perspect Med. 2017 Oct 3;7(10). pii: a024372. doi: 10.1101/cshperspect.a024372. Review.

PMID:
27940600
27.

The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.

Tofaris GK, Goedert M, Spillantini MG.

Cold Spring Harb Perspect Med. 2017 Sep 1;7(9). pii: a024380. doi: 10.1101/cshperspect.a024380. Review.

PMID:
27920026
28.

The ordered assembly of tau is the gain-of-toxic function that causes human tauopathies.

Goedert M.

Alzheimers Dement. 2016 Oct;12(10):1040-1050. doi: 10.1016/j.jalz.2016.09.001. Epub 2016 Sep 26. Review.

PMID:
27686274
29.

Tau: From research to clinical development.

Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M.

Alzheimers Dement. 2016 Oct;12(10):1033-1039. doi: 10.1016/j.jalz.2016.03.018. Epub 2016 May 4. Review.

PMID:
27154059
30.

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.

Goedert M, Masuda-Suzukake M, Falcon B.

Brain. 2017 Feb;140(2):266-278. doi: 10.1093/brain/aww230. Epub 2016 Sep 21. Review.

PMID:
27658420
31.

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.

Mazzaro N, Barini E, Spillantini MG, Goedert M, Medini P, Gasparini L.

J Neurosci. 2016 Feb 17;36(7):2086-100. doi: 10.1523/JNEUROSCI.0774-15.2016.

32.

Co-expression of truncated and full-length tau induces severe neurotoxicity.

Ozcelik S, Sprenger F, Skachokova Z, Fraser G, Abramowski D, Clavaguera F, Probst A, Frank S, Müller M, Staufenbiel M, Goedert M, Tolnay M, Winkler DT.

Mol Psychiatry. 2016 Dec;21(12):1790-1798. doi: 10.1038/mp.2015.228. Epub 2016 Feb 2.

33.

Synucleinopathies: past, present and future.

Spillantini MG, Goedert M.

Neuropathol Appl Neurobiol. 2016 Feb;42(1):3-5. doi: 10.1111/nan.12311. No abstract available.

PMID:
26819143
34.

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.

Jackson SJ, Kerridge C, Cooper J, Cavallini A, Falcon B, Cella CV, Landi A, Szekeres PG, Murray TK, Ahmed Z, Goedert M, Hutton M, O'Neill MJ, Bose S.

J Neurosci. 2016 Jan 20;36(3):762-72. doi: 10.1523/JNEUROSCI.3542-15.2016.

35.

Why has therapy development for dementia failed in the last two decades?

Gauthier S, Albert M, Fox N, Goedert M, Kivipelto M, Mestre-Ferrandiz J, Middleton LT.

Alzheimers Dement. 2016 Jan;12(1):60-4. doi: 10.1016/j.jalz.2015.12.003. Epub 2015 Dec 19.

PMID:
26710325
36.

Parkinson's disease: Crystals of a toxic core.

Goedert M, Cheng Y.

Nature. 2015 Sep 24;525(7570):458-9. doi: 10.1038/nature15630. Epub 2015 Sep 9. No abstract available.

PMID:
26352470
37.

A Brief History of Tau.

Goedert M, Spillantini MG, Crowther RA.

Clin Chem. 2015 Nov;61(11):1417-8. doi: 10.1373/clinchem.2015.245142. Epub 2015 Sep 1. No abstract available.

38.

NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.

Goedert M.

Science. 2015 Aug 7;349(6248):1255555. doi: 10.1126/science.1255555. Review.

PMID:
26250687
39.

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.

Brelstaff J, Ossola B, Neher JJ, Klingstedt T, Nilsson KP, Goedert M, Spillantini MG, Tolkovsky AM.

Front Neurosci. 2015 May 29;9:184. doi: 10.3389/fnins.2015.00184. eCollection 2015.

40.

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates.

Klingstedt T, Shirani H, Mahler J, Wegenast-Braun BM, Nyström S, Goedert M, Jucker M, Nilsson KP.

Chemistry. 2015 Jun 15;21(25):9072-82. doi: 10.1002/chem.201500556. Epub 2015 May 26.

41.

Tau silencing by siRNA in the P301S mouse model of tauopathy.

Xu H, Rösler TW, Carlsson T, de Andrade A, Fiala O, Hollerhage M, Oertel WH, Goedert M, Aigner A, Höglinger GU.

Curr Gene Ther. 2014;14(5):343-51.

PMID:
25687501
42.

PART is part of Alzheimer disease.

Duyckaerts C, Braak H, Brion JP, Buée L, Del Tredici K, Goedert M, Halliday G, Neumann M, Spillantini MG, Tolnay M, Uchihara T.

Acta Neuropathol. 2015 May;129(5):749-56. doi: 10.1007/s00401-015-1390-7. Epub 2015 Jan 28.

43.

Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging.

Ghetti B, Oblak AL, Boeve BF, Johnson KA, Dickerson BC, Goedert M.

Neuropathol Appl Neurobiol. 2015 Feb;41(1):24-46. doi: 10.1111/nan.12213. Review. Erratum in: Neuropathol Appl Neurobiol. 2015 Jun;41(4):571. Neuropathol Appl Neurobiol. 2015 Jun;41(4):571.

44.

Piericidin A aggravates Tau pathology in P301S transgenic mice.

Höllerhage M, Deck R, De Andrade A, Respondek G, Xu H, Rösler TW, Salama M, Carlsson T, Yamada ES, Gad El Hak SA, Goedert M, Oertel WH, Höglinger GU.

PLoS One. 2014 Dec 1;9(12):e113557. doi: 10.1371/journal.pone.0113557. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0122907.

45.

Conformation determines the seeding potencies of native and recombinant Tau aggregates.

Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S.

J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18.

46.

Invited review: Prion-like transmission and spreading of tau pathology.

Clavaguera F, Hench J, Goedert M, Tolnay M.

Neuropathol Appl Neurobiol. 2015 Feb;41(1):47-58. doi: 10.1111/nan.12197. Review.

PMID:
25399729
47.

Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.

Goedert M, Falcon B, Clavaguera F, Tolnay M.

Curr Neurol Neurosci Rep. 2014 Nov;14(11):495. doi: 10.1007/s11910-014-0495-z. Review.

PMID:
25218483
48.

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

Flach K, Ramminger E, Hilbrich I, Arsalan-Werner A, Albrecht F, Herrmann L, Goedert M, Arendt T, Holzer M.

Biochim Biophys Acta. 2014 Sep;1842(9):1527-38. doi: 10.1016/j.bbadis.2014.05.029. Epub 2014 Jun 4.

49.

Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).

Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG.

J Biol Chem. 2014 Apr 25;289(17):11897-905. doi: 10.1074/jbc.M113.542340. Epub 2014 Feb 28.

50.

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ.

Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16.

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