Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 138

1.

Promoting resolution in kidney disease: are we nearly there yet?

Doyle R, Godson C, Brennan E.

Curr Opin Nephrol Hypertens. 2019 Oct 9. doi: 10.1097/MNH.0000000000000558. [Epub ahead of print]

PMID:
31599748
2.

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovīte V, Pīrāgs V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC; SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium.

J Am Soc Nephrol. 2019 Oct;30(10):2000-2016. doi: 10.1681/ASN.2019030218. Epub 2019 Sep 19.

PMID:
31537649
3.

Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J.

FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19.

PMID:
30779601
4.

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications.

de Gaetano M, McEvoy C, Andrews D, Cacace A, Hunter J, Brennan E, Godson C.

Front Pharmacol. 2018 Dec 19;9:1488. doi: 10.3389/fphar.2018.01488. eCollection 2018. Review.

5.

Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism.

Hughes MF, Lenighan YM, Godson C, Roche HM.

Front Cardiovasc Med. 2018 Nov 6;5:148. doi: 10.3389/fcvm.2018.00148. eCollection 2018. Review.

6.

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms).

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ.

Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 10.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23.

PMID:
30419493
7.

Pro-resolving lipid mediators: Agents of anti-ageing?

Doyle R, Sadlier DM, Godson C.

Semin Immunol. 2018 Dec;40:36-48. doi: 10.1016/j.smim.2018.09.002. Epub 2018 Oct 4. Review.

PMID:
30293857
8.

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis.

Brennan EP, Mohan M, McClelland A, de Gaetano M, Tikellis C, Marai M, Crean D, Dai A, Beuscart O, Derouiche S, Gray SP, Pickering R, Tan SM, Godson-Treacy M, Sheehan S, Dowdall JF, Barry M, Belton O, Ali-Shah ST, Guiry PJ, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P.

Diabetes. 2018 Dec;67(12):2657-2667. doi: 10.2337/db17-1317. Epub 2018 Sep 13.

9.

Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.

Brennan EP, Mohan M, McClelland A, Tikellis C, Ziemann M, Kaspi A, Gray SP, Pickering R, Tan SM, Ali-Shah ST, Guiry PJ, El-Osta A, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P.

J Am Soc Nephrol. 2018 May;29(5):1437-1448. doi: 10.1681/ASN.2017101112. Epub 2018 Feb 28.

10.

Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes.

Doody A, Jackson S, Elliott JA, Canavan RJ, Godson C, Slattery D, Twomey PJ, McKenna MJ, le Roux CW, Docherty NG.

J Diabetes Complications. 2018 Jan;32(1):95-99. doi: 10.1016/j.jdiacomp.2017.09.007. Epub 2017 Sep 18.

PMID:
29122448
11.

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis.

Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O.

Cardiovasc Diabetol. 2017 Nov 6;16(1):143. doi: 10.1186/s12933-017-0626-3.

12.

BMP7-induced-Pten inhibits Akt and prevents renal fibrosis.

Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3095-3104. doi: 10.1016/j.bbadis.2017.09.011. Epub 2017 Sep 18.

13.

Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis.

Brennan E, Wang B, McClelland A, Mohan M, Marai M, Beuscart O, Derouiche S, Gray S, Pickering R, Tikellis C, de Gaetano M, Barry M, Belton O, Ali-Shah ST, Guiry P, Jandeleit-Dahm KAM, Cooper ME, Godson C, Kantharidis P.

Diabetes. 2017 Aug;66(8):2266-2277. doi: 10.2337/db16-1405. Epub 2017 May 9.

14.

Specialized pro-resolving mediators in renal fibrosis.

Brennan EP, Cacace A, Godson C.

Mol Aspects Med. 2017 Dec;58:102-113. doi: 10.1016/j.mam.2017.05.001. Epub 2017 May 11. Review.

PMID:
28479307
15.

AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin.

Börgeson E, Wallenius V, Syed GH, Darshi M, Lantero Rodriguez J, Biörserud C, Ragnmark Ek M, Björklund P, Quiding-Järbrink M, Fändriks L, Godson C, Sharma K.

Diabetologia. 2017 Apr;60(4):729-739. doi: 10.1007/s00125-017-4211-9. Epub 2017 Feb 10.

16.

NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells.

McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D.

Front Immunol. 2017 Jan 23;8:7. doi: 10.3389/fimmu.2017.00007. eCollection 2017.

17.

REST is a hypoxia-responsive transcriptional repressor.

Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Keogh CE, Fabian Z, Scholz CC, Nolan KA, Rocha LM, Tambuwala MM, Brown S, Wdowicz A, Corbett D, Murphy KJ, Godson C, Cummins EP, Taylor CT, Cheong A.

Sci Rep. 2016 Aug 17;6:31355. doi: 10.1038/srep31355.

18.

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis.

Wang B, Yao K, Huuskes BM, Shen HH, Zhuang J, Godson C, Brennan EP, Wilkinson-Berka JL, Wise AF, Ricardo SD.

Mol Ther. 2016 Aug;24(7):1290-301. doi: 10.1038/mt.2016.90. Epub 2016 May 18.

19.

Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.

Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27.

20.

Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease.

Todd JN, Dahlström EH, Salem RM, Sandholm N, Forsblom C; FinnDiane Study Group, McKnight AJ, Maxwell AP, Brennan E, Sadlier D, Godson C, Groop PH, Hirschhorn JN, Florez JC.

Diabetes. 2015 Dec;64(12):4238-46. doi: 10.2337/db15-0254. Epub 2015 Aug 25.

21.

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.

Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C.

Cell Metab. 2015 Jul 7;22(1):125-37. doi: 10.1016/j.cmet.2015.05.003. Epub 2015 Jun 4.

22.

Specialised lipid mediators and their targets.

Crean D, Godson C.

Semin Immunol. 2015 May;27(3):169-76. doi: 10.1016/j.smim.2015.05.002. Epub 2015 Jun 3. Review.

PMID:
26048571
23.

BMP signalling: agony and antagony in the family.

Brazil DP, Church RH, Surae S, Godson C, Martin F.

Trends Cell Biol. 2015 May;25(5):249-64. doi: 10.1016/j.tcb.2014.12.004. Epub 2015 Jan 12. Review.

PMID:
25592806
24.

Hypoxia-sensitive pathways in inflammation-driven fibrosis.

Manresa MC, Godson C, Taylor CT.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1369-80. doi: 10.1152/ajpregu.00349.2014. Epub 2014 Oct 8. Review.

25.

Paricalcitol protects against TGF-β1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia.

Nolan KA, Brennan EP, Scholz CC, Cullen C, Ryan A, Taylor CT, Godson C.

Exp Cell Res. 2015 Jan 15;330(2):371-81. doi: 10.1016/j.yexcr.2014.07.034. Epub 2014 Aug 5.

PMID:
25107382
26.

Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-β1-associated profibrotic responses in diabetic kidney disease.

Docherty NG, Murphy M, Martin F, Brennan EP, Godson C.

Exp Physiol. 2014 Sep;99(9):1154-62. doi: 10.1113/expphysiol.2014.078774. Epub 2014 Aug 1. Review.

27.

IHG-1 increases mitochondrial fusion and bioenergetic function.

Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C, Murphy M.

Diabetes. 2014 Dec;63(12):4314-25. doi: 10.2337/db13-1256. Epub 2014 Jul 9.

28.

Lipid mediators of inflammation in obesity-related glomerulopathy.

Nolan E, O'Meara YM, Godson C.

Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv22-9. doi: 10.1093/ndt/gft392. Epub 2013 Sep 29. Review.

PMID:
24081855
29.

The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation.

Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW.

Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv73-82. doi: 10.1093/ndt/gft262. Epub 2013 Sep 26. Review.

PMID:
24071659
30.

Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.

Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD; FIND Consortium, Godson C, Hirschhorn JN, Maxwell AP, Florez JC, Groop PH; FinnDiane Study Group and the GENIE Consortium.

J Am Soc Nephrol. 2013 Oct;24(10):1537-43. doi: 10.1681/ASN.2012111122. Epub 2013 Sep 12.

31.

TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation.

Faherty N, O'Donovan H, Kavanagh D, Madden S, McKay GJ, Maxwell AP, Martin F, Godson C, Crean J.

BMC Genomics. 2013 Aug 1;14:525. doi: 10.1186/1471-2164-14-525.

32.

Novel pathways in the yin-yang of immunomodulation.

Godson C, Perretti M.

Curr Opin Pharmacol. 2013 Aug;13(4):543-6. doi: 10.1016/j.coph.2013.06.010. Epub 2013 Jul 16. No abstract available.

PMID:
23871445
33.

IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses.

Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M.

Biochim Biophys Acta. 2013 Aug;1833(8):1969-78. doi: 10.1016/j.bbamcr.2013.03.027. Epub 2013 Apr 6.

34.

Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.

Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C; GENIE Consortium.

J Am Soc Nephrol. 2013 Mar;24(4):627-37. doi: 10.1681/ASN.2012060550. Epub 2013 Mar 21.

35.

The genetics of diabetic nephropathy.

Brennan E, McEvoy C, Sadlier D, Godson C, Martin F.

Genes (Basel). 2013 Nov 5;4(4):596-619. doi: 10.3390/genes4040596.

36.

IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease.

Murphy M, Hickey F, Godson C.

Curr Opin Nephrol Hypertens. 2013 Jan;22(1):77-84. doi: 10.1097/MNH.0b013e32835b54b0. Review.

PMID:
23165112
37.

Resolution of inflammation: therapeutic potential of pro-resolving lipids in type 2 diabetes mellitus and associated renal complications.

Börgeson E, Godson C.

Front Immunol. 2012 Oct 18;3:318. doi: 10.3389/fimmu.2012.00318. eCollection 2012.

38.

New susceptibility loci associated with kidney disease in type 1 diabetes.

Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola AJ, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Lithovius R, Osterholm AM, Parkkonen M, Pitkäniemi J, Rosengård-Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini SM; DCCT/EDIC Research Group, Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Ioana M, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Groop L, Lajer M, Bull SB, Waggott D, Paterson AD, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Florez JC, Groop PH, Maxwell AP.

PLoS Genet. 2012 Sep;8(9):e1002921. doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20.

39.

CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes.

Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, Crean JK.

J Cell Sci. 2012 Dec 1;125(Pt 23):5621-9. doi: 10.1242/jcs.105528. Epub 2012 Sep 12.

40.

Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy.

Williams WW, Salem RM, McKnight AJ, Sandholm N, Forsblom C, Taylor A, Guiducci C, McAteer JB, McKay GJ, Isakova T, Brennan EP, Sadlier DM, Palmer C, Söderlund J, Fagerholm E, Harjutsalo V, Lithovius R, Gordin D, Hietala K, Kytö J, Parkkonen M, Rosengård-Bärlund M, Thorn L, Syreeni A, Tolonen N, Saraheimo M, Wadén J, Pitkäniemi J, Sarti C, Tuomilehto J, Tryggvason K, Österholm AM, He B, Bain S, Martin F, Godson C, Hirschhorn JN, Maxwell AP, Groop PH, Florez JC; GENIE Consortium.

Diabetes. 2012 Aug;61(8):2187-94. Epub 2012 Jun 20.

41.

Lipoxin A4 attenuates adipose inflammation.

Börgeson E, McGillicuddy FC, Harford KA, Corrigan N, Higgins DF, Maderna P, Roche HM, Godson C.

FASEB J. 2012 Oct;26(10):4287-94. doi: 10.1096/fj.12-208249. Epub 2012 Jun 14.

PMID:
22700871
42.

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy.

Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PÓ, Roche HM, Sadlier DM, Cohen CD; GENIE Consortium, Godson C, Martin F.

Biochim Biophys Acta. 2012 Apr;1822(4):589-99. doi: 10.1016/j.bbadis.2012.01.008. Epub 2012 Jan 14.

43.

Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts.

Curran SP, Hickey FB, Watson A, Godson C, Brazil DP.

Cell Signal. 2012 Apr;24(4):889-98. doi: 10.1016/j.cellsig.2011.12.008. Epub 2011 Dec 13.

PMID:
22182508
44.

Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast.

Docherty NG, Godson C.

Kidney Int. 2011 Nov;80(10):1014-6. doi: 10.1038/ki.2011.266.

45.

Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells.

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C, Crean J.

Biochem J. 2012 Jan 1;441(1):499-510. doi: 10.1042/BJ20110910.

PMID:
21871016
46.

IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α.

Hickey FB, Corcoran JB, Docherty NG, Griffin B, Bhreathnach U, Furlong F, Martin F, Godson C, Murphy M.

J Am Soc Nephrol. 2011 Aug;22(8):1475-85. doi: 10.1681/ASN.2010111154. Epub 2011 Jul 22.

47.

Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.

Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C.

FASEB J. 2011 Sep;25(9):2967-79. doi: 10.1096/fj.11-185017. Epub 2011 May 31.

PMID:
21628447
48.

Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1.

Wan M, Godson C, Guiry PJ, Agerberth B, Haeggström JZ.

FASEB J. 2011 May;25(5):1697-705. doi: 10.1096/fj.10-175687. Epub 2011 Feb 9.

PMID:
21307335
49.

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy.

Rooney B, O'Donovan H, Gaffney A, Browne M, Faherty N, Curran SP, Sadlier D, Godson C, Brazil DP, Crean J.

FEBS Lett. 2011 Feb 4;585(3):531-8. doi: 10.1016/j.febslet.2011.01.004. Epub 2011 Jan 14.

50.

Macrophages in synovial inflammation.

Kennedy A, Fearon U, Veale DJ, Godson C.

Front Immunol. 2011 Oct 10;2:52. doi: 10.3389/fimmu.2011.00052. eCollection 2011.

Supplemental Content

Loading ...
Support Center