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Items: 1 to 50 of 69

1.

A mouse knockout library for secreted and transmembrane proteins.

Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ.

Nat Biotechnol. 2010 Jul;28(7):749-55. doi: 10.1038/nbt.1644. Epub 2010 Jun 20.

PMID:
20562862
2.

A smooth operator for LPS responses.

Godowski PJ.

Nat Immunol. 2005 Jun;6(6):544-6. No abstract available.

PMID:
15908933
3.

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.

Abbas AR, Baldwin D, Ma Y, Ouyang W, Gurney A, Martin F, Fong S, van Lookeren Campagne M, Godowski P, Williams PM, Chan AC, Clark HF.

Genes Immun. 2005 Jun;6(4):319-31.

PMID:
15789058
5.

Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis.

Iwahashi M, Yamamura M, Aita T, Okamoto A, Ueno A, Ogawa N, Akashi S, Miyake K, Godowski PJ, Makino H.

Arthritis Rheum. 2004 May;50(5):1457-67.

6.

APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.

Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ.

J Immunol. 2004 Jan 1;172(1):138-43.

7.

Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.

Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL.

J Immunol. 2003 Dec 15;171(12):6820-6.

8.

Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release.

Levy O, Jean-Jacques RM, Cywes C, Sisson RB, Zarember KA, Godowski PJ, Christianson JL, Guttormsen HK, Carroll MC, Nicholson-Weller A, Wessels MR.

Infect Immun. 2003 Nov;71(11):6344-53.

9.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A.

Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. Erratum in: Genome Res. 2003 Dec;13(12):2759.

10.

Adsorption of CO2 and coadsorption of H and CO2 on potassium-promoted Cu(115).

Onsgaard J, Hoffmann SV, Møller P, Godowski PJ, Wagner JB, Paolucci G, Baraldi A, Comelli G, Groso A.

Chemphyschem. 2003 Apr 14;4(5):466-73.

PMID:
12785260
11.

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.

Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL.

Nat Med. 2003 May;9(5):525-32. Epub 2003 Apr 14.

PMID:
12692544
12.

Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue.

Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA.

Immunology. 2003 Jan;108(1):10-5.

13.

Toll-like receptor 2 ligands as adjuvants for human Th1 responses.

Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL.

J Immunol. 2003 Jan 1;170(1):194-200.

14.

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.

Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL.

J Immunol. 2002 Aug 1;169(3):1535-41.

15.
16.

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.

Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL.

J Immunol. 2001 Aug 15;167(4):1882-5.

17.

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ.

Nat Immunol. 2001 Apr;2(4):346-52.

PMID:
11276206
18.

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.

Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.

Nat Immunol. 2000 Dec;1(6):533-40.

PMID:
11101877
19.

Induction of direct antimicrobial activity through mammalian toll-like receptors.

Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL.

Science. 2001 Feb 23;291(5508):1544-7.

20.

Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.

Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, Modlin RL.

J Immunol. 2001 Feb 15;166(4):2444-50.

21.

Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides.

Tapping RI, Akashi S, Miyake K, Godowski PJ, Tobias PS.

J Immunol. 2000 Nov 15;165(10):5780-7.

22.

Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10.

Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL.

J Immunol. 2000 Oct 1;165(7):3804-10.

23.

The apoptotic signaling pathway activated by Toll-like receptor-2.

Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A.

EMBO J. 2000 Jul 3;19(13):3325-36.

24.

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.

Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A.

Science. 1999 Jul 30;285(5428):736-9.

25.

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.

Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL.

Science. 1999 Jul 30;285(5428):732-6.

26.

Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.

Yang RB, Mark MR, Gurney AL, Godowski PJ.

J Immunol. 1999 Jul 15;163(2):639-43.

27.

The toll of innate immunity on microbial pathogens.

Modlin RL, Brightbill HD, Godowski PJ.

N Engl J Med. 1999 Jun 10;340(23):1834-5. Review. No abstract available.

PMID:
10362831
28.

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.

Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A.

Curr Biol. 1999 Feb 25;9(4):215-8.

29.

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.

Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A.

Nature. 1998 Dec 17;396(6712):699-703.

PMID:
9872321
30.

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.

Ultsch M, Lokker NA, Godowski PJ, de Vos AM.

Structure. 1998 Nov 15;6(11):1383-93.

31.

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.

Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ.

Nature. 1998 Sep 17;395(6699):284-8.

PMID:
9751057
32.

New branches on the neuregulin family tree.

Zhang D, Frantz G, Godowski PJ.

Mol Psychiatry. 1998 Mar;3(2):112-5. No abstract available.

PMID:
9577834
33.

A novel receptor for Apo2L/TRAIL contains a truncated death domain.

Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A.

Curr Biol. 1997 Dec 1;7(12):1003-6.

34.

Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7.

35.

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A.

Science. 1997 Aug 8;277(5327):818-21.

36.

Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain.

Wang MH, Julian FM, Breathnach R, Godowski PJ, Takehara T, Yoshikawa W, Hagiya M, Leonard EJ.

J Biol Chem. 1997 Jul 4;272(27):16999-7004.

38.

The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J.

J Biol Chem. 1996 Aug 9;271(32):19025-8.

39.
40.

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

Schwall RH, Chang LY, Godowski PJ, Kahn DW, Hillan KJ, Bauer KD, Zioncheck TF.

J Cell Biol. 1996 May;133(3):709-18.

41.

Modulation of megakaryocytopoiesis by human macrophage-stimulating protein, the ligand for the RON receptor.

Banu N, Price DJ, London R, Deng B, Mark M, Godowski PJ, Avraham H.

J Immunol. 1996 Apr 15;156(8):2933-40.

PMID:
8609414
42.

Identification of Gas6 as a growth factor for human Schwann cells.

Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P, Bunge R, Godowski PJ, Sliwkowski MX, Mather JP.

J Neurosci. 1996 Mar 15;16(6):2012-9.

43.

Development of neurotrophic factor therapy for Alzheimer's disease.

Hefti F, Armanini MP, Beck KD, Caras IW, Chen KS, Godowski PJ, Goodman LJ, Hammonds RG, Mark MR, Moran P, Nishimura MC, Phillips HS, Shih A, Valverde J, Winslow JW.

Ciba Found Symp. 1996;196:54-63; discussion 63-9. Review. No abstract available.

PMID:
8991782
44.

Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3.

Godowski PJ, Mark MR, Chen J, Sadick MD, Raab H, Hammonds RG.

Cell. 1995 Aug 11;82(3):355-8. No abstract available.

45.

RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.

Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM.

EMBO J. 1994 Aug 1;13(15):3524-32.

47.

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.

Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ.

J Biol Chem. 1994 May 27;269(21):15092-100.

49.

rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ.

J Biol Chem. 1994 Apr 8;269(14):10720-8.

50.

The pharmacokinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats.

Zioncheck TF, Richardson L, DeGuzman GG, Modi NB, Hansen SE, Godowski PJ.

Endocrinology. 1994 Apr;134(4):1879-87.

PMID:
8137756

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