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Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits.

Xiang R, Berg IVD, MacLeod IM, Hayes BJ, Prowse-Wilkins CP, Wang M, Bolormaa S, Liu Z, Rochfort SJ, Reich CM, Mason BA, Vander Jagt CJ, Daetwyler HD, Lund MS, Chamberlain AJ, Goddard ME.

Proc Natl Acad Sci U S A. 2019 Sep 9. pii: 201904159. doi: 10.1073/pnas.1904159116. [Epub ahead of print]


Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.

Wang H, Zhang F, Zeng J, Wu Y, Kemper KE, Xue A, Zhang M, Powell JE, Goddard ME, Wray NR, Visscher PM, McRae AF, Yang J.

Sci Adv. 2019 Aug 14;5(8):eaaw3538. doi: 10.1126/sciadv.aaw3538. eCollection 2019 Aug.


Modeling the Economic Impact of Interventions for Older Populations with Multimorbidity: A Method of Linking Multiple Single-Disease Models.

Youn JH, Stevenson MD, Thokala P, Payne K, Goddard M.

Med Decis Making. 2019 Aug 20:272989X19868987. doi: 10.1177/0272989X19868987. [Epub ahead of print]


Are Drosophila preferences for yeasts stable or contextual?

Günther CS, Knight SJ, Jones R, Goddard MR.

Ecol Evol. 2019 Jun 30;9(14):8075-8086. doi: 10.1002/ece3.5366. eCollection 2019 Jul.


Overexpression of the VvSWEET4 Transporter in Grapevine Hairy Roots Increases Sugar Transport and Contents and Enhances Resistance to Pythium irregulare, a Soilborne Pathogen.

Meteier E, La Camera S, Goddard ML, Laloue H, Mestre P, Chong J.

Front Plant Sci. 2019 Jul 9;10:884. doi: 10.3389/fpls.2019.00884. eCollection 2019.


The use of mid-infrared spectra to map genes affecting milk composition.

Benedet A, Ho PN, Xiang R, Bolormaa S, De Marchi M, Goddard ME, Pryce JE.

J Dairy Sci. 2019 Aug;102(8):7189-7203. doi: 10.3168/jds.2018-15890. Epub 2019 Jun 6.


Sodium arsenite effect on Vitis vinifera L. Physiology.

Songy A, Vallet J, Gantet M, Boos A, Ronot P, Tarnus C, Clément C, Larignon P, Goddard ML, Fontaine F.

J Plant Physiol. 2019 Jul;238:72-79. doi: 10.1016/j.jplph.2019.05.010. Epub 2019 May 23.


Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England.

Kasteridis P, Ride J, Gutacker N, Aylott L, Dare C, Doran T, Gilbody S, Goddard M, Gravelle H, Kendrick T, Mason A, Rice N, Siddiqi N, Williams R, Jacobs R.

Psychiatr Serv. 2019 Aug 1;70(8):650-656. doi: 10.1176/ Epub 2019 May 21.


Imprint of assortative mating on the human genome.

Yengo L, Robinson MR, Keller MC, Kemper KE, Yang Y, Trzaskowski M, Gratten J, Turley P, Cesarini D, Benjamin DJ, Wray NR, Goddard ME, Yang J, Visscher PM.

Nat Hum Behav. 2018 Dec;2(12):948-954. doi: 10.1038/s41562-018-0476-3. Epub 2018 Nov 26.


Overlap between eQTL and QTL associated with production traits and fertility in dairy cattle.

van den Berg I, Hayes BJ, Chamberlain AJ, Goddard ME.

BMC Genomics. 2019 Apr 15;20(1):291. doi: 10.1186/s12864-019-5656-7.


Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans: Genomic Prediction.

Wray NR, Kemper KE, Hayes BJ, Goddard ME, Visscher PM.

Genetics. 2019 Apr;211(4):1131-1141. doi: 10.1534/genetics.119.301859. Review.


From R.A. Fisher's 1918 Paper to GWAS a Century Later.

Visscher PM, Goddard ME.

Genetics. 2019 Apr;211(4):1125-1130. doi: 10.1534/genetics.118.301594.


Catastrophic sickling crisis in patient undergoing cardiac transplantation with sickle cell trait.

Ali JM, Besser M, Goddard M, Abu-Omar Y, Catarino P, Bhagra S, Berman M.

Am J Transplant. 2019 Aug;19(8):2378-2382. doi: 10.1111/ajt.15379. Epub 2019 Apr 30.


Isolated atrial amyloid: a potential contributor to morbidity and mortality following cardiac surgery.

Bhakhri K, Volpi S, Gori D, Goddard M, Ali JM, De Silva R.

Interact Cardiovasc Thorac Surg. 2019 Mar 15. pii: ivz051. doi: 10.1093/icvts/ivz051. [Epub ahead of print]


Alveolar septal widening as an "alert" signal to look into lung antibody-mediated rejection: A multicenter pilot study.

Calabrese F, Hirschi S, Neil D, Montero-Fernandez A, Timens W, Verbeken E, Chenard MP, Ivanovic M, Le Pavec J, Pena T, Dorfmüller P, Roux A, Rice A, Perissinotto E, Lunardi F, Levine DJ, Cozzi E, Goddard M.

Transplantation. 2019 Mar 1. doi: 10.1097/TP.0000000000002688. [Epub ahead of print]


Incentive schemes to increase dementia diagnoses in primary care in England: a retrospective cohort study of unintended consequences.

Liu D, Green E, Kasteridis P, Goddard M, Jacobs R, Wittenberg R, Mason A.

Br J Gen Pract. 2019 Mar;69(680):e154-e163. doi: 10.3399/bjgp19X701513. Epub 2019 Feb 25.


The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

Onwuli DO, Samuel SF, Sfyri P, Welham K, Goddard M, Abu-Omar Y, Loubani M, Rivero F, Matsakas A, Benoit DM, Wade M, Greenman J, Beltran-Alvarez P.

Int J Cardiol. 2019 May 1;282:76-80. doi: 10.1016/j.ijcard.2019.01.102. Epub 2019 Jan 31.


Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection.

Alsughayyir J, Chhabra M, Qureshi MS, Mallik M, Ali JM, Gamper I, Moseley EL, Peacock S, Kosmoliaptsis V, Goddard MJ, Linterman MA, Motallebzadeh R, Pettigrew GJ.

Front Immunol. 2019 Jan 22;9:3039. doi: 10.3389/fimmu.2018.03039. eCollection 2018.


Predicting the effect of reference population on the accuracy of within, across, and multibreed genomic prediction.

van den Berg I, Meuwissen THE, MacLeod IM, Goddard ME.

J Dairy Sci. 2019 Apr;102(4):3155-3174. doi: 10.3168/jds.2018-15231. Epub 2019 Feb 7.


Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury.

Chhabra M, Alsughayyir J, Qureshi MS, Mallik M, Ali JM, Gamper I, Moseley EL, Peacock S, Kosmoliaptsis V, Goddard MJ, Linterman MA, Motallebzadeh R, Pettigrew GJ.

Front Immunol. 2019 Jan 23;9:3038. doi: 10.3389/fimmu.2018.03038. eCollection 2018.


Data regarding transplant induced germinal center humoral autoimmunity.

Qureshi MS, Alsughayyir J, Chhabra M, Ali JM, Goddard MJ, Devine C, Conlon TM, Linterman MA, Motallebzadeh R, Pettigrew GJ.

Data Brief. 2018 Dec 28;22:647-657. doi: 10.1016/j.dib.2018.12.078. eCollection 2019 Feb.


A systems approach reveals urban pollinator hotspots and conservation opportunities.

Baldock KCR, Goddard MA, Hicks DM, Kunin WE, Mitschunas N, Morse H, Osgathorpe LM, Potts SG, Robertson KM, Scott AV, Staniczenko PPA, Stone GN, Vaughan IP, Memmott J.

Nat Ecol Evol. 2019 Mar;3(3):363-373. doi: 10.1038/s41559-018-0769-y. Epub 2019 Jan 14.


Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury.

Patel KJ, Cheng Q, Stephenson S, Allen DP, Li C, Kilkenny J, Finnegan R, Montalvo-Calero V, Esckilsen S, Vasu C, Goddard M, Nadig SN, Atkinson C.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):678-686. doi: 10.1165/rcmb.2018-0224OC.


Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy.

Qureshi MS, Alsughayyir J, Chhabra M, Ali JM, Goddard MJ, Devine CA, Conlon TM, Linterman MA, Motallebzadeh R, Pettigrew GJ.

J Autoimmun. 2019 Mar;98:44-58. doi: 10.1016/j.jaut.2018.11.006. Epub 2018 Dec 7.


Do care plans and annual reviews of physical health influence unplanned hospital utilisation for people with serious mental illness? Analysis of linked longitudinal primary and secondary healthcare records in England.

Ride J, Kasteridis P, Gutacker N, Kronenberg C, Doran T, Mason A, Rice N, Gravelle H, Goddard M, Kendrick T, Siddiqi N, Gilbody S, Dare CR, Aylott L, Williams R, Jacobs R.

BMJ Open. 2018 Nov 28;8(11):e023135. doi: 10.1136/bmjopen-2018-023135.


Public spending must improve health, not just healthcare.

Bloor K, Goddard M.

BMJ. 2018 Nov 6;363:k4673. doi: 10.1136/bmj.k4673. No abstract available.


Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle.

Khansefid M, Pryce JE, Bolormaa S, Chen Y, Millen CA, Chamberlain AJ, Vander Jagt CJ, Goddard ME.

BMC Genomics. 2018 Nov 3;19(1):793. doi: 10.1186/s12864-018-5181-0.


The feasibility of using low-density marker panels for genotype imputation and genomic prediction of crossbred dairy cattle of East Africa.

Aliloo H, Mrode R, Okeyo AM, Ni G, Goddard ME, Gibson JP.

J Dairy Sci. 2018 Oct;101(10):9108-9127. doi: 10.3168/jds.2018-14621. Epub 2018 Aug 1.


Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues.

Xiang R, Hayes BJ, Vander Jagt CJ, MacLeod IM, Khansefid M, Bowman PJ, Yuan Z, Prowse-Wilkins CP, Reich CM, Mason BA, Garner JB, Marett LC, Chen Y, Bolormaa S, Daetwyler HD, Chamberlain AJ, Goddard ME.

BMC Genomics. 2018 Jul 4;19(1):521. doi: 10.1186/s12864-018-4902-8.


Co-evolution as Tool for Diversifying Flavor and Aroma Profiles of Wines.

Morrison-Whittle P, Lee SA, Fedrizzi B, Goddard MR.

Front Microbiol. 2018 May 7;9:910. doi: 10.3389/fmicb.2018.00910. eCollection 2018.


Investigating the impact of primary care payments on underdiagnosis in dementia: A difference-in-differences analysis.

Mason A, Liu D, Kasteridis P, Goddard M, Jacobs R, Wittenberg R, McGonigal G.

Int J Geriatr Psychiatry. 2018 Aug;33(8):1090-1097. doi: 10.1002/gps.4897. Epub 2018 May 30.


Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits.

Wang M, Hancock TP, Chamberlain AJ, Vander Jagt CJ, Pryce JE, Cocks BG, Goddard ME, Hayes BJ.

BMC Genomics. 2018 May 24;19(1):395. doi: 10.1186/s12864-018-4800-0.


Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity.

Cole JE, Park I, Ahern DJ, Kassiteridi C, Danso Abeam D, Goddard ME, Green P, Maffia P, Monaco C.

Cardiovasc Res. 2018 Aug 1;114(10):1360-1371. doi: 10.1093/cvr/cvy109.


Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

Evans LM, Tahmasbi R, Vrieze SI, Abecasis GR, Das S, Gazal S, Bjelland DW, de Candia TR; Haplotype Reference Consortium, Goddard ME, Neale BM, Yang J, Visscher PM, Keller MC.

Nat Genet. 2018 May;50(5):737-745. doi: 10.1038/s41588-018-0108-x. Epub 2018 Apr 26.


Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin.

Hansen R, Gibson S, De Paiva Alves E, Goddard M, MacLaren A, Karcher AM, Berry S, Collie-Duguid ESR, El-Omar E, Munro M, Hold GL.

Sci Rep. 2018 Apr 24;8(1):6470. doi: 10.1038/s41598-018-24811-3.


Narrow-sense heritability estimation of complex traits using identity-by-descent information.

Evans LM, Tahmasbi R, Jones M, Vrieze SI, Abecasis GR, Das S, Bjelland DW, de Candia TR, Yang J, Goddard ME, Visscher PM, Keller MC; Haplotype Reference Consortium.

Heredity (Edinb). 2018 Dec;121(6):616-630. doi: 10.1038/s41437-018-0067-0. Epub 2018 Mar 28.


A multi-trait Bayesian method for mapping QTL and genomic prediction.

Kemper KE, Bowman PJ, Hayes BJ, Visscher PM, Goddard ME.

Genet Sel Evol. 2018 Mar 24;50(1):10. doi: 10.1186/s12711-018-0377-y.


Multibreed genomic prediction using multitrait genomic residual maximum likelihood and multitask Bayesian variable selection.

Calus MPL, Goddard ME, Wientjes YCJ, Bowman PJ, Hayes BJ.

J Dairy Sci. 2018 May;101(5):4279-4294. doi: 10.3168/jds.2017-13366. Epub 2018 Mar 15.


Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant.

Cheng Q, Patel K, Lei B, Rucker L, Allen DP, Zhu P, Vasu C, Martins PN, Goddard M, Nadig SN, Atkinson C.

Am J Transplant. 2018 Oct;18(10):2417-2428. doi: 10.1111/ajt.14717. Epub 2018 Apr 10.


Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.

Bouwman AC, Daetwyler HD, Chamberlain AJ, Ponce CH, Sargolzaei M, Schenkel FS, Sahana G, Govignon-Gion A, Boitard S, Dolezal M, Pausch H, Brøndum RF, Bowman PJ, Thomsen B, Guldbrandtsen B, Lund MS, Servin B, Garrick DJ, Reecy J, Vilkki J, Bagnato A, Wang M, Hoff JL, Schnabel RD, Taylor JF, Vinkhuyzen AAE, Panitz F, Bendixen C, Holm LE, Gredler B, Hozé C, Boussaha M, Sanchez MP, Rocha D, Capitan A, Tribout T, Barbat A, Croiseau P, Drögemüller C, Jagannathan V, Vander Jagt C, Crowley JJ, Bieber A, Purfield DC, Berry DP, Emmerling R, Götz KU, Frischknecht M, Russ I, Sölkner J, Van Tassell CP, Fries R, Stothard P, Veerkamp RF, Boichard D, Goddard ME, Hayes BJ.

Nat Genet. 2018 Mar;50(3):362-367. doi: 10.1038/s41588-018-0056-5. Epub 2018 Feb 19.


Gene expression analysis of blood, liver, and muscle in cattle divergently selected for high and low residual feed intake.

Khansefid M, Millen CA, Chen Y, Pryce JE, Chamberlain AJ, Vander Jagt CJ, Gondro C, Goddard ME.

J Anim Sci. 2017 Nov;95(11):4764-4775. doi: 10.2527/jas2016.1320.


Grapevine Botryosphaeria dieback fungi have specific aggressiveness factor repertory involved in wood decay and stilbene metabolization.

Stempien E, Goddard ML, Wilhelm K, Tarnus C, Bertsch C, Chong J.

PLoS One. 2017 Dec 20;12(12):e0188766. doi: 10.1371/journal.pone.0188766. eCollection 2017.


Outcome after heart transplantation from donation after circulatory-determined death donors.

Messer S, Page A, Axell R, Berman M, Hernández-Sánchez J, Colah S, Parizkova B, Valchanov K, Dunning J, Pavlushkov E, Balasubramanian SK, Parameshwar J, Omar YA, Goddard M, Pettit S, Lewis C, Kydd A, Jenkins D, Watson CJ, Sudarshan C, Catarino P, Findlay M, Ali A, Tsui S, Large SR.

J Heart Lung Transplant. 2017 Dec;36(12):1311-1318. doi: 10.1016/j.healun.2017.10.021. Epub 2017 Oct 24. Erratum in: J Heart Lung Transplant. 2018 Apr;37(4):535.


Meta-analysis of sequence-based association studies across three cattle breeds reveals 25 QTL for fat and protein percentages in milk at nucleotide resolution.

Pausch H, Emmerling R, Gredler-Grandl B, Fries R, Daetwyler HD, Goddard ME.

BMC Genomics. 2017 Nov 9;18(1):853. doi: 10.1186/s12864-017-4263-8.


From vineyard to winery: a source map of microbial diversity driving wine fermentation.

Morrison-Whittle P, Goddard MR.

Environ Microbiol. 2018 Jan;20(1):75-84. doi: 10.1111/1462-2920.13960. Epub 2017 Nov 10.


Secreted proteins produced by fungi associated with Botryosphaeria dieback trigger distinct defense responses in Vitis vinifera and Vitis rupestris cells.

Stempien E, Goddard ML, Leva Y, Bénard-Gellon M, Laloue H, Farine S, Kieffer-Mazet F, Tarnus C, Bertsch C, Chong J.

Protoplasma. 2018 Mar;255(2):613-628. doi: 10.1007/s00709-017-1175-z. Epub 2017 Oct 17.


Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.

Johnston KL, Cook DAN, Berry NG, David Hong W, Clare RH, Goddard M, Ford L, Nixon GL, O'Neill PM, Ward SA, Taylor MJ.

Sci Adv. 2017 Sep 27;3(9):eaao1551. doi: 10.1126/sciadv.aao1551. eCollection 2017 Sep.


Multi-breed genomic prediction using Bayes R with sequence data and dropping variants with a small effect.

van den Berg I, Bowman PJ, MacLeod IM, Hayes BJ, Wang T, Bolormaa S, Goddard ME.

Genet Sel Evol. 2017 Sep 21;49(1):70. doi: 10.1186/s12711-017-0347-9.


Concepts, estimation and interpretation of SNP-based heritability.

Yang J, Zeng J, Goddard ME, Wray NR, Visscher PM.

Nat Genet. 2017 Aug 30;49(9):1304-1310. doi: 10.1038/ng.3941.


Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle.

Xiang R, MacLeod IM, Bolormaa S, Goddard ME.

Sci Rep. 2017 Aug 23;7(1):9248. doi: 10.1038/s41598-017-09788-9.

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