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Bone Marrow-derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic SCI.

Norden DM, Faw TD, McKim DB, Deibert RJ, Fisher LC, Sheridan JF, Godbout JP, Basso DM Ed.D. , PT.

J Neurotrauma. 2018 Jul 17. doi: 10.1089/neu.2018.5806. [Epub ahead of print]


Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2.

Lisboa SF, Niraula A, Resstel LB, Guimaraes FS, Godbout JP, Sheridan JF.

Neuropsychopharmacology. 2018 Aug;43(9):1924-1933. doi: 10.1038/s41386-018-0064-2. Epub 2018 Apr 17.


The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer's Disease.

Kokiko-Cochran ON, Godbout JP.

Front Immunol. 2018 Apr 9;9:672. doi: 10.3389/fimmu.2018.00672. eCollection 2018. Review.


Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression.

Niraula A, Wang Y, Godbout JP, Sheridan JF.

J Neurosci. 2018 Feb 28;38(9):2328-2340. doi: 10.1523/JNEUROSCI.2568-17.2018. Epub 2018 Jan 30.


Effects of dermal wounding on distal primary tumor immunobiology in mice.

Pyter LM, McKim DB, Husain Y, Calero H, Godbout JP, Sheridan JF, Marucha PT, Engeland CG.

J Surg Res. 2018 Jan;221:328-335. doi: 10.1016/j.jss.2017.09.016. Epub 2017 Oct 17.


Ropivacaine and Bupivacaine prevent increased pain sensitivity without altering neuroimmune activation following repeated social defeat stress.

Sawicki CM, Kim JK, Weber MD, Jarrett BL, Godbout JP, Sheridan JF, Humeidan M.

Brain Behav Immun. 2018 Mar;69:113-123. doi: 10.1016/j.bbi.2017.11.005. Epub 2017 Nov 8.


MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment.

Kim B, Kusibati R, Heisler-Taylor T, Mantopoulos D, Ding J, Abdel-Rahman MH, Satoskar AR, Godbout JP, Bhattacharya SK, Cebulla CM.

Sci Rep. 2017 Oct 30;7(1):14336. doi: 10.1038/s41598-017-14298-9.


Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety.

McKim DB, Weber MD, Niraula A, Sawicki CM, Liu X, Jarrett BL, Ramirez-Chan K, Wang Y, Roeth RM, Sucaldito AD, Sobol CG, Quan N, Sheridan JF, Godbout JP.

Mol Psychiatry. 2018 Jun;23(6):1421-1431. doi: 10.1038/mp.2017.64. Epub 2017 Apr 4.


Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?

Witcher KG, Godbout JP.

JAMA Neurol. 2017 Jan 1;74(1):23-25. doi: 10.1001/jamaneurol.2016.4539. No abstract available.


BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy.

Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B.

Clin Cancer Res. 2017 Apr 1;23(7):1809-1819. doi: 10.1158/1078-0432.CCR-16-1818. Epub 2016 Nov 9.


Neuroinflammation: the devil is in the details.

DiSabato DJ, Quan N, Godbout JP.

J Neurochem. 2016 Oct;139 Suppl 2:136-153. doi: 10.1111/jnc.13607. Epub 2016 May 4. Review.


Microglia Priming with Aging and Stress.

Niraula A, Sheridan JF, Godbout JP.

Neuropsychopharmacology. 2017 Jan;42(1):318-333. doi: 10.1038/npp.2016.185. Epub 2016 Sep 8. Review.


Tumors Alter Inflammation and Impair Dermal Wound Healing in Female Mice.

Pyter LM, Husain Y, Calero H, McKim DB, Lin HY, Godbout JP, Sheridan JF, Engeland CG, Marucha PT.

PLoS One. 2016 Aug 22;11(8):e0161537. doi: 10.1371/journal.pone.0161537. eCollection 2016.


The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.

Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF.

J Neurosci. 2016 Jul 27;36(30):7946-56. doi: 10.1523/JNEUROSCI.1161-16.2016.


Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal.

Weber MD, Godbout JP, Sheridan JF.

Neuropsychopharmacology. 2017 Jan;42(1):46-61. doi: 10.1038/npp.2016.102. Epub 2016 Jun 20. Review.


Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.

Norden DM, Trojanowski PJ, Walker FR, Godbout JP.

Neurobiol Aging. 2016 Aug;44:22-41. doi: 10.1016/j.neurobiolaging.2016.04.014. Epub 2016 Apr 27.


Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury.

Hansen CN, Norden DM, Faw TD, Deibert R, Wohleb ES, Sheridan JF, Godbout JP, Basso DM.

Exp Neurol. 2016 Aug;282:86-98. doi: 10.1016/j.expneurol.2016.05.019. Epub 2016 May 16.


Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?

Ziebell JM, Rowe RK, Muccigrosso MM, Reddaway JT, Adelson PD, Godbout JP, Lifshitz J.

Brain Behav Immun. 2017 Jan;59:1-7. doi: 10.1016/j.bbi.2016.03.008. Epub 2016 Mar 11. Review.


Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat.

McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP.

J Neurosci. 2016 Mar 2;36(9):2590-604. doi: 10.1523/JNEUROSCI.2394-15.2016.


Cognitive deficits develop 1month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge.

Muccigrosso MM, Ford J, Benner B, Moussa D, Burnsides C, Fenn AM, Popovich PG, Lifshitz J, Walker FR, Eiferman DS, Godbout JP.

Brain Behav Immun. 2016 May;54:95-109. doi: 10.1016/j.bbi.2016.01.009. Epub 2016 Jan 14.


Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice.

Norden DM, McCarthy DO, Bicer S, Devine RD, Reiser PJ, Godbout JP, Wold LE.

Life Sci. 2015 Dec 15;143:65-70. doi: 10.1016/j.lfs.2015.10.020. Epub 2015 Oct 20.


Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge.

Norden DM, Trojanowski PJ, Villanueva E, Navarro E, Godbout JP.

Glia. 2016 Feb;64(2):300-16. doi: 10.1002/glia.22930. Epub 2015 Oct 15.


Priming the inflammatory pump of the CNS after traumatic brain injury.

Witcher KG, Eiferman DS, Godbout JP.

Trends Neurosci. 2015 Oct;38(10):609-620. doi: 10.1016/j.tins.2015.08.002. Review.


Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.

McKim DB, Patterson JM, Wohleb ES, Jarrett BL, Reader BF, Godbout JP, Sheridan JF.

Biol Psychiatry. 2016 May 15;79(10):803-813. doi: 10.1016/j.biopsych.2015.07.010. Epub 2015 Jul 26.


Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.

Liu X, Yamashita T, Chen Q, Belevych N, Mckim DB, Tarr AJ, Coppola V, Nath N, Nemeth DP, Syed ZW, Sheridan JF, Godbout JP, Zuo J, Quan N.

J Neurosci. 2015 Feb 18;35(7):2860-70. doi: 10.1523/JNEUROSCI.3199-14.2015.


Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior.

Wohleb ES, McKim DB, Sheridan JF, Godbout JP.

Front Neurosci. 2015 Jan 21;8:447. doi: 10.3389/fnins.2014.00447. eCollection 2014. Review.


Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety.

Reader BF, Jarrett BL, McKim DB, Wohleb ES, Godbout JP, Sheridan JF.

Neuroscience. 2015 Mar 19;289:429-42. doi: 10.1016/j.neuroscience.2015.01.001. Epub 2015 Jan 14. Review.


Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.

Norden DM, Devine R, Bicer S, Jing R, Reiser PJ, Wold LE, Godbout JP, McCarthy DO.

Physiol Behav. 2015 Mar 1;140:230-5. doi: 10.1016/j.physbeh.2014.12.045. Epub 2014 Dec 30.


Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease.

Norden DM, Muccigrosso MM, Godbout JP.

Neuropharmacology. 2015 Sep;96(Pt A):29-41. doi: 10.1016/j.neuropharm.2014.10.028. Epub 2014 Nov 13. Review.


Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain.

Sawicki CM, McKim DB, Wohleb ES, Jarrett BL, Reader BF, Norden DM, Godbout JP, Sheridan JF.

Neuroscience. 2015 Aug 27;302:151-64. doi: 10.1016/j.neuroscience.2014.10.004. Epub 2014 Oct 14.


Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.

Norden DM, Bicer S, Clark Y, Jing R, Henry CJ, Wold LE, Reiser PJ, Godbout JP, McCarthy DO.

Brain Behav Immun. 2015 Jan;43:76-85. doi: 10.1016/j.bbi.2014.07.013. Epub 2014 Aug 4.


Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice.

Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP.

J Neurotrauma. 2015 Jan 15;32(2):127-38. doi: 10.1089/neu.2014.3514. Epub 2014 Nov 13.


TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation.

Norden DM, Fenn AM, Dugan A, Godbout JP.

Glia. 2014 Jun;62(6):881-95. doi: 10.1002/glia.22647. Epub 2014 Feb 25.


Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.

Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK.

Neuron. 2014 Mar 5;81(5):1009-1023. doi: 10.1016/j.neuron.2014.01.013.


Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior.

Wohleb ES, Patterson JM, Sharma V, Quan N, Godbout JP, Sheridan JF.

J Neurosci. 2014 Feb 12;34(7):2583-91. doi: 10.1523/JNEUROSCI.3723-13.2014.


Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.

Wohleb ES, McKim DB, Shea DT, Powell ND, Tarr AJ, Sheridan JF, Godbout JP.

Biol Psychiatry. 2014 Jun 15;75(12):970-81. doi: 10.1016/j.biopsych.2013.11.029. Epub 2013 Dec 10.


Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.

Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP.

Biol Psychiatry. 2014 Oct 1;76(7):575-84. doi: 10.1016/j.biopsych.2013.10.014. Epub 2013 Oct 25.


The role of inflammatory mediators in immune-to-brain communication during health and disease.

Gomez-Nicola D, Teeling J, Guaza C, Godbout JP, Taub DD.

Mediators Inflamm. 2013;2013:429231. doi: 10.1155/2013/429231. Epub 2013 Sep 10. No abstract available.


Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron.

Lieblein-Boff JC, McKim DB, Shea DT, Wei P, Deng Z, Sawicki C, Quan N, Bilbo SD, Bailey MT, McTigue DM, Godbout JP.

J Neurosci. 2013 Oct 9;33(41):16334-45. doi: 10.1523/JNEUROSCI.0708-13.2013.


Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.

Wohleb ES, Powell ND, Godbout JP, Sheridan JF.

J Neurosci. 2013 Aug 21;33(34):13820-33. doi: 10.1523/JNEUROSCI.1671-13.2013.


Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand.

Fenn AM, Smith KM, Lovett-Racke AE, Guerau-de-Arellano M, Whitacre CC, Godbout JP.

Neurobiol Aging. 2013 Dec;34(12):2748-58. doi: 10.1016/j.neurobiolaging.2013.06.007. Epub 2013 Jul 21.


Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory.

Brothers HM, Bardou I, Hopp SC, Kaercher RM, Corona AW, Fenn AM, Godbout JP, Wenk GL.

J Neuroimmune Pharmacol. 2013 Dec;8(5):1098-105. doi: 10.1007/s11481-013-9476-2. Epub 2013 May 25.


Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.

Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, Eubank TD, Marsh CB.

PLoS One. 2013;8(3):e58488. doi: 10.1371/journal.pone.0058488. Epub 2013 Mar 8.


Basic aspects of the immunology of neuroinflammation.

Wohleb ES, Godbout JP.

Mod Trends Pharmacopsychiatry. 2013;28:1-19. doi: 10.1159/000343964. Epub 2013 Feb 27. Review.


Review: microglia of the aged brain: primed to be activated and resistant to regulation.

Norden DM, Godbout JP.

Neuropathol Appl Neurobiol. 2013 Feb;39(1):19-34. doi: 10.1111/j.1365-2990.2012.01306.x. Review.


Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.

Corona AW, Norden DM, Skendelas JP, Huang Y, O'Connor JC, Lawson M, Dantzer R, Kelley KW, Godbout JP.

Brain Behav Immun. 2013 Jul;31:134-42. doi: 10.1016/j.bbi.2012.08.008. Epub 2012 Aug 19.


Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.

Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP.

Psychoneuroendocrinology. 2012 Sep;37(9):1491-505. doi: 10.1016/j.psyneuen.2012.02.003. Epub 2012 Mar 2.


Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice.

Fenn AM, Henry CJ, Huang Y, Dugan A, Godbout JP.

Brain Behav Immun. 2012 Jul;26(5):766-77. doi: 10.1016/j.bbi.2011.10.003. Epub 2011 Oct 17.


Cognitive and behavioral consequences of impaired immunoregulation in aging.

Corona AW, Fenn AM, Godbout JP.

J Neuroimmune Pharmacol. 2012 Mar;7(1):7-23. doi: 10.1007/s11481-011-9313-4. Epub 2011 Sep 20. Review.


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