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Items: 27


SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection.

O'Connell P, Pepelyayeva Y, Blake MK, Hyslop S, Crawford RB, Rizzo MD, Pereira-Hicks C, Godbehere S, Dale L, Gulick P, Kaminski NE, Amalfitano A, Aldhamen YA.

J Immunol. 2019 Jan 1;202(1):228-238. doi: 10.4049/jimmunol.1800847. Epub 2018 Dec 10.


Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses.

Quiroga D, Aldhamen YA, Godbehere S, Harding L, Amalfitano A.

Clin Vaccine Immunol. 2017 Jun 5;24(6). pii: e00061-17. doi: 10.1128/CVI.00061-17. Print 2017 Jun.


CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets.

Aldhamen YA, Rastall DPW, Chen W, Seregin SS, Pereira-Hicks C, Godbehere S, Kaminski NE, Amalfitano A.

Vaccine. 2016 Jun 8;34(27):3109-3118. doi: 10.1016/j.vaccine.2016.04.068. Epub 2016 May 3.


In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.

Alyaqoub FS, Aldhamen YA, Koestler BJ, Bruger EL, Seregin SS, Pereira-Hicks C, Godbehere S, Waters CM, Amalfitano A.

J Immunol. 2016 Feb 15;196(4):1741-52. doi: 10.4049/jimmunol.1501272. Epub 2016 Jan 20.


Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination.

Quiroga D, Aldhamen YA, Appledorn DM, Godbehere S, Amalfitano A.

Cancer Immunol Immunother. 2015 Apr;64(4):479-91. doi: 10.1007/s00262-015-1659-7. Epub 2015 Feb 6.


Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A.

J Innate Immun. 2015;7(3):275-89. doi: 10.1159/000368899. Epub 2015 Jan 14.


Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.

Koestler BJ, Seregin SS, Rastall DP, Aldhamen YA, Godbehere S, Amalfitano A, Waters CM.

Clin Vaccine Immunol. 2014 Nov;21(11):1550-9. doi: 10.1128/CVI.00471-14. Epub 2014 Sep 17.


ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses.

Rastall DP, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A.

Int Immunol. 2014 Dec;26(12):685-95. doi: 10.1093/intimm/dxu078. Epub 2014 Aug 2.


Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy.

Aldhamen YA, Seregin SS, Aylsworth CF, Godbehere S, Amalfitano A.

Int Immunol. 2014 May;26(5):291-303. doi: 10.1093/intimm/dxt061. Epub 2013 Dec 27.


Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2.

Aldhamen YA, Seregin SS, Kousa YA, Rastall DP, Appledorn DM, Godbehere S, Schutte BC, Amalfitano A.

Cancer Gene Ther. 2013 Oct;20(10):564-75. doi: 10.1038/cgt.2013.53. Epub 2013 Aug 16.


Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen.

Aylsworth CF, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A.

Hum Immunol. 2013 Aug;74(8):916-26. doi: 10.1016/j.humimm.2013.04.035. Epub 2013 Apr 29.


Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

Aldhamen YA, Seregin SS, Schuldt NJ, Rastall DP, Liu CJ, Godbehere S, Amalfitano A.

J Immunol. 2012 Aug 1;189(3):1349-59. doi: 10.4049/jimmunol.1200736. Epub 2012 Jun 27.


Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice.

Seregin SS, Aldhamen YA, Rastall DP, Godbehere S, Amalfitano A.

Vaccine. 2012 Feb 14;30(8):1492-501. doi: 10.1016/j.vaccine.2011.12.064. Epub 2011 Dec 23.


Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.

Schuldt NJ, Aldhamen YA, Appledorn DM, Seregin SS, Kousa Y, Godbehere S, Amalfitano A.

PLoS One. 2011;6(8):e24147. doi: 10.1371/journal.pone.0024147. Epub 2011 Aug 30.


TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.

Seregin SS, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A.

PLoS One. 2011;6(7):e22064. doi: 10.1371/journal.pone.0022064. Epub 2011 Jul 8.


Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice.

Seregin SS, Aldhamen YA, Appledorn DM, Zehnder J, Voss T, Godbehere S, Amalfitano A.

Hum Gene Ther. 2011 Sep;22(9):1083-94. doi: 10.1089/hum.2010.218. Epub 2011 Apr 18.


Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens.

Aldhamen YA, Appledorn DM, Seregin SS, Liu CJ, Schuldt NJ, Godbehere S, Amalfitano A.

J Immunol. 2011 Jan 15;186(2):722-32. doi: 10.4049/jimmunol.1002105. Epub 2010 Dec 13.


Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.

Seregin SS, Aldhamen YA, Appledorn DM, Hartman ZC, Schuldt NJ, Scott J, Godbehere S, Jiang H, Frank MM, Amalfitano A.

Blood. 2010 Sep 9;116(10):1669-77. doi: 10.1182/blood-2010-03-276949. Epub 2010 May 28.


Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.

Seregin SS, Hartman ZC, Appledorn DM, Godbehere S, Jiang H, Frank MM, Amalfitano A.

J Innate Immun. 2010;2(4):353-9. doi: 10.1159/000284368. Epub 2010 Feb 11.


A new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic target.

Appledorn DM, Aldhamen YA, Depas W, Seregin SS, Liu CJ, Schuldt N, Quach D, Quiroga D, Godbehere S, Zlatkin I, Kim S, McCormick JJ, Amalfitano A.

PLoS One. 2010 Mar 8;5(3):e9579. doi: 10.1371/journal.pone.0009579.


beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.

Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A.

Virus Res. 2010 Jan;147(1):123-34. doi: 10.1016/j.virusres.2009.10.023. Epub 2009 Nov 6.


CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies.

Seregin SS, Aldhamen YA, Appledorn DM, Schuldt NJ, McBride AJ, Bujold M, Godbehere SS, Amalfitano A.

Gene Ther. 2009 Oct;16(10):1245-59. doi: 10.1038/gt.2009.77. Epub 2009 Jun 25.


Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.

Seregin SS, Appledorn DM, McBride AJ, Schuldt NJ, Aldhamen YA, Voss T, Wei J, Bujold M, Nance W, Godbehere S, Amalfitano A.

Mol Ther. 2009 Apr;17(4):685-96. doi: 10.1038/mt.2008.297. Epub 2009 Jan 27.


TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses.

Appledorn DM, Patial S, Godbehere S, Parameswaran N, Amalfitano A.

J Innate Immun. 2009;1(4):376-88. doi: 10.1159/000207194. Epub 2009 Mar 4.


Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo.

Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A.

J Immunol. 2008 Aug 1;181(3):2134-44.


Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors.

Appledorn DM, McBride A, Seregin S, Scott JM, Schuldt N, Kiang A, Godbehere S, Amalfitano A.

Gene Ther. 2008 Dec;15(24):1606-17. doi: 10.1038/gt.2008.114. Epub 2008 Jul 10.


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