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A Call for Systems Epidemiology to Tackle the Complexity of Schistosomiasis, Its Control, and Its Elimination.

Krauth SJ, Balen J, Gobert GN, Lamberton PHL.

Trop Med Infect Dis. 2019 Jan 29;4(1). pii: E21. doi: 10.3390/tropicalmed4010021.


Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium.

Oey H, Zakrzewski M, Gravermann K, Young ND, Korhonen PK, Gobert GN, Nawaratna S, Hasan S, Martínez DM, You H, Lavin M, Jones MK, Ragan MA, Stoye J, Oleaga A, Emery AM, Webster BL, Rollinson D, Gasser RB, McManus DP, Krause L.

PLoS Pathog. 2019 Jan 23;15(1):e1007513. doi: 10.1371/journal.ppat.1007513. eCollection 2019 Jan.


Co-parasitism of intestinal protozoa and Schistosoma japonicum in a rural community in the Philippines.

Weerakoon KG, Gordon CA, Williams GM, Cai P, Gobert GN, Olveda RM, Ross AG, Olveda DU, McManus DP.

Infect Dis Poverty. 2018 Dec 10;7(1):121. doi: 10.1186/s40249-018-0504-6.


Whole-genome sequence of the oriental lung fluke Paragonimus westermani.

Oey H, Zakrzewski M, Narain K, Devi KR, Agatsuma T, Nawaratna S, Gobert GN, Jones MK, Ragan MA, McManus DP, Krause L.

Gigascience. 2019 Jan 1;8(1). doi: 10.1093/gigascience/giy146.


Schistosomiasis in Malaysia: A review.

Chuah C, Gobert GN, Latif B, Heo CC, Leow CY.

Acta Trop. 2019 Feb;190:137-143. doi: 10.1016/j.actatropica.2018.11.012. Epub 2018 Nov 16. Review.


Calcium and Ca2+/Calmodulin-dependent kinase II as targets for helminth parasite control.

Nawaratna SSK, You H, Jones MK, McManus DP, Gobert GN.

Biochem Soc Trans. 2018 Dec 17;46(6):1743-1751. doi: 10.1042/BST20180480. Epub 2018 Nov 12. Review.


Live imaging of collagen deposition during experimental hepatic schistosomiasis and recovery: a view on a dynamic process.

Harvie MCG, McManus DP, You H, Rivera VA, Nawaratna SK, MacDonald KPA, Ramm GA, Gobert GN.

Lab Invest. 2019 Feb;99(2):231-243. doi: 10.1038/s41374-018-0154-0. Epub 2018 Nov 6.


Enzyme activity of Schistosoma japonicum cercarial elastase SjCE-2b ascertained by in vitro refolded recombinant protein.

Zhang T, Mo XJ, Xu B, Yang Z, Gobert GN, Yan S, Feng Z, Hu W.

Acta Trop. 2018 Nov;187:15-22. doi: 10.1016/j.actatropica.2018.07.009. Epub 2018 Jul 11.


Droplet digital PCR improves absolute quantification of viable lactic acid bacteria in faecal samples.

Gobert G, Cotillard A, Fourmestraux C, Pruvost L, Miguet J, Boyer M.

J Microbiol Methods. 2018 May;148:64-73. doi: 10.1016/j.mimet.2018.03.004. Epub 2018 Mar 14.


Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells.

Carson JP, Ramm GA, Robinson MW, McManus DP, Gobert GN.

Trends Parasitol. 2018 Jun;34(6):524-540. doi: 10.1016/ Epub 2018 Mar 8. Review.


Droplet Digital PCR Diagnosis of Human Schistosomiasis: Parasite Cell-Free DNA Detection in Diverse Clinical Samples.

Weerakoon KG, Gordon CA, Williams GM, Cai P, Gobert GN, Olveda RM, Ross AG, Olveda DU, McManus DP.

J Infect Dis. 2017 Dec 19;216(12):1611-1622. doi: 10.1093/infdis/jix521.


Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease.

Pozniak KN, Pearen MA, Pereira TN, Kramer CSM, Kalita-De Croft P, Nawaratna SK, Fernandez-Rojo MA, Gobert GN, Tirnitz-Parker JEE, Olynyk JK, Shepherd RW, Lewindon PJ, Ramm GA.

Am J Pathol. 2017 Dec;187(12):2744-2757. doi: 10.1016/j.ajpath.2017.08.024. Epub 2017 Sep 19.


Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection.

Sanchez MC, Krasnec KV, Parra AS, von Cabanlong C, Gobert GN, Umylny B, Cupit PM, Cunningham C.

PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005691. doi: 10.1371/journal.pntd.0005691. eCollection 2017 Jun.


Rodents, goats and dogs - their potential roles in the transmission of schistosomiasis in China.

VAN Dorssen CF, Gordon CA, Li Y, Williams GM, Wang Y, Luo Z, Gobert GN, You H, McManus DP, Gray DJ.

Parasitology. 2017 Oct;144(12):1633-1642. doi: 10.1017/S0031182017000907. Epub 2017 Jun 22.


A novel duplex ddPCR assay for the diagnosis of schistosomiasis japonica: proof of concept in an experimental mouse model.

Weerakoon KG, Gordon CA, Cai P, Gobert GN, Duke M, Williams GM, McManus DP.

Parasitology. 2017 Jul;144(8):1005-1015. doi: 10.1017/S003118201700021X. Epub 2017 Mar 9.


Functional characterisation of Schistosoma japonicum acetylcholinesterase.

You H, Gobert GN, Du X, Pali G, Cai P, Jones MK, McManus DP.

Parasit Vectors. 2016 Jun 10;9(1):328. doi: 10.1186/s13071-016-1615-1.


Comprehensive Transcriptome Analysis of Sex-Biased Expressed Genes Reveals Discrete Biological and Physiological Features of Male and Female Schistosoma japonicum.

Cai P, Liu S, Piao X, Hou N, Gobert GN, McManus DP, Chen Q.

PLoS Negl Trop Dis. 2016 Apr 29;10(4):e0004684. doi: 10.1371/journal.pntd.0004684. eCollection 2016 Apr.


Optimisation of a droplet digital PCR assay for the diagnosis of Schistosoma japonicum infection: A duplex approach with DNA binding dye chemistry.

Weerakoon KG, Gordon CA, Gobert GN, Cai P, McManus DP.

J Microbiol Methods. 2016 Jun;125:19-27. doi: 10.1016/j.mimet.2016.03.012. Epub 2016 Mar 26.


The Increase of Exotic Zoonotic Helminth Infections: The Impact of Urbanization, Climate Change and Globalization.

Gordon CA, McManus DP, Jones MK, Gray DJ, Gobert GN.

Adv Parasitol. 2016;91:311-97. doi: 10.1016/bs.apar.2015.12.002. Epub 2016 Feb 27. Review.


The Tao survivorship of schistosomes: implications for schistosomiasis control.

Cai P, Gobert GN, You H, McManus DP.

Int J Parasitol. 2016 Jun;46(7):453-63. doi: 10.1016/j.ijpara.2016.01.002. Epub 2016 Feb 9. Review.


Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica.

Chuah C, Jones MK, McManus DP, Nawaratna SK, Burke ML, Owen HC, Ramm GA, Gobert GN.

Int J Parasitol. 2016 Apr;46(4):239-52. doi: 10.1016/j.ijpara.2015.12.004. Epub 2016 Jan 23.


Cloning and Characterization of Two Potent Kunitz Type Protease Inhibitors from Echinococcus granulosus.

Ranasinghe SL, Fischer K, Zhang W, Gobert GN, McManus DP.

PLoS Negl Trop Dis. 2015 Dec 8;9(12):e0004268. doi: 10.1371/journal.pntd.0004268. eCollection 2015 Dec.


Exploring molecular variation in Schistosoma japonicum in China.

Young ND, Chan KG, Korhonen PK, Min Chong T, Ee R, Mohandas N, Koehler AV, Lim YL, Hofmann A, Jex AR, Qian B, Chilton NB, Gobert GN, McManus DP, Tan P, Webster BL, Rollinson D, Gasser RB.

Sci Rep. 2015 Dec 1;5:17345. doi: 10.1038/srep17345.


Clinical implications of recent findings in schistosome proteomics.

Driguez P, McManus DP, Gobert GN.

Expert Rev Proteomics. 2016;13(1):19-33. doi: 10.1586/14789450.2016.1116390. Epub 2015 Nov 26. Review.


MicroRNAs in Parasitic Helminthiases: Current Status and Future Perspectives.

Cai P, Gobert GN, McManus DP.

Trends Parasitol. 2016 Jan;32(1):71-86. doi: 10.1016/ Epub 2015 Oct 18. Review.


Lysosome-associated membrane glycoprotein (LAMP)--preliminary study on a hidden antigen target for vaccination against schistosomiasis.

Nawaratna SS, Gobert GN, Willis C, Mulvenna J, Hofmann A, McManus DP, Jones MK.

Sci Rep. 2015 Oct 16;5:15069. doi: 10.1038/srep15069.


A novel coagulation inhibitor from Schistosoma japonicum.

Ranasinghe SL, Fischer K, Gobert GN, McManus DP.

Parasitology. 2015 Dec;142(14):1663-72. doi: 10.1017/S0031182015001328. Epub 2015 Oct 14.


Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni.

Ranasinghe SL, Fischer K, Gobert GN, McManus DP.

Parasit Vectors. 2015 Aug 4;8:408. doi: 10.1186/s13071-015-1022-z.


Circulating miRNAs: Potential Novel Biomarkers for Hepatopathology Progression and Diagnosis of Schistosomiasis Japonica in Two Murine Models.

Cai P, Gobert GN, You H, Duke M, McManus DP.

PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003965. doi: 10.1371/journal.pntd.0003965. eCollection 2015.


Advances in the Diagnosis of Human Schistosomiasis.

Weerakoon KG, Gobert GN, Cai P, McManus DP.

Clin Microbiol Rev. 2015 Oct;28(4):939-67. doi: 10.1128/CMR.00137-14. Review.


Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses.

Gobert GN, Burke ML, McManus DP, Ellis MK, Chuah C, Ramm GA, Wang Y, Li Y.

Parasitology. 2015 Oct;142(12):1453-68. doi: 10.1017/S0031182015000682. Epub 2015 Jul 28.


Haem uptake is essential for egg production in the haematophagous blood fluke of humans, Schistosoma mansoni.

Toh SQ, Gobert GN, Malagón Martínez D, Jones MK.

FEBS J. 2015 Sep;282(18):3632-46. doi: 10.1111/febs.13368. Epub 2015 Aug 13.


Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum.

Driguez P, Li Y, Gaze S, Pearson MS, Nakajima R, Trieu A, Doolan DL, Felgner PL, Hou X, Cardoso FC, Jasinskas A, Gobert GN, Loukas A, McManus DP.

J Infect Dis. 2016 Jan 1;213(1):122-30. doi: 10.1093/infdis/jiv356. Epub 2015 Jul 6.


Specific humoral response of hosts with variable schistosomiasis susceptibility.

Driguez P, McWilliam HE, Gaze S, Piedrafita D, Pearson MS, Nakajima R, Duke M, Trieu A, Doolan DL, Cardoso FC, Jasinskas A, Gobert GN, Felgner PL, Loukas A, Meeusen E, McManus DP.

Immunol Cell Biol. 2016 Jan;94(1):52-65. doi: 10.1038/icb.2015.61. Epub 2015 Jun 5.


An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs.

Gobert GN, Nawaratna SK, Harvie M, Ramm GA, McManus DP.

PLoS Negl Trop Dis. 2015 May 12;9(5):e0003760. doi: 10.1371/journal.pntd.0003760. eCollection 2015 May.


Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential.

You H, Gobert GN, Cai P, Mou R, Nawaratna S, Fang G, Villinger F, McManus DP.

PLoS Negl Trop Dis. 2015 May 11;9(5):e0003730. doi: 10.1371/journal.pntd.0003730. eCollection 2015 May.


Multiplex real-time PCR monitoring of intestinal helminths in humans reveals widespread polyparasitism in Northern Samar, the Philippines.

Gordon CA, McManus DP, Acosta LP, Olveda RM, Williams GM, Ross AG, Gray DJ, Gobert GN.

Int J Parasitol. 2015 Jun;45(7):477-83. doi: 10.1016/j.ijpara.2015.02.011. Epub 2015 Apr 6.


High prevalence of Schistosoma japonicum and Fasciola gigantica in bovines from Northern Samar, the Philippines.

Gordon CA, Acosta LP, Gobert GN, Jiz M, Olveda RM, Ross AG, Gray DJ, Williams GM, Harn D, Li Y, McManus DP.

PLoS Negl Trop Dis. 2015 Feb 2;9(2):e0003108. doi: 10.1371/journal.pntd.0003108. eCollection 2015 Feb.


Real-time PCR demonstrates high prevalence of Schistosoma japonicum in the Philippines: implications for surveillance and control.

Gordon CA, Acosta LP, Gobert GN, Olveda RM, Ross AG, Williams GM, Gray DJ, Harn D, Li Y, McManus DP.

PLoS Negl Trop Dis. 2015 Jan 21;9(1):e0003483. doi: 10.1371/journal.pntd.0003483. eCollection 2015 Jan.


Transcriptional profiling of the oesophageal gland region of male worms of Schistosoma mansoni.

Nawaratna SS, Gobert GN, Willis C, Chuah C, McManus DP, Jones MK.

Mol Biochem Parasitol. 2014 Sep;196(2):82-9. doi: 10.1016/j.molbiopara.2014.08.002. Epub 2014 Aug 19.


Functional characterization of SjB10, an intracellular serpin from Schistosoma japonicum.

Molehin AJ, Gobert GN, Driguez P, McManus DP.

Parasitology. 2014 Nov;141(13):1746-60. doi: 10.1017/S0031182014001061. Epub 2014 Aug 19.


Gaining biological perspectives from schistosome genomes.

Gobert GN, You H, McManus DP.

Mol Biochem Parasitol. 2014 Aug;196(1):21-8. doi: 10.1016/j.molbiopara.2014.07.007. Epub 2014 Jul 27. Review.


Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum.

Molehin AJ, Gobert GN, Driguez P, McManus DP.

Parasit Vectors. 2014 Jul 14;7:330. doi: 10.1186/1756-3305-7-330.


Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies.

You H, Stephenson RJ, Gobert GN, McManus DP.

Front Genet. 2014 Jun 11;5:176. doi: 10.3389/fgene.2014.00176. eCollection 2014. Review.


Defining a pro-inflammatory neutrophil phenotype in response to schistosome eggs.

Chuah C, Jones MK, Burke ML, McManus DP, Owen HC, Gobert GN.

Cell Microbiol. 2014 Nov;16(11):1666-77. doi: 10.1111/cmi.12316. Epub 2014 Jun 25.


An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas.

Gaze S, Driguez P, Pearson MS, Mendes T, Doolan DL, Trieu A, McManus DP, Gobert GN, Periago MV, Correa Oliveira R, Cardoso FC, Oliveira G, Nakajima R, Jasinskas A, Hung C, Liang L, Pablo J, Bethony JM, Felgner PL, Loukas A.

PLoS Pathog. 2014 Mar 27;10(3):e1004033. doi: 10.1371/journal.ppat.1004033. eCollection 2014 Mar.


Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology.

Chuah C, Jones MK, Burke ML, McManus DP, Gobert GN.

Trends Parasitol. 2014 Mar;30(3):141-50. doi: 10.1016/ Epub 2014 Jan 13. Review.


Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni.

Jia X, Schulte L, Loukas A, Pickering D, Pearson M, Mobli M, Jones A, Rosengren KJ, Daly NL, Gobert GN, Jones MK, Craik DJ, Mulvenna J.

J Biol Chem. 2014 Mar 7;289(10):7151-63. doi: 10.1074/jbc.M113.531558. Epub 2014 Jan 15.


Schistosomajaponicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells.

Anthony BJ, James KR, Gobert GN, Ramm GA, McManus DP.

PLoS One. 2013 Jun 19;8(6):e68479. doi: 10.1371/journal.pone.0068479. Print 2013.


Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils.

Chuah C, Jones MK, Burke ML, Owen HC, Anthony BJ, McManus DP, Ramm GA, Gobert GN.

J Leukoc Biol. 2013 Aug;94(2):353-65. doi: 10.1189/jlb.1212653. Epub 2013 May 24.


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