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The role of polyamines in the regulation of macrophage polarization and function.

Latour YL, Gobert AP, Wilson KT.

Amino Acids. 2019 Apr 23. doi: 10.1007/s00726-019-02719-0. [Epub ahead of print] Review.


Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome.

Singh K, Gobert AP, Coburn LA, Barry DP, Allaman M, Asim M, Luis PB, Schneider C, Milne GL, Boone HH, Shilts MH, Washington MK, Das SR, Piazuelo MB, Wilson KT.

Front Cell Infect Microbiol. 2019 Mar 26;9:66. doi: 10.3389/fcimb.2019.00066. eCollection 2019.


α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY.

Sierra JC, Suarez G, Piazuelo MB, Luis PB, Baker DR, Romero-Gallo J, Barry DP, Schneider C, Morgan DR, Peek RM Jr, Gobert AP, Wilson KT.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5077-5085. doi: 10.1073/pnas.1814497116. Epub 2019 Feb 25.


Helicobacter: Inflammation, immunology, and vaccines.

Blosse A, Lehours P, Wilson KT, Gobert AP.

Helicobacter. 2018 Sep;23 Suppl 1:e12517. doi: 10.1111/hel.12517. Review.


Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.

Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT.

Oncogene. 2019 Feb;38(7):1067-1079. doi: 10.1038/s41388-018-0492-9. Epub 2018 Sep 10.


Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.

Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA Jr, Washington MK, Piazuelo MB, Wilson KT.

Front Immunol. 2018 Jun 5;9:1242. doi: 10.3389/fimmu.2018.01242. eCollection 2018.


BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability.

Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS.

Mucosal Immunol. 2018 Sep;11(5):1363-1374. doi: 10.1038/s41385-018-0043-2. Epub 2018 Jun 15.


Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.

Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KT.

Cancer Res. 2018 Aug 1;78(15):4303-4315. doi: 10.1158/0008-5472.CAN-18-0116. Epub 2018 May 31.


Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.

Nzoumbou-Boko R, De Muylder G, Semballa S, Lecordier L, Dauchy FA, Gobert AP, Holzmuller P, Lemesre JL, Bras-Gonçalves R, Barnabé C, Courtois P, Daulouède S, Beschin A, Pays E, Vincendeau P.

J Immunol. 2017 Sep 1;199(5):1762-1771. doi: 10.4049/jimmunol.1700179. Epub 2017 Jul 24.


Effect of CO2 on Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al.

Gobert AP, Wilson KT.

Trends Microbiol. 2017 Aug;25(8):602-603. doi: 10.1016/j.tim.2017.05.009. Epub 2017 Jun 10. No abstract available.


The NAG Sensor NagC Regulates LEE Gene Expression and Contributes to Gut Colonization by Escherichia coli O157:H7.

Le Bihan G, Sicard JF, Garneau P, Bernalier-Donadille A, Gobert AP, Garrivier A, Martin C, Hay AG, Beaudry F, Harel J, Jubelin G.

Front Cell Infect Microbiol. 2017 Apr 24;7:134. doi: 10.3389/fcimb.2017.00134. eCollection 2017.


Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis.

Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM Jr, Gobert AP, Wilson KT.

Gut. 2018 Jul;67(7):1247-1260. doi: 10.1136/gutjnl-2016-312888. Epub 2017 May 4.


EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis.

Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KT.

Oncogene. 2017 Jul 6;36(27):3807-3819. doi: 10.1038/onc.2017.23. Epub 2017 Mar 6.


Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases.

Gobert AP, Wilson KT.

Curr Top Microbiol Immunol. 2017;400:27-52. doi: 10.1007/978-3-319-50520-6_2. Review.


Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.

Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E751-E760. doi: 10.1073/pnas.1614958114. Epub 2017 Jan 17.


The human intestinal microbiota of constipated-predominant irritable bowel syndrome patients exhibits anti-inflammatory properties.

Gobert AP, Sagrestani G, Delmas E, Wilson KT, Verriere TG, Dapoigny M, Del'homme C, Bernalier-Donadille A.

Sci Rep. 2016 Dec 16;6:39399. doi: 10.1038/srep39399.


The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria.

Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KT.

PLoS Pathog. 2016 Oct 26;12(10):e1005984. doi: 10.1371/journal.ppat.1005984. eCollection 2016 Oct.


Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise.

Gobert AP, Wilson KT.

Free Radic Biol Med. 2017 Apr;105:16-27. doi: 10.1016/j.freeradbiomed.2016.09.024. Epub 2016 Sep 25. Review.


A secretome view of colonisation factors in Shiga toxin-encoding Escherichia coli (STEC): from enterohaemorrhagic E. coli (EHEC) to related enteropathotypes.

Monteiro R, Ageorges V, Rojas-Lopez M, Schmidt H, Weiss A, Bertin Y, Forano E, Jubelin G, Henderson IR, Livrelli V, Gobert AP, Rosini R, Soriani M, Desvaux M.

FEMS Microbiol Lett. 2016 Aug;363(16). pii: fnw179. doi: 10.1093/femsle/fnw179. Epub 2016 Jul 26. Review.


The Immune Battle against Helicobacter pylori Infection: NO Offense.

Gobert AP, Wilson KT.

Trends Microbiol. 2016 May;24(5):366-376. doi: 10.1016/j.tim.2016.02.005. Epub 2016 Feb 22. Review.


Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori.

Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM Jr, Chaturvedi R, Wilson KT.

J Immunol. 2014 Sep 15;193(6):3013-22. doi: 10.4049/jimmunol.1401075. Epub 2014 Aug 8.


NsrR, GadE, and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response to nitric oxide.

Branchu P, Matrat S, Vareille M, Garrivier A, Durand A, Crépin S, Harel J, Jubelin G, Gobert AP.

PLoS Pathog. 2014 Jan;10(1):e1003874. doi: 10.1371/journal.ppat.1003874. Epub 2014 Jan 9.


The c-di-GMP phosphodiesterase VmpA absent in Escherichia coli K12 strains affects motility and biofilm formation in the enterohemorrhagic O157:H7 serotype.

Branchu P, Hindré T, Fang X, Thomas R, Gomelsky M, Claret L, Harel J, Gobert AP, Martin C.

Vet Immunol Immunopathol. 2013 Mar 15;152(1-2):132-40. doi: 10.1016/j.vetimm.2012.09.029. Epub 2012 Sep 26.


Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells.

Gobert AP, Verriere T, de Sablet T, Peek RM Jr, Chaturvedi R, Wilson KT.

Cell Microbiol. 2013 Jan;15(1):145-56. doi: 10.1111/cmi.12039. Epub 2012 Nov 7.


Editorial: Orchestration of macrophage polarization by polyamines.

Gobert AP, Wilson KT.

J Leukoc Biol. 2012 May;91(5):677-9. doi: 10.1189/jlb.0112047. No abstract available.


Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT.

PLoS One. 2011;6(12):e29046. doi: 10.1371/journal.pone.0029046. Epub 2011 Dec 14.


Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1.

Gobert AP, Asim M, Piazuelo MB, Verriere T, Scull BP, de Sablet T, Glumac A, Lewis ND, Correa P, Peek RM Jr, Chaturvedi R, Wilson KT.

J Immunol. 2011 Nov 15;187(10):5370-9. doi: 10.4049/jimmunol.1102111. Epub 2011 Oct 10.


Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis.

Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT.

Amino Acids. 2012 Feb;42(2-3):627-40. doi: 10.1007/s00726-011-1038-4. Epub 2011 Aug 28.


Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA Jr, Correa P, Gobert AP, Polk DB, Peek RM Jr, Wilson KT.

Gastroenterology. 2011 Nov;141(5):1696-708.e1-2. doi: 10.1053/j.gastro.2011.07.045. Epub 2011 Aug 10.


Methods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infection.

Gobert AP, Chaturvedi R, Wilson KT.

Methods Mol Biol. 2011;720:409-25. doi: 10.1007/978-1-61779-034-8_26.


Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II.

Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KT.

J Immunol. 2011 Mar 15;186(6):3632-41. doi: 10.4049/jimmunol.1003431. Epub 2011 Feb 4.


Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.

Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA Jr, Gobert AP, Wilson KT.

Gastroenterology. 2010 Nov;139(5):1686-98, 1698.e1-6. doi: 10.1053/j.gastro.2010.06.060. Epub 2010 Jul 1.


Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages.

Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT.

J Biol Chem. 2010 Jun 25;285(26):20343-57. doi: 10.1074/jbc.M110.116988. Epub 2010 Apr 21.


Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages.

Lewis ND, Asim M, Barry DP, Singh K, de Sablet T, Boucher JL, Gobert AP, Chaturvedi R, Wilson KT.

J Immunol. 2010 Mar 1;184(5):2572-82. doi: 10.4049/jimmunol.0902436. Epub 2010 Jan 22.


Human microbiota-secreted factors inhibit shiga toxin synthesis by enterohemorrhagic Escherichia coli O157:H7.

de Sablet T, Chassard C, Bernalier-Donadille A, Vareille M, Gobert AP, Martin C.

Infect Immun. 2009 Feb;77(2):783-90. doi: 10.1128/IAI.01048-08. Epub 2008 Dec 8.


Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes.

Vareille M, Rannou F, Thélier N, Glasser AL, de Sablet T, Martin C, Gobert AP.

J Immunol. 2008 Apr 15;180(8):5720-6.


Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypes.

Gobert AP, Coste A, Guzman CA, Vareille M, Hindré T, de Sablet T, Girardeau JP, Martin C.

Microbes Infect. 2008 Feb;10(2):159-65. doi: 10.1016/j.micinf.2007.10.018. Epub 2007 Nov 9.


Differential expression of stx2 variants in Shiga toxin-producing Escherichia coli belonging to seropathotypes A and C.

de Sablet T, Bertin Y, Vareille M, Girardeau JP, Garrivier A, Gobert AP, Martin C.

Microbiology. 2008 Jan;154(Pt 1):176-86. doi: 10.1099/mic.0.2007/009704-0.


Shiga toxin produced by enterohemorrhagic Escherichia coli inhibits PI3K/NF-kappaB signaling pathway in globotriaosylceramide-3-negative human intestinal epithelial cells.

Gobert AP, Vareille M, Glasser AL, Hindré T, de Sablet T, Martin C.

J Immunol. 2007 Jun 15;178(12):8168-74. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


Nitric oxide inhibits Shiga-toxin synthesis by enterohemorrhagic Escherichia coli.

Vareille M, de Sablet T, Hindré T, Martin C, Gobert AP.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10199-204. Epub 2007 May 30.


Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system.

Gobert AP, Wilson KT, Martin C.

Arch Immunol Ther Exp (Warsz). 2005 May-Jun;53(3):234-44. Review.


Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation.

Bussière FI, Chaturvedi R, Cheng Y, Gobert AP, Asim M, Blumberg DR, Xu H, Kim PY, Hacker A, Casero RA Jr, Wilson KT.

J Biol Chem. 2005 Jan 28;280(4):2409-12. Epub 2004 Nov 17.


Protective role of arginase in a mouse model of colitis.

Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA Jr, Wilson KT.

J Immunol. 2004 Aug 1;173(3):2109-17.


Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.

Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA Jr, Wilson KT.

J Biol Chem. 2004 Sep 17;279(38):40161-73. Epub 2004 Jul 9.


Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect.

Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouède S, Boucher JL, Wilson KT, Veyret B, Gobert AP.

J Immunol. 2004 May 15;172(10):6298-303.


Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori.

Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT.

J Immunol. 2003 Oct 15;171(8):3913-7.


Arginases in parasitic diseases.

Vincendeau P, Gobert AP, Daulouède S, Moynet D, Mossalayi MD.

Trends Parasitol. 2003 Jan;19(1):9-12. No abstract available.


Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase.

Gobert AP, Mersey BD, Cheng Y, Blumberg DR, Newton JC, Wilson KT.

J Immunol. 2002 Jun 15;168(12):6002-6.


Helicobacter pylori induces macrophage apoptosis by activation of arginase II.

Gobert AP, Cheng Y, Wang JY, Boucher JL, Iyer RK, Cederbaum SD, Casero RA Jr, Newton JC, Wilson KT.

J Immunol. 2002 May 1;168(9):4692-700.

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