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Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.

Long X, Wong CC, Tong L, Chu ESH, Ho Szeto C, Go MYY, Coker OO, Chan AWH, Chan FKL, Sung JJY, Yu J.

Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.


APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target.

Chen H, Wong CC, Liu D, Go MYY, Wu B, Peng S, Kuang M, Wong N, Yu J.

Theranostics. 2019 Jul 9;9(18):5246-5260. doi: 10.7150/thno.34713. eCollection 2019.


CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis.

Li W, Wong CC, Zhang X, Kang W, Nakatsu G, Zhao Q, Chen H, Go MYY, Chiu PWY, Wang X, Ji J, Li X, Cai Z, Ng EKW, Yu J.

Oncogene. 2018 Dec;37(50):6383-6398. doi: 10.1038/s41388-018-0402-1. Epub 2018 Jul 27.


Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.

Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J.

Cancer Res. 2017 Apr 15;77(8):1968-1982. doi: 10.1158/0008-5472.CAN-16-1595. Epub 2017 Feb 15.


SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.

Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, Chen H, Go MY, Wu JL, Cheng KW, Ng SS, Sung JJ, Cai Z, Yu J.

Gastroenterology. 2016 Nov;151(5):945-960.e6. doi: 10.1053/j.gastro.2016.07.011. Epub 2016 Jul 21.


Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.

Bai AH, Wu WK, Xu L, Wong SH, Go MY, Chan AW, Harbord M, Zhang S, Chen M, Wu JC, Chan MW, Chan MT, Chan FK, Sung JJ, Yu J, Cheng AS, Ng SC.

J Crohns Colitis. 2016 Jun;10(6):726-34. doi: 10.1093/ecco-jcc/jjw020. Epub 2016 Jan 22.


CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.

Zhang X, Han J, Man K, Li X, Du J, Chu ES, Go MY, Sung JJ, Yu J.

J Hepatol. 2016 Jan;64(1):160-70. doi: 10.1016/j.jhep.2015.09.005. Epub 2015 Sep 21.


Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.

Tian Y, Wong VW, Wong GL, Yang W, Sun H, Shen J, Tong JH, Go MY, Cheung YS, Lai PB, Zhou M, Xu G, Huang TH, Yu J, To KF, Cheng AS, Chan HL.

Cancer Res. 2015 Nov 15;75(22):4803-16. doi: 10.1158/0008-5472.CAN-14-3786. Epub 2015 Sep 17.


MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.

Wang K, Liang Q, Li X, Tsoi H, Zhang J, Wang H, Go MY, Chiu PW, Ng EK, Sung JJ, Yu J.

Gut. 2016 Oct;65(10):1619-31. doi: 10.1136/gutjnl-2015-309276. Epub 2015 Jul 23.


Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.

Zhang J, Tsoi H, Li X, Wang H, Gao J, Wang K, Go MY, Ng SC, Chan FK, Sung JJ, Yu J.

Gut. 2016 Sep;65(9):1482-93. doi: 10.1136/gutjnl-2014-308614. Epub 2015 Jun 12.


Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer.

Zhao J, Dong Y, Kang W, Go MY, Tong JH, Ng EK, Chiu PW, Cheng AS, To KF, Sung JJ, Yu J.

Oncoscience. 2014 Jul 3;1(6):468-475. eCollection 2014.


A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.

Feng H, Yu Z, Tian Y, Lee YY, Li MS, Go MY, Cheung YS, Lai PB, Chan AM, To KF, Chan HL, Sung JJ, Cheng AS.

J Hepatol. 2015 May;62(5):1100-11. doi: 10.1016/j.jhep.2014.11.040. Epub 2014 Dec 9.


microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.

Wang J, Chu ES, Chen HY, Man K, Go MY, Huang XR, Lan HY, Sung JJ, Yu J.

Oncotarget. 2015 Mar 30;6(9):7325-38.


CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis.

Zhang X, Shen J, Man K, Chu ES, Yau TO, Sung JC, Go MY, Deng J, Lu L, Wong VW, Sung JJ, Farrell G, Yu J.

J Hepatol. 2014 Dec;61(6):1365-75. doi: 10.1016/j.jhep.2014.07.006. Epub 2014 Jul 15.


Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer.

Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, Go MY, Ng EK, Arakawa T, Chan FK, Sung JJ, Yu J.

J Pathol. 2014 Nov;234(3):302-15. doi: 10.1002/path.4391. Epub 2014 Aug 28.


Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.

Yu Z, Gao YQ, Feng H, Lee YY, Li MS, Tian Y, Go MY, Yu DY, Cheung YS, Lai PB, Yu J, Wong VW, Sung JJ, Chan HL, Cheng AS.

Gut. 2014 Nov;63(11):1793-804. doi: 10.1136/gutjnl-2013-305584. Epub 2014 Jan 17.


Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

Wang J, Zhao J, Chu ES, Mok MT, Go MY, Man K, Heuchel R, Lan HY, Chang Z, Sung JJ, Yu J.

J Pathol. 2013 Aug;230(4):441-52. doi: 10.1002/path.4206.


Dapper homolog 1 is a novel tumor suppressor in gastric cancer through inhibiting the nuclear factor-κB signaling pathway.

Wang S, Kang W, Go MY, Tong JH, Li L, Zhang N, Tao Q, Li X, To KF, Sung JJ, Yu J.

Mol Med. 2012 Dec 20;18:1402-11. doi: 10.2119/molmed.2012.00243.


Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.

Cheng AS, Li MS, Kang W, Cheng VY, Chou JL, Lau SS, Go MY, Lee CC, Ling TK, Ng EK, Yu J, Huang TH, To KF, Chan MW, Sung JJ, Chan FK.

Gastroenterology. 2013 Jan;144(1):122-133.e9. doi: 10.1053/j.gastro.2012.10.002. Epub 2012 Oct 8.


MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication.

Zhao F, Wang YX, Yuan J, Deng M, Wong HL, Chu ES, Go MY, Teng GJ, Ahuja AT, Yu J.

Eur Radiol. 2012 Aug;22(8):1709-16. doi: 10.1007/s00330-012-2419-0. Epub 2012 Mar 27.


Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer.

Yu J, Liang QY, Wang J, Cheng Y, Wang S, Poon TC, Go MY, Tao Q, Chang Z, Sung JJ.

Oncogene. 2013 Jan 17;32(3):307-17. doi: 10.1038/onc.2012.54. Epub 2012 Feb 27.


Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients.

Li X, Cheung KF, Ma X, Tian L, Zhao J, Go MY, Shen B, Cheng AS, Ying J, Tao Q, Sung JJ, Kung HF, Yu J.

Oncogene. 2012 Jul 19;31(29):3419-30. doi: 10.1038/onc.2011.511. Epub 2011 Nov 21. Erratum in: Oncogene. 2012 Jul 19;31(29):3482.


Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival.

Xu L, Li X, Chu ES, Zhao G, Go MY, Tao Q, Jin H, Zeng Z, Sung JJ, Yu J.

Gut. 2012 Jul;61(7):977-85. doi: 10.1136/gutjnl-2011-300411. Epub 2011 Sep 13.


Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis.

Feng H, Cheng AS, Tsang DP, Li MS, Go MY, Cheung YS, Zhao GJ, Ng SS, Lin MC, Yu J, Lai PB, To KF, Sung JJ.

J Clin Invest. 2011 Aug;121(8):3159-75. doi: 10.1172/JCI45967. Epub 2011 Jul 11.


Zinc finger E-box binding factor 1 plays a central role in regulating Epstein-Barr virus (EBV) latent-lytic switch and acts as a therapeutic target in EBV-associated gastric cancer.

Zhao J, Jin H, Cheung KF, Tong JH, Zhang S, Go MY, Tian L, Kang W, Leung PP, Zeng Z, Li X, To KF, Sung JJ, Yu J.

Cancer. 2012 Feb 15;118(4):924-36. doi: 10.1002/cncr.26184. Epub 2011 Jun 29.


T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model.

Wang YX, Yuan J, Chu ES, Go MY, Huang H, Ahuja AT, Sung JJ, Yu J.

Radiology. 2011 Jun;259(3):712-9. doi: 10.1148/radiol.11101638. Epub 2011 Mar 24.


Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway.

Liu W, Li X, Chu ES, Go MY, Xu L, Zhao G, Li L, Dai N, Si J, Tao Q, Sung JJ, Yu J.

Hepatology. 2011 Mar;53(3):843-53. doi: 10.1002/hep.24124. Epub 2011 Feb 11.


Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro.

Yu J, Zhang S, Chu ES, Go MY, Lau RH, Zhao J, Wu CW, Tong L, Zhao J, Poon TC, Sung JJ.

Int J Biochem Cell Biol. 2010 Jun;42(6):948-57. doi: 10.1016/j.biocel.2010.02.006. Epub 2010 Feb 13.


Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer.

Li J, Ng EK, Ng YP, Wong CY, Yu J, Jin H, Cheng VY, Go MY, Cheung PK, Ebert MP, Tong J, To KF, Chan FK, Sung JJ, Ip NY, Leung WK.

Br J Cancer. 2009 Aug 18;101(4):691-8. doi: 10.1038/sj.bjc.6605202.


Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus.

Ma Y, Yu J, Chan HL, Chen YC, Wang H, Chen Y, Chan CY, Go MY, Tsai SN, Ngai SM, To KF, Tong JH, He QY, Sung JJ, Kung HF, Cheng CH, He ML.

Mol Cell Proteomics. 2009 Nov;8(11):2582-94. doi: 10.1074/mcp.M900180-MCP200. Epub 2009 Aug 11.


The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen.

Go MY, Chow EM, Mogridge J.

Infect Immun. 2009 Jan;77(1):52-9. doi: 10.1128/IAI.01073-08. Epub 2008 Oct 20.


Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice.

Leung WK, Wu KC, Wong CY, Cheng AS, Ching AK, Chan AW, Chong WW, Go MY, Yu J, To KF, Wang X, Chui YL, Fan DM, Sung JJ.

Carcinogenesis. 2008 Aug;29(8):1648-54. doi: 10.1093/carcin/bgn156. Epub 2008 Jul 7.


Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice.

Yu J, Wu CW, Chu ES, Hui AY, Cheng AS, Go MY, Ching AK, Chui YL, Chan HL, Sung JJ.

Biochem Biophys Res Commun. 2008 Aug 8;372(4):571-7. doi: 10.1016/j.bbrc.2008.05.069. Epub 2008 May 27.


The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats.

Yu J, Hui AY, Chu ES, Go MY, Cheung KF, Wu CW, Chan HL, Sung JJ.

Liver Int. 2009 Jan;29(1):25-36. doi: 10.1111/j.1478-3231.2008.01760.x. Epub 2008 Apr 23.


Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis.

Yu J, Hui AY, Chu ES, Cheng AS, Go MY, Chan HL, Leung WK, Cheung KF, Ching AK, Chui YL, Chan KK, Sung JJ.

Gut. 2007 Jul;56(7):991-9. Epub 2006 Dec 5.


Polyvalent inhibitors of anthrax toxin that target host receptors.

Basha S, Rai P, Poon V, Saraph A, Gujraty K, Go MY, Sadacharan S, Frost M, Mogridge J, Kane RS.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13509-13. Epub 2006 Aug 28.


Self-association of the transmembrane domain of an anthrax toxin receptor.

Go MY, Kim S, Partridge AW, Melnyk RA, Rath A, Deber CM, Mogridge J.

J Mol Biol. 2006 Jun 30;360(1):145-56. Epub 2006 May 15.


Effects of Helicobacter pylori eradication on methylation status of E-cadherin gene in noncancerous stomach.

Leung WK, Man EP, Yu J, Go MY, To KF, Yamaoka Y, Cheng VY, Ng EK, Sung JJ.

Clin Cancer Res. 2006 May 15;12(10):3216-21.


Effect of celecoxib on experimental liver fibrosis in rat.

Hui AY, Leung WK, Chan HL, Chan FK, Go MY, Chan KK, Tang BD, Chu ES, Sung JJ.

Liver Int. 2006 Feb;26(1):125-36.


Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: implications on chemoprevention.

Yu J, Tang BD, Leung WK, To KF, Bai AH, Zeng ZR, Ma PK, Go MY, Hu PJ, Sung JJ.

World J Gastroenterol. 2005 Jan 7;11(1):41-5.


Quantitative assessment of fibrosis in liver biopsies from patients with chronic hepatitis B.

Hui AY, Liew CT, Go MY, Chim AM, Chan HL, Leung NW, Sung JJ.

Liver Int. 2004 Dec;24(6):611-8.


Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line.

Hui AY, Cheng AS, Chan HL, Go MY, Chan FK, Sakata R, Ueno T, Sata M, Sung JJ.

Prostaglandins Leukot Essent Fatty Acids. 2004 Nov;71(5):329-33.


Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2.

Cheng AS, Chan HL, Leung WK, To KF, Go MY, Chan JY, Liew CT, Sung JJ.

Mod Pathol. 2004 Oct;17(10):1169-79.


Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma.

Leung WK, To KF, Go MY, Chan KK, Chan FK, Ng EK, Chung SC, Sung JJ.

Int J Oncol. 2003 Nov;23(5):1317-22.


Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions.

Yu J, Leung WK, Go MY, Chan MC, To KF, Ng EK, Chan FK, Ling TK, Chung SC, Sung JJ.

Gut. 2002 Oct;51(4):480-4.


Increased expression of survivin in gastric cancer patients and in first degree relatives.

Yu J, Leung WK, Ebert MP, Ng EK, Go MY, Wang HB, Chung SC, Malfertheiner P, Sung JJ.

Br J Cancer. 2002 Jul 1;87(1):91-7.


Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia.

Yu J, Leung WK, Ng EK, To KF, Ebert MP, Go MY, Chan WY, Chan FK, Chung SC, Malfertheiner P, Sung JJ.

Aliment Pharmacol Ther. 2001 Sep;15(9):1505-11.


Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia.

Leung WK, Yu J, To KF, Go MY, Ma PK, Chan FK, Sung JJ.

Aliment Pharmacol Ther. 2001 Sep;15(9):1467-72.


Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues.

Leung WK, Yu J, Ng EK, To KF, Ma PK, Lee TL, Go MY, Chung SC, Sung JJ.

Cancer. 2001 Jun 15;91(12):2294-301.


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