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Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry.

Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH.

BMC Musculoskelet Disord. 2018 Oct 30;19(1):388. doi: 10.1186/s12891-018-2307-0.


Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis.

Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C.

Front Mol Neurosci. 2018 Sep 25;11:351. doi: 10.3389/fnmol.2018.00351. eCollection 2018.


Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.

Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G.

Mov Disord. 2019 Jan;34(1):114-123. doi: 10.1002/mds.27482. Epub 2018 Oct 11.


Exercise Performance, Muscle Oxygen Extraction and Blood Cell Mitochondrial Respiration after Repeated-Sprint and Sprint Interval Training in Hypoxia: A Pilot Study.

Gatterer H, Menz V, Salazar-Martinez E, Sumbalova Z, Garcia-Souza LF, Velika B, Gnaiger E, Burtscher M.

J Sports Sci Med. 2018 Aug 14;17(3):339-347. eCollection 2018 Sep.


Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells.

Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE.

Int J Mol Sci. 2018 Jul 21;19(7). pii: E2129. doi: 10.3390/ijms19072129.


Comparison of Mitochondrial Incubation Media for Measurement of Respiration and Hydrogen Peroxide Production.

Komlódi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E.

Methods Mol Biol. 2018;1782:137-155. doi: 10.1007/978-1-4939-7831-1_8.


High-Resolution FluoRespirometry and OXPHOS Protocols for Human Cells, Permeabilized Fibers from Small Biopsies of Muscle, and Isolated Mitochondria.

Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E.

Methods Mol Biol. 2018;1782:31-70. doi: 10.1007/978-1-4939-7831-1_3.


Molecular structural diversity of mitochondrial cardiolipins.

Oemer G, Lackner K, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4158-4163. doi: 10.1073/pnas.1719407115. Epub 2018 Apr 4.


Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.

Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC.

J Biol Chem. 2018 May 4;293(18):6659-6671. doi: 10.1074/jbc.RA117.000470. Epub 2018 Mar 14.


Dietary iron loading negatively affects liver mitochondrial function.

Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G.

Metallomics. 2017 Nov 15;9(11):1634-1644. doi: 10.1039/c7mt00177k.


Metabolic basis to Sherpa altitude adaptation.

Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6382-6387. doi: 10.1073/pnas.1700527114. Epub 2017 May 22.


Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race.

Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M.

PLoS One. 2017 Apr 26;12(4):e0174874. doi: 10.1371/journal.pone.0174874. eCollection 2017.


From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".

Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT.

Basic Res Cardiol. 2016 Nov;111(6):69. Epub 2016 Oct 14. Review.


Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.

Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E.

FEBS J. 2016 Jun;283(11):2181-96. doi: 10.1111/febs.13733. Epub 2016 Apr 29.


Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity.

Boushel R, Gnaiger E, Larsen FJ, Helge JW, González-Alonso J, Ara I, Munch-Andersen T, van Hall G, Søndergaard H, Saltin B, Calbet JA.

Scand J Med Sci Sports. 2015 Dec;25 Suppl 4:135-43. doi: 10.1111/sms.12613.


Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter.

Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B.

Scand J Med Sci Sports. 2015 Dec;25 Suppl 4:126-34. doi: 10.1111/sms.12612.


Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry.

Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E.

Mitochondrion. 2015 Nov;25:104-12. doi: 10.1016/j.mito.2015.10.007. Epub 2015 Oct 26.


Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate.

Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE.

PLoS One. 2015 Aug 18;10(8):e0135704. doi: 10.1371/journal.pone.0135704. eCollection 2015.


Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia.

Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E.

J Appl Physiol (1985). 2015 Nov 15;119(10):1210-8. doi: 10.1152/japplphysiol.00146.2015. Epub 2015 Aug 6.


Amphotericin B Resistance in Aspergillus terreus Is Overpowered by Coapplication of Pro-oxidants.

Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D.

Antioxid Redox Signal. 2015 Dec 20;23(18):1424-38. doi: 10.1089/ars.2014.6220. Epub 2015 Oct 8.


Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.

Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E.

Methods Mol Biol. 2015;1264:245-61. doi: 10.1007/978-1-4939-2257-4_22.


Thermal plasticity of skeletal muscle mitochondrial activity and whole animal respiration in a common intertidal triplefin fish, Forsterygion lapillum (Family: Tripterygiidae).

Khan JR, Iftikar FI, Herbert NA, Gnaiger E, Hickey AJ.

J Comp Physiol B. 2014 Dec;184(8):991-1001. doi: 10.1007/s00360-014-0861-9. Epub 2014 Oct 1.


High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria.

Chicco AJ, Le CH, Schlater A, Nguyen A, Kaye S, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB.

J Exp Biol. 2014 Aug 15;217(Pt 16):2947-55. doi: 10.1242/jeb.105916. Epub 2014 Jun 4.


Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry.

Krumschnabel G, Eigentler A, Fasching M, Gnaiger E.

Methods Enzymol. 2014;542:163-81. doi: 10.1016/B978-0-12-416618-9.00009-1.


Low-intensity training increases peak arm VO2 by enhancing both convective and diffusive O2 delivery.

Boushel R, Ara I, Gnaiger E, Helge JW, González-Alonso J, Munck-Andersen T, Sondergaard H, Damsgaard R, van Hall G, Saltin B, Calbet JA.

Acta Physiol (Oxf). 2014 May;211(1):122-34. doi: 10.1111/apha.12258. Epub 2014 Mar 17.


The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry?

Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F.

Anal Biochem. 2014 Feb 1;446:64-8. doi: 10.1016/j.ab.2013.10.023. Epub 2013 Oct 23.


Arnold Durig (1872-1961): life and work. An Austrian pioneer in exercise and high altitude physiology.

Burtscher M, Gnaiger E, Burtscher J, Nachbauer W, Brugger A.

High Alt Med Biol. 2012 Sep;13(3):224-31.


Cryopreservation of human skeletal muscle impairs mitochondrial function.

Larsen S, Wright-Paradis C, Gnaiger E, Helge JW, Boushel R.

Cryo Letters. 2012 May-Jun;33(3):170-6.


The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes.

Robach P, Siebenmann C, Jacobs RA, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Díaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C.

Br J Sports Med. 2012 Sep;46(11):822-7. doi: 10.1136/bjsports-2012-091078. Epub 2012 Jul 12.


Mitochondrial function in human skeletal muscle following high-altitude exposure.

Jacobs RA, Boushel R, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C.

Exp Physiol. 2013 Jan;98(1):245-55. doi: 10.1113/expphysiol.2012.066092. Epub 2012 May 25.


Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle.

Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D.

PLoS One. 2012;7(4):e34890. doi: 10.1371/journal.pone.0034890. Epub 2012 Apr 18. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/e24ced68-9c2d-4303-9553-0661decb9a51.


Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells.

Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr.

Hum Gene Ther. 2012 Jun;23(6):647-57. doi: 10.1089/hum.2011.177. Epub 2012 Apr 17.


High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle.

Pesta D, Gnaiger E.

Methods Mol Biol. 2012;810:25-58. doi: 10.1007/978-1-61779-382-0_3.


Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?

Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA.

J Biol Chem. 2011 Dec 16;286(50):43417-28. doi: 10.1074/jbc.M111.227553. Epub 2011 Sep 19.


Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes.

Jacobs RA, Rasmussen P, Siebenmann C, Díaz V, Gassmann M, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C.

J Appl Physiol (1985). 2011 Nov;111(5):1422-30. doi: 10.1152/japplphysiol.00625.2011. Epub 2011 Sep 1.


Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart.

Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E.

Int J Biochem Cell Biol. 2011 Dec;43(12):1729-38. doi: 10.1016/j.biocel.2011.08.008. Epub 2011 Aug 16.


Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans.

Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E.

Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1078-87. doi: 10.1152/ajpregu.00285.2011. Epub 2011 Jul 20.


Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia.

Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K.

Biochim Biophys Acta. 2011 Jun;1807(6):719-25. doi: 10.1016/j.bbabio.2010.12.010. Epub 2011 Jan 13.


Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans.

Boushel R, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B.

Mitochondrion. 2011 Mar;11(2):303-7. doi: 10.1016/j.mito.2010.12.006. Epub 2010 Dec 13.


Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis.

Sjövall F, Morota S, Hansson MJ, Friberg H, Gnaiger E, Elmér E.

Crit Care. 2010;14(6):R214. doi: 10.1186/cc9337. Epub 2010 Nov 24.


Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.

Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N.

Eur Respir J. 2010 Nov;36(5):1056-66. doi: 10.1183/09031936.00013809. Epub 2010 Jun 1.


Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics.

Scandurra FM, Gnaiger E.

Adv Exp Med Biol. 2010;662:7-25. doi: 10.1007/978-1-4419-1241-1_2. Review.


Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney.

Kozlov AV, van Griensven M, Haindl S, Kehrer I, Duvigneau JC, Hartl RT, Ebel T, Jafarmadar M, Calzia E, Gnaiger E, Redl H, Radermacher P, Bahrami S.

Inflammation. 2010 Oct;33(5):295-305. doi: 10.1007/s10753-010-9185-4.


Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells.

Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S.

Biochim Biophys Acta. 2010 May;1797(5):557-65. doi: 10.1016/j.bbabio.2010.01.033. Epub 2010 Feb 6.


Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia.

Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Jezek P, Rossignol R.

J Bioenerg Biomembr. 2010 Feb;42(1):55-67. doi: 10.1007/s10863-009-9267-x. Epub 2010 Jan 19.


Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology.

Gnaiger E.

Int J Biochem Cell Biol. 2009 Oct;41(10):1837-45. doi: 10.1016/j.biocel.2009.03.013. Epub 2009 Apr 2. Review.


Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions.

Schneeberger S, Kuznetsov AV, Seiler R, Renz O, Meusburger H, Mark W, Brandacher G, Margreiter R, Gnaiger E.

Shock. 2008 Oct;30(4):365-71. doi: 10.1097/SHK.0b013e318164f09f.


Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.

Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6.


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