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Items: 25

1.

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.

Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M, Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F.

Nature. 2016 Sep 8;537(7619):229-233. doi: 10.1038/nature19339. Epub 2016 Aug 8.

2.

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.

Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F.

PLoS Pathog. 2015 Jul 17;11(7):e1005058. doi: 10.1371/journal.ppat.1005058. eCollection 2015 Jul.

3.

A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.

Pitman JL, Wheeler MC, Lloyd DJ, Walker JR, Glynne RJ, Gekakis N.

PLoS One. 2014 Oct 16;9(10):e110226. doi: 10.1371/journal.pone.0110226. eCollection 2014.

4.

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.

Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, van de Vegte-Bolmer M, van Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler EA, Glynne RJ, Diagana TT.

Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7. doi: 10.1128/AAC.02727-13. Epub 2014 Jun 9.

5.

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ╬▓' subunit of RNA polymerase.

Song T, Park Y, Shamputa IC, Seo S, Lee SY, Jeon HS, Choi H, Lee M, Glynne RJ, Barnes SW, Walker JR, Batalov S, Yusim K, Feng S, Tung CS, Theiler J, Via LE, Boshoff HI, Murakami KS, Korber B, Barry CE 3rd, Cho SN.

Mol Microbiol. 2014 Mar;91(6):1106-19. doi: 10.1111/mmi.12520. Epub 2014 Feb 26.

6.

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.

Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, Glynne RJ, Chatterjee AK, Nagle A, Roland J, Winzeler EA, Leroy D, Campo B, Diagana TT, Yeung BK, Thomas AW, Kocken CH.

Antimicrob Agents Chemother. 2014;58(3):1586-95. doi: 10.1128/AAC.01927-13. Epub 2013 Dec 23.

7.

Targeting Plasmodium PI(4)K to eliminate malaria.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA.

Nature. 2013 Dec 12;504(7479):248-253. doi: 10.1038/nature12782. Epub 2013 Nov 27.

8.

An in vivo screen of secreted proteins identifies adiponectin as a regulator of murine cutaneous wound healing.

Salathia NS, Shi J, Zhang J, Glynne RJ.

J Invest Dermatol. 2013 Mar;133(3):812-821. doi: 10.1038/jid.2012.374. Epub 2012 Oct 25.

9.

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.

Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, Petersen F, Supek F, Glynne RJ, Tallarico JA, Porter JA, Fishman MC, Bodenreider C, Diagana TT, Movva NR, Winzeler EA.

Cell Host Microbe. 2012 Jun 14;11(6):654-63. doi: 10.1016/j.chom.2012.04.015.

10.

Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.

Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA.

Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936. Epub 2011 Nov 17.

11.

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.

Vilch├Ęze C, Av-Gay Y, Barnes SW, Larsen MH, Walker JR, Glynne RJ, Jacobs WR Jr.

Antimicrob Agents Chemother. 2011 Sep;55(9):4422-3. doi: 10.1128/AAC.00564-11. Epub 2011 Jun 27.

12.

Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.

Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, Brinker A, Engels IH, Taylor J, Chatterjee AK, Fantauzzi P, Glynne RJ, Van Voorhis WC, Kuhen KL.

Mol Biochem Parasitol. 2011 Jan;175(1):21-9. doi: 10.1016/j.molbiopara.2010.08.005. Epub 2010 Sep 15.

13.

Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.

Sharif O, Hu H, Klock H, Hampton EN, Nigoghossian E, Knuth MW, Matzen J, Anderson P, Trager R, Uno T, Glynne RJ, Azarian SM, Caldwell JS, Brinker A.

Anal Biochem. 2009 Sep 15;392(2):162-8. doi: 10.1016/j.ab.2009.05.038. Epub 2009 May 29.

PMID:
19482004
14.

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.

Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103. doi: 10.1073/pnas.0812819106. Epub 2009 Feb 5.

15.

Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.

Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, Larsen MH, Jacobs WR Jr.

Vaccine. 2009 Feb 18;27(8):1201-9. doi: 10.1016/j.vaccine.2008.12.018. Epub 2009 Jan 9.

16.

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.

Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI.

PLoS Genet. 2008 May 9;4(5):e1000070. doi: 10.1371/journal.pgen.1000070.

17.

Design considerations for array CGH to oligonucleotide arrays.

Baldocchi RA, Glynne RJ, Chin K, Kowbel D, Collins C, Mack DH, Gray JW.

Cytometry A. 2005 Oct;67(2):129-36.

18.

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ, Nelms KA, Goodnow CC.

Immunity. 2003 Jun;18(6):751-62.

19.

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.

Wiltshire T, Pletcher MT, Batalov S, Barnes SW, Tarantino LM, Cooke MP, Wu H, Smylie K, Santrosyan A, Copeland NG, Jenkins NA, Kalush F, Mural RJ, Glynne RJ, Kay SA, Adams MD, Fletcher CF.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3380-5. Epub 2003 Feb 28.

20.

Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes.

Eaves IA, Wicker LS, Ghandour G, Lyons PA, Peterson LB, Todd JA, Glynne RJ.

Genome Res. 2002 Feb;12(2):232-43.

21.

The immune system and gene expression microarrays--new answers to old questions.

Glynne RJ, Watson SR.

J Pathol. 2001 Sep;195(1):20-30. Review.

PMID:
11568888
22.

Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.

Glynne RJ, Ghandour G, Goodnow CC.

Curr Opin Immunol. 2000 Apr;12(2):210-4. Review.

PMID:
10712948
23.

Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J.

J Mol Biol. 1996 Jan 12;255(1):1-13.

PMID:
8568858
24.

DNA sequencing of the MHC class II region and the chromosome 6 sequencing effort at the Sanger Centre.

Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Radley E, Sanseau P, Thorpe KL, Trowsdale J, Beck S.

DNA Seq. 1996;7(1):5-7.

PMID:
9063628
25.

Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins.

Belich MP, Glynne RJ, Senger G, Sheer D, Trowsdale J.

Curr Biol. 1994 Sep 1;4(9):769-76.

PMID:
7820546

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