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Integration of Diffraction Phase Microscopy and Raman Imaging for Label-free Morpho-molecular Assessment of Live Cells.

Pandey R, Zhou R, Bordett R, Hunter C, Glunde K, Barman I, Valdez T, Finck C.

J Biophotonics. 2018 Nov 12:e201800291. doi: 10.1002/jbio.201800291. [Epub ahead of print]


Mapping the genetic basis of breast microcalcifications and their role in metastasis.

Rizwan A, Paidi SK, Zheng C, Cheng M, Barman I, Glunde K.

Sci Rep. 2018 Jul 23;8(1):11067. doi: 10.1038/s41598-018-29330-9.


Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells.

Shah T, Krishnamachary B, Wildes F, Wijnen JP, Glunde K, Bhujwalla ZM.

NMR Biomed. 2018 Aug;31(8):e3936. doi: 10.1002/nbm.3936. Epub 2018 Jun 21.


Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer.

Cheng M, Glunde K.

Methods Mol Biol. 2018;1718:331-345. doi: 10.1007/978-1-4939-7531-0_20.


Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer.

Cheng M, Rizwan A, Jiang L, Bhujwalla ZM, Glunde K.

Neoplasia. 2017 Aug;19(8):617-627. doi: 10.1016/j.neo.2017.05.004. Epub 2017 Jun 24.


Targeting Phospholipid Metabolism in Cancer.

Cheng M, Bhujwalla ZM, Glunde K.

Front Oncol. 2016 Dec 27;6:266. doi: 10.3389/fonc.2016.00266. eCollection 2016. Review.


Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer.

Paidi SK, Rizwan A, Zheng C, Cheng M, Glunde K, Barman I.

Cancer Res. 2017 Jan 15;77(2):247-256. doi: 10.1158/0008-5472.CAN-16-1862. Epub 2016 Nov 15.


The Tumor Microenvironment Modulates Choline and Lipid Metabolism.

Mori N, Wildes F, Takagi T, Glunde K, Bhujwalla ZM.

Front Oncol. 2016 Dec 22;6:262. doi: 10.3389/fonc.2016.00262. eCollection 2016.


Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers.

Kakkad S, Zhang J, Akhbardeh A, Jacob D, Krishnamachary B, Solaiyappan M, Jacobs MA, Raman V, Leibfritz D, Glunde K, Bhujwalla ZM.

Neoplasia. 2016 Oct;18(10):585-593. doi: 10.1016/j.neo.2016.08.004. Epub 2016 Sep 19.


Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion.

Cao MD, Cheng M, Rizwan A, Jiang L, Krishnamachary B, Bhujwalla ZM, Bathen TF, Glunde K.

NMR Biomed. 2016 Aug;29(8):1098-107. doi: 10.1002/nbm.3573. Epub 2016 Jun 30.


CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response.

Chan KW, Jiang L, Cheng M, Wijnen JP, Liu G, Huang P, van Zijl PC, McMahon MT, Glunde K.

NMR Biomed. 2016 Jun;29(6):806-16. doi: 10.1002/nbm.3526. Epub 2016 Apr 21.


Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model.

Mascini NE, Cheng M, Jiang L, Rizwan A, Podmore H, Bhandari DR, Römpp A, Glunde K, Heeren RM.

Anal Chem. 2016 Mar 15;88(6):3107-14. doi: 10.1021/acs.analchem.5b04032. Epub 2016 Feb 29.


Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival.

Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM.

NMR Biomed. 2015 Dec;28(12):1697-706. doi: 10.1002/nbm.3429. Epub 2015 Oct 27.


Breast cancer cell adhesome and degradome interact to drive metastasis.

Rizwan A, Cheng M, Bhujwalla ZM, Krishnamachary B, Jiang L, Glunde K.

NPJ Breast Cancer. 2015 Oct 28;1:15017. doi: 10.1038/npjbcancer.2015.17. eCollection 2015.


The effect of neurosphere culture conditions on the cellular metabolism of glioma cells.

Kahlert UD, Koch K, Suwala AK, Hartmann R, Cheng M, Maciaczyk D, Willbold D, Eberhart CG, Glunde K, Maciaczyk J.

Folia Neuropathol. 2015;53(3):219-25. doi: 10.5114/fn.2015.54422.


Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.

Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart CG.

Int J Cancer. 2016 Mar 1;138(5):1246-55. doi: 10.1002/ijc.29873. Epub 2015 Oct 13.


MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model.

Jiang L, Chughtai K, Purvine SO, Bhujwalla ZM, Raman V, Paša-Tolić L, Heeren RMA, Glunde K.

Anal Chem. 2015 Jun 16;87(12):5947-5956. doi: 10.1021/ac504503x. Epub 2015 Jun 4.


Metastatic breast cancer cells in lymph nodes increase nodal collagen density.

Rizwan A, Bulte C, Kalaichelvan A, Cheng M, Krishnamachary B, Bhujwalla ZM, Jiang L, Glunde K.

Sci Rep. 2015 May 7;5:10002. doi: 10.1038/srep10002.


Choline metabolism-based molecular diagnosis of cancer: an update.

Glunde K, Penet MF, Jiang L, Jacobs MA, Bhujwalla ZM.

Expert Rev Mol Diagn. 2015 Jun;15(6):735-47. doi: 10.1586/14737159.2015.1039515. Epub 2015 Apr 28. Review.


1H/31P polarization transfer at 9.4 Tesla for improved specificity of detecting phosphomonoesters and phosphodiesters in breast tumor models.

Wijnen JP, Jiang L, Greenwood TR, van der Kemp WJ, Klomp DW, Glunde K.

PLoS One. 2014 Jul 18;9(7):e102256. doi: 10.1371/journal.pone.0102256. eCollection 2014.


Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31) P MRS.

Wijnen JP, Jiang L, Greenwood TR, Cheng M, Döpkens M, Cao MD, Bhujwalla ZM, Krishnamachary B, Klomp DW, Glunde K.

NMR Biomed. 2014 Jun;27(6):692-9. doi: 10.1002/nbm.3106. Epub 2014 Apr 24.


Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.

Gadiya M, Mori N, Cao MD, Mironchik Y, Kakkad S, Gribbestad IS, Glunde K, Krishnamachary B, Bhujwalla ZM.

Cancer Biol Ther. 2014 May;15(5):593-601. doi: 10.4161/cbt.28165. Epub 2014 Feb 20.


Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport.

Kakkad SM, Penet MF, Akhbardeh A, Pathak AP, Solaiyappan M, Raman V, Leibfritz D, Glunde K, Bhujwalla ZM.

PLoS One. 2013 Dec 12;8(12):e81869. doi: 10.1371/journal.pone.0081869. eCollection 2013.


Characterization of choline kinase in human endothelial cells.

Mori N, Gadiya M, Wildes F, Krishnamachary B, Glunde K, Bhujwalla ZM.

NMR Biomed. 2013 Nov;26(11):1501-7. doi: 10.1002/nbm.2983. Epub 2013 Jun 18.


Malignant transformation: the role of MRS.

Jiang L, Wijnen JP, Glunde K.

Eur J Radiol. 2012 Sep;81 Suppl 1:S66-8. doi: 10.1016/S0720-048X(12)70026-8. No abstract available.


Mass spectrometric imaging of red fluorescent protein in breast tumor xenografts.

Chughtai K, Jiang L, Post H, Winnard PT Jr, Greenwood TR, Raman V, Bhujwalla ZM, Heeren RM, Glunde K.

J Am Soc Mass Spectrom. 2013 May;24(5):711-7. doi: 10.1007/s13361-012-0503-y. Epub 2012 Nov 27.


Collagen I fiber density increases in lymph node positive breast cancers: pilot study.

Kakkad SM, Solaiyappan M, Argani P, Sukumar S, Jacobs LK, Leibfritz D, Bhujwalla ZM, Glunde K.

J Biomed Opt. 2012 Nov;17(11):116017. doi: 10.1117/1.JBO.17.11.116017.


Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models.

Jiang L, Greenwood TR, Artemov D, Raman V, Winnard PT Jr, Heeren RM, Bhujwalla ZM, Glunde K.

Neoplasia. 2012 Aug;14(8):732-41.


Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft model.

Jiang L, Greenwood TR, van Hove ER, Chughtai K, Raman V, Winnard PT Jr, Heeren RM, Artemov D, Glunde K.

NMR Biomed. 2013 Mar;26(3):285-98. doi: 10.1002/nbm.2846. Epub 2012 Sep 4.


Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.

Chughtai K, Jiang L, Greenwood TR, Glunde K, Heeren RM.

J Lipid Res. 2013 Feb;54(2):333-44. doi: 10.1194/jlr.M027961. Epub 2012 Aug 28.


PSMA-targeted theranostic nanoplex for prostate cancer therapy.

Chen Z, Penet MF, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM.

ACS Nano. 2012 Sep 25;6(9):7752-7762. doi: 10.1021/nn301725w. Epub 2012 Aug 9.


Prostaglandin E2 promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cells.

Stasinopoulos I, Greenwood T, Glunde K, Bhujwalla ZM.

Prostaglandins Other Lipid Mediat. 2012 Oct;99(1-2):9-14. doi: 10.1016/j.prostaglandins.2012.05.002. Epub 2012 May 29.


Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments.

Liu W, Glunde K, Bhujwalla ZM, Raman V, Sharma A, Phang JM.

Cancer Res. 2012 Jul 15;72(14):3677-86. doi: 10.1158/0008-5472.CAN-12-0080. Epub 2012 May 18.


Fiducial markers for combined 3-dimensional mass spectrometric and optical tissue imaging.

Chughtai K, Jiang L, Greenwood TR, Klinkert I, Amstalden van Hove ER, Heeren RM, Glunde K.

Anal Chem. 2012 Feb 21;84(4):1817-23. doi: 10.1021/ac203373h. Epub 2012 Feb 7.


Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.

Cao MD, Döpkens M, Krishnamachary B, Vesuna F, Gadiya MM, Lønning PE, Bhujwalla ZM, Gribbestad IS, Glunde K.

NMR Biomed. 2012 Sep;25(9):1033-42. doi: 10.1002/nbm.2766. Epub 2012 Jan 26.


Choline metabolism in malignant transformation.

Glunde K, Bhujwalla ZM, Ronen SM.

Nat Rev Cancer. 2011 Nov 17;11(12):835-48. doi: 10.1038/nrc3162. Review.


An alternative paper based tissue washing method for mass spectrometry imaging: localized washing and fragile tissue analysis.

van Hove ER, Smith DF, Fornai L, Glunde K, Heeren RM.

J Am Soc Mass Spectrom. 2011 Oct;22(10):1885-90. doi: 10.1007/s13361-011-0203-z. Epub 2011 Jul 19.


MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.

Glunde K, Jiang L, Moestue SA, Gribbestad IS.

NMR Biomed. 2011 Jul;24(6):673-90. doi: 10.1002/nbm.1751. Review.


Exploiting the tumor microenvironment for theranostic imaging.

Stasinopoulos I, Penet MF, Chen Z, Kakkad S, Glunde K, Bhujwalla ZM.

NMR Biomed. 2011 Jul;24(6):636-47. doi: 10.1002/nbm.1664. Epub 2011 Jan 28. Review.


Metabolic tumor imaging using magnetic resonance spectroscopy.

Glunde K, Bhujwalla ZM.

Semin Oncol. 2011 Feb;38(1):26-41. doi: 10.1053/j.seminoncol.2010.11.001. Review.


Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models.

Amstalden van Hove ER, Blackwell TR, Klinkert I, Eijkel GB, Heeren RM, Glunde K.

Cancer Res. 2010 Nov 15;70(22):9012-21. doi: 10.1158/0008-5472.CAN-10-0360. Epub 2010 Nov 2.


Hypoxic tumor microenvironments reduce collagen I fiber density.

Kakkad SM, Solaiyappan M, O'Rourke B, Stasinopoulos I, Ackerstaff E, Raman V, Bhujwalla ZM, Glunde K.

Neoplasia. 2010 Aug;12(8):608-17.


Applications of molecular MRI and optical imaging in cancer.

Penet MF, Mikhaylova M, Li C, Krishnamachary B, Glunde K, Pathak AP, Bhujwalla ZM.

Future Med Chem. 2010 Jun;2(6):975-88. Review.


Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells.

Shah T, Wildes F, Penet MF, Winnard PT Jr, Glunde K, Artemov D, Ackerstaff E, Gimi B, Kakkad S, Raman V, Bhujwalla ZM.

NMR Biomed. 2010 Jul;23(6):633-42. doi: 10.1002/nbm.1510.


Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer.

Glunde K, Artemov D, Penet MF, Jacobs MA, Bhujwalla ZM.

Chem Rev. 2010 May 12;110(5):3043-59. doi: 10.1021/cr9004007. Review. No abstract available.


Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells.

Iorio E, Ricci A, Bagnoli M, Pisanu ME, Castellano G, Di Vito M, Venturini E, Glunde K, Bhujwalla ZM, Mezzanzanica D, Canevari S, Podo F.

Cancer Res. 2010 Mar 1;70(5):2126-35. doi: 10.1158/0008-5472.CAN-09-3833. Epub 2010 Feb 23.


Toward digital staining using imaging mass spectrometry and random forests.

Hanselmann M, Köthe U, Kirchner M, Renard BY, Amstalden ER, Glunde K, Heeren RM, Hamprecht FA.

J Proteome Res. 2009 Jul;8(7):3558-67. doi: 10.1021/pr900253y.


ADAM17: the new face of breast cancer-promoting metalloprotease activity.

Glunde K, Stasinopoulos I.

Cancer Biol Ther. 2009 Jun;8(11):1055-7. Epub 2009 Jun 17. No abstract available.


Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells.

Nimmagadda S, Glunde K, Pomper MG, Bhujwalla ZM.

Neoplasia. 2009 May;11(5):477-84.


Metabolomics of cancer.

Serkova NJ, Glunde K.

Methods Mol Biol. 2009;520:273-95. doi: 10.1007/978-1-60327-811-9_20.


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