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Items: 1 to 50 of 150

1.

Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations.

Lessel D, Ozel AB, Campbell SE, Saadi A, Arlt MF, McSweeney KM, Plaiasu V, Szakszon K, Szőllős A, Rusu C, Rojas AJ, Lopez-Valdez J, Thiele H, Nürnberg P, Nickerson DA, Bamshad MJ, Li JZ, Kubisch C, Glover TW, Gordon LB.

Hum Genet. 2018 Dec;137(11-12):921-939. doi: 10.1007/s00439-018-1957-1. Epub 2018 Nov 19.

2.

Effects of hydroxyurea on CNV induction in the mouse germline.

Arlt MF, Rajendran S, Holmes SN, Wang K, Bergin IL, Ahmed S, Wilson TE, Glover TW.

Environ Mol Mutagen. 2018 Oct;59(8):698-714. doi: 10.1002/em.22233. Epub 2018 Sep 15.

PMID:
30218578
3.

Fragile sites in cancer: more than meets the eye.

Glover TW, Wilson TE, Arlt MF.

Nat Rev Cancer. 2017 Jul 25;17(8):489-501. doi: 10.1038/nrc.2017.52. Review.

4.

Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.

Walline HM, Goudsmit CM, McHugh JB, Tang AL, Owen JH, Teh BT, McKean E, Glover TW, Graham MP, Prince ME, Chepeha DB, Chinn SB, Ferris RL, Gollin SM, Hoffmann TK, Bier H, Brakenhoff R, Bradford CR, Carey TE; University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program.

Head Neck. 2017 May;39(5):840-852. doi: 10.1002/hed.24729. Epub 2017 Feb 25.

5.

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.

Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.

J Med Genet. 2017 Mar;54(3):212-216. doi: 10.1136/jmedgenet-2016-104295. Epub 2016 Dec 5.

6.

Paracentric Inversion of Chromosome 21 Leading to Disruption of the HLCS Gene in a Family with Holocarboxylase Synthetase Deficiency.

Quinonez SC, Seeley AH, Lam C, Glover TW, Barshop BA, Keegan CE.

JIMD Rep. 2017;34:55-61. doi: 10.1007/8904_2016_9. Epub 2016 Aug 13.

7.

Molecular biology: Breaks in the brain.

Glover TW, Wilson TE.

Nature. 2016 Apr 7;532(7597):46-7. doi: 10.1038/nature17316. Epub 2016 Mar 23. No abstract available.

PMID:
27007850
8.

Large transcription units unify copy number variants and common fragile sites arising under replication stress.

Wilson TE, Arlt MF, Park SH, Rajendran S, Paulsen M, Ljungman M, Glover TW.

Genome Res. 2015 Feb;25(2):189-200. doi: 10.1101/gr.177121.114. Epub 2014 Nov 4.

9.

Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation.

Kato T, Franconi CP, Sheridan MB, Hacker AM, Inagakai H, Glover TW, Arlt MF, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS.

Cancer Genet. 2014 Apr;207(4):133-40. doi: 10.1016/j.cancergen.2014.03.004. Epub 2014 Mar 18.

10.

Copy number variants are produced in response to low-dose ionizing radiation in cultured cells.

Arlt MF, Rajendran S, Birkeland SR, Wilson TE, Glover TW.

Environ Mol Mutagen. 2014 Mar;55(2):103-13. doi: 10.1002/em.21840. Epub 2013 Dec 10.

11.

The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.

Mason JM, Das I, Arlt M, Patel N, Kraftson S, Glover TW, Sekiguchi JM.

Hum Mol Genet. 2013 Dec 15;22(24):4901-13. doi: 10.1093/hmg/ddt340. Epub 2013 Jul 17.

12.

9p partial monosomy and disorders of sex development: review and postulation of a pathogenetic mechanism.

Quinonez SC, Park JM, Rabah R, Owens KM, Yashar BM, Glover TW, Keegan CE.

Am J Med Genet A. 2013 Aug;161A(8):1882-96. doi: 10.1002/ajmg.a.36018. Epub 2013 Jul 3. Review.

PMID:
23824832
13.

Breaking news on fragile sites in cancer.

Glover TW, Wilson TE.

Cancer Cell. 2013 Feb 11;23(2):137-9. doi: 10.1016/j.ccr.2013.01.017.

14.

De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining.

Arlt MF, Rajendran S, Birkeland SR, Wilson TE, Glover TW.

PLoS Genet. 2012 Sep;8(9):e1002981. doi: 10.1371/journal.pgen.1002981. Epub 2012 Sep 20.

15.

Harnessing genomics to identify environmental determinants of heritable disease.

Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB.

Mutat Res. 2013 Jan-Mar;752(1):6-9. doi: 10.1016/j.mrrev.2012.08.002. Epub 2012 Aug 28.

16.

Maternal intrachromosomal insertional translocation leads to recurrent 1q21.3q23.3 deletion in two siblings.

Quinonez SC, Hedera P, Barr M, Ackley T, Lam C, Purkayastha A, Glover TW, Innis JW.

Am J Med Genet A. 2012 Oct;158A(10):2591-601. doi: 10.1002/ajmg.a.35563. Epub 2012 Aug 17.

17.

Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation.

Butler MG, Dagenais SL, Garcia-Perez JL, Brouillard P, Vikkula M, Strouse P, Innis JW, Glover TW.

Am J Med Genet A. 2012 Apr;158A(4):839-49. doi: 10.1002/ajmg.a.35229. Epub 2012 Mar 9.

18.

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.

Lin L, Bass AJ, Lockwood WW, Wang Z, Silvers AL, Thomas DG, Chang AC, Lin J, Orringer MB, Li W, Glover TW, Giordano TJ, Lam WL, Meyerson M, Beer DG.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4251-6. doi: 10.1073/pnas.1011989109. Epub 2012 Feb 28.

19.

Replication stress and mechanisms of CNV formation.

Arlt MF, Wilson TE, Glover TW.

Curr Opin Genet Dev. 2012 Jun;22(3):204-10. doi: 10.1016/j.gde.2012.01.009. Epub 2012 Feb 23. Review.

20.

Hydroxyurea induces de novo copy number variants in human cells.

Arlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17360-5. doi: 10.1073/pnas.1109272108. Epub 2011 Oct 10.

21.

REV1 and polymerase ζ facilitate homologous recombination repair.

Sharma S, Hicks JK, Chute CL, Brennan JR, Ahn JY, Glover TW, Canman CE.

Nucleic Acids Res. 2012 Jan;40(2):682-91. doi: 10.1093/nar/gkr769. Epub 2011 Sep 16.

22.

Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting.

Saadi I, Alkuraya FS, Gisselbrecht SS, Goessling W, Cavallesco R, Turbe-Doan A, Petrin AL, Harris J, Siddiqui U, Grix AW Jr, Hove HD, Leboulch P, Glover TW, Morton CC, Richieri-Costa A, Murray JC, Erickson RP, Maas RL.

Am J Hum Genet. 2011 Jul 15;89(1):44-55. doi: 10.1016/j.ajhg.2011.05.023. Epub 2011 Jun 23.

23.

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.

Arlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE.

Genetics. 2011 Mar;187(3):675-83. doi: 10.1534/genetics.110.124776. Epub 2011 Jan 6.

24.

Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.

Arlt MF, Glover TW.

DNA Repair (Amst). 2010 Jun 4;9(6):678-89. doi: 10.1016/j.dnarep.2010.03.005. Epub 2010 Apr 21.

25.

Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE.

Mol Cell Biol. 2010 Mar;30(5):1217-30. doi: 10.1128/MCB.00993-09. Epub 2009 Dec 22.

26.

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.

Howlett NG, Harney JA, Rego MA, Kolling FW 4th, Glover TW.

J Biol Chem. 2009 Oct 16;284(42):28935-42. doi: 10.1074/jbc.M109.016352. Epub 2009 Aug 24.

27.

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response.

Ragland RL, Arlt MF, Hughes ED, Saunders TL, Glover TW.

Mamm Genome. 2009 Jun;20(6):375-85. doi: 10.1007/s00335-009-9195-4. Epub 2009 Jun 7.

PMID:
19504344
28.

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.

Arlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW.

Am J Hum Genet. 2009 Mar;84(3):339-50. doi: 10.1016/j.ajhg.2009.01.024. Epub 2009 Feb 19.

29.

Stably transfected common fragile site sequences exhibit instability at ectopic sites.

Ragland RL, Glynn MW, Arlt MF, Glover TW.

Genes Chromosomes Cancer. 2008 Oct;47(10):860-72. doi: 10.1002/gcc.20591.

30.

Replication stress induces tumor-like microdeletions in FHIT/FRA3B.

Durkin SG, Ragland RL, Arlt MF, Mulle JG, Warren ST, Glover TW.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):246-51. Epub 2007 Dec 27.

31.

Interaction on health care teams. 1980.

Thornton BC, McCoy ED, Glover TW, Baldwin DC Jr.

J Interprof Care. 2007 Oct;21 Suppl 1:76-85. No abstract available.

PMID:
17917945
32.

Chromosome fragile sites.

Durkin SG, Glover TW.

Annu Rev Genet. 2007;41:169-92. Review.

PMID:
17608616
33.

A novel VEGFR3 mutation causes Milroy disease.

Butler MG, Dagenais SL, Rockson SG, Glover TW.

Am J Med Genet A. 2007 Jun 1;143A(11):1212-7.

34.

A Gata2 intronic enhancer confers its pan-endothelia-specific regulation.

Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD.

Development. 2007 May;134(9):1703-12. Epub 2007 Mar 29.

35.

Common fragile sites as targets for chromosome rearrangements.

Arlt MF, Durkin SG, Ragland RL, Glover TW.

DNA Repair (Amst). 2006 Sep 8;5(9-10):1126-35. Epub 2006 Jun 27. Review.

PMID:
16807141
36.

Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites.

Durkin SG, Arlt MF, Howlett NG, Glover TW.

Oncogene. 2006 Jul 27;25(32):4381-8. Epub 2006 May 29.

PMID:
16732333
37.

Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma.

Lin L, Wang Z, Prescott MS, van Dekken H, Thomas DG, Giordano TJ, Chang AC, Orringer MB, Gruber SB, Moran JV, Glover TW, Beer DG.

Genes Chromosomes Cancer. 2006 Apr;45(4):319-31.

38.

Mechanisms of common fragile site instability.

Glover TW, Arlt MF, Casper AM, Durkin SG.

Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R197-205. Review.

PMID:
16244318
39.

Common fragile sites.

Glover TW.

Cancer Lett. 2006 Jan 28;232(1):4-12. Epub 2005 Oct 17. Review.

PMID:
16229941
40.

Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma.

Miller CT, Lin L, Casper AM, Lim J, Thomas DG, Orringer MB, Chang AC, Chambers AF, Giordano TJ, Glover TW, Beer DG.

Oncogene. 2006 Jan 19;25(3):409-18.

PMID:
16186806
41.
42.

The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.

Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW.

Hum Mol Genet. 2005 Mar 1;14(5):693-701. Epub 2005 Jan 20.

PMID:
15661754
43.

Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome.

Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW.

Gene Expr Patterns. 2004 Oct;4(6):611-9.

PMID:
15465483
44.

Chromosomal instability at common fragile sites in Seckel syndrome.

Casper AM, Durkin SG, Arlt MF, Glover TW.

Am J Hum Genet. 2004 Oct;75(4):654-60. Epub 2004 Aug 12.

45.

BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function.

Arlt MF, Xu B, Durkin SG, Casper AM, Kastan MB, Glover TW.

Mol Cell Biol. 2004 Aug;24(15):6701-9.

46.

Mutation of the FOXC2 gene in familial distichiasis.

Brooks BP, Dagenais SL, Nelson CC, Glynn MW, Caulder MS, Downs CA, Glover TW.

J AAPOS. 2003 Oct;7(5):354-7.

PMID:
14566319
47.

Common fragile sites.

Arlt MF, Casper AM, Glover TW.

Cytogenet Genome Res. 2003;100(1-4):92-100. Review.

PMID:
14526169
48.

Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas.

Miller CT, Aggarwal S, Lin TK, Dagenais SL, Contreras JI, Orringer MB, Glover TW, Beer DG, Lin L.

Cancer Res. 2003 Jul 15;63(14):4136-43.

49.

Age of onset in hereditary lymphedema.

Levinson KL, Feingold E, Ferrell RE, Glover TW, Traboulsi EI, Finegold DN.

J Pediatr. 2003 Jun;142(6):704-8.

PMID:
12838201
50.

FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.

Kriederman BM, Myloyde TL, Witte MH, Dagenais SL, Witte CL, Rennels M, Bernas MJ, Lynch MT, Erickson RP, Caulder MS, Miura N, Jackson D, Brooks BP, Glover TW.

Hum Mol Genet. 2003 May 15;12(10):1179-85.

PMID:
12719382

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