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Items: 1 to 50 of 55

1.

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.

Lauer J, Segeletz S, Cezanne A, Guaitoli G, Raimondi F, Gentzel M, Alva V, Habeck M, Kalaidzidis Y, Ueffing M, Lupas AN, Gloeckner CJ, Zerial M.

Elife. 2019 Nov 13;8. pii: e46302. doi: 10.7554/eLife.46302.

PMID:
31718772
2.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J.

Blood. 2019 Oct 3;134(14):1159-1175. doi: 10.1182/blood.2019000095. Epub 2019 Jul 31.

PMID:
31366618
3.

Understanding the role of genetic variability in LRRK2 in Indian population.

Kishore A, Ashok Kumar Sreelatha A, Sturm M, von-Zweydorf F, Pihlstrøm L, Raimondi F, Russell R, Lichtner P, Banerjee M, Krishnan S, Rajan R, Puthenveedu DK, Chung SJ; International Parkinson's Disease Genomics Consortium (IPDGC); Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD), Bauer P, Riess O, Gloeckner CJ, Kruger R, Gasser T, Sharma M.

Mov Disord. 2019 Apr;34(4):496-505. doi: 10.1002/mds.27558. Epub 2018 Nov 28.

PMID:
30485545
4.

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

Weishäupl D, Schneider J, Peixoto Pinheiro B, Ruess C, Dold SM, von Zweydorf F, Gloeckner CJ, Schmidt J, Riess O, Schmidt T.

J Biol Chem. 2019 Jan 11;294(2):644-661. doi: 10.1074/jbc.RA118.005801. Epub 2018 Nov 19.

PMID:
30455355
5.

Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.

Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ.

Sci Rep. 2018 Nov 1;8(1):16196. doi: 10.1038/s41598-018-34480-x.

6.

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ.

J Biol Chem. 2018 Oct 12;293(41):16083-16099. doi: 10.1074/jbc.RA118.003440. Epub 2018 Aug 17.

7.

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A.

Biol Chem. 2018 Nov 27;399(12):1447-1456. doi: 10.1515/hsz-2018-0227.

PMID:
30067506
8.

Phosphorylation Modulates the Subcellular Localization of SOX11.

Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC.

Front Mol Neurosci. 2018 Jun 19;11:211. doi: 10.3389/fnmol.2018.00211. eCollection 2018.

9.

Regulation of LRRK2: insights from structural and biochemical analysis.

Gilsbach BK, Eckert M, Gloeckner CJ.

Biol Chem. 2018 Jun 27;399(7):637-642. doi: 10.1515/hsz-2018-0132. Review.

PMID:
29894291
10.

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.

Jung M, Häberle BM, Tschaikowsky T, Wittmann MT, Balta EA, Stadler VC, Zweier C, Dörfler A, Gloeckner CJ, Lie DC.

Mol Autism. 2018 Mar 22;9:20. doi: 10.1186/s13229-018-0200-1. eCollection 2018.

11.

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

Perez Carrion M, Pischedda F, Biosa A, Russo I, Straniero L, Civiero L, Guida M, Gloeckner CJ, Ticozzi N, Tiloca C, Mariani C, Pezzoli G, Duga S, Pichler I, Pan L, Landers JE, Greggio E, Hess MW, Goldwurm S, Piccoli G.

Front Mol Neurosci. 2018 Feb 28;11:64. doi: 10.3389/fnmol.2018.00064. eCollection 2018.

12.

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

Marrone L, Bus C, Schöndorf D, Fitzgerald JC, Kübler M, Schmid B, Reinhardt P, Reinhardt L, Deleidi M, Levin T, Meixner A, Klink B, Glatza M, Gloeckner CJ, Gasser T, Sterneckert J.

PLoS One. 2018 Mar 7;13(3):e0192497. doi: 10.1371/journal.pone.0192497. eCollection 2018.

13.

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W.

Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4.

14.

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

Carrion MDP, Marsicano S, Daniele F, Marte A, Pischedda F, Di Cairano E, Piovesana E, von Zweydorf F, Kremmer E, Gloeckner CJ, Onofri F, Perego C, Piccoli G.

Sci Rep. 2017 Jul 14;7(1):5377. doi: 10.1038/s41598-017-05760-9.

15.

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

Weber JJ, Golla M, Guaitoli G, Wanichawan P, Hayer SN, Hauser S, Krahl AC, Nagel M, Samer S, Aronica E, Carlson CR, Schöls L, Riess O, Gloeckner CJ, Nguyen HP, Hübener-Schmid J.

Brain. 2017 May 1;140(5):1280-1299. doi: 10.1093/brain/awx039.

PMID:
28334907
16.

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

Guaitoli G, Gilsbach BK, Raimondi F, Gloeckner CJ.

Biochem Soc Trans. 2016 Dec 15;44(6):1635-1641. Review.

PMID:
27913672
17.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66. doi: 10.1073/pnas.1523708113. Epub 2016 Jun 29.

18.

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Dernayka L, Rauch N, Jarboui MA, Zebisch A, Texier Y, Horn N, Romano D, Gloeckner CJ, Kriegsheim Av, Ueffing M, Kolch W, Boldt K.

Cell Signal. 2016 Sep;28(9):1432-9. doi: 10.1016/j.cellsig.2016.06.016. Epub 2016 Jun 21.

19.

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma.

Engel K, Rudelius M, Slawska J, Jacobs L, Ahangarian Abhari B, Altmann B, Kurutz J, Rathakrishnan A, Fernández-Sáiz V, Brunner A, Targosz BS, Loewecke F, Gloeckner CJ, Ueffing M, Fulda S, Pfreundschuh M, Trümper L, Klapper W, Keller U, Jost PJ, Rosenwald A, Peschel C, Bassermann F.

EMBO Mol Med. 2016 Aug 1;8(8):851-62. doi: 10.15252/emmm.201506047. Print 2016 Aug.

20.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; UK10K Rare Diseases Group.

Nat Commun. 2016 May 13;7:11491. doi: 10.1038/ncomms11491.

21.

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.

Porras P, Duesbury M, Fabregat A, Ueffing M, Orchard S, Gloeckner CJ, Hermjakob H.

Proteomics. 2015 Apr;15(8):1390-404. doi: 10.1002/pmic.201400390. Epub 2015 Mar 21. Review.

22.

LRRK2 transport is regulated by its novel interacting partner Rab32.

Waschbüsch D, Michels H, Strassheim S, Ossendorf E, Kessler D, Gloeckner CJ, Barnekow A.

PLoS One. 2014 Oct 31;9(10):e111632. doi: 10.1371/journal.pone.0111632. eCollection 2014.

23.

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.

Sabag AD, Smolkin T, Mumblat Y, Ueffing M, Kessler O, Gloeckner CJ, Neufeld G.

J Cell Sci. 2014 Dec 15;127(Pt 24):5240-52. doi: 10.1242/jcs.155960. Epub 2014 Oct 21.

24.

Applying SILAC for the differential analysis of protein complexes.

Boldt K, Gloeckner CJ, Texier Y, von Zweydorf F, Ueffing M.

Methods Mol Biol. 2014;1188:177-90. doi: 10.1007/978-1-4939-1142-4_13.

PMID:
25059612
25.

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ.

Mol Cell Biol. 2014 Jun;34(12):2147-61. doi: 10.1128/MCB.00914-13. Epub 2014 Mar 31.

26.

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.

Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18.

27.

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ.

J Neurosci Methods. 2013 Mar 30;214(1):62-8. doi: 10.1016/j.jneumeth.2012.12.015. Epub 2013 Jan 12.

PMID:
23318290
28.

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.

Dong G, Gross K, Qiao F, Ferguson J, Callegari EA, Rezvani K, Zhang D, Gloeckner CJ, Ueffing M, Wang H.

J Neurochem. 2012 Nov;123(3):437-46. doi: 10.1111/j.1471-4159.2012.07919.x. Epub 2012 Sep 10.

29.

Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.

Dong G, Callegari E, Gloeckner CJ, Ueffing M, Wang H.

Proteomics. 2012 Jun;12(12):2060-4. doi: 10.1002/pmic.201100380.

30.

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

Dong G, Callegari EA, Gloeckner CJ, Ueffing M, Wang H.

J Biol Chem. 2012 Jan 6;287(2):1279-89. doi: 10.1074/jbc.M111.294280. Epub 2011 Nov 22.

31.

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing M, Lickert H.

Dev Cell. 2011 Sep 13;21(3):479-91. doi: 10.1016/j.devcel.2011.08.003.

32.

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

Coene KL, Mans DA, Boldt K, Gloeckner CJ, van Reeuwijk J, Bolat E, Roosing S, Letteboer SJ, Peters TA, Cremers FP, Ueffing M, Roepman R.

Hum Mol Genet. 2011 Sep 15;20(18):3592-605. doi: 10.1093/hmg/ddr280. Epub 2011 Jun 17.

PMID:
21685204
33.

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice.

Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJ, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, Gloeckner CJ, Nishina PM, Roepman R, Ueffing M.

J Clin Invest. 2011 Jun;121(6):2169-80. doi: 10.1172/JCI45627. Epub 2011 May 23.

34.

The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish.

Webb KJ, Coolen M, Gloeckner CJ, Stigloher C, Bahn B, Topp S, Ueffing M, Bally-Cuif L.

BMC Dev Biol. 2011 May 17;11:27. doi: 10.1186/1471-213X-11-27.

35.

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M.

J Neurosci. 2011 Feb 9;31(6):2225-37. doi: 10.1523/JNEUROSCI.3730-10.2011.

36.

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.

Sibbing D, Pfeufer A, Perisic T, Mannes AM, Fritz-Wolf K, Unwin S, Sinner MF, Gieger C, Gloeckner CJ, Wichmann HE, Kremmer E, Schäfer Z, Walch A, Hinterseer M, Näbauer M, Kääb S, Kastrati A, Schömig A, Meitinger T, Bornkamm GW, Conrad M, von Beckerath N.

Eur Heart J. 2011 May;32(9):1121-33. doi: 10.1093/eurheartj/ehq507. Epub 2011 Jan 18.

PMID:
21247928
37.

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.

Haebig K, Gloeckner CJ, Miralles MG, Gillardon F, Schulte C, Riess O, Ueffing M, Biskup S, Bonin M.

PLoS One. 2010 Oct 29;5(10):e13762. doi: 10.1371/journal.pone.0013762.

38.

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M.

Mol Cell Proteomics. 2011 Jan;10(1):M110.001172. doi: 10.1074/mcp.M110.001172. Epub 2010 Sep 27.

39.

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M.

J Proteome Res. 2010 Apr 5;9(4):1738-45. doi: 10.1021/pr9008578.

PMID:
20108944
40.

ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations.

Kortvely E, Hauck SM, Duetsch G, Gloeckner CJ, Kremmer E, Alge-Priglinger CS, Deeg CA, Ueffing M.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):79-88. doi: 10.1167/iovs.09-3850. Epub 2009 Aug 20.

PMID:
19696174
41.

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions.

Gloeckner CJ, Boldt K, Ueffing M.

Curr Protoc Protein Sci. 2009 Aug;Chapter 19:Unit19.20. doi: 10.1002/0471140864.ps1920s57.

PMID:
19688738
42.

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

Gloeckner CJ, Boldt K, Schumacher A, Ueffing M.

Methods Mol Biol. 2009;564:359-72. doi: 10.1007/978-1-60761-157-8_21.

PMID:
19544034
43.

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.

Gloeckner CJ, Schumacher A, Boldt K, Ueffing M.

J Neurochem. 2009 May;109(4):959-68. doi: 10.1111/j.1471-4159.2009.06024.x. Epub 2009 Mar 3.

44.

Tandem affinity purification of ciliopathy-associated protein complexes.

Boldt K, van Reeuwijk J, Gloeckner CJ, Ueffing M, Roepman R.

Methods Cell Biol. 2009;91:143-60. doi: 10.1016/S0091-679X(08)91009-8. Epub 2009 Dec 1.

PMID:
20409786
45.

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.

Favor J, Gloeckner CJ, Neuhäuser-Klaus A, Pretsch W, Sandulache R, Saule S, Zaus I.

Genetics. 2008 Jul;179(3):1345-55. doi: 10.1534/genetics.108.088591. Epub 2008 Jun 18.

46.

Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach.

Hauck SM, Gloeckner CJ, Harley ME, Schoeffmann S, Boldt K, Ekstrom PA, Ueffing M.

Mol Cell Proteomics. 2008 Jul;7(7):1349-61. doi: 10.1074/mcp.M700456-MCP200. Epub 2008 Apr 23.

47.

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.

Gloeckner CJ, Boldt K, Schumacher A, Roepman R, Ueffing M.

Proteomics. 2007 Dec;7(23):4228-34.

PMID:
17979178
48.

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells.

Swiatek-De Lange M, Stampfl A, Hauck SM, Zischka H, Gloeckner CJ, Deeg CA, Ueffing M.

Glia. 2007 Aug 1;55(10):1061-73.

PMID:
17551930
50.

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis.

Zischka H, Braun RJ, Marantidis EP, Büringer D, Bornhövd C, Hauck SM, Demmer O, Gloeckner CJ, Reichert AS, Madeo F, Ueffing M.

Mol Cell Proteomics. 2006 Nov;5(11):2185-200. Epub 2006 Aug 17.

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