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Items: 1 to 20 of 83

1.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J.

Blood. 2019 Oct 3;134(14):1159-1175. doi: 10.1182/blood.2019000095. Epub 2019 Jul 31.

PMID:
31366618
2.

Understanding the role of genetic variability in LRRK2 in Indian population.

Kishore A, Ashok Kumar Sreelatha A, Sturm M, von-Zweydorf F, Pihlstrøm L, Raimondi F, Russell R, Lichtner P, Banerjee M, Krishnan S, Rajan R, Puthenveedu DK, Chung SJ; International Parkinson's Disease Genomics Consortium (IPDGC); Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD), Bauer P, Riess O, Gloeckner CJ, Kruger R, Gasser T, Sharma M.

Mov Disord. 2019 Apr;34(4):496-505. doi: 10.1002/mds.27558. Epub 2018 Nov 28.

PMID:
30485545
3.

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

Weishäupl D, Schneider J, Peixoto Pinheiro B, Ruess C, Dold SM, von Zweydorf F, Gloeckner CJ, Schmidt J, Riess O, Schmidt T.

J Biol Chem. 2019 Jan 11;294(2):644-661. doi: 10.1074/jbc.RA118.005801. Epub 2018 Nov 19.

PMID:
30455355
4.

Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.

Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ.

Sci Rep. 2018 Nov 1;8(1):16196. doi: 10.1038/s41598-018-34480-x.

5.

Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway.

Guo H, Hamilton Ii M, Offutt SJ, Gloeckner CD, Li T, Kim Y, Legon W, Alford JK, Lim HH.

Neuron. 2018 Aug 22;99(4):866. doi: 10.1016/j.neuron.2018.07.049. No abstract available.

6.

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ.

J Biol Chem. 2018 Oct 12;293(41):16083-16099. doi: 10.1074/jbc.RA118.003440. Epub 2018 Aug 17.

PMID:
30120199
7.

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A.

Biol Chem. 2018 Nov 27;399(12):1447-1456. doi: 10.1515/hsz-2018-0227.

PMID:
30067506
8.

Phosphorylation Modulates the Subcellular Localization of SOX11.

Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC.

Front Mol Neurosci. 2018 Jun 19;11:211. doi: 10.3389/fnmol.2018.00211. eCollection 2018.

9.

Regulation of LRRK2: insights from structural and biochemical analysis.

Gilsbach BK, Eckert M, Gloeckner CJ.

Biol Chem. 2018 Jun 27;399(7):637-642. doi: 10.1515/hsz-2018-0132. Review.

PMID:
29894291
10.

Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway.

Guo H, Hamilton M 2nd, Offutt SJ, Gloeckner CD, Li T, Kim Y, Legon W, Alford JK, Lim HH.

Neuron. 2018 Jun 6;98(5):1020-1030.e4. doi: 10.1016/j.neuron.2018.04.036. Epub 2018 May 24. Erratum in: Neuron. 2018 Aug 22;99(4):866.

11.

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.

Jung M, Häberle BM, Tschaikowsky T, Wittmann MT, Balta EA, Stadler VC, Zweier C, Dörfler A, Gloeckner CJ, Lie DC.

Mol Autism. 2018 Mar 22;9:20. doi: 10.1186/s13229-018-0200-1. eCollection 2018.

12.

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

Perez Carrion M, Pischedda F, Biosa A, Russo I, Straniero L, Civiero L, Guida M, Gloeckner CJ, Ticozzi N, Tiloca C, Mariani C, Pezzoli G, Duga S, Pichler I, Pan L, Landers JE, Greggio E, Hess MW, Goldwurm S, Piccoli G.

Front Mol Neurosci. 2018 Feb 28;11:64. doi: 10.3389/fnmol.2018.00064. eCollection 2018.

13.

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

Marrone L, Bus C, Schöndorf D, Fitzgerald JC, Kübler M, Schmid B, Reinhardt P, Reinhardt L, Deleidi M, Levin T, Meixner A, Klink B, Glatza M, Gloeckner CJ, Gasser T, Sterneckert J.

PLoS One. 2018 Mar 7;13(3):e0192497. doi: 10.1371/journal.pone.0192497. eCollection 2018.

14.

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W.

Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4.

15.

Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens.

Müller JN, Falk M, Talwar J, Neemann N, Mariotti E, Bertrand M, Zacherle T, Lakis S, Menon R, Gloeckner C, Tiemann M, Heukamp LC, Thomas RK, Griesinger F, Heuckmann JM.

J Thorac Oncol. 2017 Oct;12(10):1503-1511. doi: 10.1016/j.jtho.2017.07.014. Epub 2017 Jul 24.

16.

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

Carrion MDP, Marsicano S, Daniele F, Marte A, Pischedda F, Di Cairano E, Piovesana E, von Zweydorf F, Kremmer E, Gloeckner CJ, Onofri F, Perego C, Piccoli G.

Sci Rep. 2017 Jul 14;7(1):5377. doi: 10.1038/s41598-017-05760-9.

17.

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

Weber JJ, Golla M, Guaitoli G, Wanichawan P, Hayer SN, Hauser S, Krahl AC, Nagel M, Samer S, Aronica E, Carlson CR, Schöls L, Riess O, Gloeckner CJ, Nguyen HP, Hübener-Schmid J.

Brain. 2017 May 1;140(5):1280-1299. doi: 10.1093/brain/awx039.

PMID:
28334907
18.

Improved genome sequencing using an engineered transposase.

Kia A, Gloeckner C, Osothprarop T, Gormley N, Bomati E, Stephenson M, Goryshin I, He MM.

BMC Biotechnol. 2017 Jan 17;17(1):6. doi: 10.1186/s12896-016-0326-1.

19.

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

Guaitoli G, Gilsbach BK, Raimondi F, Gloeckner CJ.

Biochem Soc Trans. 2016 Dec 15;44(6):1635-1641. Review.

PMID:
27913672
20.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66. doi: 10.1073/pnas.1523708113. Epub 2016 Jun 29.

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