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The multiple roles of the unfolded protein response regulator IRE1α in cancer.

Chalmers F, Mogre S, Son J, Blazanin N, Glick AB.

Mol Carcinog. 2019 Sep;58(9):1623-1630. doi: 10.1002/mc.23031. Epub 2019 Apr 30.


Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.

Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH.

Toxicol Sci. 2017 Nov 1;160(1):83-94. doi: 10.1093/toxsci/kfx160.


ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras.

Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9900-9905. doi: 10.1073/pnas.1701757114. Epub 2017 Aug 28.


Estrogen modulates mesenchyme-epidermis interactions in the adult nipple.

Wu HJ, Oh JW, Spandau DF, Tholpady S, Diaz J 3rd, Schroeder LJ, Offutt CD, Glick AB, Plikus MV, Koyama S, Foley J.

Development. 2017 Apr 15;144(8):1498-1509. doi: 10.1242/dev.141630. Epub 2017 Mar 13.


Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V-Induced Squamous Tumors.

Podolsky MA, Bailey JT, Gunderson AJ, Oakes CJ, Breech K, Glick AB.

Cancer Immunol Res. 2017 Mar;5(3):198-210. doi: 10.1158/2326-6066.CIR-16-0304. Epub 2017 Jan 30.


Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation.

van den Bogaard EH, Podolsky MA, Smits JP, Cui X, John C, Gowda K, Desai D, Amin SG, Schalkwijk J, Perdew GH, Glick AB.

J Invest Dermatol. 2015 May;135(5):1320-1328. doi: 10.1038/jid.2015.6. Epub 2015 Jan 20.


The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.

Zhu B, Ferry CH, Markell LK, Blazanin N, Glick AB, Gonzalez FJ, Peters JM.

J Biol Chem. 2014 Jul 18;289(29):20102-19. doi: 10.1074/jbc.M114.551069. Epub 2014 Jun 4.


Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.

Ravindran A, Mohammed J, Gunderson AJ, Cui X, Glick AB.

Carcinogenesis. 2014 Apr;35(4):959-66. doi: 10.1093/carcin/bgt486. Epub 2013 Dec 20.


PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.

Zhu B, Ferry CH, Blazanin N, Bility MT, Khozoie C, Kang BH, Glick AB, Gonzalez FJ, Peters JM.

Oncogene. 2014 Nov 13;33(46):5348-59. doi: 10.1038/onc.2013.477. Epub 2013 Nov 11.


The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.

Hogan KA, Ravindran A, Podolsky MA, Glick AB.

Cytokine. 2013 Dec;64(3):652-9. doi: 10.1016/j.cyto.2013.09.004. Epub 2013 Sep 24.


Impairment of regulatory T-cell function in autoimmune thyroid disease.

Glick AB, Wodzinski A, Fu P, Levine AD, Wald DN.

Thyroid. 2013 Jul;23(7):871-8. doi: 10.1089/thy.2012.0514.


The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models.

Glick AB.

J Skin Cancer. 2012;2012:249063. doi: 10.1155/2012/249063. Epub 2012 Dec 26.


CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ.

Gunderson AJ, Mohammed J, Horvath FJ, Podolsky MA, Anderson CR, Glick AB.

J Invest Dermatol. 2013 Apr;133(4):955-63. doi: 10.1038/jid.2012.390. Epub 2012 Nov 15.


Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth.

Plichta KA, Mathers JL, Gestl SA, Glick AB, Gunther EJ.

Cancer Res. 2012 Nov 15;72(22):5856-66. doi: 10.1158/0008-5472.CAN-12-1635. Epub 2012 Sep 24.


TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.

Mohammed J, Gunderson AJ, Khong HH, Koubek RD, Udey MC, Glick AB.

J Invest Dermatol. 2013 Jan;133(1):135-43. doi: 10.1038/jid.2012.241. Epub 2012 Jul 26.


S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion.

Shi C, Cooper TK, McCloskey DE, Glick AB, Shantz LM, Feith DJ.

Carcinogenesis. 2012 Jul;33(7):1310-8. doi: 10.1093/carcin/bgs184. Epub 2012 May 19.


Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells.

Zhu B, Khozoie C, Bility MT, Ferry CH, Blazanin N, Glick AB, Gonzalez FJ, Peters JM.

Mol Cell Biol. 2012 Jun;32(11):2065-82. doi: 10.1128/MCB.00092-12. Epub 2012 Apr 2.


Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS.

Markell LM, Masiuk KE, Blazanin N, Glick AB.

Mol Cancer Res. 2011 Jun;9(6):746-56. doi: 10.1158/1541-7786.MCR-11-0112. Epub 2011 Apr 26.


Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression.

Mordasky Markell L, Pérez-Lorenzo R, Masiuk KE, Kennett MJ, Glick AB.

Carcinogenesis. 2010 Dec;31(12):2127-35. doi: 10.1093/carcin/bgq191. Epub 2010 Sep 17.


Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.

Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hähnel B, Hosser H, Gröne HJ, Kriz W.

Am J Pathol. 2010 Aug;177(2):632-43. doi: 10.2353/ajpath.2010.091012. Epub 2010 Jul 8.


TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17.

Mohammed J, Ryscavage A, Perez-Lorenzo R, Gunderson AJ, Blazanin N, Glick AB.

J Invest Dermatol. 2010 Sep;130(9):2295-303. doi: 10.1038/jid.2010.92. Epub 2010 Apr 22.


Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.

Pérez-Lorenzo R, Markell LM, Hogan KA, Yuspa SH, Glick AB.

Carcinogenesis. 2010 Jun;31(6):1116-23. doi: 10.1093/carcin/bgq041. Epub 2010 Feb 19.


The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.

Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC.

J Pathol. 2009 Oct;219(2):263-74. doi: 10.1002/path.2600.


Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.

Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA.

Nat Genet. 2008 Sep;40(9):1130-5. doi: 10.1038/ng.192.


Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3.

Bae DS, Blazanin N, Licata M, Lee J, Glick AB.

Mol Carcinog. 2009 May;48(5):441-53. doi: 10.1002/mc.20482.


Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling.

Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z.

J Invest Dermatol. 2009 Mar;129(3):742-51. doi: 10.1038/jid.2008.295. Epub 2008 Oct 2.


Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis.

Bility MT, Devlin-Durante MK, Blazanin N, Glick AB, Ward JM, Kang BH, Kennett MJ, Gonzalez FJ, Peters JM.

Carcinogenesis. 2008 Dec;29(12):2406-14. doi: 10.1093/carcin/bgn219. Epub 2008 Sep 17.


An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R.

Nat Med. 2008 Sep;14(9):979-84. doi: 10.1038/nm.1865.


Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis.

Shukla A, Ho Y, Liu X, Ryscavage A, Glick AB.

Mol Cancer Res. 2008 Mar;6(3):509-16. doi: 10.1158/1541-7786.MCR-07-0396.


Context-dependent regulation of cutaneous immunological responses by TGFbeta1 and its role in skin carcinogenesis.

Glick AB, Perez-Lorenzo R, Mohammed J.

Carcinogenesis. 2008 Jan;29(1):9-14. Epub 2007 Sep 24. Review.


Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.

Garcia RJ, Ittah A, Mirabal S, Figueroa J, Lopez L, Glick AB, Kos L.

J Invest Dermatol. 2008 Jan;128(1):131-42. Epub 2007 Jul 5.


Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.

Darwiche N, Ryscavage A, Perez-Lorenzo R, Wright L, Bae DS, Hennings H, Yuspa SH, Glick AB.

Oncogene. 2007 Oct 18;26(48):6885-95. Epub 2007 May 21.


Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.

Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH.

Cancer Res. 2006 Nov 15;66(22):10861-9. Epub 2006 Nov 6.


Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers.

Glick AB, Yuspa SH.

Semin Cancer Biol. 2005 Apr;15(2):75-83. Review.


Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes.

Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB, Schäfer-Korting M, Roberts AB, Kleuser B.

J Biol Chem. 2004 Sep 10;279(37):38471-9. Epub 2004 Jul 9.


TGFbeta1, back to the future: revisiting its role as a transforming growth factor.

Glick AB.

Cancer Biol Ther. 2004 Mar;3(3):276-83. Epub 2004 Mar 8. Review.


Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.

Vijayachandra K, Lee J, Glick AB.

Cancer Res. 2003 Jul 1;63(13):3447-52.


Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response.

Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB.

Nat Cell Biol. 1999 Sep;1(5):260-6.


Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.

Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ.

Genes Dev. 1998 Aug 15;12(16):2469-74.


Identification of differentially expressed genes in chemically induced skin tumors.

Rutberg SE, Lee EJ, Hansen LH, Glick AB, Yuspa SH.

Mol Carcinog. 1997 Sep;20(1):88-98.


Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.

Glick AB, Weinberg WC, Wu IH, Quan W, Yuspa SH.

Cancer Res. 1996 Aug 15;56(16):3645-50. Erratum in: Cancer Res 1997 May 15;57(10):2079.


Multistage carcinogenesis in the skin.

Yuspa SH, Dlugosz AA, Denning MF, Glick AB.

J Investig Dermatol Symp Proc. 1996 Apr;1(2):147-50. Review.


A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis.

Tennenbaum T, Belanger AJ, Glick AB, Tamura R, Quaranta V, Yuspa SH.

Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7041-5.


Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors.

Darwiche N, Celli G, Tennenbaum T, Glick AB, Yuspa SH, De Luca LM.

Cancer Res. 1995 Jul 1;55(13):2774-82.


Isolation and utilization of epidermal keratinocytes for oncogene research.

Dlugosz AA, Glick AB, Tennenbaum T, Weinberg WC, Yuspa SH.

Methods Enzymol. 1995;254:3-20. No abstract available.


Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.

Yuspa SH, Długosz AA, Cheng CK, Denning MF, Tennenbaum T, Glick AB, Weinberg WC.

J Invest Dermatol. 1994 Nov;103(5 Suppl):90S-95S. Review.


Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

Glick AB, Lee MM, Darwiche N, Kulkarni AB, Karlsson S, Yuspa SH.

Genes Dev. 1994 Oct 15;8(20):2429-40.


FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin.

Hennings H, Glick AB, Lowry DT, Krsmanovic LS, Sly LM, Yuspa SH.

Carcinogenesis. 1993 Nov;14(11):2353-8.


The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.

Tennenbaum T, Weiner AK, Belanger AJ, Glick AB, Hennings H, Yuspa SH.

Cancer Res. 1993 Oct 15;53(20):4803-10.


Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, Sporn MB, Karlsson S, Yuspa SH.

Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6076-80.

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