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Items: 1 to 50 of 128

1.

ER Protein Quality Control and the Unfolded Protein Response in the Heart.

Arrieta A, Blackwood EA, Glembotski CC.

Curr Top Microbiol Immunol. 2018;414:193-213. doi: 10.1007/82_2017_54. Review.

PMID:
29026925
2.

Expanding the Paracrine Hypothesis of Stem Cell-Mediated Repair in the Heart: When the Unconventional Becomes Conventional.

Glembotski CC.

Circ Res. 2017 Mar 3;120(5):772-774. doi: 10.1161/CIRCRESAHA.116.310298. No abstract available.

3.

CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.

Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH.

J Mol Cell Cardiol. 2017 Feb;103:48-55. doi: 10.1016/j.yjmcc.2017.01.002. Epub 2017 Jan 7.

4.

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.

Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC.

Circ Res. 2017 Mar 3;120(5):862-875. doi: 10.1161/CIRCRESAHA.116.310266. Epub 2016 Dec 8.

5.

S100A4 protects the myocardium against ischemic stress.

Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M.

J Mol Cell Cardiol. 2016 Nov;100:54-63. doi: 10.1016/j.yjmcc.2016.10.001. Epub 2016 Oct 6.

6.

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.

Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH.

Int J Cardiol. 2016 Dec 15;225:371-380. doi: 10.1016/j.ijcard.2016.10.021. Epub 2016 Oct 8.

7.

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.

Yu Z, Sheng H, Liu S, Zhao S, Glembotski CC, Warner DS, Paschen W, Yang W.

J Cereb Blood Flow Metab. 2017 Mar;37(3):1069-1079. doi: 10.1177/0271678X16650218. Epub 2016 Jul 20.

8.

Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart.

Glembotski CC.

Circ Res. 2015 Nov 6;117(11):914-6. doi: 10.1161/CIRCRESAHA.115.307644. No abstract available.

9.

Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC.

Circ Res. 2015 Aug 28;117(6):536-46. doi: 10.1161/CIRCRESAHA.115.306993. Epub 2015 Jul 2.

10.

Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart.

Glembotski CC.

Circ Res. 2014 Aug 29;115(6):546-8. doi: 10.1161/CIRCRESAHA.114.304855. No abstract available.

11.

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.

Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA.

EMBO Mol Med. 2014 Jan;6(1):57-65. doi: 10.1002/emmm.201303183.

12.

Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer.

Glembotski CC.

Circ Res. 2013 Oct 25;113(10):1112-6. doi: 10.1161/CIRCRESAHA.113.302490. No abstract available.

13.

Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart.

Glembotski CC.

J Mol Cell Cardiol. 2014 Jun;71:11-5. doi: 10.1016/j.yjmcc.2013.09.018. Epub 2013 Oct 16. Review.

14.

Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.

Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA.

Circulation. 2013 Nov 5;128(19):2132-44. doi: 10.1161/CIRCULATIONAHA.113.003638. Epub 2013 Sep 5.

15.

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.

Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12661-6. doi: 10.1073/pnas.1301455110. Epub 2013 Jul 10.

16.

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA.

Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13.

17.

ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response.

Doroudgar S, Glembotski CC.

Circ Res. 2013 Jan 4;112(1):9-12. doi: 10.1161/CIRCRESAHA.112.280560. No abstract available. Erratum in: Circ Res. 2013 Feb 1;112(3):e31.

18.

Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control.

Glembotski CC.

Physiology (Bethesda). 2012 Dec;27(6):343-50. doi: 10.1152/physiol.00034.2012. Review.

19.

New concepts of endoplasmic reticulum function in the heart: programmed to conserve.

Doroudgar S, Glembotski CC.

J Mol Cell Cardiol. 2013 Feb;55:85-91. doi: 10.1016/j.yjmcc.2012.10.006. Epub 2012 Oct 23. Review.

20.

Clarifying the cardiac proteasome paradox: protein quality control.

Glembotski CC.

Circ Res. 2012 Aug 17;111(5):509-12. doi: 10.1161/CIRCRESAHA.112.275917. No abstract available.

21.

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.

Eletto D, Maganty A, Eletto D, Dersh D, Makarewich C, Biswas C, Paton JC, Paton AW, Doroudgar S, Glembotski CC, Argon Y.

J Cell Sci. 2012 Oct 15;125(Pt 20):4865-75. doi: 10.1242/jcs.108928. Epub 2012 Aug 1.

22.

Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.

Glembotski CC, Thuerauf DJ, Huang C, Vekich JA, Gottlieb RA, Doroudgar S.

J Biol Chem. 2012 Jul 27;287(31):25893-904. doi: 10.1074/jbc.M112.356345. Epub 2012 May 25.

23.

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death.

Vekich JA, Belmont PJ, Thuerauf DJ, Glembotski CC.

J Mol Cell Cardiol. 2012 Aug;53(2):259-67. doi: 10.1016/j.yjmcc.2012.05.005. Epub 2012 May 17.

24.

Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response.

Belmont PJ, Chen WJ, Thuerauf DJ, Glembotski CC.

J Mol Cell Cardiol. 2012 May;52(5):1176-82. doi: 10.1016/j.yjmcc.2012.01.017. Epub 2012 Feb 1.

25.

The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart.

Doroudgar S, Glembotski CC.

Trends Mol Med. 2011 Apr;17(4):207-14. doi: 10.1016/j.molmed.2010.12.003. Epub 2011 Feb 1. Review.

26.

Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.

Glembotski CC.

J Mol Cell Cardiol. 2011 Oct;51(4):512-7. doi: 10.1016/j.yjmcc.2010.10.008. Epub 2010 Oct 21. Review.

27.

PHLPP-1 negatively regulates Akt activity and survival in the heart.

Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH.

Circ Res. 2010 Aug 20;107(4):476-84. doi: 10.1161/CIRCRESAHA.109.215020. Epub 2010 Jun 24.

28.

Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA.

Circ Res. 2010 Apr 16;106(7):1265-74. doi: 10.1161/CIRCRESAHA.109.212035. Epub 2010 Mar 4.

29.

Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.

Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC.

Circ Res. 2010 Feb 5;106(2):307-16. doi: 10.1161/CIRCRESAHA.109.203901. Epub 2009 Nov 25.

30.

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.

Meex SJ, Weissglas-Volkov D, van der Kallen CJ, Thuerauf DJ, van Greevenbroek MM, Schalkwijk CG, Stehouwer CD, Feskens EJ, Heldens L, Ayoubi TA, Hofker MH, Wouters BG, Vlietinck R, Sinsheimer JS, Taskinen MR, Kuusisto J, Laakso M, de Bruin TW, Pajukanta P, Glembotski CC.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1322-7. doi: 10.1161/ATVBAHA.108.180240. Epub 2009 Aug 10.

31.

Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.

Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC.

J Biol Chem. 2009 Oct 23;284(43):29735-45. doi: 10.1074/jbc.M109.018036. Epub 2009 Jul 21.

32.

Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia.

Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glembotski CC.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1633-42. doi: 10.1152/ajpheart.01227.2008. Epub 2009 Feb 27.

33.

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.

Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H470-9. doi: 10.1152/ajpheart.01051.2008. Epub 2008 Dec 19.

34.

Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.

Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC.

Circ Res. 2008 Nov 21;103(11):1249-58. doi: 10.1161/CIRCRESAHA.108.180679. Epub 2008 Oct 16.

35.

Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.

Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC.

J Biol Chem. 2008 May 16;283(20):14012-21. doi: 10.1074/jbc.M709776200. Epub 2008 Mar 3.

36.

The role of the unfolded protein response in the heart.

Glembotski CC.

J Mol Cell Cardiol. 2008 Mar;44(3):453-9. Epub 2007 Dec 3. Review.

37.

Pim-1 regulates cardiomyocyte survival downstream of Akt.

Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA.

Nat Med. 2007 Dec;13(12):1467-75. Epub 2007 Nov 25. Erratum in: Nat Med. 2008 Mar;14(3):350.

PMID:
18037896
38.

Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion.

Jin JK, Whittaker R, Glassy MS, Barlow SB, Gottlieb RA, Glembotski CC.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H337-44. Epub 2007 Nov 9.

39.

Endoplasmic reticulum stress in the heart.

Glembotski CC.

Circ Res. 2007 Nov 9;101(10):975-84. Review.

PMID:
17991891
40.

Getting a G--RRP on regulated exocytosis in the heart.

Glembotski CC.

J Cell Biol. 2007 Nov 5;179(3):371-3. Epub 2007 Oct 29.

41.

Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability.

Thuerauf DJ, Marcinko M, Belmont PJ, Glembotski CC.

J Biol Chem. 2007 Aug 3;282(31):22865-78. Epub 2007 May 23.

42.

Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.

Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC.

Circ Res. 2006 Aug 4;99(3):275-82. Epub 2006 Jun 22.

PMID:
16794188
43.

Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6.

Wall JA, Wei J, Ly M, Belmont P, Martindale JJ, Tran D, Sun J, Chen WJ, Yu W, Oeller P, Briggs S, Gustafsson AB, Sayen MR, Gottlieb RA, Glembotski CC.

Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2462-72. Epub 2006 Jun 9.

44.

Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.

Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA, Glembotski CC.

Circ Res. 2006 May 12;98(9):1186-93. Epub 2006 Apr 6.

PMID:
16601230
45.

Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.

Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA.

J Clin Invest. 2005 Oct;115(10):2716-30.

46.

Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.

McMullen ME, Bryant PW, Glembotski CC, Vincent PA, Pumiglia KM.

J Biol Chem. 2005 Jun 3;280(22):20995-1003. Epub 2005 Mar 24.

47.

Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.

Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC.

J Biol Chem. 2005 Jan 7;280(1):669-76. Epub 2004 Oct 18.

48.

Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.

Thuerauf DJ, Morrison L, Glembotski CC.

J Biol Chem. 2004 May 14;279(20):21078-84. Epub 2004 Feb 18.

49.

Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model.

Morrison LE, Whittaker RJ, Klepper RE, Wawrousek EF, Glembotski CC.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H847-55. Epub 2003 Oct 30.

50.

The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT.

Andrews C, Ho PD, Dillmann WH, Glembotski CC, McDonough PM.

Cardiovasc Res. 2003 Jul 1;59(1):46-56.

PMID:
12829175

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