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Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production.

Tan JZA, Fourriere L, Wang J, Perez F, Boncompain G, Gleeson PA.

Mol Biol Cell. 2020 Jan 1;31(1):27-44. doi: 10.1091/mbc.E19-09-0487. Epub 2019 Nov 20.


The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease.

Webers A, Heneka MT, Gleeson PA.

Immunol Cell Biol. 2020 Jan;98(1):28-41. doi: 10.1111/imcb.12301. Epub 2019 Nov 20. Review.


FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.

Toh WH, Louber J, Mahmoud IS, Chia J, Bass GT, Dower SK, Verhagen AM, Gleeson PA.

J Cell Sci. 2019 Oct 1;133(5). pii: jcs235416. doi: 10.1242/jcs.235416.


Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling.

Kulkarni-Gosavi P, Makhoul C, Gleeson PA.

FEBS Lett. 2019 Sep;593(17):2289-2305. doi: 10.1002/1873-3468.13567. Epub 2019 Aug 19. Review.


Golgi Dynamics: The Morphology of the Mammalian Golgi Apparatus in Health and Disease.

Makhoul C, Gosavi P, Gleeson PA.

Front Cell Dev Biol. 2019 Jul 3;7:112. doi: 10.3389/fcell.2019.00112. eCollection 2019.


A role for Rab11 in the homeostasis of the endosome-lysosomal pathway.

Zulkefli KL, Houghton FJ, Gosavi P, Gleeson PA.

Exp Cell Res. 2019 Jul 1;380(1):55-68. doi: 10.1016/j.yexcr.2019.04.010. Epub 2019 Apr 11.


The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.

Tan JZA, Gleeson PA.

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):697-712. doi: 10.1016/j.bbamem.2018.11.013. Epub 2019 Jan 11. Review.


The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons.

Tan JZA, Gleeson PA.

J Biol Chem. 2019 Feb 1;294(5):1618-1631. doi: 10.1074/jbc.RA118.005222. Epub 2018 Dec 13.


Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture.

Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA.

Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12.


The Golgi architecture and cell sensing.

Makhoul C, Gosavi P, Gleeson PA.

Biochem Soc Trans. 2018 Oct 19;46(5):1063-1072. doi: 10.1042/BST20180323. Epub 2018 Sep 20. Review.


Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway.

Chia J, Louber J, Glauser I, Taylor S, Bass GT, Dower SK, Gleeson PA, Verhagen AM.

J Biol Chem. 2018 Apr 27;293(17):6363-6373. doi: 10.1074/jbc.M117.817064. Epub 2018 Mar 9.


The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity.

Gosavi P, Houghton FJ, McMillan PJ, Hanssen E, Gleeson PA.

J Cell Sci. 2018 Feb 8;131(3). pii: jcs211987. doi: 10.1242/jcs.211987.


GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.

Toh WH, Chia PZC, Hossain MI, Gleeson PA.

Mol Biol Cell. 2018 Jan 15;29(2):191-208. doi: 10.1091/mbc.E17-05-0270. Epub 2017 Nov 15.


The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!

Gosavi P, Gleeson PA.

Bioessays. 2017 Nov;39(11). doi: 10.1002/bies.201700063. Epub 2017 Oct 6. Review.


C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RAK, Levina V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE, Atkin JD.

Hum Mol Genet. 2017 Oct 15;26(20):4093-4094. doi: 10.1093/hmg/ddx309. No abstract available.


Signal dependent transport of a membrane cargo from early endosomes to recycling endosomes.

Mahmoud IS, Louber J, Dower SK, Verhagen AM, Gleeson PA.

Eur J Cell Biol. 2017 Aug;96(5):418-431. doi: 10.1016/j.ejcb.2017.06.005. Epub 2017 Jun 17.


Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.

Toh WH, Tan JZ, Zulkefli KL, Houghton FJ, Gleeson PA.

Traffic. 2017 Mar;18(3):159-175. doi: 10.1111/tra.12465. Epub 2017 Jan 30.


Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation-induced gastric autoimmunity in mice.

Overall SA, Bourges D, van Driel IR, Gleeson PA.

Eur J Immunol. 2017 Jan;47(1):155-167. doi: 10.1002/eji.201646572. Epub 2016 Nov 15.


Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions.

Toh WH, Gleeson PA.

Biochem J. 2016 Jul 15;473(14):1977-93. doi: 10.1042/BCJ20160147. Review.


Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture.

Overall SA, van Driel IR, Gleeson PA.

Int Immunol. 2016 Oct;28(10):513-518. Epub 2016 Jun 30.


Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?

Toh WH, Gleeson PA.

Front Cell Dev Biol. 2016 Feb 29;4:12. doi: 10.3389/fcell.2016.00012. eCollection 2016. Review.


Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages.

Lim JP, Gosavi P, Mintern JD, Ross EM, Gleeson PA.

J Cell Sci. 2015 Dec 1;128(23):4407-19. doi: 10.1242/jcs.174359. Epub 2015 Oct 12.


Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.

Toh WH, Houghton FJ, Chia PZ, Ramdzan YM, Hatters DM, Gleeson PA.

Methods Mol Biol. 2015;1270:227-38. doi: 10.1007/978-1-4939-2309-0_17.


Membrane tethering.

Chia PZ, Gleeson PA.

F1000Prime Rep. 2014 Sep 4;6:74. doi: 10.12703/P6-74. eCollection 2014. Review.


Transient Treg-cell depletion in adult mice results in persistent self-reactive CD4(+) T-cell responses.

Nyström SN, Bourges D, Garry S, Ross EM, van Driel IR, Gleeson PA.

Eur J Immunol. 2014 Dec;44(12):3621-31. doi: 10.1002/eji.201344432. Epub 2014 Nov 2.


Transient systemic inflammation does not alter the induction of tolerance to gastric autoantigens by migratory dendritic cells.

Bourges D, Ross EM, Allen S, Read S, Houghton FJ, Bedoui S, Boon L, Gleeson PA, van Driel IR.

J Immunol. 2014 Jun 1;192(11):5023-30. doi: 10.4049/jimmunol.1303429. Epub 2014 Apr 23.


Helios defines T cells being driven to tolerance in the periphery and thymus.

Ross EM, Bourges D, Hogan TV, Gleeson PA, van Driel IR.

Eur J Immunol. 2014 Jul;44(7):2048-58. doi: 10.1002/eji.201343999. Epub 2014 Jun 5.


The role of endosomes in innate and adaptive immunity.

Gleeson PA.

Semin Cell Dev Biol. 2014 Jul;31:64-72. doi: 10.1016/j.semcdb.2014.03.002. Epub 2014 Mar 12. Review.


High-throughput quantitation of intracellular trafficking and organelle disruption by flow cytometry.

Chia PZ, Ramdzan YM, Houghton FJ, Hatters DM, Gleeson PA.

Traffic. 2014 May;15(5):572-82. doi: 10.1111/tra.12161. Epub 2014 Mar 11.


C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE, Atkin JD.

Hum Mol Genet. 2014 Jul 1;23(13):3579-95. doi: 10.1093/hmg/ddu068. Epub 2014 Feb 18. Erratum in: Hum Mol Genet. 2017 Oct 15;26(20):4093-4094.


Cargo trafficking between endosomes and the trans-Golgi network.

Chia PZ, Gunn P, Gleeson PA.

Histochem Cell Biol. 2013 Sep;140(3):307-15. doi: 10.1007/s00418-013-1125-6. Epub 2013 Jul 14. Review.


Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.

Chia PZ, Toh WH, Sharples R, Gasnereau I, Hill AF, Gleeson PA.

Traffic. 2013 Sep;14(9):997-1013. doi: 10.1111/tra.12088. Epub 2013 Jul 8.


Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages.

Micaroni M, Stanley AC, Khromykh T, Venturato J, Wong CX, Lim JP, Marsh BJ, Storrie B, Gleeson PA, Stow JL.

PLoS One. 2013;8(2):e57034. doi: 10.1371/journal.pone.0057034. Epub 2013 Feb 21.


Pathogenic T cells persist after reversal of autoimmune disease by immunosuppression with regulatory T cells.

Tu E, Bourges D, Gleeson PA, Ang DK, van Driel IR.

Eur J Immunol. 2013 May;43(5):1286-96. doi: 10.1002/eji.201242771. Epub 2013 Mar 25.


Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways.

Chia PZ, Gleeson PA.

Cells. 2013 Feb 22;2(1):105-23. doi: 10.3390/cells2010105.


SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages.

Lim JP, Teasdale RD, Gleeson PA.

Biol Open. 2012 Sep 15;1(9):904-14. doi: 10.1242/bio.20122204. Epub 2012 Jul 25.


Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice.

Nguyen N, Kozer-Gorevich N, Gliddon BL, Smolka AJ, Clayton AH, Gleeson PA, van Driel IR.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G157-66. doi: 10.1152/ajpgi.00346.2012. Epub 2012 Nov 15.


Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages.

Stanley AC, Lieu ZZ, Wall AA, Venturato J, Khromykh T, Hamilton NA, Gleeson PA, Stow JL.

J Leukoc Biol. 2012 Dec;92(6):1227-39. doi: 10.1189/jlb.0412191. Epub 2012 Sep 25.


Conjugation of transferrin to azide-modified CdSe/ZnS core-shell quantum dots using cyclooctyne click chemistry.

Schieber C, Bestetti A, Lim JP, Ryan AD, Nguyen TL, Eldridge R, White AR, Gleeson PA, Donnelly PS, Williams SJ, Mulvaney P.

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10523-7. doi: 10.1002/anie.201202876. Epub 2012 Sep 20.


Tracking protein aggregation and mislocalization in cells with flow cytometry.

Ramdzan YM, Polling S, Chia CP, Ng IH, Ormsby AR, Croft NP, Purcell AW, Bogoyevitch MA, Ng DC, Gleeson PA, Hatters DM.

Nat Methods. 2012 Mar 18;9(5):467-70. doi: 10.1038/nmeth.1930.


Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.

Houghton FJ, Bellingham SA, Hill AF, Bourges D, Ang DK, Gemetzis T, Gasnereau I, Gleeson PA.

Exp Cell Res. 2012 Mar 10;318(5):464-77. doi: 10.1016/j.yexcr.2011.12.023. Epub 2012 Jan 5.


A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.

Tu E, Ang DK, Hogan TV, Read S, Chia CP, Gleeson PA, van Driel IR.

PLoS One. 2011;6(11):e27153. doi: 10.1371/journal.pone.0027153. Epub 2011 Nov 9.


Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling.

Gasnereau I, Herr P, Chia PZ, Basler K, Gleeson PA.

J Biol Chem. 2011 Dec 16;286(50):43324-33. doi: 10.1074/jbc.M111.307231. Epub 2011 Oct 25.


The Golgi apparatus in the endomembrane-rich gastric parietal cells exist as functional stable mini-stacks dispersed throughout the cytoplasm.

Gunn PA, Gliddon BL, Londrigan SL, Lew AM, van Driel IR, Gleeson PA.

Biol Cell. 2011 Dec 1;103(12):559-72. doi: 10.1042/BC20110074.


Intracellular trafficking of the β-secretase and processing of amyloid precursor protein.

Chia PZ, Gleeson PA.

IUBMB Life. 2011 Sep;63(9):721-9. doi: 10.1002/iub.512. Epub 2011 Aug 10. Review. Erratum in: IUBMB Life. 2011 Nov;63(11):1045. Zhi, Pei [removed]; Chia, Cheryl [corrected to Chia, Pei Zhi Cheryl].


Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin.

Chia PZ, Gasnereau I, Lieu ZZ, Gleeson PA.

J Cell Sci. 2011 Jul 15;124(Pt 14):2401-13. doi: 10.1242/jcs.083782. Epub 2011 Jun 21.


The regulation of endosome-to-Golgi retrograde transport by tethers and scaffolds.

Chia PZ, Gleeson PA.

Traffic. 2011 Aug;12(8):939-47. doi: 10.1111/j.1600-0854.2011.01185.x. Epub 2011 Apr 8. Review.


Macropinocytosis: an endocytic pathway for internalising large gulps.

Lim JP, Gleeson PA.

Immunol Cell Biol. 2011 Nov;89(8):836-43. doi: 10.1038/icb.2011.20. Epub 2011 Mar 22. Review.


Endosome-to-Golgi transport pathways in physiological processes.

Lieu ZZ, Gleeson PA.

Histol Histopathol. 2011 Mar;26(3):395-408. doi: 10.14670/HH-26.395. Review.


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