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Items: 50


Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.

Burman A, Kropski JA, Calvi CL, Serezani AP, Pascoalino BD, Han W, Sherrill T, Gleaves L, Lawson WE, Young LR, Blackwell TS, Tanjore H.

JCI Insight. 2018 Aug 23;3(16). pii: 99543. doi: 10.1172/jci.insight.99543. eCollection 2018 Aug 23.


p52 expression enhances lung cancer progression.

Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS.

Sci Rep. 2018 Apr 17;8(1):6078. doi: 10.1038/s41598-018-24488-8.


Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.

Sucre JMS, Jetter CS, Loomans H, Williams J, Plosa EJ, Benjamin JT, Young LR, Kropski JA, Calvi CL, Kook S, Wang P, Gleaves L, Eskaros A, Goetzl L, Blackwell TS, Guttentag SH, Zijlstra A.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):158-166. doi: 10.1165/rcmb.2017-0442MA.


A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.

Sucre JMS, Deutsch GH, Jetter CS, Ambalavanan N, Benjamin JT, Gleaves LA, Millis BA, Young LR, Blackwell TS, Kropski JA, Guttentag SH.

Am J Pathol. 2018 Apr;188(4):853-862. doi: 10.1016/j.ajpath.2017.12.004. Epub 2018 Jan 31.


Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.

Richmond BW, Du RH, Han W, Benjamin JT, van der Meer R, Gleaves L, Guo M, McKissack A, Zhang Y, Cheng DS, Polosukhin VV, Blackwell TS.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):736-744. doi: 10.1165/rcmb.2017-0329OC.


Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment.

Saxon JA, Sherrill TP, Polosukhin VV, Sai J, Zaynagetdinov R, McLoed AG, Gulleman PM, Barham W, Cheng DS, Hunt RP, Gleaves LA, Richmond A, Young LR, Yull FE, Blackwell TS.

Oncoimmunology. 2016 Mar 30;5(6):e1168549. doi: 10.1080/2162402X.2016.1168549. eCollection 2016 Jun.


Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS.

Cell Rep. 2016 Jun 28;16(1):120-132. doi: 10.1016/j.celrep.2016.05.085. Epub 2016 Jun 16.


Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development.

Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS.

Am J Pathol. 2016 Jul;186(7):1786-1800. doi: 10.1016/j.ajpath.2016.02.016. Epub 2016 May 12.


Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.

Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV.

Nat Commun. 2016 Apr 5;7:11240. doi: 10.1038/ncomms11240.


p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment.

Saxon JA, Cheng DS, Han W, Polosukhin VV, McLoed AG, Richmond BW, Gleaves LA, Tanjore H, Sherrill TP, Barham W, Yull FE, Blackwell TS.

J Immunol. 2016 Feb 15;196(4):1891-9. doi: 10.4049/jimmunol.1501555. Epub 2016 Jan 15.


Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs.

Zaynagetdinov R, Sherrill TP, Gleaves LA, Hunt P, Han W, McLoed AG, Saxon JA, Tanjore H, Gulleman PM, Young LR, Blackwell TS.

Oncotarget. 2016 Feb 2;7(5):5470-82. doi: 10.18632/oncotarget.6562.


Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis.

Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD.

Pulm Circ. 2015 Dec;5(4):681-90. doi: 10.1086/683811.


Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L249-62. doi: 10.1152/ajplung.00258.2015. Epub 2015 Dec 4.


Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ.

Barham W, Chen L, Tikhomirov O, Onishko H, Gleaves L, Stricker TP, Blackwell TS, Yull FE.

BMC Cancer. 2015 Sep 30;15:647. doi: 10.1186/s12885-015-1652-8.


Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS Jr, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS.

Cancer Res. 2015 Apr 15;75(8):1624-1634. doi: 10.1158/0008-5472.CAN-14-2379. Epub 2015 Feb 17.


Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R.

Development. 2014 Dec;141(24):4751-62. doi: 10.1242/dev.117200. Epub 2014 Nov 13.


Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):417-26. doi: 10.1164/rccm.201406-1162OC.


Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.

Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS.

Am J Respir Cell Mol Biol. 2015 Jul;53(1):50-9. doi: 10.1165/rcmb.2014-0289OC.


Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):325-34. doi: 10.1164/rccm.201306-1086OC.


Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease.

Kropski JA, Pritchett JM, Mason WR, Sivarajan L, Gleaves LA, Johnson JE, Lancaster LH, Lawson WE, Blackwell TS, Steele MP, Loyd JE, Rickman OB.

PLoS One. 2013 Nov 12;8(11):e78674. doi: 10.1371/journal.pone.0078674. eCollection 2013.


Targeting the Wnt pathway in synovial sarcoma models.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE.

Cancer Discov. 2013 Nov;3(11):1286-301. doi: 10.1158/2159-8290.CD-13-0138. Epub 2013 Aug 6.


NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.

Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS.

J Immunol. 2013 May 1;190(9):4786-94. doi: 10.4049/jimmunol.1201809. Epub 2013 Mar 25.


β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.

Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):630-9. doi: 10.1164/rccm.201205-0972OC. Epub 2013 Jan 10.


Testosterone negatively regulates right ventricular load stress responses in mice.

Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH.

Pulm Circ. 2012 Jul;2(3):352-8. doi: 10.4103/2045-8932.101647.


A potential role for insulin resistance in experimental pulmonary hypertension.

West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR.

Eur Respir J. 2013 Apr;41(4):861-71. doi: 10.1183/09031936.00030312. Epub 2012 Aug 30.


Telomerase deficiency does not alter bleomycin-induced fibrosis in mice.

Degryse AL, Xu XC, Newman JL, Mitchell DB, Tanjore H, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Phillips JA 3rd, Cogan JD, Blackwell TS, Lawson WE.

Exp Lung Res. 2012 Apr;38(3):124-34. doi: 10.3109/01902148.2012.658148.


Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis.

Karabela SP, Psallidas I, Sherrill TP, Kairi CA, Zaynagetdinov R, Cheng DS, Vassiliou S, McMahon F, Gleaves LA, Han W, Stathopoulos I, Zakynthinos SG, Yull FE, Roussos C, Kalomenidis I, Blackwell TS, Stathopoulos GT.

Carcinogenesis. 2012 Apr;33(4):859-67. doi: 10.1093/carcin/bgs024. Epub 2012 Jan 27.


A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.

Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS.

J Immunol. 2011 Dec 1;187(11):5703-11. doi: 10.4049/jimmunol.1100558. Epub 2011 Nov 2.


TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L887-97. doi: 10.1152/ajplung.00397.2010. Epub 2011 Mar 25.


Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

Siddiquee K, Hampton J, Khan S, Zadory D, Gleaves L, Vaughan DE, Smith LH.

J Hypertens. 2011 Apr;29(4):724-31. doi: 10.1097/HJH.0b013e32834347de.


Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition.

Ghosh AK, Bradham WS, Gleaves LA, De Taeye B, Murphy SB, Covington JW, Vaughan DE.

Circulation. 2010 Sep 21;122(12):1200-9. doi: 10.1161/CIRCULATIONAHA.110.955245. Epub 2010 Sep 7.


Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L442-52. doi: 10.1152/ajplung.00026.2010. Epub 2010 Jun 18.


Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice.

Devin JK, Johnson JE, Eren M, Gleaves LA, Bradham WS, Bloodworth JR Jr, Vaughan DE.

J Mol Endocrinol. 2007 Jul;39(1):9-16.


Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity.

De Taeye BM, Novitskaya T, McGuinness OP, Gleaves L, Medda M, Covington JW, Vaughan DE.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E713-25. Epub 2007 Jun 19.


Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice.

Eren M, Gleaves LA, Atkinson JB, King LE, Declerck PJ, Vaughan DE.

J Thromb Haemost. 2007 Jul;5(7):1500-8. Epub 2007 Apr 16.


Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: a potential prothrombotic mechanism of drug-eluting stents.

Muldowney JA 3rd, Stringham JR, Levy SE, Gleaves LA, Eren M, Piana RN, Vaughan DE.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):400-6. Epub 2006 Dec 7.


Bone marrow plasminogen activator inhibitor-1 influences the development of obesity.

De Taeye BM, Novitskaya T, Gleaves L, Covington JW, Vaughan DE.

J Biol Chem. 2006 Oct 27;281(43):32796-805. Epub 2006 Aug 23.


Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo.

Yang Y, Zhu WZ, Joiner ML, Zhang R, Oddis CV, Hou Y, Yang J, Price EE, Gleaves L, Eren M, Ni G, Vaughan DE, Xiao RP, Anderson ME.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3065-75. Epub 2006 Jul 21.


Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression.

Fujita H, Kang M, Eren M, Gleaves LA, Vaughan DE, Kume T.

Circ Res. 2006 Mar 17;98(5):626-34. Epub 2006 Feb 2.


Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice.

Eren M, Painter CA, Gleaves LA, Schoenhard JA, Atkinson JB, Brown NJ, Vaughan DE.

J Thromb Haemost. 2003 Nov;1(11):2389-96.


Mothers' responses during the child's stem cell transplantation: pilot study.

Nelson AE, Gleaves L, Nuss S.

Pediatr Nurs. 2003 May-Jun;29(3):219-23.


The skeletal muscle ryanodine receptor isoform 1 is found at the intercalated discs in human and mouse hearts.

Jeyakumar LH, Gleaves LA, Ridley BD, Chang P, Atkinson J, Barnett JV, Fleischer S.

J Muscle Res Cell Motil. 2002;23(4):285-92.


Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.

Yoshida H, Hasty AH, Major AS, Ishiguro H, Su YR, Gleaves LA, Babaev VR, Linton MF, Fazio S.

Circulation. 2001 Dec 4;104(23):2820-5.


Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.

Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV Jr.

J Clin Invest. 2001 Jan;107(2):163-71.


Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A.

Babaev VR, Gleaves LA, Carter KJ, Suzuki H, Kodama T, Fazio S, Linton MF.

Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2593-9.


Children's responses to immunizations: lullabies as a distraction.

Megel ME, Houser CW, Gleaves LS.

Issues Compr Pediatr Nurs. 1998 Jul-Sep;21(3):129-45.


A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation.

Linton MF, Babaev VR, Gleaves LA, Fazio S.

J Biol Chem. 1999 Jul 2;274(27):19204-10.


Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo.

Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, Linton MF.

J Clin Invest. 1999 Jun;103(12):1697-705.


Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation.

Hasty AH, Linton MF, Brandt SJ, Babaev VR, Gleaves LA, Fazio S.

Circulation. 1999 May 18;99(19):2571-6.


Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages.

Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, Atkinson JB, Linton MF.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4647-52.

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