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Items: 1 to 50 of 229

1.

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51.

Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM.

Sci Transl Med. 2019 May 15;11(492). pii: eaav4508. doi: 10.1126/scitranslmed.aav4508.

PMID:
31092693
2.

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells.

Turchick A, Liu Y, Zhao W, Cohen I, Glazer PM.

Oncotarget. 2019 Feb 12;10(13):1272-1283. doi: 10.18632/oncotarget.26654. eCollection 2019 Feb 12.

3.

High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation.

Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM.

Sci Rep. 2019 Feb 28;9(1):3148. doi: 10.1038/s41598-019-39760-8.

4.

Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells.

Wen Z, Peng J, Tuttle PR, Ren Y, Garcia C, Debnath D, Rishi S, Hanson C, Ward S, Kumar A, Liu Y, Zhao W, Glazer PM, Liu Y, Sevilla MD, Adhikary A, Wnuk SF.

Org Lett. 2018 Dec 7;20(23):7400-7404. doi: 10.1021/acs.orglett.8b03035. Epub 2018 Nov 20.

PMID:
30457873
5.

Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.

Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM, Neel BG.

Cancer Res. 2018 Dec 1;78(23):6539-6548. doi: 10.1158/0008-5472.CAN-18-0901. Epub 2018 Oct 8.

PMID:
30297534
6.

Two Robust Strategies toward Hydrogels from Quenched Block Copolymer Nanofibrillar Micelles.

Zhang K, Suratkar A, Vedaraman S, Lakshminarayanan V, Jennings L, Glazer PJ, van Esch JH, Mendes E.

Macromolecules. 2018 Aug 14;51(15):5788-5797. doi: 10.1021/acs.macromol.8b01158. Epub 2018 Jul 24.

7.

Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease.

Cassini MF, Kakade VR, Kurtz E, Sulkowski P, Glazer P, Torres R, Somlo S, Cantley LG.

J Am Soc Nephrol. 2018 Oct;29(10):2471-2481. doi: 10.1681/ASN.2018050518. Epub 2018 Sep 12.

PMID:
30209078
8.

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.

Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM.

Nat Genet. 2018 Aug;50(8):1086-1092. doi: 10.1038/s41588-018-0170-4. Epub 2018 Jul 16.

9.

In utero nanoparticle delivery for site-specific genome editing.

Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM.

Nat Commun. 2018 Jun 26;9(1):2481. doi: 10.1038/s41467-018-04894-2.

10.

Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1.

Lu Y, Liu Y, Oeck S, Glazer PM.

Mol Cancer Res. 2018 Oct;16(10):1458-1469. doi: 10.1158/1541-7786.MCR-17-0637. Epub 2018 Jun 22.

11.

PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF.

Sulkowski PL, Scanlon SE, Oeck S, Glazer PM.

Mol Cancer Res. 2018 Aug;16(8):1241-1254. doi: 10.1158/1541-7786.MCR-17-0581. Epub 2018 May 8.

PMID:
29739874
12.

Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing.

Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM.

Molecules. 2018 Mar 11;23(3). pii: E632. doi: 10.3390/molecules23030632. Review.

13.

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Kim H, Lin Q, Glazer PM, Yun Z.

Breast Cancer Res. 2018 Mar 6;20(1):16. doi: 10.1186/s13058-018-0944-8.

14.

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma.

Scanlon SE, Hegan DC, Sulkowski PL, Glazer PM.

Oncotarget. 2017 Dec 19;9(4):4647-4660. doi: 10.18632/oncotarget.23470. eCollection 2018 Jan 12.

15.

Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities.

Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM.

Yale J Biol Med. 2017 Dec 19;90(4):583-598. eCollection 2017 Dec. Review.

16.

Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.

Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM.

Mol Ther Nucleic Acids. 2017 Dec 15;9:111-119. doi: 10.1016/j.omtn.2017.09.001. Epub 2017 Sep 12.

17.

A cell-penetrating antibody inhibits human RAD51 via direct binding.

Turchick A, Hegan DC, Jensen RB, Glazer PM.

Nucleic Acids Res. 2017 Nov 16;45(20):11782-11799. doi: 10.1093/nar/gkx871.

18.

Chemical physics of electroactive materials - the oft-overlooked faces of electrochemistry.

Kostiuchenko ZA, Glazer PJ, Mendes E, Lemay SG.

Faraday Discuss. 2017 Jul 1;199:9-28. doi: 10.1039/c7fd00117g. Epub 2017 Jun 27.

PMID:
28654123
19.

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells.

Scanlon SE, Scanlon CD, Hegan DC, Sulkowski PL, Glazer PM.

Carcinogenesis. 2017 Jun 1;38(6):627-637. doi: 10.1093/carcin/bgx038.

20.

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.

Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal2463. doi: 10.1126/scitranslmed.aal2463.

21.

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.

Nemec AA, Abriola L, Merkel JS, de Stanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB.

Mol Cancer Res. 2017 Mar;15(3):269-280. doi: 10.1158/1541-7786.MCR-16-0227-T. Epub 2017 Jan 10.

22.

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.

Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM.

Nat Commun. 2016 Oct 26;7:13304. doi: 10.1038/ncomms13304.

23.

A facile approach for the fabrication of 2D supermicelle networks.

Zhang K, Glazer PJ, Jennings L, Vedaraman S, Oldenhof S, Wang Y, Schosseler F, van Esch JH, Mendes E.

Chem Commun (Camb). 2016 Oct 11;52(83):12360-12363.

PMID:
27709193
24.

The role of confinement and corona crystallinity on the bending modulus of copolymer micelles measured directly by AFM flexural tests.

Jennings L, Glazer P, Laan AC, de Kruijff RM, Waton G, Schosseler F, Mendes E.

Soft Matter. 2016 Sep 21;12(35):7324-9. doi: 10.1039/c6sm00983b. Epub 2016 Aug 10.

PMID:
27506248
25.

miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair.

Czochor JR, Sulkowski P, Glazer PM.

Mol Cancer Res. 2016 Apr;14(4):363-73. doi: 10.1158/1541-7786.MCR-15-0399. Epub 2016 Feb 5.

26.

Nanotechnology for delivery of peptide nucleic acids (PNAs).

Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM.

J Control Release. 2016 Oct 28;240:302-311. doi: 10.1016/j.jconrel.2016.01.005. Epub 2016 Jan 8. Review.

27.

Affordable techniques for fabricating large array of functional nanowires: From DNA to micellar systems.

Glazer PJ, Warringa Q, Bergen L, Boukany PE.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:2187-90. doi: 10.1109/EMBC.2015.7318824.

PMID:
26736724
28.

DNA-dependent targeting of cell nuclei by a lupus autoantibody.

Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE.

Sci Rep. 2015 Jul 9;5:12022. doi: 10.1038/srep12022.

29.

YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.

Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM.

Mol Cancer Res. 2015 Oct;13(10):1389-97. doi: 10.1158/1541-7786.MCR-15-0036. Epub 2015 Jun 26.

30.

Tumor suppressor p53 stole the AKT in hypoxia.

Yun Z, Glazer PM.

J Clin Invest. 2015 Jun;125(6):2264-6. doi: 10.1172/JCI82058. Epub 2015 May 11.

31.

Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment.

Scanlon SE, Glazer PM.

DNA Repair (Amst). 2015 Aug;32:180-189. doi: 10.1016/j.dnarep.2015.04.030. Epub 2015 May 1. Review.

32.

Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium.

McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME.

Nat Commun. 2015 Apr 27;6:6952. doi: 10.1038/ncomms7952.

33.

Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.

Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB.

J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22.

34.

LKB1 preserves genome integrity by stimulating BRCA1 expression.

Gupta R, Liu AY, Glazer PM, Wajapeyee N.

Nucleic Acids Res. 2015 Jan;43(1):259-71. doi: 10.1093/nar/gku1294. Epub 2014 Dec 8.

35.

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ.

Nature. 2015 Feb 5;518(7537):107-10. doi: 10.1038/nature13905. Epub 2014 Nov 17.

36.

Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules.

Reza F, Glazer PM.

Methods Mol Biol. 2015;1239:39-73. doi: 10.1007/978-1-4939-1862-1_4.

PMID:
25408401
37.

Primary Extradural Tumors of the Spine - Case Review with Evidence-guided Management.

Lam FC, Arle JE, Glazer PA, Kasper EM.

Surg Neurol Int. 2014 Aug 28;5(Suppl 7):S373-5. doi: 10.4103/2152-7806.139673. eCollection 2014.

38.

A cardiovascular occlusion method based on the use of a smart hydrogel.

Jackson N, Verbrugghe P, Cuypers D, Adesanya K, Engel L, Glazer P, Dubruel P, Shacham-Diamand Y, Mendes E, Herijgers P, Stam F.

IEEE Trans Biomed Eng. 2015 Feb;62(2):399-406. doi: 10.1109/TBME.2014.2353933. Epub 2014 Sep 4.

PMID:
25203979
39.

Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.

Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Lopez-Giraldez F, Fields RJ, Saltzman WM, Ly DH, Glazer PM.

Curr Gene Ther. 2014;14(5):331-42.

40.

Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.

Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM.

Adv Healthc Mater. 2015 Feb 18;4(3):361-6. doi: 10.1002/adhm.201400355. Epub 2014 Aug 25.

41.

Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1.

Lu Y, Wajapeyee N, Turker MS, Glazer PM.

Cell Rep. 2014 Jul 24;8(2):501-13. doi: 10.1016/j.celrep.2014.06.035. Epub 2014 Jul 17.

42.

Targeted genome modification via triple helix formation.

Ricciardi AS, McNeer NA, Anandalingam KK, Saltzman WM, Glazer PM.

Methods Mol Biol. 2014;1176:89-106. doi: 10.1007/978-1-4939-0992-6_8.

43.

HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.

Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X.

Mol Cell. 2014 Jul 3;55(1):31-46. doi: 10.1016/j.molcel.2014.04.028. Epub 2014 May 29.

44.

The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB.

Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11.

45.

Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

Scanlon SE, Glazer PM.

Mol Cancer Res. 2014 Jul;12(7):1016-28. doi: 10.1158/1541-7786.MCR-13-0628. Epub 2014 Mar 31.

46.

Triplex-mediated genome targeting and editing.

Reza F, Glazer PM.

Methods Mol Biol. 2014;1114:115-42. doi: 10.1007/978-1-62703-761-7_8.

PMID:
24557900
47.

Generating aligned micellar nanowire arrays by dewetting of micropatterned surfaces.

Glazer PJ, Bergen L, Jennings L, Houtepen AJ, Mendes E, Boukany PE.

Small. 2014 May 14;10(9):1729-34. doi: 10.1002/smll.201303414. Epub 2014 Feb 13. No abstract available.

PMID:
24532372
48.

Introduction.

Sweasy JB, Glazer PM.

Yale J Biol Med. 2013 Dec;86(4):441-2. No abstract available.

49.

Interplay between DNA repair and inflammation, and the link to cancer.

Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB.

Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):116-39. doi: 10.3109/10409238.2013.875514. Epub 2014 Jan 13. Review.

50.

Hypoxia and DNA repair.

Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE.

Yale J Biol Med. 2013 Dec 13;86(4):443-51.

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