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To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment.

César Fassoni A, Roeder I, Glauche I.

Bull Math Biol. 2019 Jul;81(7):2345-2395. doi: 10.1007/s11538-019-00608-x. Epub 2019 May 1.


Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach.

Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I.

Stem Cells. 2019 Jul;37(7):948-957. doi: 10.1002/stem.3005. Epub 2019 Apr 3.


The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia.

Hoffmann H, Thiede C, Glauche I, Kramer M, Röllig C, Ehninger G, Bornhäuser M, Roeder I.

Leukemia. 2019 Jun;33(6):1531-1534. doi: 10.1038/s41375-018-0371-y. Epub 2019 Jan 23. No abstract available.


Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma.

Roh V, Abramowski P, Hiou-Feige A, Cornils K, Rivals JP, Zougman A, Aranyossy T, Thielecke L, Truan Z, Mermod M, Monnier Y, Prassolov V, Glauche I, Nowrouzi A, Abdollahi A, Fehse B, Simon C, Tolstonog GV.

Cell Rep. 2018 Nov 20;25(8):2208-2222.e7. doi: 10.1016/j.celrep.2018.10.090.


A track of the clones: new developments in cellular barcoding.

Lyne AM, Kent DG, Laurenti E, Cornils K, Glauche I, Perié L.

Exp Hematol. 2018 Dec;68:15-20. doi: 10.1016/j.exphem.2018.11.005. Epub 2018 Nov 15.


Aging alters the epigenetic asymmetry of HSC division.

Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H.

PLoS Biol. 2018 Sep 20;16(9):e2003389. doi: 10.1371/journal.pbio.2003389. eCollection 2018 Sep.


Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison.

Glauche I, Kuhn M, Baldow C, Schulze P, Rothe T, Liebscher H, Roy A, Wang X, Roeder I.

Sci Rep. 2018 Aug 17;8(1):12330. doi: 10.1038/s41598-018-29923-4.


Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data.

Fassoni AC, Baldow C, Roeder I, Glauche I.

Haematologica. 2018 Nov;103(11):1825-1834. doi: 10.3324/haematol.2018.194522. Epub 2018 Jun 28.


Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.

Suttorp M, Schulze P, Glauche I, Göhring G, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Balduzzi A, Lausen B, Aleinikova O, Sufliarska S, Henze G, Strauss G, Eggert A, Kremens B, Groll AH, Berthold F, Klein C, Groß-Wieltsch U, Sykora KW, Borkhardt A, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez A, Harbott J, Kreipe HH, Schlegelberger B, Thiede C.

Leukemia. 2018 Jul;32(7):1657-1669. doi: 10.1038/s41375-018-0179-9. Epub 2018 Jun 20.


Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B.

Nat Commun. 2018 May 15;9(1):1898. doi: 10.1038/s41467-018-04188-7.


Correction: Incidence of Diabetic Ketoacidosis of New-Onset Type 1 Diabetes in Children and Adolescents in Different Countries Correlates with Human Development Index (HDI): An Updated Systematic Review, Meta-Analysis, and Meta-Regression.

Große J, Hornstein H, Manuwald U, Kugler J, Glauche I, Rothe U.

Horm Metab Res. 2018 Mar;50(3):e2. doi: 10.1055/a-0584-6211. Epub 2018 Mar 9. No abstract available.


Incidence of Diabetic Ketoacidosis of New-Onset Type 1 Diabetes in Children and Adolescents in Different Countries Correlates with Human Development Index (HDI): An Updated Systematic Review, Meta-Analysis, and Meta-Regression.

Große J, Hornstein H, Manuwald U, Kugler J, Glauche I, Rothe U.

Horm Metab Res. 2018 Mar;50(3):209-222. doi: 10.1055/s-0044-102090. Epub 2018 Mar 9. Review. Erratum in: Horm Metab Res. 2018 Mar;50(3):e2.


MAGPIE: Simplifying access and execution of computational models in the life sciences.

Baldow C, Salentin S, Schroeder M, Roeder I, Glauche I.

PLoS Comput Biol. 2017 Dec 15;13(12):e1005898. doi: 10.1371/journal.pcbi.1005898. eCollection 2017 Dec. Erratum in: PLoS Comput Biol. 2018 Mar 26;14 (3):e1006083.


Genetic Barcodes Facilitate Competitive Clonal Analyses In Vivo.

Aranyossy T, Thielecke L, Glauche I, Fehse B, Cornils K.

Hum Gene Ther. 2017 Oct;28(10):926-937. doi: 10.1089/hum.2017.124.


Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion.

Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I.

Mol Cancer. 2017 Jul 14;16(1):120. doi: 10.1186/s12943-017-0668-x.


Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification.

Zerjatke T, Gak IA, Kirova D, Fuhrmann M, Daniel K, Gonciarz M, Müller D, Glauche I, Mansfeld J.

Cell Rep. 2017 May 30;19(9):1953-1966. doi: 10.1016/j.celrep.2017.05.022.


Limitations and challenges of genetic barcode quantification.

Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.

Sci Rep. 2017 Mar 3;7:43249. doi: 10.1038/srep43249.


Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny.

Chacón-Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA.

EMBO J. 2017 Jan 17;36(2):151-164. doi: 10.15252/embj.201694902. Epub 2016 Dec 9.


Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy.

Proschmann R, Baldow C, Rothe T, Suttorp M, Thiede C, Tauer JT, Müller MC, Hochhaus A, Roeder I, Glauche I.

Haematologica. 2017 Feb;102(2):e39-e42. doi: 10.3324/haematol.2016.154138. Epub 2016 Nov 17. No abstract available.


Implant survival and patient satisfaction of reduced diameter implants made from a titanium-zirconium alloy: A retrospective cohort study with 550 implants in 311 patients.

Herrmann J, Hentschel A, Glauche I, Vollmer A, Schlegel KA, Lutz R.

J Craniomaxillofac Surg. 2016 Dec;44(12):1940-1944. doi: 10.1016/j.jcms.2016.09.007. Epub 2016 Sep 23.


Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia.

Baldow C, Thielecke L, Glauche I.

PLoS One. 2016 Oct 20;11(10):e0165129. doi: 10.1371/journal.pone.0165129. eCollection 2016.


Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics.

Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I.

J R Soc Interface. 2016 Apr;13(117). pii: 20160167. doi: 10.1098/rsif.2016.0167.


Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing rats.

Tauer JT, Hofbauer LC, Jung R, Gerdes S, Glauche I, Erben RG, Suttorp M.

PLoS One. 2015 Jun 24;10(6):e0131192. doi: 10.1371/journal.pone.0131192. eCollection 2015.


Survival and patient satisfaction of short implants during the first 2 years of function: a retrospective cohort study with 694 implants in 416 patients.

Hentschel A, Herrmann J, Glauche I, Vollmer A, Schlegel KA, Lutz R.

Clin Oral Implants Res. 2016 May;27(5):591-6. doi: 10.1111/clr.12626. Epub 2015 Jun 10.


Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients?

Gurrea Salas D, Glauche I, Tauer JT, Thiede C, Suttorp M.

Ann Hematol. 2015 Aug;94(8):1363-71. doi: 10.1007/s00277-015-2367-2. Epub 2015 Apr 19.


Factor graph analysis of live cell-imaging data reveals mechanisms of cell fate decisions.

Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder I, Schroeder T, Tresch A.

Bioinformatics. 2015 Jun 1;31(11):1816-23. doi: 10.1093/bioinformatics/btv040. Epub 2015 Jan 31.


Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies.

Herberg M, Zerjatke T, de Back W, Glauche I, Roeder I.

Cytometry A. 2015 Jun;87(6):481-90. doi: 10.1002/cyto.a.22598. Epub 2015 Jan 20.


Elucidating functional heterogeneity in hematopoietic progenitor cells: a combined experimental and modeling approach.

Bach E, Zerjatke T, Herklotz M, Scherf N, Niederwieser D, Roeder I, Pompe T, Cross M, Glauche I.

Exp Hematol. 2014 Sep;42(9):826-37.e1-17. doi: 10.1016/j.exphem.2014.05.011. Epub 2014 May 28.


Long-term imatinib treatment does not cause testicular toxicity in male adolescents with chronic myeloid leukemia and in a juvenile rat model.

Tauer JT, Ulmer A, Glauche I, Jung R, Suttorp M.

Klin Padiatr. 2014 May;226(3):169-74. doi: 10.1055/s-0034-1372643. Epub 2014 May 12.


A model-based analysis of culture-dependent phenotypes of mESCs.

Herberg M, Kalkan T, Glauche I, Smith A, Roeder I.

PLoS One. 2014 Mar 18;9(3):e92496. doi: 10.1371/journal.pone.0092496. eCollection 2014.


Multiplexing clonality: combining RGB marking and genetic barcoding.

Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B.

Nucleic Acids Res. 2014 Apr;42(7):e56. doi: 10.1093/nar/gku081. Epub 2014 Jan 29.


Mathematical modeling of oncogenesis control in mature T-cell populations.

Gerdes S, Newrzela S, Glauche I, von Laer D, Hansmann ML, Roeder I.

Front Immunol. 2013 Nov 21;4:380. doi: 10.3389/fimmu.2013.00380. eCollection 2013.


TK inhibitor treatment disrupts growth hormone axis: clinical observations in children with CML and experimental data from a juvenile animal model.

Ulmer A, Tabea Tauer J, Glauche I, Jung R, Suttorp M.

Klin Padiatr. 2013 May;225(3):120-6. doi: 10.1055/s-0033-1343483. Epub 2013 May 28.


Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges.

Glauche I, Bystrykh L, Eaves C, Roeder I; other participants.

Blood Cells Mol Dis. 2013 Apr;50(4):232-40. doi: 10.1016/j.bcmd.2013.01.007. Epub 2013 Feb 19. Review.


Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia.

Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, Roeder I.

Blood. 2013 Jan 10;121(2):378-84. doi: 10.1182/blood-2012-07-441956. Epub 2012 Nov 21.


Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector.

Cornils K, Bartholomae CC, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B.

Exp Hematol. 2013 Jan;41(1):28-38.e3. doi: 10.1016/j.exphem.2012.09.003. Epub 2012 Sep 16.


Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions.

Scherf N, Herberg M, Thierbach K, Zerjatke T, Kalkan T, Humphreys P, Smith A, Glauche I, Roeder I.

Bioinformatics. 2012 Sep 15;28(18):i556-i561. doi: 10.1093/bioinformatics/bts404.


Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations.

Glauche I, Horn K, Horn M, Thielecke L, Essers MA, Trumpp A, Roeder I.

Br J Cancer. 2012 May 22;106(11):1742-52. doi: 10.1038/bjc.2012.142. Epub 2012 Apr 26.


On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

Scherf N, Franke K, Glauche I, Kurth I, Bornhäuser M, Werner C, Pompe T, Roeder I.

Exp Hematol. 2012 Feb;40(2):119-30.e9. doi: 10.1016/j.exphem.2011.10.009. Epub 2011 Nov 13.


Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies.

Roeder I, Loeffler M, Glauche I; other participants.

Blood Cells Mol Dis. 2011 Apr 15;46(4):308-17. doi: 10.1016/j.bcmd.2011.03.001. Epub 2011 Mar 29.


Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective.

Glauche I, Thielecke L, Roeder I.

Aging Cell. 2011 Jun;10(3):457-65. doi: 10.1111/j.1474-9726.2011.00692.x. Epub 2011 Apr 5.


Immunohistochemical and flow cytometric analysis of long-term label-retaining cells in the adult heart.

Meinhardt A, Spicher A, Roehrich ME, Glauche I, Vogt P, Vassalli G.

Stem Cells Dev. 2011 Feb;20(2):211-22. doi: 10.1089/scd.2009.0203. Epub 2010 Sep 14.


Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.

Glauche I, Herberg M, Roeder I.

PLoS One. 2010 Jun 21;5(6):e11238. doi: 10.1371/journal.pone.0011238.


Stem cell proliferation and quiescence--two sides of the same coin.

Glauche I, Moore K, Thielecke L, Horn K, Loeffler M, Roeder I.

PLoS Comput Biol. 2009 Jul;5(7):e1000447. doi: 10.1371/journal.pcbi.1000447. Epub 2009 Jul 24.


A novel view on stem cell development: analysing the shape of cellular genealogies.

Glauche I, Lorenz R, Hasenclever D, Roeder I.

Cell Prolif. 2009 Apr;42(2):248-63. doi: 10.1111/j.1365-2184.2009.00586.x. Epub 2009 Feb 27.


Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia--insights from mathematical model analyses.

Roeder I, Glauche I.

J Mol Med (Berl). 2008 Jan;86(1):17-27. Epub 2007 Jul 28. Review.


Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications.

Glauche I, Cross M, Loeffler M, Roeder I.

Stem Cells. 2007 Jul;25(7):1791-9. Epub 2007 Apr 5.


Leukaemia stem cells: hit or miss?

Glauche I, Horn M, Roeder I.

Br J Cancer. 2007 Feb 26;96(4):677-8; author reply 679-80. Epub 2007 Feb 6. No abstract available.


Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications.

Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M.

Nat Med. 2006 Oct;12(10):1181-4. Epub 2006 Oct 1.


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