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Pivotal role of membrane substrate transporters on the metabolic alterations in the pressure-overloaded heart.

Geraets IME, Glatz JFC, Luiken JJFP, Nabben M.

Cardiovasc Res. 2019 May 1;115(6):1000-1012. doi: 10.1093/cvr/cvz060.


The power of metabolism - Linking energy supply and demand with cardiac contractile function.

Schwarzer M, Doenst T, Des Rosiers C, Glatz JFC.

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):725-727. doi: 10.1016/j.bbadis.2019.02.006. Epub 2019 Feb 18. No abstract available.


Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop.

Liu Y, Rodriguez-Calvo R, Wang S, Zhu X, Broers JLV, Glatz JFC, Luiken JJFP, Neumann D.

PLoS One. 2019 Jan 23;14(1):e0210704. doi: 10.1371/journal.pone.0210704. eCollection 2019.


The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target.

Chanda D, Neumann D, Glatz JFC.

Prostaglandins Leukot Essent Fatty Acids. 2019 Jan;140:51-56. doi: 10.1016/j.plefa.2018.11.016. Epub 2018 Nov 29. Review.


Metabolic remodelling in heart failure revisited.

Nabben M, Luiken JJFP, Glatz JFC.

Nat Rev Cardiol. 2018 Dec;15(12):780. doi: 10.1038/s41569-018-0115-8. No abstract available.


Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.

Dodd MS, Sousa Fialho MDL, Montes Aparicio CN, Kerr M, Timm KN, Griffin JL, Luiken JJFP, Glatz JFC, Tyler DJ, Heather LC.

JACC Basic Transl Sci. 2018 Aug 28;3(4):485-498. doi: 10.1016/j.jacbts.2018.04.005. eCollection 2018 Aug.


Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism.

Simsek Papur O, Sun A, Glatz JFC, Luiken JJFP, Nabben M.

Front Cardiovasc Med. 2018 Jun 7;5:65. doi: 10.3389/fcvm.2018.00065. eCollection 2018. Review.


Managing chest pain patients in general practice: an interview-based study.

Biesemans L, Cleef LE, Willemsen RTA, Hoorweg BBN, Renier WS, Buntinx F, Glatz JFC, Dinant GJ.

BMC Fam Pract. 2018 Jun 2;19(1):80. doi: 10.1186/s12875-018-0771-0.


Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization.

Glatz JFC, Luiken JJFP.

J Lipid Res. 2018 Jul;59(7):1084-1093. doi: 10.1194/jlr.R082933. Epub 2018 Apr 7.


Assessment of AMPK-Stimulated Cellular Long-Chain Fatty Acid and Glucose Uptake.

Luiken JJFP, Neumann D, Glatz JFC, Coumans WA, Chanda D, Nabben M.

Methods Mol Biol. 2018;1732:343-361. doi: 10.1007/978-1-4939-7598-3_22.


Cardiac adaptations to obesity, diabetes and insulin resistance.

Glatz JFC, Dyck JRB, Des Rosiers C.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1905-1907. doi: 10.1016/j.bbadis.2018.01.024. Epub 2018 Jan 31. No abstract available.


Assessing fatty acid oxidation flux in rodent cardiomyocyte models.

Rech M, Luiken JJFP, Glatz JFC, van Bilsen M, Schroen B, Nabben M.

Sci Rep. 2018 Jan 24;8(1):1505. doi: 10.1038/s41598-018-19478-9.

Free PMC Article

Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance.

Geraets IME, Chanda D, van Tienen FHJ, van den Wijngaard A, Kamps R, Neumann D, Liu Y, Glatz JFC, Luiken JJFP, Nabben M.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1960-1967. doi: 10.1016/j.bbadis.2017.12.025. Epub 2017 Dec 20. Review.


Early health technology assessment of future clinical decision rule aided triage of patients presenting with acute chest pain in primary care.

Willemsen RTA, Kip MMA, Koffijberg H, Kusters R, Buntinx F, Glatz JFC, Dinant GJ; ‘RAPIDA’ – Study Team (‘RAPIDA’: RAPid Test for Investigating Complaints Possibly Due to Acute Coronary Syndrome).

Prim Health Care Res Dev. 2018 Mar;19(2):176-188. doi: 10.1017/S146342361700069X. Epub 2017 Dec 18.


Propionic acidemia as a cause of adult-onset dilated cardiomyopathy.

Riemersma M, Hazebroek MR, Helderman-van den Enden ATJM, Salomons GS, Ferdinandusse S, Brouwers MCGJ, van der Ploeg L, Heymans S, Glatz JFC, van den Wijngaard A, Krapels IPC, Bierau J, Brunner HG.

Eur J Hum Genet. 2017 Nov;25(11):1195-1201. doi: 10.1038/ejhg.2017.127. Epub 2017 Aug 30.


Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses.

Hoorweg BB, Willemsen RT, Cleef LE, Boogaerts T, Buntinx F, Glatz JF, Dinant GJ.

Heart. 2017 Nov;103(21):1727-1732. doi: 10.1136/heartjnl-2016-310905. Epub 2017 Jun 20.


Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations.

Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schäfers M, Nicolay K, Faber C, Hermann S, Prompers JJ.

Cardiovasc Res. 2017 Aug 1;113(10):1148-1160. doi: 10.1093/cvr/cvx100.


Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Mansor LS, Sousa Fialho MDL, Yea G, Coumans WA, West JA, Kerr M, Carr CA, Luiken JJFP, Glatz JFC, Evans RD, Griffin JL, Tyler DJ, Clarke K, Heather LC.

Cardiovasc Res. 2017 Jun 1;113(7):737-748. doi: 10.1093/cvr/cvx045.


2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes.

Chanda D, Oligschlaeger Y, Geraets I, Liu Y, Zhu X, Li J, Nabben M, Coumans W, Luiken JJFP, Glatz JFC, Neumann D.

J Biol Chem. 2017 Apr 28;292(17):7105-7114. doi: 10.1074/jbc.M116.767384. Epub 2017 Mar 20.


Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction.

Liu Y, Steinbusch LKM, Nabben M, Kapsokalyvas D, van Zandvoort M, Schönleitner P, Antoons G, Simons PJ, Coumans WA, Geomini A, Chanda D, Glatz JFC, Neumann D, Luiken JJFP.

Diabetes. 2017 Jun;66(6):1521-1534. doi: 10.2337/db16-0727. Epub 2017 Mar 16.


Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes.

Rodríguez-Calvo R, Chanda D, Oligschlaeger Y, Miglianico M, Coumans WA, Barroso E, Tajes M, Luiken JJ, Glatz JF, Vázquez-Carrera M, Neumann D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):541-551. doi: 10.1016/j.bbalip.2017.02.006. Epub 2017 Feb 16.


From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake.

Glatz JF, Luiken JJ.

Biochimie. 2017 May;136:21-26. doi: 10.1016/j.biochi.2016.12.007. Epub 2016 Dec 22. Review.


A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36.

Momken I, Chabowski A, Dirkx E, Nabben M, Jain SS, McFarlan JT, Glatz JF, Luiken JJ, Bonen A.

Biochem J. 2017 Jan 1;474(1):149-162. doi: 10.1042/BCJ20160804. Epub 2016 Nov 8.


The role of post-translational protein modifications on heart and vascular metabolism.

Dyck JR, Glatz JF.

Biochim Biophys Acta. 2016 Dec;1862(12):2197-2198. doi: 10.1016/j.bbadis.2016.09.018. Epub 2016 Sep 28. No abstract available.


Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake.

Luiken JJ, Chanda D, Nabben M, Neumann D, Glatz JF.

Biochim Biophys Acta. 2016 Dec;1862(12):2253-2258. doi: 10.1016/j.bbadis.2016.09.004. Epub 2016 Sep 9. Review.


Signaling pathways involved in cardiac energy metabolism.

Chanda D, Luiken JJ, Glatz JF.

FEBS Lett. 2016 Aug;590(15):2364-74. doi: 10.1002/1873-3468.12297. Epub 2016 Jul 23. Review.


Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction.

Liu Y, Neumann D, Glatz JFC, Luiken JJFP.

Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:131-141. doi: 10.1016/j.plefa.2016.06.002. Epub 2016 Jun 13. Review.


Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus.

van der Leeuw J, Beulens JW, van Dieren S, Schalkwijk CG, Glatz JF, Hofker MH, Verschuren WM, Boer JM, van der Graaf Y, Visseren FL, Peelen LM, van der Schouw YT.

J Am Heart Assoc. 2016 May 31;5(6). pii: e003048. doi: 10.1161/JAHA.115.003048.


Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization.

Glatz JF, Nabben M, Heather LC, Bonen A, Luiken JJ.

Biochim Biophys Acta. 2016 Oct;1861(10):1461-71. doi: 10.1016/j.bbalip.2016.04.008. Epub 2016 Apr 16. Review.


Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Review. Erratum in: Circ Res. 2016 May 13;118(10):e35.


The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content.

Oligschlaeger Y, Miglianico M, Dahlmans V, Rubio-Villena C, Chanda D, Garcia-Gimeno MA, Coumans WA, Liu Y, Voncken JW, Luiken JJ, Glatz JF, Sanz P, Neumann D.

Biochem J. 2016 Apr 1;473(7):937-47. doi: 10.1042/BJ20151035. Epub 2016 Feb 1.


Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring.

van Ewijk PA, Paglialunga S, Kooi ME, Nunes PM, Gemmink A, Slenter J, Kornips E, Jörgensen JA, Hoeks J, Wildberger JE, Hesselink MK, Glatz JF, Heerschap A, Kersten S, Schrauwen P, Schrauwen-Hinderling VB.

Obesity (Silver Spring). 2015 Nov;23(11):2242-50. doi: 10.1002/oby.21235.


Fatty acid transport and transporters in muscle are critically regulated by Akt2.

Jain SS, Luiken JJ, Snook LA, Han XX, Holloway GP, Glatz JF, Bonen A.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2769-75. doi: 10.1016/j.febslet.2015.08.010. Epub 2015 Aug 18.


Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.

Bonen A, Jain SS, Snook LA, Han XX, Yoshida Y, Buddo KH, Lally JS, Pask ED, Paglialunga S, Beaudoin MS, Glatz JF, Luiken JJ, Harasim E, Wright DC, Chabowski A, Holloway GP.

Diabetologia. 2015 Oct;58(10):2381-91. doi: 10.1007/s00125-015-3691-8. Epub 2015 Jul 22.


Cardiac contraction-induced GLUT4 translocation requires dual signaling input.

Luiken JJ, Glatz JF, Neumann D.

Trends Endocrinol Metab. 2015 Aug;26(8):404-10. doi: 10.1016/j.tem.2015.06.002. Epub 2015 Jun 29. Review.


MRS: a noninvasive window into cardiac metabolism.

van Ewijk PA, Schrauwen-Hinderling VB, Bekkers SC, Glatz JF, Wildberger JE, Kooi ME.

NMR Biomed. 2015 Jul;28(7):747-66. doi: 10.1002/nbm.3320. Epub 2015 May 25. Review.


Letter by Neumann et al regarding article, "Myostatin regulates energy homeostasis in the heart and prevents heart failure".

Neumann D, Luiken JJ, Nabben M, Glatz JF.

Circ Res. 2015 May 8;116(10):e95-6. doi: 10.1161/CIRCRESAHA.115.306463. No abstract available.


Suspected acute coronary syndrome in the emergency room: Limited added value of heart type fatty acid binding protein point of care or ELISA tests: The FAME-ER (Fatty Acid binding protein in Myocardial infarction Evaluation in the Emergency Room) study.

Bank IE, Dekker MS, Hoes AW, Zuithoff NP, Verheggen PW, de Vrey EA, Wildbergh TX, Timmers L, de Kleijn DP, Glatz JF, Mosterd A.

Eur Heart J Acute Cardiovasc Care. 2016 Aug;5(4):364-74. doi: 10.1177/2048872615584077. Epub 2015 Apr 23.


Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models.

Abdurrachim D, Luiken JJ, Nicolay K, Glatz JF, Prompers JJ, Nabben M.

Cardiovasc Res. 2015 May 1;106(2):194-205. doi: 10.1093/cvr/cvv105. Epub 2015 Mar 12. Review.


Heart-type fatty acid binding protein (H-FABP) in patients in an emergency department setting, suspected of acute coronary syndrome: optimal cut-off point, diagnostic value and future opportunities in primary care.

Willemsen RT, van Severen E, Vandervoort PM, Grieten L, Buntinx F, Glatz JF, Dinant GJ.

Eur J Gen Pract. 2015;21(3):156-63. doi: 10.3109/13814788.2015.1013934. Epub 2015 Mar 9. Erratum in: Eur J Gen Pract. 2015;21(3):x.


Rapidly rule out acute myocardial infarction by combining copeptin and heart-type fatty acid-binding protein with cardiac troponin.

Jacobs LH, van Borren M, Gemen E, van Eck M, van Son B, Glatz JF, Daniels M, Kusters R.

Ann Clin Biochem. 2015 Sep;52(Pt 5):550-61. doi: 10.1177/0004563215578189. Epub 2015 Mar 2.


Spotlight on cellular lipid binding proteins.

Glatz JF.

Prostaglandins Leukot Essent Fatty Acids. 2015 Feb;93:1. doi: 10.1016/j.plefa.2014.12.007. Epub 2014 Dec 24. No abstract available.


Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure.

Franekova V, Angin Y, Hoebers NT, Coumans WA, Simons PJ, Glatz JF, Luiken JJ, Larsen TS.

Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C297-307. doi: 10.1152/ajpcell.00073.2014. Epub 2014 Dec 3.


Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, Gijbels MJJ, Glatz JFC, da Silva GJJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XHT, Schrauwen P.

Basic Res Cardiol. 2014;109(6):447. doi: 10.1007/s00395-014-0447-4. Epub 2014 Oct 25.


Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance.

Dirkx E, van Eys GJ, Schwenk RW, Steinbusch LK, Hoebers N, Coumans WA, Peters T, Janssen BJ, Brans B, Vogg AT, Neumann D, Glatz JF, Luiken JJ.

J Mol Cell Cardiol. 2014 Nov;76:208-17. doi: 10.1016/j.yjmcc.2014.08.017. Epub 2014 Aug 28.


Lipids and lipid binding proteins: a perfect match.

Glatz JF.

Prostaglandins Leukot Essent Fatty Acids. 2015 Feb;93:45-9. doi: 10.1016/j.plefa.2014.07.011. Epub 2014 Jul 19. Review.


Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake.

Angin Y, Schwenk RW, Nergiz-Unal R, Hoebers N, Heemskerk JW, Kuijpers MJ, Coumans WA, van Zandvoort MA, Bonen A, Neumann D, Glatz JF, Luiken JJ.

Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E225-36. doi: 10.1152/ajpendo.00655.2013. Epub 2014 Jun 3.


Fatty acids in cell signaling: historical perspective and future outlook.

Glatz JF, Luiken JJ.

Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:57-62. doi: 10.1016/j.plefa.2014.02.007. Epub 2014 Mar 18.


Cardiac troponin in ischemic cardiomyocytes: intracellular decrease before onset of cell death.

Streng AS, Jacobs LH, Schwenk RW, Cardinaels EP, Meex SJ, Glatz JF, Wodzig WK, van Dieijen-Visser MP.

Exp Mol Pathol. 2014 Jun;96(3):339-45. doi: 10.1016/j.yexmp.2014.02.012. Epub 2014 Mar 4.


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