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Items: 1 to 50 of 324

1.

Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells.

Chen Y, Wu Y, Xiao W, Jia H, Glatt H, Shi M, Liu Y.

Toxicology. 2019 Nov 14;429:152329. doi: 10.1016/j.tox.2019.152329. [Epub ahead of print]

PMID:
31733235
2.

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine.

Ebmeyer J, Braeuning A, Glatt H, These A, Hessel-Pras S, Lampen A.

Food Chem Toxicol. 2019 Aug;130:79-88. doi: 10.1016/j.fct.2019.05.019. Epub 2019 May 16.

PMID:
31103741
3.

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence.

Wiesner-Reinhold M, Barknowitz G, Florian S, Mewis I, Schumacher F, Schreiner M, Glatt H.

Arch Toxicol. 2019 Jun;93(6):1515-1527. doi: 10.1007/s00204-019-02452-3. Epub 2019 Apr 15.

PMID:
30993378
4.

Sensitization of Human Liver Cells Toward Fas-Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine.

Ebmeyer J, Franz L, Lim R, Niemann B, Glatt H, Braeuning A, Lampen A, Hessel-Pras S.

Mol Nutr Food Res. 2019 Jun;63(12):e1801206. doi: 10.1002/mnfr.201801206. Epub 2019 Apr 1.

PMID:
30900802
5.

Interleukin-22 protects intestinal stem cells against genotoxic stress.

Gronke K, Hernández PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A.

Nature. 2019 Feb;566(7743):249-253. doi: 10.1038/s41586-019-0899-7. Epub 2019 Jan 30.

6.

Mutagenic Activity of N-Nitrosodiethylamine in Cell Lines Expressing Human CYP2E1-Adequacy of Dimethylsulfoxide as Solvent.

Jin G, Cai L, Hu K, Luo Y, Chen Y, Glatt H, Liu Y.

Environ Mol Mutagen. 2019 Apr;60(3):214-226. doi: 10.1002/em.22264. Epub 2018 Nov 29.

PMID:
30387191
7.

Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice.

Li Y, Chen Z, Paonessa JD, Meinl W, Bhattacharya A, Glatt H, Vouros P, Zhang Y.

Cancer Med. 2018 Nov;7(11):5604-5610. doi: 10.1002/cam4.1779. Epub 2018 Oct 10.

8.

Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.

Monien BH, Sachse B, Meinl W, Abraham K, Lampen A, Glatt H.

Toxicol Lett. 2018 Oct 1;295:173-178. doi: 10.1016/j.toxlet.2018.06.008. Epub 2018 Jun 13.

PMID:
29908303
9.

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM.

Arch Toxicol. 2017 Oct;91(10):3329-3339. doi: 10.1007/s00204-017-1955-4. Epub 2017 Mar 22.

PMID:
28326452
10.

Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.

Chevereau M, Glatt H, Zalko D, Cravedi JP, Audebert M.

Arch Toxicol. 2017 Sep;91(9):3175-3184. doi: 10.1007/s00204-017-1935-8. Epub 2017 Feb 3.

PMID:
28160022
11.

Erratum to: Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the health-related indication value (HRIV) concept.

Prantl EM, Kramer M, Schmidt CK, Knauer M, Gartiser S, Shuliakevich A, Milas J, Glatt H, Meinl W, Hollert H.

Environ Sci Pollut Res Int. 2018 Feb;25(5):4011. doi: 10.1007/s11356-017-8464-0. No abstract available.

PMID:
28127693
12.

Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the "health-related indication value (HRIV) concept.

Prantl EM, Kramer M, Schmidt CK, Knauer M, Gartiser S, Shuliakevich A, Milas J, Glatt H, Meinl W, Hollert H.

Environ Sci Pollut Res Int. 2018 Feb;25(5):3996-4010. doi: 10.1007/s11356-016-8166-z. Epub 2016 Dec 8. Erratum in: Environ Sci Pollut Res Int. 2017 Jan 27;:.

PMID:
27928753
13.

Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme.

Liu Y, Hu K, Jia H, Jin G, Glatt H, Jiang H.

Arch Toxicol. 2017 Jul;91(7):2663-2676. doi: 10.1007/s00204-016-1904-7. Epub 2016 Dec 2.

PMID:
27913846
14.

Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems.

Förster N, Mewis I, Glatt H, Haack M, Brigelius-Flohé R, Schreiner M, Ulrichs C.

Food Funct. 2016 Nov 9;7(11):4660-4674.

PMID:
27775133
15.

Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1.

Jia H, Zhang C, Glatt H, Liu Y.

Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 15;808:27-37. doi: 10.1016/j.mrgentox.2016.08.004. Epub 2016 Aug 20.

PMID:
27637483
16.

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, Schmeiser HH.

Arch Toxicol. 2017 Apr;91(4):1957-1975. doi: 10.1007/s00204-016-1808-6. Epub 2016 Aug 24.

17.

Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats.

Bendadani C, Steinhauser L, Albert K, Glatt H, Monien BH.

Toxicology. 2016 Jul 29;366-367:43-52. doi: 10.1016/j.tox.2016.08.006. Epub 2016 Aug 5.

PMID:
27501763
18.

Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenol.

Honda H, Minegawa K, Fujita Y, Yamaguchi N, Oguma Y, Glatt H, Nishiyama N, Kasamatsu T.

Genes Environ. 2016 Feb 7;38:1. doi: 10.1186/s41021-016-0028-x. eCollection 2016.

19.

An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol.

Huffman MP, Høie AH, Svendsen C, Brunborg G, Murkovic M, Glatt H, Husøy T.

Mutagenesis. 2016 Sep;31(5):597-602. doi: 10.1093/mutage/gew025. Epub 2016 May 25.

20.

DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2.

Høie AH, Monien BH, Glatt H, Hjertholm H, Husøy T.

Toxicol Lett. 2016 Apr 25;248:34-8. doi: 10.1016/j.toxlet.2016.02.017. Epub 2016 Mar 3.

21.

Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes.

Glatt H, Sabbioni G, Monien BH, Meinl W.

Environ Mol Mutagen. 2016 May;57(4):299-311. doi: 10.1002/em.22005. Epub 2016 Feb 29.

PMID:
26924705
22.

The influence of the SULT1A status - wild-type, knockout or humanized - on the DNA adduct formation by methyleugenol in extrahepatic tissues of mice.

Herrmann K, Engst W, Florian S, Lampen A, Meinl W, Glatt HR.

Toxicol Res (Camb). 2016 Feb 12;5(3):808-815. doi: 10.1039/c5tx00358j. eCollection 2016 May 1.

23.

Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2.

Sachse B, Meinl W, Glatt H, Monien BH.

Carcinogenesis. 2016 Mar;37(3):314-319. doi: 10.1093/carcin/bgw006. Epub 2016 Jan 16.

PMID:
26775039
24.

Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells.

Zhang C, Lai Y, Jin G, Glatt H, Wei Q, Liu Y.

Chemosphere. 2016 Feb;144:1908-15. doi: 10.1016/j.chemosphere.2015.10.083. Epub 2015 Nov 11.

PMID:
26547025
25.

In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.

Rakers C, Schumacher F, Meinl W, Glatt H, Kleuser B, Wolber G.

J Biol Chem. 2016 Jan 1;291(1):58-71. doi: 10.1074/jbc.M115.685610. Epub 2015 Nov 5.

26.

Conversion of Suspected Food Carcinogen 5-Hydroxymethylfurfural by Sulfotransferases and Aldehyde Dehydrogenases in Postmitochondrial Tissue Preparations of Humans, Mice, and Rats.

Sachse B, Meinl W, Glatt H, Monien BH.

Toxicol Sci. 2016 Jan;149(1):192-201. doi: 10.1093/toxsci/kfv228. Epub 2015 Oct 9.

PMID:
26454887
27.

Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice.

Budnowski J, Hanske L, Schumacher F, Glatt H, Platz S, Rohn S, Blaut M.

J Agric Food Chem. 2015 Sep 30;63(38):8418-28. doi: 10.1021/acs.jafc.5b02948. Epub 2015 Sep 22.

PMID:
26365197
28.

Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay.

Høie AH, Svendsen C, Brunborg G, Glatt H, Alexander J, Meinl W, Husøy T.

Environ Mol Mutagen. 2015 Oct;56(8):709-14. doi: 10.1002/em.21963. Epub 2015 Aug 13.

29.

Formation of DNA adducts in wild-type and transgenic mice expressing human sulfotransferases 1A1 and 1A2 after oral exposure to furfuryl alcohol.

Høie AH, Monien BH, Sakhi AK, Glatt H, Hjertholm H, Husøy T.

Mutagenesis. 2015 Sep;30(5):643-9. doi: 10.1093/mutage/gev023. Epub 2015 Apr 22.

30.

The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.

Ehlers A, Florian S, Schumacher F, Meinl W, Lenze D, Hummel M, Heise T, Seidel A, Glatt H, Lampen A.

Mol Nutr Food Res. 2015 Apr;59(4):685-97. doi: 10.1002/mnfr.201400707. Epub 2015 Feb 9.

PMID:
25559983
31.

Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS.

Monien BH, Schumacher F, Herrmann K, Glatt H, Turesky RJ, Chesné C.

Anal Chem. 2015 Jan 6;87(1):641-8. doi: 10.1021/ac503803m. Epub 2014 Dec 8.

32.

Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.

Sachse B, Meinl W, Sommer Y, Glatt H, Seidel A, Monien BH.

Arch Toxicol. 2016 Jan;90(1):137-48. doi: 10.1007/s00204-014-1392-6. Epub 2014 Nov 5.

33.

The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models.

Sachse B, Meinl W, Glatt H, Monien BH.

Carcinogenesis. 2014 Oct;35(10):2339-45. doi: 10.1093/carcin/bgu152. Epub 2014 Jul 22.

PMID:
25053625
34.

Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models.

Bendadani C, Meinl W, Monien B, Dobbernack G, Florian S, Engst W, Nolden T, Himmelbauer H, Glatt H.

Chem Res Toxicol. 2014 Jun 16;27(6):1060-9. doi: 10.1021/tx500129g. Epub 2014 May 22.

35.

Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently.

Lippmann D, Lehmann C, Florian S, Barknowitz G, Haack M, Mewis I, Wiesner M, Schreiner M, Glatt H, Brigelius-Flohé R, Kipp AP.

Food Funct. 2014 Jun;5(6):1073-81. doi: 10.1039/c3fo60676g. Epub 2014 Apr 9.

PMID:
24714741
36.
37.

Identification and quantification of protein adducts formed by metabolites of 1-methoxy-3-indolylmethyl glucosinolate in vitro and in mouse models.

Barknowitz G, Engst W, Schmidt S, Bernau M, Monien BH, Kramer M, Florian S, Glatt H.

Chem Res Toxicol. 2014 Feb 17;27(2):188-99. doi: 10.1021/tx400277w. Epub 2014 Jan 14.

PMID:
24422435
38.

The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester.

Bendadani C, Meinl W, Monien BH, Dobbernack G, Glatt H.

Arch Toxicol. 2014 Mar;88(3):815-21. doi: 10.1007/s00204-013-1182-6. Epub 2013 Dec 13.

PMID:
24337722
39.

Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2.

Herrmann K, Engst W, Meinl W, Florian S, Cartus AT, Schrenk D, Appel KE, Nolden T, Himmelbauer H, Glatt H.

Carcinogenesis. 2014 Apr;35(4):935-41. doi: 10.1093/carcin/bgt408. Epub 2013 Dec 6.

PMID:
24318996
40.

A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.

Schumacher F, Florian S, Schnapper A, Monien BH, Mewis I, Schreiner M, Seidel A, Engst W, Glatt H.

Arch Toxicol. 2014 Mar;88(3):823-36. doi: 10.1007/s00204-013-1149-7. Epub 2013 Oct 24.

PMID:
24154822
41.

Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium.

Meinl W, Tsoi C, Swedmark S, Tibbs ZE, Falany CN, Glatt H.

Mutagenesis. 2013 Sep;28(5):609-19. doi: 10.1093/mutage/get039. Epub 2013 Jul 26.

PMID:
23894158
42.

Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.

Glatt H, Pietsch KE, Sturla SJ, Meinl W.

Arch Toxicol. 2014 Jan;88(1):161-9. doi: 10.1007/s00204-013-1097-2. Epub 2013 Jul 24.

PMID:
23881331
43.

Induced production of 1-methoxy-indol-3-ylmethyl glucosinolate by jasmonic acid and methyl jasmonate in sprouts and leaves of pak choi (Brassica rapa ssp. chinensis).

Wiesner M, Hanschen FS, Schreiner M, Glatt H, Zrenner R.

Int J Mol Sci. 2013 Jul 18;14(7):14996-5016. doi: 10.3390/ijms140714996.

45.

Genotypic variation of the glucosinolate profile in pak choi (Brassica rapa ssp. chinensis).

Wiesner M, Zrenner R, Krumbein A, Glatt H, Schreiner M.

J Agric Food Chem. 2013 Feb 27;61(8):1943-53. doi: 10.1021/jf303970k. Epub 2013 Feb 18.

PMID:
23350944
46.

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples.

Herrmann K, Schumacher F, Engst W, Appel KE, Klein K, Zanger UM, Glatt H.

Carcinogenesis. 2013 May;34(5):1025-30. doi: 10.1093/carcin/bgt013. Epub 2013 Jan 18.

PMID:
23334163
47.

Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.

Schumacher F, Herrmann K, Florian S, Engst W, Glatt H.

Anal Biochem. 2013 Mar 1;434(1):4-11. doi: 10.1016/j.ab.2012.11.001. Epub 2012 Nov 9.

PMID:
23142629
48.

Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.

Schumacher F, Engst W, Monien BH, Florian S, Schnapper A, Steinhauser L, Albert K, Frank H, Seidel A, Glatt H.

Anal Chem. 2012 Jul 17;84(14):6256-62. doi: 10.1021/ac301436q. Epub 2012 Jul 3.

PMID:
22816785
49.

Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation.

Cartus AT, Herrmann K, Weishaupt LW, Merz KH, Engst W, Glatt H, Schrenk D.

Toxicol Sci. 2012 Sep;129(1):21-34. doi: 10.1093/toxsci/kfs181. Epub 2012 May 18.

PMID:
22610610
50.

Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed.

Monien BH, Engst W, Barknowitz G, Seidel A, Glatt H.

Chem Res Toxicol. 2012 Jul 16;25(7):1484-92. doi: 10.1021/tx300150n. Epub 2012 May 15.

PMID:
22563731

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