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Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine.

Wang G, Zhang G, Li Z, Fawcett CH, Coble M, Sosa MX, Tsai T, Malesky K, Thibodeaux SJ, Zhu P, Glass DJ, Fishman MC.

iScience. 2019 Jul 4;17:325-333. doi: 10.1016/j.isci.2019.06.039. [Epub ahead of print]


mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.

Castets P, Rion N, Théodore M, Falcetta D, Lin S, Reischl M, Wild F, Guérard L, Eickhorst C, Brockhoff M, Guridi M, Ibebunjo C, Cruz J, Sinnreich M, Rudolf R, Glass DJ, Rüegg MA.

Nat Commun. 2019 Jul 18;10(1):3187. doi: 10.1038/s41467-019-11227-4.


Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia.

Joseph GA, Wang S, Jacobs CE, Zhou W, Kimble GC, Tse HW, Eash JK, Shavlakadze T, Glass DJ.

Mol Cell Biol. 2019 Jul 15. pii: MCB.00141-19. doi: 10.1128/MCB.00141-19. [Epub ahead of print]


Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space.

Cadena SM, Zhang Y, Fang J, Brachat S, Kuss P, Giorgetti E, Stodieck LS, Kneissel M, Glass DJ.

Sci Rep. 2019 Jun 28;9(1):9397. doi: 10.1038/s41598-019-45821-9.


The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis.

Egerman MA, Glass DJ.

Crit Rev Biochem Mol Biol. 2019 Apr;54(2):174-183. doi: 10.1080/10409238.2019.1610722.


Activin type II receptor signaling in cardiac aging and heart failure.

Roh JD, Hobson R, Chaudhari V, Quintero P, Yeri A, Benson M, Xiao C, Zlotoff D, Bezzerides V, Houstis N, Platt C, Damilano F, Lindman BR, Elmariah S, Biersmith M, Lee SJ, Seidman CE, Seidman JG, Gerszten RE, Lach-Trifilieff E, Glass DJ, Rosenzweig A.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaau8680. doi: 10.1126/scitranslmed.aau8680.


Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.

Koziczak-Holbro M, Rigel DF, Dumotier B, Sykes DA, Tsao J, Nguyen NH, Bösch J, Jourdain M, Flotte L, Adachi Y, Kiffe M, Azria M, Fairhurst RA, Charlton SJ, Richardson BP, Lach-Trifilieff E, Glass DJ, Ullrich T, Hatakeyama S.

J Pharmacol Exp Ther. 2019 May;369(2):188-199. doi: 10.1124/jpet.118.255307. Epub 2019 Feb 28.


Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial.

Grunseich C, Miller R, Swan T, Glass DJ, El Mouelhi M, Fornaro M, Petricoul O, Vostiar I, Roubenoff R, Meriggioli MN, Kokkinis A, Guber RD, Budron MS, Vissing J, Soraru G, Mozaffar T, Ludolph A, Kissel JT, Fischbeck KH; BVS857 study group.

Lancet Neurol. 2018 Dec;17(12):1043-1052. doi: 10.1016/S1474-4422(18)30320-X. Epub 2018 Oct 15.


TORC1 inhibition enhances immune function and reduces infections in the elderly.

Mannick JB, Morris M, Hockey HP, Roma G, Beibel M, Kulmatycki K, Watkins M, Shavlakadze T, Zhou W, Quinn D, Glass DJ, Klickstein LB.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaaq1564. doi: 10.1126/scitranslmed.aaq1564.


Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy.

Cruz JM, Hupper N, Wilson LS, Concannon JB, Wang Y, Oberhauser B, Patora-Komisarska K, Zhang Y, Glass DJ, Trendelenburg AU, Clarke BA.

J Biol Chem. 2018 Jul 27;293(30):11837-11849. doi: 10.1074/jbc.RA118.002633. Epub 2018 Jun 13.


Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15.

Jones JE, Cadena SM, Gong C, Wang X, Chen Z, Wang SX, Vickers C, Chen H, Lach-Trifilieff E, Hadcock JR, Glass DJ.

Cell Rep. 2018 Mar 20;22(12):3375. doi: 10.1016/j.celrep.2018.03.024. No abstract available.


Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15.

Jones JE, Cadena SM, Gong C, Wang X, Chen Z, Wang SX, Vickers C, Chen H, Lach-Trifilieff E, Hadcock JR, Glass DJ.

Cell Rep. 2018 Feb 6;22(6):1522-1530. doi: 10.1016/j.celrep.2018.01.044. Erratum in: Cell Rep. 2018 Mar 20;22(12 ):3375.


Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Shavlakadze T, Zhu J, Wang S, Zhou W, Morin B, Egerman MA, Fan L, Wang Y, Iartchouk O, Meyer A, Valdez RA, Mannick JB, Klickstein LB, Glass DJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):845-852. doi: 10.1093/gerona/glx249.


ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation.

Das S, Morvan F, Morozzi G, Jourde B, Minetti GC, Kahle P, Rivet H, Brebbia P, Toussaint G, Glass DJ, Fornaro M.

Cell Rep. 2017 Dec 12;21(11):3003-3011. doi: 10.1016/j.celrep.2017.11.038.


Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia.

Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):93-105. doi: 10.1002/jcsm.12252. Epub 2017 Dec 6.


Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions.

Glass DJ, Flier JS.

Cell Metab. 2017 Nov 7;26(5):695-696. doi: 10.1016/j.cmet.2017.10.010.


Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.

Morvan F, Rondeau JM, Zou C, Minetti G, Scheufler C, Scharenberg M, Jacobi C, Brebbia P, Ritter V, Toussaint G, Koelbing C, Leber X, Schilb A, Witte F, Lehmann S, Koch E, Geisse S, Glass DJ, Lach-Trifilieff E.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12448-12453. doi: 10.1073/pnas.1707925114. Epub 2017 Nov 6.


What's So Special about FGF19-Unique Effects Reported on Skeletal Muscle Mass and Function.

Glass DJ.

Cell Metab. 2017 Aug 1;26(2):287-288. doi: 10.1016/j.cmet.2017.07.017.


Ken Fearon.

Skipworth RJ, Stephens NA, Johns N, Guttridge DC, Tisdale MJ, Baracos VE, Glass DJ.

Cell Metab. 2016 Dec 13;24(6):765-766. doi: 10.1016/j.cmet.2016.11.010. Epub 2016 Dec 13. No abstract available.


Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.

Summermatter S, Bouzan A, Pierrel E, Melly S, Stauffer D, Gutzwiller S, Nolin E, Dornelas C, Fryer C, Leighton-Davies J, Glass DJ, Fournier B.

Mol Cell Biol. 2017 Feb 15;37(5). pii: e00305-16. doi: 10.1128/MCB.00305-16. Print 2017 Mar 1.


Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.

Lodka D, Pahuja A, Geers-Knörr C, Scheibe RJ, Nowak M, Hamati J, Köhncke C, Purfürst B, Kanashova T, Schmidt S, Glass DJ, Morano I, Heuser A, Kraft T, Bassel-Duby R, Olson EN, Dittmar G, Sommer T, Fielitz J.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):165-80. doi: 10.1002/jcsm.12057. Epub 2015 Sep 7.


Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly.

Brzeszczyńska J, Johns N, Schilb A, Degen S, Degen M, Langen R, Schols A, Glass DJ, Roubenoff R, Greig CA, Jacobi C, Fearon KCh, Ross JA.

Aging (Albany NY). 2016 Aug;8(8):1690-702. doi: 10.18632/aging.101006.


Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans.

Glass DJ.

Cell Metab. 2016 Jul 12;24(1):7-8. doi: 10.1016/j.cmet.2016.06.017.


Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.

Gingras J, Gawor M, Bernadzki KM, Grady RM, Hallock P, Glass DJ, Sanes JR, Proszynski TJ.

J Cell Sci. 2016 Mar 1;129(5):898-911. doi: 10.1242/jcs.181180. Epub 2016 Jan 14.


Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.

Hallock PT, Chin S, Blais S, Neubert TA, Glass DJ.

Mol Cell Biol. 2015 Nov 2;36(2):262-70. doi: 10.1128/MCB.00775-15. Print 2016 Jan 15.


A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation.

Gong C, Li Z, Ramanujan K, Clay I, Zhang Y, Lemire-Brachat S, Glass DJ.

Dev Cell. 2015 Jul 27;34(2):181-91. doi: 10.1016/j.devcel.2015.05.009. Epub 2015 Jul 2.


The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.

Rodríguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DJ, Frederick CB, Yoder BC, Lalush DS, Patterson C, Willis MS.

Mol Cell Endocrinol. 2015 Sep 15;413:36-48. doi: 10.1016/j.mce.2015.06.008. Epub 2015 Jun 25.


ATP citrate lyase improves mitochondrial function in skeletal muscle.

Das S, Morvan F, Jourde B, Meier V, Kahle P, Brebbia P, Toussaint G, Glass DJ, Fornaro M.

Cell Metab. 2015 Jun 2;21(6):868-76. doi: 10.1016/j.cmet.2015.05.006.


GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.

Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ.

Cell Metab. 2015 Jul 7;22(1):164-74. doi: 10.1016/j.cmet.2015.05.010. Epub 2015 May 19.


The understanding and experience of mixed emotions in 3-5-year-old children.

Smith JP, Glass DJ, Fireman G.

J Genet Psychol. 2015 Jan-Apr;176(1-2):65-81. doi: 10.1080/00221325.2014.1002750. Epub 2015 Feb 19.


mTOR inhibition improves immune function in the elderly.

Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB.

Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892.


Treatment of sporadic inclusion body myositis with bimagrumab.

Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J, Lach-Trifilieff E, Trendelenburg AU, Laurent D, Glass DJ, Roubenoff R, Tseng BS, Greenberg SA.

Neurology. 2014 Dec 9;83(24):2239-46. doi: 10.1212/WNL.0000000000001070. Epub 2014 Nov 7.


G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15756-61. doi: 10.1073/pnas.1417898111. Epub 2014 Oct 21.


Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy.

Iyer CC, McGovern VL, Wise DO, Glass DJ, Burghes AH.

Neuromuscul Disord. 2014 May;24(5):436-44. doi: 10.1016/j.nmd.2014.02.007. Epub 2014 Feb 25.


MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart.

Baskin KK, Rodriguez MR, Kansara S, Chen W, Carranza S, Frazier OH, Glass DJ, Taegtmeyer H.

J Mol Cell Cardiol. 2014 Jul;72:168-76. doi: 10.1016/j.yjmcc.2014.03.006. Epub 2014 Mar 18.


NIH grants: Focus on questions, not hypotheses.

Glass DJ.

Nature. 2014 Mar 20;507(7492):306. doi: 10.1038/507306d. No abstract available.


Skeletal muscle's 3rd year anniversary.

Glass DJ, Campbell KP, Rudnicki MA.

Skelet Muscle. 2014 Jan 24;4(1):3. doi: 10.1186/2044-5040-4-3. No abstract available.


Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle.

Johns N, Hatakeyama S, Stephens NA, Degen M, Degen S, Frieauff W, Lambert C, Ross JA, Roubenoff R, Glass DJ, Jacobi C, Fearon KC.

PLoS One. 2014 Jan 3;9(1):e83618. doi: 10.1371/journal.pone.0083618. eCollection 2014.


An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy.

Lach-Trifilieff E, Minetti GC, Sheppard K, Ibebunjo C, Feige JN, Hartmann S, Brachat S, Rivet H, Koelbing C, Morvan F, Hatakeyama S, Glass DJ.

Mol Cell Biol. 2014 Feb;34(4):606-18. doi: 10.1128/MCB.01307-13. Epub 2013 Dec 2.


Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.

Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M.

Mol Cell Biol. 2014 Feb;34(4):619-30. doi: 10.1128/MCB.00957-13. Epub 2013 Dec 2.


Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.

Fornaro M, Hinken AC, Needle S, Hu E, Trendelenburg AU, Mayer A, Rosenstiel A, Chang C, Meier V, Billin AN, Becherer JD, Brace AD, Evans WJ, Glass DJ, Russell AJ.

Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E150-6. doi: 10.1152/ajpendo.00408.2013. Epub 2013 Nov 19.


Signaling pathways controlling skeletal muscle mass.

Egerman MA, Glass DJ.

Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):59-68. doi: 10.3109/10409238.2013.857291. Epub 2013 Nov 18. Review.


MG53's new identity.

Levy JR, Campbell KP, Glass DJ.

Skelet Muscle. 2013 Nov 1;3(1):25. doi: 10.1186/2044-5040-3-25.


Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.

Li Z, Zhang Y, Ramanujan K, Ma Y, Kirsch DG, Glass DJ.

Cancer Res. 2013 May 15;73(10):3041-50. doi: 10.1158/0008-5472.CAN-12-3947. Epub 2013 Mar 27.


Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.

Willis MS, Wadosky KM, Rodríguez JE, Schisler JC, Lockyer P, Hilliard EG, Glass DJ, Patterson C.

Cell Biochem Funct. 2014 Jan;32(1):39-50. doi: 10.1002/cbf.2969. Epub 2013 Mar 20.


Evaluation of the authenticity of a highly novel environmental sequence from boreal forest soil using ribosomal RNA secondary structure modeling.

Glass DJ, Takebayashi N, Olson LE, Taylor DL.

Mol Phylogenet Evol. 2013 Apr;67(1):234-45. doi: 10.1016/j.ympev.2013.01.018. Epub 2013 Feb 9.


An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.

Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, Ramanujan K, Shavlakadze T, Eash JK, Scaramozza A, Goddeeris MM, Kirsch DG, Campbell KP, Brack AS, Glass DJ.

Dev Cell. 2012 Dec 11;23(6):1176-88. doi: 10.1016/j.devcel.2012.10.019. Epub 2012 Nov 21. Erratum in: Dev Cell. 2013 Jan 14;24(1):112.


Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.

Ibebunjo C, Chick JM, Kendall T, Eash JK, Li C, Zhang Y, Vickers C, Wu Z, Clarke BA, Shi J, Cruz J, Fournier B, Brachat S, Gutzwiller S, Ma Q, Markovits J, Broome M, Steinkrauss M, Skuba E, Galarneau JR, Gygi SP, Glass DJ.

Mol Cell Biol. 2013 Jan;33(2):194-212. doi: 10.1128/MCB.01036-12. Epub 2012 Oct 29.


Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysis.

Zaglia T, Milan G, Franzoso M, Bertaggia E, Pianca N, Piasentini E, Voltarelli VA, Chiavegato D, Brum PC, Glass DJ, Schiaffino S, Sandri M, Mongillo M.

Cardiovasc Res. 2013 Feb 1;97(2):240-50. doi: 10.1093/cvr/cvs320. Epub 2012 Oct 22.


Cancer cachexia: mediators, signaling, and metabolic pathways.

Fearon KC, Glass DJ, Guttridge DC.

Cell Metab. 2012 Aug 8;16(2):153-66. doi: 10.1016/j.cmet.2012.06.011. Epub 2012 Jul 12. Review.

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