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Items: 1 to 50 of 318

1.

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC.

Elife. 2019 Aug 13;8. pii: e48609. doi: 10.7554/eLife.48609.

2.

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M.

Neuron. 2019 Jul 30. pii: S0896-6273(19)30600-2. doi: 10.1016/j.neuron.2019.07.002. [Epub ahead of print]

PMID:
31375314
3.

Leducq Epigenetics of Atherosclerosis Network.

de Winther MPJ, Glass CK.

Circ Res. 2019 Jun 7;124(12):1697-1700. doi: 10.1161/CIRCRESAHA.119.315187. Epub 2019 Jun 6. No abstract available.

PMID:
31170047
4.

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.

Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, Durden DL.

Mol Cancer Ther. 2019 Jun;18(6):1036-1044. doi: 10.1158/1535-7163.MCT-18-1206. Epub 2019 Apr 24.

PMID:
31018997
5.

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages.

Fonseca GJ, Tao J, Westin EM, Duttke SH, Spann NJ, Strid T, Shen Z, Stender JD, Sakai M, Link VM, Benner C, Glass CK.

Nat Commun. 2019 Jan 24;10(1):414. doi: 10.1038/s41467-018-08236-0.

6.

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice.

Moore SM, Seidman JS, Ellegood J, Gao R, Savchenko A, Troutman TD, Abe Y, Stender J, Lee D, Wang S, Voytek B, Lerch JP, Suh H, Glass CK, Muotri AR.

Transl Psychiatry. 2019 Jan 17;9(1):24. doi: 10.1038/s41398-018-0344-y.

7.

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH.

Nat Neurosci. 2019 Feb;22(2):243-255. doi: 10.1038/s41593-018-0295-x. Epub 2019 Jan 7.

8.

A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela.

Carlin AF, Wen J, Vizcarra EA, McCauley M, Chaillon A, Akrami K, Kim C, Ngono AE, Lara-Marquez ML, Smith DM, Glass CK, Schooley RT, Benner C, Shresta S.

PLoS Negl Trop Dis. 2018 Dec 31;12(12):e0007053. doi: 10.1371/journal.pntd.0007053. eCollection 2018 Dec.

9.

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity.

Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W.

Cell Metab. 2019 Feb 5;29(2):457-474.e5. doi: 10.1016/j.cmet.2018.12.003. Epub 2018 Dec 27.

10.

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge.

Shemer A, Grozovski J, Tay TL, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim JS, David E, Chappell-Maor L, Thielecke L, Glass CK, Cornils K, Prinz M, Jung S.

Nat Commun. 2018 Dec 6;9(1):5206. doi: 10.1038/s41467-018-07548-5.

11.

Microbiome-microglia connections via the gut-brain axis.

Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK.

J Exp Med. 2019 Jan 7;216(1):41-59. doi: 10.1084/jem.20180794. Epub 2018 Nov 1. Review.

12.

Nature and nurture of tissue-specific macrophage phenotypes.

Hoeksema MA, Glass CK.

Atherosclerosis. 2019 Feb;281:159-167. doi: 10.1016/j.atherosclerosis.2018.10.005. Epub 2018 Oct 6. Review.

PMID:
30343819
13.

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.

Carlin AF, Vizcarra EA, Branche E, Viramontes KM, Suarez-Amaran L, Ley K, Heinz S, Benner C, Shresta S, Glass CK.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9172-E9181. doi: 10.1073/pnas.1807690115. Epub 2018 Sep 11.

14.

A monocyte gene expression signature in the early clinical course of Parkinson's disease.

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J.

Sci Rep. 2018 Jul 17;8(1):10757. doi: 10.1038/s41598-018-28986-7.

15.

Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x.

PMID:
30013121
16.

MMARGE: Motif Mutation Analysis for Regulatory Genomic Elements.

Link VM, Romanoski CE, Metzler D, Glass CK.

Nucleic Acids Res. 2018 Aug 21;46(14):7006-7021. doi: 10.1093/nar/gky491.

17.

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Erratum in: Nature. 2018 Sep;561(7724):E43.

18.

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH.

Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105.

19.

Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.

Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK.

Cell. 2018 Jun 14;173(7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. Epub 2018 May 17.

20.

NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes.

Fei J, Ishii H, Hoeksema MA, Meitinger F, Kassavetis GA, Glass CK, Ren B, Kadonaga JT.

Genes Dev. 2018 May 1;32(9-10):682-694. doi: 10.1101/gad.313973.118. Epub 2018 May 14.

21.

Immune memory in the brain.

Nott A, Glass CK.

Nature. 2018 Apr;556(7701):312-313. doi: 10.1038/d41586-018-03800-6. No abstract available.

PMID:
29662132
22.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.

Muse ED, Yu S, Edillor CR, Tao J, Spann NJ, Troutman TD, Seidman JS, Henke A, Roland JT, Ozeki KA, Thompson BM, McDonald JG, Bahadorani J, Tsimikas S, Grossman TR, Tremblay MS, Glass CK.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689. doi: 10.1073/pnas.1714518115. Epub 2018 Apr 9.

23.

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.

Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY.

Mol Cell. 2018 Mar 1;69(5):915. doi: 10.1016/j.molcel.2018.02.014. No abstract available.

24.

Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies.

Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL.

J Immunol. 2018 Mar 1;200(5):1702-1717. doi: 10.4049/jimmunol.1700568. Epub 2018 Jan 29.

25.

Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock.

Wang J, Saijo K, Skola D, Jin C, Ma Q, Merkurjev D, Glass CK, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E244-E252. doi: 10.1073/pnas.1718759114. Epub 2017 Dec 20.

26.

An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses.

Carlin AF, Plummer EM, Vizcarra EA, Sheets N, Joo Y, Tang W, Day J, Greenbaum J, Glass CK, Diamond MS, Shresta S.

Cell Rep. 2017 Nov 7;21(6):1600-1612. doi: 10.1016/j.celrep.2017.10.054.

27.

Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.

Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sánchez NM, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI.

Nat Med. 2017 Nov;23(11):1309-1318. doi: 10.1038/nm.4422. Epub 2017 Oct 9.

PMID:
29035364
28.

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.

Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH.

J Exp Med. 2017 Nov 6;214(11):3331-3346. doi: 10.1084/jem.20171178. Epub 2017 Sep 28.

29.

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.

Rahnamoun H, Lu H, Duttke SH, Benner C, Glass CK, Lauberth SM.

Nat Commun. 2017 Sep 29;8(1):754. doi: 10.1038/s41467-017-01117-y.

30.

Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity.

Glass CK, Mitchell RN.

Cardiovasc Pathol. 2017 Sep - Oct;30:55-63. doi: 10.1016/j.carpath.2017.06.009. Epub 2017 Jun 30. Review.

PMID:
28759820
31.

Transcriptional control of microglia phenotypes in health and disease.

Holtman IR, Skola D, Glass CK.

J Clin Invest. 2017 Sep 1;127(9):3220-3229. doi: 10.1172/JCI90604. Epub 2017 Jul 31. Review.

32.

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.

Hogan NT, Whalen MB, Stolze LK, Hadeli NK, Lam MT, Springstead JR, Glass CK, Romanoski CE.

Elife. 2017 Jun 6;6. pii: e22536. doi: 10.7554/eLife.22536.

33.

An environment-dependent transcriptional network specifies human microglia identity.

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK.

Science. 2017 Jun 23;356(6344). pii: eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25.

34.

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity.

Phan AT, Goldrath AW, Glass CK.

Immunity. 2017 May 16;46(5):714-729. doi: 10.1016/j.immuni.2017.04.016. Review.

35.

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, Lin CY, Frasor J, Nettles KW, Glass CK.

Mol Cell. 2017 Mar 16;65(6):1122-1135.e5. doi: 10.1016/j.molcel.2017.02.008.

36.

Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.

Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A.

J Immunol. 2017 Mar 15;198(6):2366-2373. doi: 10.4049/jimmunol.1601471. Epub 2017 Feb 1.

37.

Genome-Wide Approaches to Defining Macrophage Identity and Function.

Fonseca GJ, Seidman JS, Glass CK.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.MCHD-0039-2016. Review.

38.

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK.

Cell Metab. 2017 Feb 7;25(2):412-427. doi: 10.1016/j.cmet.2016.11.009. Epub 2016 Dec 29.

39.

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function.

Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton BA, Mikulski Z, Jain MK, Glass CK, Hedrick CC.

Immunity. 2016 Nov 15;45(5):975-987. doi: 10.1016/j.immuni.2016.10.011. Epub 2016 Nov 1.

40.

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages.

Eichenfield DZ, Troutman TD, Link VM, Lam MT, Cho H, Gosselin D, Spann NJ, Lesch HP, Tao J, Muto J, Gallo RL, Evans RM, Glass CK.

Elife. 2016 Jul 27;5. pii: e13024. doi: 10.7554/eLife.13024.

41.

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K.

J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081.

42.

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK.

Elife. 2016 Jul 4;5. pii: e10134. doi: 10.7554/eLife.10134.

43.

Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases.

Yu S, Li S, Henke A, Muse ED, Cheng B, Welzel G, Chatterjee AK, Wang D, Roland J, Glass CK, Tremblay M.

FASEB J. 2016 Jul;30(7):2570-9. doi: 10.1096/fj.201600244R. Epub 2016 Mar 29.

44.

Molecular control of activation and priming in macrophages.

Glass CK, Natoli G.

Nat Immunol. 2016 Jan;17(1):26-33. doi: 10.1038/ni.3306. Review.

45.

Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers.

Link VM, Gosselin D, Glass CK.

Cold Spring Harb Symp Quant Biol. 2015;80:213-21. doi: 10.1101/sqb.2015.80.027367. Epub 2015 Nov 18. Review.

46.

Perspectives on Unidirectional versus Divergent Transcription.

Duttke SH, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U.

Mol Cell. 2015 Nov 5;60(3):348-9. doi: 10.1016/j.molcel.2015.10.014. No abstract available.

47.

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.

Shaked I, Hanna RN, Shaked H, Chodaczek G, Nowyhed HN, Tweet G, Tacke R, Basat AB, Mikulski Z, Togher S, Miller J, Blatchley A, Salek-Ardakani S, Darvas M, Kaikkonen MU, Thomas GD, Lai-Wing-Sun S, Rezk A, Bar-Or A, Glass CK, Bandukwala H, Hedrick CC.

Nat Immunol. 2015 Dec;16(12):1228-34. doi: 10.1038/ni.3321. Epub 2015 Nov 2.

48.

Exploiting genomics and natural genetic variation to decode macrophage enhancers.

Romanoski CE, Link VM, Heinz S, Glass CK.

Trends Immunol. 2015 Sep;36(9):507-18. doi: 10.1016/j.it.2015.07.006. Epub 2015 Aug 19. Review.

49.

Daniel Steinberg, 1922-2015.

Glass CK, Witztum JL.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9791-2. doi: 10.1073/pnas.1512413112. Epub 2015 Jul 24. No abstract available.

50.

Transcription factor ISL1 is essential for pacemaker development and function.

Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM.

J Clin Invest. 2015 Aug 3;125(8):3256-68. doi: 10.1172/JCI68257. Epub 2015 Jul 20.

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