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Items: 1 to 50 of 344

1.

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN.

Cell Metab. 2019 Jul 19. pii: S1550-4131(19)30372-9. doi: 10.1016/j.cmet.2019.06.018. [Epub ahead of print]

PMID:
31353263
2.

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Yim SH, Clish CB, Gladyshev VN.

Cell Rep. 2019 May 28;27(9):2785-2797.e3. doi: 10.1016/j.celrep.2019.05.001.

3.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.

PMID:
31002797
4.

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7.

PMID:
30853213
5.

svist4get: a simple visualization tool for genomic tracks from sequencing experiments.

Egorov AA, Sakharova EA, Anisimova AS, Dmitriev SE, Gladyshev VN, Kulakovskiy IV.

BMC Bioinformatics. 2019 Mar 6;20(1):113. doi: 10.1186/s12859-019-2706-8.

6.

Utilization of selenocysteine in early-branching fungal phyla.

Mariotti M, Salinas G, Gabaldón T, Gladyshev VN.

Nat Microbiol. 2019 May;4(5):759-765. doi: 10.1038/s41564-018-0354-9. Epub 2019 Feb 11.

7.

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

O'Connell AE, Gerashchenko MV, O'Donohue MF, Rosen SM, Huntzinger E, Gleeson D, Galli A, Ryder E, Cao S, Murphy Q, Kazerounian S, Morton SU, Schmitz-Abe K, Gladyshev VN, Gleizes PE, Séraphin B, Agrawal PB.

PLoS Genet. 2019 Feb 1;15(2):e1007917. doi: 10.1371/journal.pgen.1007917. eCollection 2019 Feb.

8.

Protein synthesis and quality control in aging.

Anisimova AS, Alexandrov AI, Makarova NE, Gladyshev VN, Dmitriev SE.

Aging (Albany NY). 2018 Dec 18;10(12):4269-4288. doi: 10.18632/aging.101721.

9.

Reversibility of irreversible aging.

Galkin F, Zhang B, Dmitriev SE, Gladyshev VN.

Ageing Res Rev. 2019 Jan;49:104-114. doi: 10.1016/j.arr.2018.11.008. Epub 2018 Dec 1. Review.

PMID:
30513346
10.

A whole lifespan mouse multi-tissue DNA methylation clock.

Meer MV, Podolskiy DI, Tyshkovskiy A, Gladyshev VN.

Elife. 2018 Nov 14;7. pii: e40675. doi: 10.7554/eLife.40675.

11.

Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.

12.

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Ogrodnik M, Salmonowicz H, Gladyshev VN.

Aging Cell. 2019 Feb;18(1):e12841. doi: 10.1111/acel.12841. Epub 2018 Oct 22. Review. Erratum in: Aging Cell. 2019 Apr;18(2):e12942.

13.

A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts.

Lee SG, Mikhalchenko AE, Yim SH, Gladyshev VN.

Stem Cell Res. 2018 Aug;31:197-200. doi: 10.1016/j.scr.2018.06.010. Epub 2018 Jun 20.

14.

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS.

Sci Signal. 2018 Jul 10;11(538). pii: eaaq0702. doi: 10.1126/scisignal.aaq0702.

15.

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.

16.

Selenoproteins in colon cancer.

Peters KM, Carlson BA, Gladyshev VN, Tsuji PA.

Free Radic Biol Med. 2018 Nov 1;127:14-25. doi: 10.1016/j.freeradbiomed.2018.05.075. Epub 2018 May 22. Review.

PMID:
29793041
17.

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN.

Cell Rep. 2018 May 1;23(5):1387-1398. doi: 10.1016/j.celrep.2018.04.009.

18.

Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation.

Na J, Jung J, Bang J, Lu Q, Carlson BA, Guo X, Gladyshev VN, Kim J, Hatfield DL, Lee BJ.

Free Radic Biol Med. 2018 Nov 1;127:190-197. doi: 10.1016/j.freeradbiomed.2018.04.577. Epub 2018 Apr 30. Review.

PMID:
29715549
19.

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

Ma S, Avanesov AS, Porter E, Lee BC, Mariotti M, Zemskaya N, Guigo R, Moskalev AA, Gladyshev VN.

Aging Cell. 2018 Aug;17(4):e12740. doi: 10.1111/acel.12740. Epub 2018 Apr 19.

20.

Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.

Zhou X, Guang X, Sun D, Xu S, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R, Fang X, Yang G.

Nat Commun. 2018 Apr 10;9(1):1276. doi: 10.1038/s41467-018-03722-x.

21.

Mechanisms of cancer resistance in long-lived mammals.

Seluanov A, Gladyshev VN, Vijg J, Gorbunova V.

Nat Rev Cancer. 2018 Jul;18(7):433-441. doi: 10.1038/s41568-018-0004-9. Review.

22.

Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

Zhou X, Sun D, Guang X, Ma S, Fang X, Mariotti M, Nielsen R, Gladyshev VN, Yang G.

Genome Biol Evol. 2018 Mar 1;10(3):967-975. doi: 10.1093/gbe/evy062.

23.

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

Sziráki A, Tyshkovskiy A, Gladyshev VN.

Aging Cell. 2018 Jun;17(3):e12738. doi: 10.1111/acel.12738. Epub 2018 Mar 25.

24.

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. doi: 10.1073/pnas.1721160115. Epub 2018 Feb 5.

25.

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.

Lee BC, Lee HM, Kim S, Avanesov AS, Lee A, Chun BH, Vorbruggen G, Gladyshev VN.

Sci Rep. 2018 Jan 17;8(1):1010. doi: 10.1038/s41598-017-15090-5.

26.

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.

Yordanova MM, Loughran G, Zhdanov AV, Mariotti M, Kiniry SJ, O'Connor PBF, Andreev DE, Tzani I, Saffert P, Michel AM, Gladyshev VN, Papkovsky DB, Atkins JF, Baranov PV.

Nature. 2018 Jan 18;553(7688):356-360. doi: 10.1038/nature25174. Epub 2018 Jan 3.

PMID:
29310120
27.

Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives.

Tang Q, Gu Y, Zhou X, Jin L, Guan J, Liu R, Li J, Long K, Tian S, Che T, Hu S, Liang Y, Yang X, Tao X, Zhong Z, Wang G, Chen X, Li D, Ma J, Wang X, Mai M, Jiang A, Luo X, Lv X, Gladyshev VN, Li X, Li M.

Gigascience. 2017 Dec 1;6(12):1-9. doi: 10.1093/gigascience/gix105.

28.

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Lee SG, Mikhalchenko AE, Yim SH, Lobanov AV, Park JK, Choi KH, Bronson RT, Lee CK, Park TJ, Gladyshev VN.

Stem Cell Reports. 2017 Nov 14;9(5):1706-1720. doi: 10.1016/j.stemcr.2017.09.013. Epub 2017 Oct 26.

29.

Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.

Kim KY, Kwak GH, Singh MP, Gladyshev VN, Kim HY.

Arch Biochem Biophys. 2017 Nov 15;634:69-75. doi: 10.1016/j.abb.2017.09.020. Epub 2017 Oct 3.

30.

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

Tarrago L, Oheix E, Péterfi Z, Gladyshev VN.

Methods Mol Biol. 2018;1661:285-299. doi: 10.1007/978-1-4939-7258-6_20.

31.

Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.

Carlson BA, Lee BJ, Tsuji PA, Copeland PR, Schweizer U, Gladyshev VN, Hatfield DL.

Methods Mol Biol. 2018;1661:43-60. doi: 10.1007/978-1-4939-7258-6_4.

32.

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

Golubev A, Hanson AD, Gladyshev VN.

Antioxid Redox Signal. 2018 Oct 1;29(10):1003-1017. doi: 10.1089/ars.2017.7105. Epub 2017 Oct 17.

PMID:
28874059
33.

Molecular signatures of longevity: Insights from cross-species comparative studies.

Ma S, Gladyshev VN.

Semin Cell Dev Biol. 2017 Oct;70:190-203. doi: 10.1016/j.semcdb.2017.08.007. Epub 2017 Aug 8. Review.

34.

Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes.

Kaya A, Mariotti M, Gladyshev VN.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8678-8680. doi: 10.1073/pnas.1710943114. Epub 2017 Aug 1. No abstract available.

35.

Gene expression signatures of human cell and tissue longevity.

Seim I, Ma S, Gladyshev VN.

NPJ Aging Mech Dis. 2016 Jul 7;2:16014. doi: 10.1038/npjamd.2016.14. eCollection 2016.

36.

Translation fidelity coevolves with longevity.

Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V.

Aging Cell. 2017 Oct;16(5):988-993. doi: 10.1111/acel.12628. Epub 2017 Jul 13.

37.

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.

Lee BC, Lee SG, Choo MK, Kim JH, Lee HM, Kim S, Fomenko DE, Kim HY, Park JM, Gladyshev VN.

Sci Rep. 2017 Jul 11;7(1):5119. doi: 10.1038/s41598-017-05230-2.

38.

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L.

Sci Rep. 2017 Jun 29;7(1):4391. doi: 10.1038/s41598-017-04586-9.

39.

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

Salinas G, Gao W, Wang Y, Bonilla M, Yu L, Novikov A, Virginio VG, Ferreira HB, Vieites M, Gladyshev VN, Gambino D, Dai S.

Antioxid Redox Signal. 2017 Dec 20;27(18):1491-1504. doi: 10.1089/ars.2016.6816. Epub 2017 Jun 26.

40.

Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN.

Cell Metab. 2017 Apr 4;25(4):954-960.e6. doi: 10.1016/j.cmet.2017.03.016.

41.

Non-enzymatic molecular damage as a prototypic driver of aging.

Golubev A, Hanson AD, Gladyshev VN.

J Biol Chem. 2017 Apr 14;292(15):6029-6038. doi: 10.1074/jbc.R116.751164. Epub 2017 Mar 6. Review.

42.

Age-associated molecular changes are deleterious and may modulate life span through diet.

Lee SG, Kaya A, Avanesov AS, Podolskiy DI, Song EJ, Go DM, Jin GD, Hwang JY, Kim EB, Kim DY, Gladyshev VN.

Sci Adv. 2017 Feb 17;3(2):e1601833. doi: 10.1126/sciadv.1601833. eCollection 2017 Feb.

43.

Regulated methionine oxidation by monooxygenases.

Manta B, Gladyshev VN.

Free Radic Biol Med. 2017 Aug;109:141-155. doi: 10.1016/j.freeradbiomed.2017.02.010. Epub 2017 Feb 14. Review.

44.

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

Payne NC, Geissler A, Button A, Sasuclark AR, Schroll AL, Ruggles EL, Gladyshev VN, Hondal RJ.

Free Radic Biol Med. 2017 Mar;104:249-261. doi: 10.1016/j.freeradbiomed.2017.01.028. Epub 2017 Jan 17.

45.

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN.

Elife. 2016 Nov 22;5. pii: e19130. doi: 10.7554/eLife.19130.

46.

Position-dependent termination and widespread obligatory frameshifting in Euplotes translation.

Lobanov AV, Heaphy SM, Turanov AA, Gerashchenko MV, Pucciarelli S, Devaraj RR, Xie F, Petyuk VA, Smith RD, Klobutcher LA, Atkins JF, Miceli C, Hatfield DL, Baranov PV, Gladyshev VN.

Nat Struct Mol Biol. 2017 Jan;24(1):61-68. doi: 10.1038/nsmb.3330. Epub 2016 Nov 21.

47.

Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.

Heo JY, Cha HN, Kim KY, Lee E, Kim SJ, Kim YW, Kim JY, Lee IK, Gladyshev VN, Kim HY, Park SY.

Free Radic Res. 2017 Jan;51(1):24-37. doi: 10.1080/10715762.2016.1261133. Epub 2016 Dec 9.

48.

A Disease or Not a Disease? Aging As a Pathology.

Gladyshev TV, Gladyshev VN.

Trends Mol Med. 2016 Dec;22(12):995-996. doi: 10.1016/j.molmed.2016.09.009. Epub 2016 Oct 25.

49.

Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.

Péterfi Z, Tarrago L, Gladyshev VN.

Methods. 2016 Oct 15;109:149-157. doi: 10.1016/j.ymeth.2016.06.022. Epub 2016 Jun 23. Review.

50.

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL, Conrad M.

Redox Biol. 2016 Oct;9:22-31. doi: 10.1016/j.redox.2016.05.003. Epub 2016 May 26.

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