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Items: 1 to 50 of 391

1.

Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and QM/MM Theoretical Investigations into Preferred Fe-NO Ligand Orientations in Myoglobin Distal Pockets.

Wang B, Shi Y, Tejero J, Powell SM, Thomas LM, Gladwin MT, Shiva S, Zhang Y, Richter-Addo GB.

Biochemistry. 2018 Jul 12. doi: 10.1021/acs.biochem.8b00542. [Epub ahead of print]

PMID:
29999305
2.

Metformin Therapy for Pulmonary Hypertension Associated with HFpEF versus PAH.

Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC.

Am J Respir Crit Care Med. 2018 May 4. doi: 10.1164/rccm.201801-0022LE. [Epub ahead of print] No abstract available.

PMID:
29727194
3.

Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning.

Rose JJ, Nouraie M, Gauthier MC, Pizon AF, Saul MI, Donahoe MP, Gladwin MT.

Crit Care Med. 2018 Jul;46(7):e649-e655. doi: 10.1097/CCM.0000000000003135.

PMID:
29629990
4.

Nitric oxide pathology and therapeutics in sickle cell disease.

Kim-Shapiro DB, Gladwin MT.

Clin Hemorheol Microcirc. 2018;68(2-3):223-237. doi: 10.3233/CH-189009.

PMID:
29614634
5.

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.

Huertas A, Guignabert C, Barberà JA, Bärtsch P, Bhattacharya J, Bhattacharya S, Bonsignore MR, Dewachter L, Dinh-Xuan AT, Dorfmüller P, Gladwin MT, Humbert M, Kotsimbos T, Vassilakopoulos T, Sanchez O, Savale L, Testa U, Wilkins MR.

Eur Respir J. 2018 Apr 4;51(4). pii: 1700745. doi: 10.1183/13993003.00745-2017. Print 2018 Apr. Review.

PMID:
29545281
6.

Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction.

Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA.

JAMA Cardiol. 2018 Apr 1;3(4):298-306. doi: 10.1001/jamacardio.2018.0128.

PMID:
29541759
7.

Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.

Helms CC, Gladwin MT, Kim-Shapiro DB.

Front Physiol. 2018 Feb 22;9:125. doi: 10.3389/fphys.2018.00125. eCollection 2018. Review.

8.

Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis.

Groetzinger LM, Miller TJ, Rivosecchi RM, Smith RE, Gladwin MT, Rivera-Lebron BN.

Clin Appl Thromb Hemost. 2018 Jan 1:1076029618755311. doi: 10.1177/1076029618755311. [Epub ahead of print]

PMID:
29455567
9.

Emerging therapeutics in pulmonary hypertension.

Hensley MK, Levine A, Gladwin MT, Lai YC.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L769-L781. doi: 10.1152/ajplung.00259.2017. Epub 2018 Feb 1.

PMID:
29388467
10.

Redefining pulmonary hypertension.

Maron BA, Brittain EL, Choudhary G, Gladwin MT.

Lancet Respir Med. 2018 Mar;6(3):168-170. doi: 10.1016/S2213-2600(17)30498-8. Epub 2017 Dec 18. No abstract available.

PMID:
29269004
11.

Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.

Potoka KP, Wood KC, Baust JJ, Bueno M, Hahn SA, Vanderpool RR, Bachman T, Mallampalli GM, Osei-Hwedieh DO, Schrott V, Sun B, Bullock GC, Becker-Pelster EM, Wittwer M, Stampfuss J, Mathar I, Stasch JP, Truebel H, Sandner P, Mora AL, Straub AC, Gladwin MT.

Am J Respir Cell Mol Biol. 2018 May;58(5):636-647. doi: 10.1165/rcmb.2017-0292OC.

PMID:
29268036
12.

What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?

Willen SM, Gladwin MT.

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):431-434. doi: 10.1182/asheducation-2017.1.431. Review.

PMID:
29222289
13.

Cardiovascular complications in patients with sickle cell disease.

Gladwin MT.

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):423-430. doi: 10.1182/asheducation-2017.1.423. Review.

PMID:
29222288
14.

Under Pressure to Clarify Pulmonary Hypertension Clinical Risk.

Maron BA, Wertheim BM, Gladwin MT.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):423-426. doi: 10.1164/rccm.201711-2306ED. No abstract available.

PMID:
29216444
15.

Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling.

Rochon ER, Corti P, Gladwin MT.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):639-641. doi: 10.1165/rcmb.2017-0272ED. No abstract available.

PMID:
29192832
16.

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.

17.

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.

Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT.

Blood Adv. 2017 Jun 27;1(15):1132-1141. doi: 10.1182/bloodadvances.2017004820.

18.

Cytoglobin at the Crossroads of Vascular Remodeling.

Amdahl MB, DeMartino AW, Tejero J, Gladwin MT.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1803-1805. doi: 10.1161/ATVBAHA.117.310058. No abstract available.

PMID:
28954806
19.

Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts.

Saraf SL, Akingbola TS, Shah BN, Ezekekwu CA, Sonubi O, Zhang X, Hsu LL, Gladwin MT, Machado RF, Cooper RS, Gordeuk VR, Tayo BO.

Blood Adv. 2017 Apr 25;1(11):693-698. doi: 10.1182/bloodadvances.2017005231.

20.

Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek PM, Maul T, Wearden P, Sharma M, Viegas M, Munoz R, Gladwin MT, Bayir H.

Crit Care Med. 2017 Nov;45(11):e1123-e1130. doi: 10.1097/CCM.0000000000002703.

PMID:
28863013
21.

A 53-Year-Old Woman with Severe Carbon Monoxide Poisoning.

Rose JJ, Nolley E, Gladwin MT.

Ann Am Thorac Soc. 2017 Sep;14(9):1475-1478. doi: 10.1513/AnnalsATS.201701-002CC. No abstract available.

PMID:
28862502
22.

Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease.

Milanese C, Tapias V, Gabriels S, Cerri S, Levandis G, Blandini F, Tresini M, Shiva S, Greenamyre JT, Gladwin MT, Mastroberardino PG.

Antioxid Redox Signal. 2018 Jan 1;28(1):44-61. doi: 10.1089/ars.2017.6992. Epub 2017 Sep 21.

PMID:
28816057
23.

Do BRD(4)S of a Feather Flock Together? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease.

Dutta P, Gomez D, Gladwin MT.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1428-1430. doi: 10.1161/ATVBAHA.117.309632. No abstract available.

PMID:
28747456
24.

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT.

Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09016. doi: 10.1161/HYPERTENSIONAHA.117.09016. [Epub ahead of print]

PMID:
28739973
25.

Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System.

Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J.

Biochemistry. 2017 Aug 1;56(30):3993-4004. doi: 10.1021/acs.biochem.7b00224. Epub 2017 Jul 19.

PMID:
28671819
26.

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC.

Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5.

27.

Potential therapeutic action of nitrite in sickle cell disease.

Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB.

Redox Biol. 2017 Aug;12:1026-1039. doi: 10.1016/j.redox.2017.05.006. Epub 2017 May 10.

28.

Reply: Carbon Monoxide Exposure in Workplaces, Including Coffee Processing Facilities.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1081-1082. doi: 10.1164/rccm.201704-0773LE. No abstract available.

PMID:
28471722
29.

Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity.

Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S.

JCI Insight. 2017 Mar 9;2(5):e91415. doi: 10.1172/jci.insight.91415.

30.

Intravascular hemolysis and the pathophysiology of sickle cell disease.

Kato GJ, Steinberg MH, Gladwin MT.

J Clin Invest. 2017 Mar 1;127(3):750-760. doi: 10.1172/JCI89741. Epub 2017 Mar 1. Review.

31.

Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):694-695. doi: 10.1164/rccm.201612-2463LE. No abstract available.

PMID:
28248143
32.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.

PMID:
28173069
33.

Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction.

Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):497-505. doi: 10.1165/rcmb.2016-0177OC.

34.

Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe.

Maitra P, Caughey M, Robinson L, Desai PC, Jones S, Nouraie M, Gladwin MT, Hinderliter A, Cai J, Ataga KI.

Haematologica. 2017 Apr;102(4):626-636. doi: 10.3324/haematol.2016.153791. Epub 2017 Jan 19.

35.

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.

Bennewitz MF, Jimenez MA, Vats R, Tutuncuoglu E, Jonassaint J, Kato GJ, Gladwin MT, Sundd P.

JCI Insight. 2017 Jan 12;2(1):e89761. doi: 10.1172/jci.insight.89761.

36.

Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor.

Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):488-496. doi: 10.1165/rcmb.2016-0176OC.

37.

How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis.

Gladwin MT.

Circulation. 2017 Jan 10;135(2):177-179. doi: 10.1161/CIRCULATIONAHA.116.024752. No abstract available.

38.
39.

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.

Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ.

Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635. Epub 2017 Feb 3. No abstract available.

40.

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A.

Free Radic Biol Med. 2017 Apr;105:48-67. doi: 10.1016/j.freeradbiomed.2016.12.015. Epub 2016 Dec 16. Review.

41.

Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT.

Sci Transl Med. 2016 Dec 7;8(368):368ra173.

42.

Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.

Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J 3rd, Parsley EL, Gladwin MT.

JCI Insight. 2016 Nov 3;1(18):e89620.

43.
44.

Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):596-606. doi: 10.1164/rccm.201606-1275CI. Review. Erratum in: Am J Respir Crit Care Med. 2017 Aug 1;196 (3):398-399.

45.

Automated Measurement of Blood Vessels in Tissues from Microscopy Images.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD.

Curr Protoc Cytom. 2016 Oct 10;78:12.44.1-12.44.13. doi: 10.1002/cpcy.10.

PMID:
27723088
46.

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years' experience.

Makubi A, Mmbando BP, Novelli EM, Lwakatare J, Soka D, Marik H, Tibarazwa K, Ngaeje M, Newton CR, Gladwin MT, Makani J.

Br J Haematol. 2017 Jun;177(6):930-937. doi: 10.1111/bjh.14330. Epub 2016 Sep 21.

47.

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC.

J Proteome Res. 2016 Oct 7;15(10):3883-3895. Epub 2016 Sep 27.

48.

Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.

Osei-Hwedieh DO, Kanias T, Croix CS, Jessup M, Xiong Z, Sinchar D, Franks J, Xu Q, M Novelli E, Sertorio JT, Potoka K, Binder RJ, Basu S, Belanger AM, Kim-Shapiro DB, Triulzi D, Lee JS, Gladwin MT.

EBioMedicine. 2016 Sep;11:239-248. doi: 10.1016/j.ebiom.2016.08.006. Epub 2016 Aug 4.

49.

Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease.

Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, Waterman HR, de Wolski KS, Acker JP, Gladwin MT.

Transfusion. 2016 Oct;56(10):2571-2583. doi: 10.1111/trf.13745. Epub 2016 Aug 9.

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