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Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease.

Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez E, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P.

Am J Respir Crit Care Med. 2019 Sep 9. doi: 10.1164/rccm.201807-1370OC. [Epub ahead of print]


Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.

Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, Kato GJ, Knight-Madden J, Kopp BT, Koumbourlis AC, Lanzkron SM, Liem RI, Machado RF, Mehari A, Morris CR, Ogunlesi FO, Rosen CL, Smith-Whitley K, Tauber D, Terry N, Thein SL, Vichinsky E, Weir NA, Cohen RT, Klings ES.

Ann Am Thorac Soc. 2019 Sep;16(9):e17-e32. doi: 10.1513/AnnalsATS.201906-433ST.


Validation of a composite vascular high risk profile for adult patients with sickle cell disease.

Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT.

Am J Hematol. 2019 Aug 23. doi: 10.1002/ajh.25624. [Epub ahead of print] No abstract available.


The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution.

Amdahl MB, Petersen EE, Bocian K, Kaliszuk SJ, DeMartino AW, Tiwari S, Sparacino-Watkins CE, Corti P, Rose JJ, Gladwin MT, Fago A, Tejero J.

Biochemistry. 2019 Jul 23;58(29):3212-3223. doi: 10.1021/acs.biochem.9b00406. Epub 2019 Jul 10.


Current good manufacturing practices-compliant manufacture and measurement of biotin-labeled red blood cells.

Donnenberg AD, Kanias T, Triulzi DJ, Dennis CJ, Moore LR, Meyer EM, Sinchar D, Kiss JE, Normolle DP, Gladwin MT.

Cytotherapy. 2019 Jul;21(7):793-800. doi: 10.1016/j.jcyt.2019.04.052. Epub 2019 May 14.


Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.

Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20.


Effects of aged stored autologous red blood cells on human plasma metabolome.

D'Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi DJ, Donadee C, Barge S, Badlam J, Jain S, Risbano MG, Gladwin MT.

Blood Adv. 2019 Mar 26;3(6):884-896. doi: 10.1182/bloodadvances.2018029629.


Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.

de Jesus DS, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, Kaufman BA, Gladwin MT, Pagano PJ.

Redox Biol. 2019 Apr;22:101138. doi: 10.1016/j.redox.2019.101138. Epub 2019 Feb 8.


Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage.

Stone M, Keating SM, Kanias T, Lanteri MC, Lebedeva M, Sinchar D, Hampton D, Jakub A, Rychka V, Brewer G, Bakkour S, Gefter N, Murcia K, Page GP, Endres-Dighe S, Bialkowski W, Fu X, Zimring J, Raife TJ, Kleinman S, Gladwin MT, Busch MP; National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Program.

Transfusion. 2019 Jan;59(1):57-66. doi: 10.1111/trf.15099. Epub 2018 Dec 19.


Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction.

Lai YC, Wang L, Gladwin MT.

J Physiol. 2019 Feb;597(4):1143-1156. doi: 10.1113/JP275858. Epub 2018 Dec 30.


Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.

Kanias T, Stone M, Page GP, Guo Y, Endres-Dighe SM, Lanteri MC, Spencer BR, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Gladwin MT, Busch MP, Mast AE; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program.

Transfusion. 2019 Jan;59(1):67-78. doi: 10.1111/trf.14998. Epub 2018 Nov 26.


Erythrocytic bioactivation of nitrite and its potentiation by far-red light.

Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB.

Redox Biol. 2019 Jan;20:442-450. doi: 10.1016/j.redox.2018.11.001. Epub 2018 Nov 3.


Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study.

Lanteri MC, Kanias T, Keating S, Stone M, Guo Y, Page GP, Brambilla DJ, Endres-Dighe SM, Mast AE, Bialkowski W, D'Andrea P, Cable RG, Spencer BR, Triulzi DJ, Murphy EL, Kleinman S, Gladwin MT, Busch MP; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program.

Transfusion. 2019 Jan;59(1):79-88. doi: 10.1111/trf.14987. Epub 2018 Nov 8.


Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival.

Blaine KP, Cortés-Puch I, Sun J, Wang D, Solomon SB, Feng J, Gladwin MT, Kim-Shapiro DB, Basu S, Perlegas A, West K, Klein HG, Natanson C.

Transfusion. 2019 Jan;59(1):347-358. doi: 10.1111/trf.14997. Epub 2018 Nov 1.


Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero J, Shiva S, Gladwin MT.

Physiol Rev. 2019 Jan 1;99(1):311-379. doi: 10.1152/physrev.00036.2017. Review.


Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2019 Jan;59(1):89-100. doi: 10.1111/trf.14979. Epub 2018 Oct 24.


Pathophysiology of Sickle Cell Disease.

Sundd P, Gladwin MT, Novelli EM.

Annu Rev Pathol. 2019 Jan 24;14:263-292. doi: 10.1146/annurev-pathmechdis-012418-012838. Epub 2018 Oct 17.


Escorting α-globin to eNOS: α-globin-stabilizing protein paves the way.

Straub AC, Gladwin MT.

J Clin Invest. 2018 Nov 1;128(11):4755-4757. doi: 10.1172/JCI124302. Epub 2018 Oct 8.


Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities.

Endres-Dighe SM, Guo Y, Kanias T, Lanteri M, Stone M, Spencer B, Cable RG, Kiss JE, Kleinman S, Gladwin MT, Brambilla DJ, D'Andrea P, Triulzi DJ, Mast AE, Page GP, Busch MP; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program.

Transfusion. 2019 Jan;59(1):46-56. doi: 10.1111/trf.14971. Epub 2018 Sep 28.


Haptoglobin improves shock, lung injury, and survival in canine pneumonia.

Remy KE, Cortés-Puch I, Solomon SB, Sun J, Pockros BM, Feng J, Lertora JJ, Hantgan RR, Liu X, Perlegas A, Warren HS, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C.

JCI Insight. 2018 Sep 20;3(18). pii: 123013. doi: 10.1172/jci.insight.123013. eCollection 2018 Sep 20.


Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Levine AR, Simon MA, Gladwin MT.

Trends Cardiovasc Med. 2019 May;29(4):207-217. doi: 10.1016/j.tcm.2018.08.005. Epub 2018 Aug 17. Review.


Sleep phenotype in the Townes mouse model of sickle cell disease.

O'Donnell BJ, Guo L, Ghosh S, Shah FA, Strollo PJ Jr, McVerry BJ, Gladwin MT, Ofori-Acquah SF, Kato GJ, O'Donnell CP.

Sleep Breath. 2019 Mar;23(1):333-339. doi: 10.1007/s11325-018-1711-x. Epub 2018 Aug 29.


Nitrite and nitrate chemical biology and signalling.

DeMartino AW, Kim-Shapiro DB, Patel RP, Gladwin MT.

Br J Pharmacol. 2019 Jan;176(2):228-245. doi: 10.1111/bph.14484. Epub 2018 Oct 3. Review.


Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease.

Raslan R, Shah BN, Zhang X, Kanias T, Han J, Machado RF, Gladwin MT, Gordeuk VR, Saraf SL.

Am J Hematol. 2018 Nov;93(11):E376-E380. doi: 10.1002/ajh.25258. Epub 2018 Oct 17. No abstract available.


Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply.

Simon MA, Nouraie M, Gladwin MT.

JAMA Cardiol. 2018 Oct 1;3(10):1023-1024. doi: 10.1001/jamacardio.2018.1936. No abstract available.


Hemolysis-mediated Toxicity during Cardiopulmonary Bypass Ameliorated by Inhaled Nitric Oxide Gas.

Satoh T, Xu Q, Wang L, Gladwin MT.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1244-1246. doi: 10.1164/rccm.201806-1165ED. No abstract available.


Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Bilan VP, Schneider F, Novelli EM, Kelley EE, Shiva S, Gladwin MT, Jackson EK, Tofovic SP.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018791557. doi: 10.1177/2045894018791557. Epub 2018 Jul 13.


Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets.

Wang B, Shi Y, Tejero J, Powell SM, Thomas LM, Gladwin MT, Shiva S, Zhang Y, Richter-Addo GB.

Biochemistry. 2018 Aug 14;57(32):4788-4802. doi: 10.1021/acs.biochem.8b00542. Epub 2018 Jul 27.


Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.

Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):681-684. doi: 10.1164/rccm.201801-0022LE. No abstract available.


Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning.

Rose JJ, Nouraie M, Gauthier MC, Pizon AF, Saul MI, Donahoe MP, Gladwin MT.

Crit Care Med. 2018 Jul;46(7):e649-e655. doi: 10.1097/CCM.0000000000003135.


Nitric oxide pathology and therapeutics in sickle cell disease.

Kim-Shapiro DB, Gladwin MT.

Clin Hemorheol Microcirc. 2018;68(2-3):223-237. doi: 10.3233/CH-189009.


Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.

Huertas A, Guignabert C, Barberà JA, Bärtsch P, Bhattacharya J, Bhattacharya S, Bonsignore MR, Dewachter L, Dinh-Xuan AT, Dorfmüller P, Gladwin MT, Humbert M, Kotsimbos T, Vassilakopoulos T, Sanchez O, Savale L, Testa U, Wilkins MR.

Eur Respir J. 2018 Apr 4;51(4). pii: 1700745. doi: 10.1183/13993003.00745-2017. Print 2018 Apr. Review.


Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction.

Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA.

JAMA Cardiol. 2018 Apr 1;3(4):298-306. doi: 10.1001/jamacardio.2018.0128.


Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.

Helms CC, Gladwin MT, Kim-Shapiro DB.

Front Physiol. 2018 Feb 22;9:125. doi: 10.3389/fphys.2018.00125. eCollection 2018. Review.


Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis.

Groetzinger LM, Miller TJ, Rivosecchi RM, Smith RE, Gladwin MT, Rivera-Lebron BN.

Clin Appl Thromb Hemost. 2018 Sep;24(6):908-913. doi: 10.1177/1076029618755311. Epub 2018 Feb 18.


Emerging therapeutics in pulmonary hypertension.

Hensley MK, Levine A, Gladwin MT, Lai YC.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L769-L781. doi: 10.1152/ajplung.00259.2017. Epub 2018 Feb 1. Review.


Redefining pulmonary hypertension.

Maron BA, Brittain EL, Choudhary G, Gladwin MT.

Lancet Respir Med. 2018 Mar;6(3):168-170. doi: 10.1016/S2213-2600(17)30498-8. Epub 2017 Dec 18. No abstract available.


Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.

Potoka KP, Wood KC, Baust JJ, Bueno M, Hahn SA, Vanderpool RR, Bachman T, Mallampalli GM, Osei-Hwedieh DO, Schrott V, Sun B, Bullock GC, Becker-Pelster EM, Wittwer M, Stampfuss J, Mathar I, Stasch JP, Truebel H, Sandner P, Mora AL, Straub AC, Gladwin MT.

Am J Respir Cell Mol Biol. 2018 May;58(5):636-647. doi: 10.1165/rcmb.2017-0292OC.


What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?

Willen SM, Gladwin MT.

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):431-434. doi: 10.1182/asheducation-2017.1.431. Review.


Cardiovascular complications in patients with sickle cell disease.

Gladwin MT.

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):423-430. doi: 10.1182/asheducation-2017.1.423. Review.


Under Pressure to Clarify Pulmonary Hypertension Clinical Risk.

Maron BA, Wertheim BM, Gladwin MT.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):423-426. doi: 10.1164/rccm.201711-2306ED. No abstract available.


Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling.

Rochon ER, Corti P, Gladwin MT.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):639-641. doi: 10.1165/rcmb.2017-0272ED. No abstract available.


The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.


Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.

Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT.

Blood Adv. 2017 Jun 27;1(15):1132-1141. doi: 10.1182/bloodadvances.2017004820.


Cytoglobin at the Crossroads of Vascular Remodeling.

Amdahl MB, DeMartino AW, Tejero J, Gladwin MT.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1803-1805. doi: 10.1161/ATVBAHA.117.310058. No abstract available.


Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts.

Saraf SL, Akingbola TS, Shah BN, Ezekekwu CA, Sonubi O, Zhang X, Hsu LL, Gladwin MT, Machado RF, Cooper RS, Gordeuk VR, Tayo BO.

Blood Adv. 2017 Apr 25;1(11):693-698. doi: 10.1182/bloodadvances.2017005231.


Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek PM, Maul T, Wearden P, Sharma M, Viegas M, Munoz R, Gladwin MT, Bayir H.

Crit Care Med. 2017 Nov;45(11):e1123-e1130. doi: 10.1097/CCM.0000000000002703.


A 53-Year-Old Woman with Severe Carbon Monoxide Poisoning.

Rose JJ, Nolley E, Gladwin MT.

Ann Am Thorac Soc. 2017 Sep;14(9):1475-1478. doi: 10.1513/AnnalsATS.201701-002CC. No abstract available.


Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease.

Milanese C, Tapias V, Gabriels S, Cerri S, Levandis G, Blandini F, Tresini M, Shiva S, Greenamyre JT, Gladwin MT, Mastroberardino PG.

Antioxid Redox Signal. 2018 Jan 1;28(1):44-61. doi: 10.1089/ars.2017.6992. Epub 2017 Sep 21.

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