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Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy.

Cao X, Rao Allu S, Jiang S, Jia M, Gunn JR, Yao C, LaRochelle EP, Shell JR, Bruza P, Gladstone DJ, Jarvis LA, Tian J, Vinogradov SA, Pogue BW.

Nat Commun. 2020 Jan 29;11(1):573. doi: 10.1038/s41467-020-14415-9.


Isohemagglutinin titering performed on an automated solid-phase and hemagglutinin-based analyzer is comparable to results obtained by manual gel testing.

Lally K, Kruse RL, Smetana H, Davis R, Roots A, Marshall C, Ness PM, DeZern AE, Gladstone DE, Brennan DC, Desai NM, Tobian AAR, Bloch EM, Gehrie EA.

Transfusion. 2020 Jan 20. doi: 10.1111/trf.15671. [Epub ahead of print]


Atrial Cardiopathy and Nonstenosing Large Artery Plaque in Patients With Embolic Stroke of Undetermined Source.

Kamel H, Pearce LA, Ntaios G, Gladstone DJ, Perera K, Roine RO, Meseguer E, Shoamanesh A, Berkowitz SD, Mundl H, Sharma M, Connolly SJ, Hart RG, Healey JS.

Stroke. 2020 Mar;51(3):938-943. doi: 10.1161/STROKEAHA.119.028154. Epub 2020 Jan 2.


Reinitiation of Anticoagulation After Surgical Evacuation of Subdural Hematomas.

Nassiri F, Hachem LD, Wang JZ, Badhiwala JH, Zadeh G, Gladstone D, Scales DC, Pirouzmand F.

World Neurosurg. 2019 Dec 23. pii: S1878-8750(19)33109-2. doi: 10.1016/j.wneu.2019.12.080. [Epub ahead of print]


Reclassification of Ischemic Stroke Etiological Subtypes on the Basis of High-Risk Nonstenosing Carotid Plaque.

Kamel H, Navi BB, Merkler AE, Baradaran H, Díaz I, Parikh NS, Kasner SE, Gladstone DJ, Iadecola C, Gupta A.

Stroke. 2020 Feb;51(2):504-510. doi: 10.1161/STROKEAHA.119.027970. Epub 2019 Dec 18.


Optical imaging method to quantify spatial dose variation due to the electron return effect in an MR-linac.

Andreozzi JM, Brůža P, Cammin J, Pogue BW, Gladstone DJ, Green O.

Med Phys. 2019 Dec 10. doi: 10.1002/mp.13954. [Epub ahead of print]


Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration.

Schnabel RB, Haeusler KG, Healey JS, Freedman B, Boriani G, Brachmann J, Brandes A, Bustamante A, Casadei B, Crijns HJGM, Doehner W, Engström G, Fauchier L, Friberg L, Gladstone DJ, Glotzer TV, Goto S, Hankey GJ, Harbison JA, Hobbs FDR, Johnson LSB, Kamel H, Kirchhof P, Korompoki E, Krieger DW, Lip GYH, Løchen ML, Mairesse GH, Montaner J, Neubeck L, Ntaios G, Piccini JP, Potpara TS, Quinn TJ, Reiffel JA, Ribeiro ALP, Rienstra M, Rosenqvist M, Themistoclakis S, Sinner MF, Svendsen JH, Van Gelder IC, Wachter R, Wijeratne T, Yan B.

Circulation. 2019 Nov 26;140(22):1834-1850. doi: 10.1161/CIRCULATIONAHA.119.040267. Epub 2019 Nov 25. Erratum in: Circulation. 2020 Feb 25;141(8):e99.


Prevalence of undiagnosed atrial fibrillation in elderly individuals and potential cost-effectiveness of non-invasive ambulatory electrocardiographic screening: The ASSERT-III study.

McIntyre WF, Yong JHE, Sandhu RK, Gladstone DJ, Simek K, Liu YY, Quinn FR, Tytus R, Zizzo D, Henein S, Ivers N, Healey JS.

J Electrocardiol. 2020 Jan - Feb;58:56-60. doi: 10.1016/j.jelectrocard.2019.11.040. Epub 2019 Nov 9.


Correction to: White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximab.

Estephan F, Ye X, Dzaye O, Wagner-Johnston N, Swinnen L, Gladstone DE, Ambinder R, Kamson DO, Lambrecht S, Grossman SA, Lin DDM, Holdhoff M.

J Neurooncol. 2019 Dec;145(3):467. doi: 10.1007/s11060-019-03346-1.


Allogeneic Haploidentical Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide in Chronic Lymphocytic Leukemia.

Paul S, Tsai HL, Lowery P, Fuchs EJ, Luznik L, Bolaños-Meade J, Swinnen LJ, Shanbhag S, Wagner-Johnston N, Varadhan R, Ambinder RF, Jones RJ, Gladstone DE.

Biol Blood Marrow Transplant. 2020 Mar;26(3):502-508. doi: 10.1016/j.bbmt.2019.11.008. Epub 2019 Nov 12.


Left Atrial Enlargement Could Be Detected on Extended Computed Tomography Angiography Within Initial Stroke Assessment-Reply.

Healey JS, Gladstone DJ, Hart RG.

JAMA Neurol. 2019 Nov 11. doi: 10.1001/jamaneurol.2019.3794. [Epub ahead of print] No abstract available.


Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy.

Tendler II, Hartford A, Jermyn M, LaRochelle E, Cao X, Borza V, Alexander D, Bruza P, Hoopes J, Moodie K, Marr BP, Williams BB, Pogue BW, Gladstone DJ, Jarvis LA.

Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):422-429. doi: 10.1016/j.ijrobp.2019.10.031. Epub 2019 Oct 25.


White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximab.

Estephan F, Ye X, Dzaye O, Wagner-Johnston N, Swinnen L, Gladstone DE, Ambinder R, Kamson DO, Lambrecht S, Grossman SA, Lin DDM, Holdhoff M.

J Neurooncol. 2019 Dec;145(3):461-466. doi: 10.1007/s11060-019-03279-9. Epub 2019 Oct 16. Erratum in: J Neurooncol. 2019 Nov 22;:.


Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor.

Brůža P, Pétusseau A, Tisa S, Jermyn M, Jarvis LA, Gladstone DJ, Pogue BW.

Opt Lett. 2019 Sep 15;44(18):4546-4549. doi: 10.1364/OL.44.004546.


Checkpoint inhibitor-induced autoimmune encephalitis reversed by rituximab after allogeneic bone marrow transplant in a patient with Hodgkin lymphoma.

Thummalapalli R, Sena LA, Probasco JC, Gladstone DE.

Leuk Lymphoma. 2020 Jan;61(1):228-230. doi: 10.1080/10428194.2019.1658104. Epub 2019 Sep 10. No abstract available.


Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70.

Imus PH, Tsai HL, Luznik L, Fuchs EJ, Huff CA, Gladstone DE, Lowery P, Ambinder RF, Borrello IM, Swinnen LJ, Wagner-Johnston N, Gocke CB, Ali SA, Bolaños-Meade FJ, Varadhan R, Jones RJ.

Blood Adv. 2019 Sep 10;3(17):2608-2616. doi: 10.1182/bloodadvances.2019000155.


Optical imaging provides rapid verification of static small beams, radiosurgery, and VMAT plans with millimeter resolution.

Ashraf MR, Bruza P, Pogue BW, Nelson N, Williams BB, Jarvis LA, Gladstone DJ.

Med Phys. 2019 Nov;46(11):5227-5237. doi: 10.1002/mp.13797. Epub 2019 Oct 4.


Effect of Recombinant Activated Coagulation Factor VII on Hemorrhage Expansion Among Patients With Spot Sign-Positive Acute Intracerebral Hemorrhage: The SPOTLIGHT and STOP-IT Randomized Clinical Trials.

Gladstone DJ, Aviv RI, Demchuk AM, Hill MD, Thorpe KE, Khoury JC, Sucharew HJ, Al-Ajlan F, Butcher K, Dowlatshahi D, Gubitz G, De Masi S, Hall J, Gregg D, Mamdani M, Shamy M, Swartz RH, Del Campo CM, Cucchiara B, Panagos P, Goldstein JN, Carrozzella J, Jauch EC, Broderick JP, Flaherty ML; SPOTLIGHT and STOP-IT Investigators and Coordinators.

JAMA Neurol. 2019 Aug 19. doi: 10.1001/jamaneurol.2019.2636. [Epub ahead of print]


Severe Cytokine Release Syndrome after Haploidentical Peripheral Blood Stem Cell Transplantation.

Imus PH, Blackford AL, Bettinotti M, Luznik L, Fuchs EJ, Huff CA, Gladstone DE, Ambinder RF, Borrello IM, Fuchs RJ, Swinnen LJ, Wagner-Johnston N, Gocke CB, Ali SA, Bolaños-Meade FJ, Jones RJ, Dezern AE.

Biol Blood Marrow Transplant. 2019 Dec;25(12):2431-2437. doi: 10.1016/j.bbmt.2019.07.027. Epub 2019 Aug 5.


Improvements to an optical scintillator imaging-based tissue dosimetry system.

Tendler II, Bruza P, Jermyn M, Fleury A, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ.

J Biomed Opt. 2019 Jul;24(7):1-6. doi: 10.1117/1.JBO.24.7.075001.


Fibrinogen consumption and use of heparin are risk factors for delayed bleeding during acute promyelocytic leukemia induction.

Hambley BC, Norsworthy KJ, Jasem J, Zimmerman JW, Shenderov E, Webster JA, Showel MM, Gondek LP, Dalton WB, Prince G, Gladstone DE, Streiff MB, Pratz KW, Gojo I, Ghiaur G, Levis MJ, Smith BD, DeZern AE.

Leuk Res. 2019 Aug;83:106174. doi: 10.1016/j.leukres.2019.106174. Epub 2019 Jun 21. No abstract available.


Prolonged Cardiac Rhythm Monitoring and Secondary Stroke Prevention in Patients With Cryptogenic Cerebral Ischemia.

Tsivgoulis G, Katsanos AH, Grory BM, Köhrmann M, Ricci BA, Tsioufis K, Cutting S, Krogias C, Schellinger PD, Campello AR, Cuadrado-Godia E, Gladstone DJ, Sanna T, Wachter R, Furie K, Alexandrov AV, Yaghi S.

Stroke. 2019 Aug;50(8):2175-2180. doi: 10.1161/STROKEAHA.119.025169. Epub 2019 Jun 20.


Technical Note: Quality assurance and relative dosimetry testing of a 60 Co total body irradiator using optical imaging.

Tendler II, Bredfeldt JS, Zhang R, Bruza P, Jermyn M, Pogue BW, Gladstone DJ.

Med Phys. 2019 Aug;46(8):3674-3678. doi: 10.1002/mp.13637. Epub 2019 Jun 25.


Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy.

Alexander DA, Tendler II, Bruza P, Cao X, Schaner PE, Marshall BS, Jarvis LA, Gladstone DJ, Pogue BW.

Phys Med Biol. 2019 Jul 18;64(14):145021. doi: 10.1088/1361-6560/ab25a3.


Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy.

Tendler II, Bruza P, Jermyn M, Cao X, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ.

Phys Med Biol. 2019 Jun 21;64(12):125025. doi: 10.1088/1361-6560/ab1d8a.


Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry.

Jia MJ, Bruza P, Andreozzi JM, Jarvis LA, Gladstone DJ, Pogue BW.

Med Phys. 2019 Jul;46(7):3067-3077. doi: 10.1002/mp.13545. Epub 2019 May 18.


Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation: Secondary Analysis of the NAVIGATE ESUS Randomized Clinical Trial.

Healey JS, Gladstone DJ, Swaminathan B, Eckstein J, Mundl H, Epstein AE, Haeusler KG, Mikulik R, Kasner SE, Toni D, Arauz A, Ntaios G, Hankey GJ, Perera K, Pagola J, Shuaib A, Lutsep H, Yang X, Uchiyama S, Endres M, Coutts SB, Karlinski M, Czlonkowska A, Molina CA, Santo G, Berkowitz SD, Hart RG, Connolly SJ.

JAMA Neurol. 2019 Jul 1;76(7):764-773. doi: 10.1001/jamaneurol.2019.0617.


Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging.

Pogue BW, Feng J, LaRochelle EP, Bruža P, Lin H, Zhang R, Shell JR, Dehghani H, Davis SC, Vinogradov SA, Gladstone DJ, Jarvis LA.

Nat Biomed Eng. 2018 Apr;2(4):254-264. doi: 10.1038/s41551-018-0220-3. Epub 2018 Apr 13.


Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial.

Bolaños-Meade J, Cooke KR, Gamper CJ, Ali SA, Ambinder RF, Borrello IM, Fuchs EJ, Gladstone DE, Gocke CB, Huff CA, Luznik L, Swinnen LJ, Symons HJ, Terezakis SA, Wagner-Johnston N, Jones RJ, Brodsky RA.

Lancet Haematol. 2019 Apr;6(4):e183-e193. doi: 10.1016/S2352-3026(19)30031-6. Epub 2019 Mar 14. Erratum in: Lancet Haematol. 2019 May;6(5):e238.


Comparison of phosphorescent agents for noninvasive sensing of tumor oxygenation via Cherenkov-excited luminescence imaging.

Shell J, LaRochelle EP, Bruza P, Gunn J, Jarvis L, Gladstone D, Pogue B.

J Biomed Opt. 2019 Mar;24(3):1-8. doi: 10.1117/1.JBO.24.3.036001.


First application of a Spanish version simplified modified Rankin Scale questionnaire.

Bruno A, Sethuraman S, Sedler MJ, Gladstone D, Cagino K, Del Brutto VJ, Sarmiento-Bobadilla M, Costa AF, Del Brutto OH.

Int J Stroke. 2019 Jul;14(5):NP12. doi: 10.1177/1747493019832983. Epub 2019 Feb 21. No abstract available.


Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.

Jia MJ, Bruza P, Jarvis LA, Gladstone DJ, Pogue BW.

Biomed Opt Express. 2018 Aug 14;9(9):4217-4234. doi: 10.1364/BOE.9.004217. eCollection 2018 Sep 1.


Development of Grade II Acute Graft-versus-Host Disease Is Associated with Improved Survival after Myeloablative HLA-Matched Bone Marrow Transplantation using Single-Agent Post-Transplant Cyclophosphamide.

McCurdy SR, Kanakry CG, Tsai HL, Gojo I, Smith BD, Gladstone DE, Bolaños-Meade J, Borrello I, Matsui WH, Swinnen LJ, Huff CA, Brodsky RA, Ambinder RF, Fuchs EJ, Rosner GL, Jones RJ, Luznik L.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1128-1135. doi: 10.1016/j.bbmt.2018.12.767. Epub 2018 Dec 30.


Robustness Analysis for External Beam Radiation Therapy Treatment Plans: Describing Uncertainty Scenarios and Reporting Their Dosimetric Consequences.

Yock AD, Mohan R, Flampouri S, Bosch W, Taylor PA, Gladstone D, Kim S, Sohn J, Wallace R, Xiao Y, Buchsbaum J.

Pract Radiat Oncol. 2019 Jul - Aug;9(4):200-207. doi: 10.1016/j.prro.2018.12.002. Epub 2018 Dec 15. Review.


Technical Note: Time-gating to medical linear accelerator pulses: Stray radiation detector.

Ashraf MR, Bruza P, Krishnaswamy V, Gladstone DJ, Pogue BW.

Med Phys. 2019 Feb;46(2):1044-1048. doi: 10.1002/mp.13311. Epub 2018 Dec 14.


Cherenkov imaging for linac beam shape analysis as a remote electronic quality assessment verification tool.

Miao T, Bruza P, Pogue BW, Jermyn M, Krishnaswamy V, Ware W, Rafie F, Gladstone DJ, Williams BB.

Med Phys. 2019 Feb;46(2):811-821. doi: 10.1002/mp.13303. Epub 2018 Dec 14.


Rapid Multisite Remote Surface Dosimetry for Total Skin Electron Therapy: Scintillator Target Imaging.

Tendler I, Brůža P, Andreozzi J, Jermyn M, Williams B, Jarvis L, Pogue B, Gladstone D.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):767-774. doi: 10.1016/j.ijrobp.2018.10.030. Epub 2018 Nov 10.


Correcting Cherenkov light attenuation in tissue using spatial frequency domain imaging for quantitative surface dosimetry during whole breast radiation therapy.

Hachadorian R, Bruza P, Jermyn M, Mazhar A, Cuccia D, Jarvis L, Gladstone D, Pogue B.

J Biomed Opt. 2018 Nov;24(7):1-10. doi: 10.1117/1.JBO.24.7.071609.


2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation.

Andrade JG, Verma A, Mitchell LB, Parkash R, Leblanc K, Atzema C, Healey JS, Bell A, Cairns J, Connolly S, Cox J, Dorian P, Gladstone D, McMurtry MS, Nair GM, Pilote L, Sarrazin JF, Sharma M, Skanes A, Talajic M, Tsang T, Verma S, Wyse DG, Nattel S, Macle L; CCS Atrial Fibrillation Guidelines Committee.

Can J Cardiol. 2018 Nov;34(11):1371-1392. doi: 10.1016/j.cjca.2018.08.026. Review.


ABVD plus rituximab versus ABVD alone for advanced stage, high-risk classical Hodgkin lymphoma: a randomized phase 2 study.

Strati P, Fanale MA, Oki Y, Turturro F, Fayad LE, Bartlett NL, Gladstone DE, Kasamon YL, Portlock CS, Wilson WH, Goy A, Younes A, Lee HJ.

Haematologica. 2019 Feb;104(2):e65-e67. doi: 10.3324/haematol.2018.199844. Epub 2018 Sep 6. No abstract available.


Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide.

Schoch LK, Cooke KR, Wagner-Johnston ND, Gojo I, Swinnen LJ, Imus P, Fuchs EJ, Levis M, Ambinder RF, Jones RJ, Gladstone DE.

Blood Adv. 2018 Sep 11;2(17):2226-2229. doi: 10.1182/bloodadvances.2018019208.


Is Screening for Atrial Fibrillation in Canadian Family Practices Cost-Effective in Patients 65 Years and Older?

Tarride JE, Quinn FR, Blackhouse G, Sandhu RK, Burke N, Gladstone DJ, Ivers NM, Dolovich L, Thornton A, Nakamya J, Ramasundarahettige C, Frydrych PA, Henein S, Ng K, Congdon V, Birtwhistle RV, Ward R, Healey JS.

Can J Cardiol. 2018 Nov;34(11):1522-1525. doi: 10.1016/j.cjca.2018.05.016. Epub 2018 Jun 21.


Diagnostic accuracy and yield of screening tests for atrial fibrillation in the family practice setting: a multicentre cohort study.

Quinn FR, Gladstone DJ, Ivers NM, Sandhu RK, Dolovich L, Ling A, Nakamya J, Ramasundarahettige C, Frydrych PA, Henein S, Ng K, Congdon V, Birtwhistle RV, Ward R, Healey JS.

CMAJ Open. 2018 Aug 2;6(3):E308-E315. doi: 10.9778/cmajo.20180001. Print 2018 Jul-Sep.


Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia.

Kreitman RJ, Dearden C, Zinzani PL, Delgado J, Karlin L, Robak T, Gladstone DE, le Coutre P, Dietrich S, Gotic M, Larratt L, Offner F, Schiller G, Swords R, Bacon L, Bocchia M, Bouabdallah K, Breems DA, Cortelezzi A, Dinner S, Doubek M, Gjertsen BT, Gobbi M, Hellmann A, Lepretre S, Maloisel F, Ravandi F, Rousselot P, Rummel M, Siddiqi T, Tadmor T, Troussard X, Yi CA, Saglio G, Roboz GJ, Balic K, Standifer N, He P, Marshall S, Wilson W, Pastan I, Yao NS, Giles F.

Leukemia. 2018 Aug;32(8):1768-1777. doi: 10.1038/s41375-018-0210-1. Epub 2018 Jul 20.


Early Fever after Haploidentical Bone Marrow Transplantation Correlates with Class II HLA-Mismatching and Myeloablation but Not Outcomes.

McCurdy SR, Muth ST, Tsai HL, Symons HJ, Huff CA, Matsui WH, Borrello I, Gladstone DE, Swinnen LJ, Cooke KR, Brodsky RA, Bolaños-Meade J, Ambinder RF, Varadhan R, Luznik L, Jones RJ, Bettinot MP, Fuchs EJ.

Biol Blood Marrow Transplant. 2018 Oct;24(10):2056-2064. doi: 10.1016/j.bbmt.2018.06.004. Epub 2018 Jun 15.


Remote Cherenkov imaging-based quality assurance of a magnetic resonance image-guided radiotherapy system.

Andreozzi JM, Mooney KE, Brůža P, Curcuru A, Gladstone DJ, Pogue BW, Green O.

Med Phys. 2018 Jun;45(6):2647-2659. doi: 10.1002/mp.12919. Epub 2018 May 3.


Improving treatment geometries in total skin electron therapy: Experimental investigation of linac angles and floor scatter dose contributions using Cherenkov imaging.

Andreozzi JM, Brůža P, Tendler II, Mooney KE, Jarvis LA, Cammin J, Li H, Pogue BW, Gladstone DJ.

Med Phys. 2018 Jun;45(6):2639-2646. doi: 10.1002/mp.12917. Epub 2018 May 6.


Inverse relationship between the evans index and cognitive performance in non-disabled, stroke-free, community-dwelling older adults. A population-based study.

Del Brutto OH, Mera RM, Gladstone D, Sarmiento-Bobadilla M, Cagino K, Zambrano M, Costa AF, Sedler MJ.

Clin Neurol Neurosurg. 2018 Jun;169:139-143. doi: 10.1016/j.clineuro.2018.03.021. Epub 2018 Mar 30.


Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation.

Hoopes PJ, Wagner RJ, Duval K, Kang K, Gladstone DJ, Moodie KL, Crary-Burney M, Ariaspulido H, Veliz FA, Steinmetz NF, Fiering SN.

Mol Pharm. 2018 Sep 4;15(9):3717-3722. doi: 10.1021/acs.molpharmaceut.8b00126. Epub 2018 Apr 12.


Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy.

Bruza P, Gollub SL, Andreozzi JM, Tendler II, Williams BB, Jarvis LA, Gladstone DJ, Pogue BW.

Phys Med Biol. 2018 May 2;63(9):095009. doi: 10.1088/1361-6560/aaba19.

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