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Items: 46


Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery.

Chen W, Glackin CA, Horwitz MA, Zink JI.

Acc Chem Res. 2019 Jun 18;52(6):1531-1542. doi: 10.1021/acs.accounts.9b00116. Epub 2019 May 13.


Protein kinase Cα-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it.

Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G.

J Biol Chem. 2019 Mar 29;294(13):5082-5093. doi: 10.1074/jbc.RA118.005921. Epub 2019 Feb 7.


Nanoparticle Delivery of TWIST Small Interfering RNA and Anticancer Drugs: A Therapeutic Approach for Combating Cancer.

Glackin CA.

Enzymes. 2018;44:83-101. doi: 10.1016/bs.enz.2018.08.004. Epub 2018 Oct 5. Review.


p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT.

Yang-Hartwich Y, Tedja R, Roberts CM, Goodner-Bingham J, Cardenas C, Gurea M, Sumi NJ, Alvero AB, Glackin CA, Mor G.

Mol Cancer Res. 2019 Jan;17(1):153-164. doi: 10.1158/1541-7786.MCR-18-0238. Epub 2018 Aug 21.


Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway.

Wen W, Lowe G, Roberts CM, Finlay J, Han ES, Glackin CA, Dellinger TH.

Int J Mol Sci. 2018 Jul 7;19(7). pii: E1983. doi: 10.3390/ijms19071983.


Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer.

Hojo N, Huisken AL, Wang H, Chirshev E, Kim NS, Nguyen SM, Campos H, Glackin CA, Ioffe YJ, Unternaehrer JJ.

Sci Rep. 2018 Jun 7;8(1):8704. doi: 10.1038/s41598-018-27021-z.


Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer.

Shahin SA, Wang R, Simargi SI, Contreras A, Parra Echavarria L, Qu L, Wen W, Dellinger T, Unternaehrer J, Tamanoi F, Zink JI, Glackin CA.

Nanomedicine. 2018 Jun;14(4):1381-1394. doi: 10.1016/j.nano.2018.04.008. Epub 2018 Apr 14.


Tyrosine kinase receptor c-ros-oncogene 1 inhibition alleviates aberrant bone formation of TWIST-1 haploinsufficient calvarial cells from Saethre-Chotzen syndrome patients.

Camp E, Anderson PJ, Zannettino ACW, Glackin CA, Gronthos S.

J Cell Physiol. 2018 Sep;233(9):7320-7332. doi: 10.1002/jcp.26563. Epub 2018 Apr 16.


Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer.

Wen W, Lowe G, Roberts CM, Finlay J, Han ES, Glackin CA, Dellinger TH.

Sci Rep. 2017 Oct 6;7(1):12754. doi: 10.1038/s41598-017-12922-2.


Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target.

Roberts CM, Shahin SA, Loeza J, Dellinger TH, Williams JC, Glackin CA.

BMC Cancer. 2017 Mar 10;17(1):184. doi: 10.1186/s12885-017-3169-9.


Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models.

Roberts CM, Shahin SA, Wen W, Finlay JB, Dong J, Wang R, Dellinger TH, Zink JI, Tamanoi F, Glackin CA.

Nanomedicine. 2017 Apr;13(3):965-976. doi: 10.1016/j.nano.2016.11.010. Epub 2016 Nov 25.


TWIST1 drives cisplatin resistance and cell survival in an ovarian cancer model, via upregulation of GAS6, L1CAM, and Akt signalling.

Roberts CM, Tran MA, Pitruzzello MC, Wen W, Loeza J, Dellinger TH, Mor G, Glackin CA.

Sci Rep. 2016 Nov 23;6:37652. doi: 10.1038/srep37652.


15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia.

Gunasekara DC, Zheng MM, Mojtahed T, Woods JR, Fandy TE, Riofski MV, Glackin CA, Hassan HE, Kirshner J, Colby DA.

ChemMedChem. 2016 Nov 7;11(21):2392-2397. doi: 10.1002/cmdc.201600334. Epub 2016 Sep 28.


Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression.

Arthur A, Cakouros D, Cooper L, Nguyen T, Isenmann S, Zannettino AC, Glackin CA, Gronthos S.

Stem Cells. 2016 Feb;34(2):504-9. doi: 10.1002/stem.2265. Epub 2015 Dec 31.


Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden.

Finlay J, Roberts CM, Dong J, Zink JI, Tamanoi F, Glackin CA.

Nanomedicine. 2015 Oct;11(7):1657-66. doi: 10.1016/j.nano.2015.05.011. Epub 2015 Jun 24.


RNA-based TWIST1 inhibition via dendrimer complex to reduce breast cancer cell metastasis.

Finlay J, Roberts CM, Lowe G, Loeza J, Rossi JJ, Glackin CA.

Biomed Res Int. 2015;2015:382745. doi: 10.1155/2015/382745. Epub 2015 Feb 11.


The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines.

Perrigue PM, Silva ME, Warden CD, Feng NL, Reid MA, Mota DJ, Joseph LP, Tian YI, Glackin CA, Gutova M, Najbauer J, Aboody KS, Barish ME.

Mol Cancer Res. 2015 Apr;13(4):636-50. doi: 10.1158/1541-7786.MCR-13-0268. Epub 2015 Feb 4.


Targeting the Twist and Wnt signaling pathways in metastatic breast cancer.

Glackin CA.

Maturitas. 2014 Sep;79(1):48-51. doi: 10.1016/j.maturitas.2014.06.015. Epub 2014 Jul 18. Review.


A reconstructed metastasis model to recapitulate the metastatic spread in vitro.

Parikh MR, Minser KE, Rank LM, Glackin CA, Kirshner J.

Biotechnol J. 2014 Sep;9(9):1129-39. doi: 10.1002/biot.201400121. Epub 2014 Jul 7.


Dkk-1 and IL-7 in plasma of patients with multiple myeloma prevent differentiation of mesenchymal stem cells into osteoblasts.

Nierste BA, Glackin CA, Kirshner J.

Am J Blood Res. 2014 Dec 15;4(2):73-85. eCollection 2014.


TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production.

Li S, Kendall SE, Raices R, Finlay J, Covarrubias M, Liu Z, Lowe G, Lin YH, Teh YH, Leigh V, Dhillon S, Flanagan S, Aboody KS, Glackin CA.

BMC Biol. 2012 Aug 14;10:73. doi: 10.1186/1741-7007-10-73.


Cellular host responses to gliomas.

Najbauer J, Huszthy PC, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H, Kendall SE, Glackin CA, Bjerkvig R, Aboody KS.

PLoS One. 2012;7(4):e35150. doi: 10.1371/journal.pone.0035150. Epub 2012 Apr 23.


Human neural stem cell tropism to metastatic breast cancer.

Zhao D, Najbauer J, Annala AJ, Garcia E, Metz MZ, Gutova M, Polewski MD, Gilchrist M, Glackin CA, Kim SU, Aboody KS.

Stem Cells. 2012 Feb;30(2):314-25. doi: 10.1002/stem.784.


The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.

Gunn EJ, Williams JT, Huynh DT, Iannotti MJ, Han C, Barrios FJ, Kendall S, Glackin CA, Colby DA, Kirshner J.

Leuk Lymphoma. 2011 Jun;52(6):1085-97. doi: 10.3109/10428194.2011.555891. Epub 2011 Mar 21.


TWIST1 promotes invasion through mesenchymal change in human glioblastoma.

Mikheeva SA, Mikheev AM, Petit A, Beyer R, Oxford RG, Khorasani L, Maxwell JP, Glackin CA, Wakimoto H, González-Herrero I, Sánchez-García I, Silber JR, Horner PJ, Rostomily RC.

Mol Cancer. 2010 Jul 20;9:194. doi: 10.1186/1476-4598-9-194.


Twist-ing cell fate: mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesis.

Cakouros D, Raices RM, Gronthos S, Glackin CA.

J Cell Biochem. 2010 Aug 15;110(6):1288-98. doi: 10.1002/jcb.22651. Review.


Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies.

Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS.

PLoS One. 2009 Dec 15;4(12):e8314. doi: 10.1371/journal.pone.0008314.


TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment.

Isenmann S, Arthur A, Zannettino AC, Turner JL, Shi S, Glackin CA, Gronthos S.

Stem Cells. 2009 Oct;27(10):2457-68. doi: 10.1002/stem.181.


Neural stem cell tropism to glioma: critical role of tumor hypoxia.

Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, Glackin CA, Kim SU, Aboody KS.

Mol Cancer Res. 2008 Dec;6(12):1819-29. doi: 10.1158/1541-7786.MCR-08-0146.


Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors.

Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Guevorkian M, Edmiston M, Zhao D, Glackin CA, Kim SU, Aboody KS.

Stem Cells. 2008 Jun;26(6):1406-13. doi: 10.1634/stemcells.2008-0141. Epub 2008 Apr 10.


Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling.

Kendall SE, Najbauer J, Johnston HF, Metz MZ, Li S, Bowers M, Garcia E, Kim SU, Barish ME, Aboody KS, Glackin CA.

Stem Cells. 2008 Jun;26(6):1575-86. doi: 10.1634/stemcells.2007-0887. Epub 2008 Mar 13.


Development of a tumor-selective approach to treat metastatic cancer.

Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, Justus KA, Phelps DA, Remack JS, Yoon KJ, Gillespie S, Kim SU, Glackin CA, Potter PM, Danks MK.

PLoS One. 2006 Dec 20;1:e23.


TWIST is expressed in human gliomas and promotes invasion.

Elias MC, Tozer KR, Silber JR, Mikheeva S, Deng M, Morrison RS, Manning TC, Silbergeld DL, Glackin CA, Reh TA, Rostomily RC.

Neoplasia. 2005 Sep;7(9):824-37.


NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade.

Kendall SE, Battelli C, Irwin S, Mitchell JG, Glackin CA, Verdi JM.

Mol Cell Biol. 2005 Sep;25(17):7711-24. Erratum in: Mol Cell Biol. 2006 May;26(9):3681.


Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c.

Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, Jeon SH, Seong RH, Park SD, Kim JB.

Nucleic Acids Res. 2003 Dec 15;31(24):7165-74.


Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor.

Dupont J, Fernandez AM, Glackin CA, Helman L, LeRoith D.

J Biol Chem. 2001 Jul 13;276(28):26699-707. Epub 2001 Apr 25.


Human Dermo-1 has attributes similar to twist in early bone development.

Lee MS, Lowe G, Flanagan S, Kuchler K, Glackin CA.

Bone. 2000 Nov;27(5):591-602.


TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage.

Lee MS, Lowe GN, Strong DD, Wergedal JE, Glackin CA.

J Cell Biochem. 1999 Dec 15;75(4):566-77.


Endochondral and intramembranous fetal bone development: osteoblastic cell proliferation, and expression of alkaline phosphatase, m-twist, and histone H4.

Alborzi A, Mac K, Glackin CA, Murray SS, Zernik JH.

J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):94-106.


Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells.

Murray SS, Glackin CA, Winters KA, Gazit D, Kahn AJ, Murray EJ.

J Bone Miner Res. 1992 Oct;7(10):1131-8.


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