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Items: 1 to 50 of 133

1.

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.

Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG.

Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x.

2.

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure.

Rainer PP, Dong P, Sorge M, Fert-Bober J, Holewinski RJ, Wang Y, Foss CA, An SS, Baracca A, Solaini G, Glabe CG, Pomper MG, Van Eyk JE, Tomaselli GF, Paolocci N, Agnetti G.

Circ Res. 2018 May 11;122(10):e75-e83. doi: 10.1161/CIRCRESAHA.117.312082. Epub 2018 Feb 26.

PMID:
29483093
3.

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.

PMID:
29282295
4.

Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide.

Hatami A, Monjazeb S, Milton S, Glabe CG.

J Biol Chem. 2017 Feb 24;292(8):3172-3185. doi: 10.1074/jbc.M116.755264. Epub 2017 Jan 3.

5.

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.

6.

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.

Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4976-84. doi: 10.1073/pnas.1600749113. Epub 2016 Jul 28.

7.

Structural differences between amyloid beta oligomers.

Breydo L, Kurouski D, Rasool S, Milton S, Wu JW, Uversky VN, Lednev IK, Glabe CG.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):700-705. doi: 10.1016/j.bbrc.2016.06.122. Epub 2016 Jun 27.

PMID:
27363332
8.

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes.

Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW.

Neurol Neuroimmunol Neuroinflamm. 2016 May 10;3(3):e237. doi: 10.1212/NXI.0000000000000237. eCollection 2016 Jun.

9.

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization.

Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM.

Neurobiol Dis. 2015 Oct;82:552-560. doi: 10.1016/j.nbd.2015.09.002. Epub 2015 Sep 12.

10.

Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT.

J Am Heart Assoc. 2014 Dec 2;3(6):e001384. doi: 10.1161/JAHA.114.001384.

11.

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ 2nd, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT.

J Mol Cell Cardiol. 2015 Feb;79:295-302. doi: 10.1016/j.yjmcc.2014.11.013. Epub 2014 Nov 18.

12.

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.

Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG.

Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1.

13.

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.

Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC.

J Clin Invest. 2014 Aug;124(8):3489-500. doi: 10.1172/JCI71981. Epub 2014 Jul 18.

14.

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.

Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe CG, Buhimschi CS.

Sci Transl Med. 2014 Jul 16;6(245):245ra92. doi: 10.1126/scitranslmed.3008808.

15.

Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples.

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT.

J Histochem Cytochem. 2014 Jul;62(7):479-87. doi: 10.1369/0022155414535782. Epub 2014 Apr 30.

16.

Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice.

Rasool S, Martinez-Coria H, Milton S, Glabe CG.

Mol Neurobiol. 2013 Dec;48(3):931-40. doi: 10.1007/s12035-013-8478-7. Epub 2013 Jun 15.

PMID:
23771815
17.

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice.

Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG.

J Neurochem. 2013 Aug;126(4):473-82. doi: 10.1111/jnc.12305. Epub 2013 Jun 16.

18.

A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.

Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T.

J Neurosci. 2013 Apr 10;33(15):6245-56. doi: 10.1523/JNEUROSCI.3672-12.2013.

19.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3077-82. doi: 10.1073/pnas.1222663110. Epub 2013 Jan 30.

20.

Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers.

Ringman JM, Tomic JL, Coppola G, Elashoff D, Gylys KH, Glabe CG.

Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):652-7. doi: 10.1159/000345771. Epub 2012 Dec 15.

21.

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.

Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20913-8. doi: 10.1073/pnas.1218792109. Epub 2012 Dec 3.

22.

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Rasool S, Albay R 3rd, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG.

Mol Neurodegener. 2012 Aug 6;7:37. doi: 10.1186/1750-1326-7-37.

23.

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S.

Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31.

24.

Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.

Cheng PN, Spencer R, Woods RJ, Glabe CG, Nowick JS.

J Am Chem Soc. 2012 Aug 29;134(34):14179-84. doi: 10.1021/ja305416a. Epub 2012 Aug 17.

25.

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM.

J Huntingtons Dis. 2012;1(1):119-32. doi: 10.3233/JHD-2012-129004.

26.

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS.

Nature. 2012 May 2;485(7400):651-5. doi: 10.1038/nature11060.

27.

Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance.

Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE.

PLoS One. 2012;7(4):e35090. doi: 10.1371/journal.pone.0035090. Epub 2012 Apr 26.

28.

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain.

Lasagna-Reeves CA, Glabe CG, Kayed R.

J Biol Chem. 2011 Jun 24;286(25):22122-30. doi: 10.1074/jbc.M111.236257. Epub 2011 Apr 20.

29.

CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.

Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J.

J Neurosci. 2011 Jan 26;31(4):1355-65. doi: 10.1523/JNEUROSCI.3268-10.2011.

30.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC.

Curr Alzheimer Res. 2011 Feb;8(1):4-23.

PMID:
21143159
31.

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.

Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW.

Neurobiol Aging. 2012 Jan;33(1):108-20. doi: 10.1016/j.neurobiolaging.2010.02.008. Epub 2010 Apr 30.

32.

Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.

Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP.

J Alzheimers Dis. 2010;20(2):637-46. doi: 10.3233/JAD-2010-1397.

33.

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.

Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC.

Am J Pathol. 2010 Feb;176(2):861-9. doi: 10.2353/ajpath.2010.090532. Epub 2009 Dec 30.

34.

Soluble and mature amyloid fibrils in drusen deposits.

Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10. doi: 10.1167/iovs.09-4207. Epub 2009 Nov 5.

35.

Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice.

Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J, Tan Z.

Am J Pathol. 2009 Nov;175(5):2099-110. doi: 10.2353/ajpath.2009.090159. Epub 2009 Oct 15. Erratum in: Am J Pathol. 2010 Apr;176(4):2055.

36.

Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro.

Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R.

J Mol Biol. 2009 Aug 21;391(3):577-85. doi: 10.1016/j.jmb.2009.06.024. Epub 2009 Jun 12.

PMID:
19524592
37.

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.

Tomic JL, Pensalfini A, Head E, Glabe CG.

Neurobiol Dis. 2009 Sep;35(3):352-8. doi: 10.1016/j.nbd.2009.05.024. Epub 2009 Jun 10.

38.

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J.

J Neurosci. 2009 Apr 1;29(13):4004-15. doi: 10.1523/JNEUROSCI.5980-08.2009.

39.

Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.

Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H.

Int J Alzheimers Dis. 2009 Jul 14;2009. pii: 689285. doi: 10.4061/2009/689285.

40.

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.

Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J.

Mol Neurodegener. 2008 Oct 21;3:16. doi: 10.1186/1750-1326-3-16.

41.

Structural classification of toxic amyloid oligomers.

Glabe CG.

J Biol Chem. 2008 Oct 31;283(44):29639-43. doi: 10.1074/jbc.R800016200. Epub 2008 Aug 22. Review.

42.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW.

J Neuroinflammation. 2008 Apr 9;5:13. doi: 10.1186/1742-2094-5-13.

43.

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.

Kostka M, Högen T, Danzer KM, Levin J, Habeck M, Wirth A, Wagner R, Glabe CG, Finger S, Heinzelmann U, Garidel P, Duan W, Ross CA, Kretzschmar H, Giese A.

J Biol Chem. 2008 Apr 18;283(16):10992-1003. doi: 10.1074/jbc.M709634200. Epub 2008 Feb 7.

44.

Pore-forming proteins share structural and functional homology with amyloid oligomers.

Yoshiike Y, Kayed R, Milton SC, Takashima A, Glabe CG.

Neuromolecular Med. 2007;9(3):270-5.

PMID:
17914185
45.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.

Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG.

Mol Neurodegener. 2007 Sep 26;2:18.

46.

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe CG.

Biochemistry. 2007 Jul 31;46(30):8850-60. Epub 2007 Jun 27.

PMID:
17595112
47.

Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.

Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG.

J Biol Chem. 2007 Aug 3;282(31):22376-86. Epub 2007 Jun 1.

48.

Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.

Maloyan A, Gulick J, Glabe CG, Kayed R, Robbins J.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5995-6000. Epub 2007 Mar 26.

50.

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