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Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation.

Qvortrup K, Hultqvist LD, Nilsson M, Jakobsen TH, Jansen CU, Uhd J, Andersen JB, Nielsen TE, Givskov M, Tolker-Nielsen T.

Front Chem. 2019 Nov 1;7:742. doi: 10.3389/fchem.2019.00742. eCollection 2019. Review.


Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance.

Nilsson M, Givskov M, Twetman S, Tolker-Nielsen T.

Microorganisms. 2019 Sep 3;7(9). pii: E310. doi: 10.3390/microorganisms7090310.


Reactivity and Synthetic Applications of Multicomponent Petasis Reactions.

Wu P, Givskov M, Nielsen TE.

Chem Rev. 2019 Oct 23;119(20):11245-11290. doi: 10.1021/acs.chemrev.9b00214. Epub 2019 Aug 27.


Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma.

Lindahl LM, Willerslev-Olsen A, Gjerdrum LMR, Nielsen PR, Blümel E, Rittig AH, Celis P, Herpers B, Becker JC, Stausbøl-Grøn B, Wasik MA, Gluud M, Fredholm S, Buus TB, Johansen C, Nastasi C, Peiffer L, Kubat L, Bzorek M, Eriksen JO, Krejsgaard T, Bonefeld CM, Geisler C, Mustelin T, Langhoff E, Givskov M, Woetmann A, Kilian M, Litman T, Iversen L, Odum N.

Blood. 2019 Sep 26;134(13):1072-1083. doi: 10.1182/blood.2018888107. Epub 2019 Jul 22.


Visualizing biofilm by targeting eDNA with long wavelength probe CDr15.

Kwon HY, Kim JY, Liu X, Lee JY, Yam JKH, Dahl Hultqvist L, Xu W, Rybtke M, Tolker-Nielsen T, Heo W, Kim JJ, Kang NY, Joo T, Yang L, Park SJ, Givskov M, Chang YT.

Biomater Sci. 2019 Aug 20;7(9):3594-3598. doi: 10.1039/c9bm00152b.


Transposon Mutagenesis in Streptococcus Species.

Nilsson M, Givskov M, Tolker-Nielsen T.

Methods Mol Biol. 2019;2016:39-49. doi: 10.1007/978-1-4939-9570-7_4.


Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia.

Richter AM, Fazli M, Schmid N, Shilling R, Suppiger A, Givskov M, Eberl L, Tolker-Nielsen T.

Front Microbiol. 2019 Jan 10;9:3286. doi: 10.3389/fmicb.2018.03286. eCollection 2018.


Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Fong J, Mortensen KT, Nørskov A, Qvortrup K, Yang L, Tan CH, Nielsen TE, Givskov M.

Front Cell Infect Microbiol. 2019 Jan 7;8:443. doi: 10.3389/fcimb.2018.00443. eCollection 2018.


Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms.

Nilsson M, Jakobsen TH, Givskov M, Twetman S, Tolker-Nielsen T.

Microbiology. 2019 Mar;165(3):334-342. doi: 10.1099/mic.0.000773. Epub 2019 Jan 21.


High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content.

Almblad H, Rybtke M, Hendiani S, Andersen JB, Givskov M, Tolker-Nielsen T.

Microbiology. 2019 Mar;165(3):324-333. doi: 10.1099/mic.0.000772. Epub 2019 Jan 21.


Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells.

Teh WK, Dramsi S, Tolker-Nielsen T, Yang L, Givskov M.

J Bacteriol. 2019 Feb 25;201(6). pii: e00597-18. doi: 10.1128/JB.00597-18. Print 2019 Mar 15.


Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents.

Yuan M, Chua SL, Liu Y, Drautz-Moses DI, Yam JKH, Aung TT, Beuerman RW, Salido MMS, Schuster SC, Tan CH, Givskov M, Yang L, Nielsen TE.

Beilstein J Org Chem. 2018 Dec 14;14:3059-3069. doi: 10.3762/bjoc.14.284. eCollection 2018.


Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus.

Chew SC, Yam JKH, Matysik A, Seng ZJ, Klebensberger J, Givskov M, Doyle P, Rice SA, Yang L, Kjelleberg S.

mBio. 2018 Nov 6;9(6). pii: e00585-18. doi: 10.1128/mBio.00585-18.


Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICETn4371 6385.

Ding Y, Teo JWP, Drautz-Moses DI, Schuster SC, Givskov M, Yang L.

Commun Biol. 2018 May 31;1:57. doi: 10.1038/s42003-018-0064-0. eCollection 2018.


CDy14: a novel biofilm probe targeting exopolysaccharide Psl.

Kwon HY, Kim JY, Lee JY, Yam JKH, Hultqvist LD, Xu W, Rybtke M, Tolker-Nielsen T, Kim JJ, Kang NY, Yang L, Park SJ, Givskov M, Chang YT.

Chem Commun (Camb). 2018 Oct 18;54(84):11865-11868. doi: 10.1039/c8cc05544k.


Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul.

Ding Y, Zwe YH, Chin SF, Kohli GS, Drautz-Moses DI, Givskov M, Schlundt J, Schuster SC, Yuk HG, Yang L.

Gut Pathog. 2018 Jun 4;10:20. doi: 10.1186/s13099-018-0249-6. eCollection 2018.


The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells.

Gall-Mas L, Fabbri A, Namini MRJ, Givskov M, Fiorentini C, Krejsgaard T.

Int J Mol Sci. 2018 May 8;19(5). pii: E1408. doi: 10.3390/ijms19051408.


Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin.

Woetmann A, Alhede M, Dabelsteen S, Bjarnsholt T, Rybtke M, Nastasi C, Krejsgaard T, Andersen MH, Bonefeld CM, Geisler C, Givskov M, Odum N.

Oncotarget. 2018 Apr 13;9(28):19481-19489. doi: 10.18632/oncotarget.24603. eCollection 2018 Apr 13.


Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa.

Fong J, Zhang C, Yang R, Boo ZZ, Tan SK, Nielsen TE, Givskov M, Liu XW, Bin W, Su H, Yang L.

Sci Rep. 2018 Jan 18;8(1):1155. doi: 10.1038/s41598-018-19504-w.


Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro.

Jakobsen TH, Alhede M, Hultqvist LD, Bjarnsholt T, Givskov M.

Methods Mol Biol. 2018;1673:275-285. doi: 10.1007/978-1-4939-7309-5_21.


Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo.

Hultqvist LD, Alhede M, Jakobsen TH, Givskov M, Bjarnsholt T.

Methods Mol Biol. 2018;1673:203-212. doi: 10.1007/978-1-4939-7309-5_16.


Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa.

Lin Chua S, Liu Y, Li Y, Jun Ting H, Kohli GS, Cai Z, Suwanchaikasem P, Kau Kit Goh K, Pin Ng S, Tolker-Nielsen T, Yang L, Givskov M.

Front Cell Infect Microbiol. 2017 Oct 17;7:451. doi: 10.3389/fcimb.2017.00451. eCollection 2017.


Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries.

Belstrøm D, Constancias F, Liu Y, Yang L, Drautz-Moses DI, Schuster SC, Kohli GS, Jakobsen TH, Holmstrup P, Givskov M.

NPJ Biofilms Microbiomes. 2017 Oct 2;3:23. doi: 10.1038/s41522-017-0031-4. eCollection 2017.


Correction to 'Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels'.

Chua SL, Ding Y, Liu Y, Cai Z, Zhou J, Swarup S, Drautz-Moses DI, Schuster SC, Kjelleberg S, Givskov M, Yang L.

Open Biol. 2017 Sep;7(9). pii: 170197. doi: 10.1098/rsob.170197. No abstract available.


Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.

Jakobsen TH, Tolker-Nielsen T, Givskov M.

Int J Mol Sci. 2017 Sep 13;18(9). pii: E1970. doi: 10.3390/ijms18091970. Review.


High-Throughput Screening for Compounds that Modulate the Cellular c-di-GMP Level in Bacteria.

Groizeleau J, Andersen JB, Givskov M, Berthelsen J, Tolker-Nielsen T.

Methods Mol Biol. 2017;1657:455-470. doi: 10.1007/978-1-4939-7240-1_33.


Gauging and Visualizing c-di-GMP Levels in Pseudomonas aeruginosa Using Fluorescence-Based Biosensors.

Rybtke M, Chua SL, Yam JKH, Givskov M, Yang L, Tolker-Nielsen T.

Methods Mol Biol. 2017;1657:87-98. doi: 10.1007/978-1-4939-7240-1_8.


A broad range quorum sensing inhibitor working through sRNA inhibition.

Jakobsen TH, Warming AN, Vejborg RM, Moscoso JA, Stegger M, Lorenzen F, Rybtke M, Andersen JB, Petersen R, Andersen PS, Nielsen TE, Tolker-Nielsen T, Filloux A, Ingmer H, Givskov M.

Sci Rep. 2017 Aug 29;7(1):9857. doi: 10.1038/s41598-017-09886-8.


In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy.

Roizman D, Vidaillac C, Givskov M, Yang L.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01088-17. doi: 10.1128/AAC.01088-17. Print 2017 Oct.


A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors.

Bang CG, Jensen JF, O'Hanlon Cohrt E, Olsen LB, Siyum SG, Mortensen KT, Skovgaard T, Berthelsen J, Yang L, Givskov M, Qvortrup K, Nielsen TE.

ACS Comb Sci. 2017 Oct 9;19(10):657-669. doi: 10.1021/acscombsci.7b00068. Epub 2017 Sep 6.


Discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis.

Aung TT, Chor WHJ, Yam JKH, Givskov M, Yang L, Beuerman RW.

Ocul Surf. 2017 Oct;15(4):770-783. doi: 10.1016/j.jtos.2017.06.002. Epub 2017 Jun 27.


In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm.

Tan JH, Vidaillac C, Yam JKH, Chua SL, Givskov M, Yang L.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02223-16. doi: 10.1128/AAC.02223-16. Print 2017 Jul.


Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T.

Microbiologyopen. 2017 Aug;6(4). doi: 10.1002/mbo3.480. Epub 2017 Apr 16.


Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis.

Køllgaard T, Enevold C, Bendtzen K, Hansen PR, Givskov M, Holmstrup P, Nielsen CH.

PLoS One. 2017 Feb 24;12(2):e0172773. doi: 10.1371/journal.pone.0172773. eCollection 2017.


Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors.

Tung TT, Jakobsen TH, Dao TT, Fuglsang AT, Givskov M, Christensen SB, Nielsen J.

Eur J Med Chem. 2017 Jan 27;126:1011-1020. doi: 10.1016/j.ejmech.2016.11.044. Epub 2016 Nov 24.


Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction.

Hansen GM, Belstrøm D, Nilsson M, Helqvist S, Nielsen CH, Holmstrup P, Tolker-Nielsen T, Givskov M, Hansen PR.

PLoS One. 2016 Dec 28;11(12):e0168771. doi: 10.1371/journal.pone.0168771. eCollection 2016.


Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Fong J, Yuan M, Jakobsen TH, Mortensen KT, Delos Santos MM, Chua SL, Yang L, Tan CH, Nielsen TE, Givskov M.

J Med Chem. 2017 Jan 12;60(1):215-227. doi: 10.1021/acs.jmedchem.6b01025. Epub 2016 Dec 28.


Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels.

Chua SL, Ding Y, Liu Y, Cai Z, Zhou J, Swarup S, Drautz-Moses DI, Schuster SC, Kjelleberg S, Givskov M, Yang L.

Open Biol. 2016 Nov;6(11). pii: 160162. Erratum in: Open Biol. 2017 Sep;7(9):.


The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T.

Microbiology. 2016 Oct;162(10):1797-1807. doi: 10.1099/mic.0.000354. Epub 2016 Aug 15.


The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms.

Nilsson M, Rybtke M, Givskov M, Høiby N, Twetman S, Tolker-Nielsen T.

Int J Antimicrob Agents. 2016 Sep;48(3):298-304. doi: 10.1016/j.ijantimicag.2016.06.019. Epub 2016 Jul 28.


Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms.

Chua SL, Yam JK, Hao P, Adav SS, Salido MM, Liu Y, Givskov M, Sze SK, Tolker-Nielsen T, Yang L.

Nat Commun. 2016 Feb 19;7:10750. doi: 10.1038/ncomms10750.


Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay.

Hansen GM, Nilsson M, Nielsen CH, Holmstrup P, Helqvist S, Tolker-Nielsen T, Givskov M, Hansen PR.

PLoS One. 2015 Dec 22;10(12):e0145657. doi: 10.1371/journal.pone.0145657. eCollection 2015.


Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11.

Kim JY, Sahu S, Yau YH, Wang X, Shochat SG, Nielsen PH, Dueholm MS, Otzen DE, Lee J, Delos Santos MM, Yam JK, Kang NY, Park SJ, Kwon H, Seviour T, Yang L, Givskov M, Chang YT.

J Am Chem Soc. 2016 Jan 13;138(1):402-7. doi: 10.1021/jacs.5b11357. Epub 2016 Jan 4.


RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via Modulating the PqsR Quorum Sensing Regulator.

Cai Z, Liu Y, Chen Y, Yam JK, Chew SC, Chua SL, Wang K, Givskov M, Yang L.

Int J Mol Sci. 2015 Nov 30;16(12):28311-9. doi: 10.3390/ijms161226103.


Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli.

Sun J, Marais JP, Khoo C, LaPlante K, Vejborg RM, Givskov M, Tolker-Nielsen T, Seeram NP, Rowley DC.

J Funct Foods. 2015 Aug;17:235-242.


Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll.

Jeffries TC, Ostrowski M, Williams RB, Xie C, Jensen RM, Grzymski JJ, Senstius SJ, Givskov M, Hoeke R, Philip GK, Neches RY, Drautz-Moses DI, Chénard C, Paulsen IT, Lauro FM.

Sci Rep. 2015 Oct 20;5:15383. doi: 10.1038/srep15383.


Biofilms of Pathogenic Nontuberculous Mycobacteria Targeted by New Therapeutic Approaches.

Aung TT, Yam JK, Lin S, Salleh SM, Givskov M, Liu S, Lwin NC, Yang L, Beuerman RW.

Antimicrob Agents Chemother. 2015 Oct 12;60(1):24-35. doi: 10.1128/AAC.01509-15. Print 2016 Jan.


The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface.

Rybtke M, Berthelsen J, Yang L, Høiby N, Givskov M, Tolker-Nielsen T.

Microbiologyopen. 2015 Dec;4(6):917-30. doi: 10.1002/mbo3.301. Epub 2015 Oct 12.


Chemical Biology Strategies for Biofilm Control.

Yang L, Givskov M.

Microbiol Spectr. 2015 Aug;3(4). doi: 10.1128/microbiolspec.MB-0019-2015. Review.


In silico analyses of metagenomes from human atherosclerotic plaque samples.

Mitra S, Drautz-Moses DI, Alhede M, Maw MT, Liu Y, Purbojati RW, Yap ZH, Kushwaha KK, Gheorghe AG, Bjarnsholt T, Hansen GM, Sillesen HH, Hougen HP, Hansen PR, Yang L, Tolker-Nielsen T, Schuster SC, Givskov M.

Microbiome. 2015 Sep 3;3:38. doi: 10.1186/s40168-015-0100-y.

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