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Items: 48


Structural Bases of Atypical Whisker Responses in a Mouse Model of CDKL5 Deficiency Disorder.

Pizzo R, Lamarca A, Sassoè-Pognetto M, Giustetto M.

Neuroscience. 2019 Aug 28. pii: S0306-4522(19)30606-2. doi: 10.1016/j.neuroscience.2019.08.033. [Epub ahead of print]


Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome-Like Sensorimotor Defects.

Morello N, Schina R, Pilotto F, Phillips M, Melani R, Plicato O, Pizzorusso T, Pozzo-Miller L, Giustetto M.

eNeuro. 2018 Sep 24;5(5). pii: ENEURO.0086-18.2018. doi: 10.1523/ENEURO.0086-18.2018. eCollection 2018 Sep-Oct.


A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent.

Gioelli N, Maione F, Camillo C, Ghitti M, Valdembri D, Morello N, Darche M, Zentilin L, Cagnoni G, Qiu Y, Giacca M, Giustetto M, Paques M, Cascone I, Musco G, Tamagnone L, Giraudo E, Serini G.

Sci Transl Med. 2018 May 23;10(442). pii: eaah4807. doi: 10.1126/scitranslmed.aah4807. Erratum in: Sci Transl Med. 2018 Jul 25;10(451):.


p140Cap Regulates GABAergic Synaptogenesis and Development of Hippocampal Inhibitory Circuits.

Russo I, Gavello D, Menna E, Vandael D, Veglia C, Morello N, Corradini I, Focchi E, Alfieri A, Angelini C, Bianchi FT, Morellato A, Marcantoni A, Sassoè-Pognetto M, Ottaviani MM, Yekhlef L, Giustetto M, Taverna S, Carabelli V, Matteoli M, Carbone E, Turco E, Defilippi P.

Cereb Cortex. 2019 Jan 1;29(1):91-105. doi: 10.1093/cercor/bhx306.


Homer1b/c clustering is impaired in Phelan-McDermid Syndrome iPSCs derived neurons.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):637. doi: 10.1038/mp.2017.82. No abstract available.


Effects of Forced Swimming Stress on ERK and Histone H3 Phosphorylation in Limbic Areas of Roman High- and Low-Avoidance Rats.

Morello N, Plicato O, Piludu MA, Poddighe L, Serra MP, Quartu M, Corda MG, Giorgi O, Giustetto M.

PLoS One. 2017 Jan 20;12(1):e0170093. doi: 10.1371/journal.pone.0170093. eCollection 2017.


Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex.

Pizzo R, Gurgone A, Castroflorio E, Amendola E, Gross C, Sassoè-Pognetto M, Giustetto M.

Front Cell Neurosci. 2016 Nov 28;10:261. eCollection 2016.


Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.

Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P.

Hum Mol Genet. 2016 Jun 1;25(11):2314-2323. Epub 2016 May 4.


Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):784. doi: 10.1038/mp.2016.70. Epub 2016 Apr 26. No abstract available.


Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C.

Mol Psychiatry. 2017 May;22(5):689-702. doi: 10.1038/mp.2016.30. Epub 2016 Mar 29. Erratum in: Mol Psychiatry. 2017 May;22(5):784.


Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1.

Della Sala G, Putignano E, Chelini G, Melani R, Calcagno E, Michele Ratto G, Amendola E, Gross CT, Giustetto M, Pizzorusso T.

Biol Psychiatry. 2016 Aug 15;80(4):302-311. doi: 10.1016/j.biopsych.2015.08.028. Epub 2015 Sep 3.


Developmental abnormalities of cortical interneurons precede symptoms onset in a mouse model of Rett syndrome.

Tomassy GS, Morello N, Calcagno E, Giustetto M.

J Neurochem. 2014 Oct;131(1):115-27. doi: 10.1111/jnc.12803. Epub 2014 Aug 5.


Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

Amendola E, Zhan Y, Mattucci C, Castroflorio E, Calcagno E, Fuchs C, Lonetti G, Silingardi D, Vyssotski AL, Farley D, Ciani E, Pizzorusso T, Giustetto M, Gross CT.

PLoS One. 2014 May 16;9(5):e91613. doi: 10.1371/journal.pone.0091613. eCollection 2014.


Role of ERK signaling in activity-dependent modifications of histone proteins.

Ciccarelli A, Giustetto M.

Neuropharmacology. 2014 May;80:34-44. doi: 10.1016/j.neuropharm.2014.01.039. Epub 2014 Jan 31. Review.


p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.

Repetto D, Camera P, Melani R, Morello N, Russo I, Calcagno E, Tomasoni R, Bianchi F, Berto G, Giustetto M, Berardi N, Pizzorusso T, Matteoli M, Di Stefano P, Missler M, Turco E, Di Cunto F, Defilippi P.

J Neurosci. 2014 Jan 22;34(4):1542-53. doi: 10.1523/JNEUROSCI.2341-13.2014.


Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.

Arroyo AI, Camoletto PG, Morando L, Sassoe-Pognetto M, Giustetto M, Van Veldhoven PP, Schuchman EH, Ledesma MD.

EMBO Mol Med. 2014 Mar;6(3):398-413. doi: 10.1002/emmm.201302649. Epub 2014 Jan 21.


Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Pérez-Otaño I, Padovani A, Giustetto M, Gardoni F, Di Luca M.

J Clin Invest. 2013 Jun;123(6):2523-38. doi: 10.1172/JCI65401. Epub 2013 May 8.


Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum.

Ciccarelli A, Calza A, Santoru F, Grasso F, Concas A, Sassoè-Pognetto M, Giustetto M.

Neuropharmacology. 2013 Jul;70:168-79. doi: 10.1016/j.neuropharm.2012.12.010. Epub 2013 Jan 21.


Preclinical research in Rett syndrome: setting the foundation for translational success.

Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA.

Dis Model Mech. 2012 Nov;5(6):733-45. doi: 10.1242/dmm.011007. Review.


Organization of GABAergic synaptic circuits in the rat ventral tegmental area.

Ciccarelli A, Calza A, Panzanelli P, Concas A, Giustetto M, Sassoè-Pognetto M.

PLoS One. 2012;7(10):e46250. doi: 10.1371/journal.pone.0046250. Epub 2012 Oct 8.


Hippocampal CA1 pyramidal neurons of Mecp2 mutant mice show a dendritic spine phenotype only in the presymptomatic stage.

Chapleau CA, Boggio EM, Calfa G, Percy AK, Giustetto M, Pozzo-Miller L.

Neural Plast. 2012;2012:976164. doi: 10.1155/2012/976164. Epub 2012 Jul 30.


The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome.

Landi S, Putignano E, Boggio EM, Giustetto M, Pizzorusso T, Ratto GM.

Sci Rep. 2011;1:45. doi: 10.1038/srep00045. Epub 2011 Jul 25.


CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

Lopez-Atalaya JP, Ciccarelli A, Viosca J, Valor LM, Jimenez-Minchan M, Canals S, Giustetto M, Barco A.

EMBO J. 2011 Aug 16;30(20):4287-98. doi: 10.1038/emboj.2011.299.


Synaptic pruning by microglia is necessary for normal brain development.

Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Giustetto M, Ferreira TA, Guiducci E, Dumas L, Ragozzino D, Gross CT.

Science. 2011 Sep 9;333(6048):1456-8. doi: 10.1126/science.1202529. Epub 2011 Jul 21.


Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

Ricciardi S, Boggio EM, Grosso S, Lonetti G, Forlani G, Stefanelli G, Calcagno E, Morello N, Landsberger N, Biffo S, Pizzorusso T, Giustetto M, Broccoli V.

Hum Mol Genet. 2011 Mar 15;20(6):1182-96. doi: 10.1093/hmg/ddq563. Epub 2011 Jan 6.


Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.

Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M.

Brain. 2010 Nov;133(11):3323-35. doi: 10.1093/brain/awq217. Epub 2010 Aug 30.


Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions.

Pavlowsky A, Zanchi A, Pallotto M, Giustetto M, Chelly J, Sala C, Billuart P.

Commun Integr Biol. 2010 May;3(3):245-7.


Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.

Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W.

EMBO J. 2010 Jun 2;29(11):1889-902. doi: 10.1038/emboj.2010.72. Epub 2010 Apr 20.


Early environmental enrichment moderates the behavioral and synaptic phenotype of MeCP2 null mice.

Lonetti G, Angelucci A, Morando L, Boggio EM, Giustetto M, Pizzorusso T.

Biol Psychiatry. 2010 Apr 1;67(7):657-65. doi: 10.1016/j.biopsych.2009.12.022. Epub 2010 Feb 20.


A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation.

Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, Valnegri P, Rezai X, Bassani S, Brambilla D, Kumpost J, Blahos J, Roux MJ, Humeau Y, Chelly J, Passafaro M, Giustetto M, Billuart P, Sala C.

Curr Biol. 2010 Jan 26;20(2):103-15. doi: 10.1016/j.cub.2009.12.030. Epub 2010 Jan 21.


Synaptic determinants of rett syndrome.

Boggio EM, Lonetti G, Pizzorusso T, Giustetto M.

Front Synaptic Neurosci. 2010 Aug 6;2:28. doi: 10.3389/fnsyn.2010.00028. eCollection 2010.


ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I.

Vara H, Onofri F, Benfenati F, Sassoè-Pognetto M, Giustetto M.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9872-7. doi: 10.1073/pnas.0900077106. Epub 2009 Jun 1.


Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.

Fasano S, D'Antoni A, Orban PC, Valjent E, Putignano E, Vara H, Pizzorusso T, Giustetto M, Yoon B, Soloway P, Maldonado R, Caboche J, Brambilla R.

Biol Psychiatry. 2009 Oct 15;66(8):758-68. doi: 10.1016/j.biopsych.2009.03.014. Epub 2009 May 15.


Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.

Camoletto PG, Vara H, Morando L, Connell E, Marletto FP, Giustetto M, Sassoè-Pognetto M, Van Veldhoven PP, Ledesma MD.

PLoS One. 2009;4(4):e5310. doi: 10.1371/journal.pone.0005310. Epub 2009 Apr 23.


Visual stimulation activates ERK in synaptic and somatic compartments of rat cortical neurons with parallel kinetics.

Boggio EM, Putignano E, Sassoè-Pognetto M, Pizzorusso T, Giustetto M.

PLoS One. 2007 Jul 11;2(7):e604.


Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.

Pilo Boyl P, Di Nardo A, Mulle C, Sassoè-Pognetto M, Panzanelli P, Mele A, Kneussel M, Costantini V, Perlas E, Massimi M, Vara H, Giustetto M, Witke W.

EMBO J. 2007 Jun 20;26(12):2991-3002. Epub 2007 May 31.


A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz AM, Miniaci MC, Kim JH, Zhu H, Kandel ER.

Cell. 2003 Dec 26;115(7):893-904.


Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse.

Giustetto M, Hegde AN, Si K, Casadio A, Inokuchi K, Pei W, Kandel ER, Schwartz JH.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13680-5. Epub 2003 Oct 24.


Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure.

Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER.

Cell. 2002 Nov 15;111(4):483-93.


Is heterosynaptic modulation essential for stabilizing Hebbian plasticity and memory?

Bailey CH, Giustetto M, Huang YY, Hawkins RD, Kandel ER.

Nat Rev Neurosci. 2000 Oct;1(1):11-20. Review.


Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2.

Bartsch D, Ghirardi M, Casadio A, Giustetto M, Karl KA, Zhu H, Kandel ER.

Cell. 2000 Nov 10;103(4):595-608.


A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

Casadio A, Martin KC, Giustetto M, Zhu H, Chen M, Bartsch D, Bailey CH, Kandel ER.

Cell. 1999 Oct 15;99(2):221-37.


Postsynaptic colocalization of gephyrin and GABAA receptors.

Sassoè-Pognetto M, Giustetto M, Panzanelli P, Cantino D, Kirsch J, Fritschy JM.

Ann N Y Acad Sci. 1999 Apr 30;868:693-6. No abstract available.


Immunocytochemical localization of glutamate and gamma-aminobutyric acid in the accessory olfactory bulb of the rat.

Quaglino E, Giustetto M, Panzanelli P, Cantino D, Fasolo A, Sassoè-Pognetto M.

J Comp Neurol. 1999 May 24;408(1):61-72.


Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat.

Giustetto M, Kirsch J, Fritschy JM, Cantino D, Sassoè-Pognetto M.

J Comp Neurol. 1998 Jun 1;395(2):231-44.


Presynaptic co-localization of carnosine and glutamate in olfactory neurones.

Sassoè-Pognetto M, Cantino D, Panzanelli P, Verdun di Cantogno L, Giustetto M, Margolis FL, De Biasi S, Fasolo A.

Neuroreport. 1993 Oct 25;5(1):7-10.


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