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Fatty vessels shed tonnes on programmed cardiovascular risk.

Giussani DA.

J Physiol. 2019 Sep 18. doi: 10.1113/JP278732. [Epub ahead of print] No abstract available.


Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion.

Shaw CJ, Rivens I, Civale J, Botting KJ, Allison BJ, Brain KL, Niu Y, Ter Haar G, Giussani DA, Lees CC.

J R Soc Interface. 2019 May 31;16(154):20190013. doi: 10.1098/rsif.2019.0013.


Scaling of cardiac morphology is interrupted by birth in the developing sheep Ovis aries.

Snelling EP, Seymour RS, Giussani DA, Fuller A, Maloney SK, Farrell AP, Mitchell D, George KP, Dzialowski EM, Jonker SS, Wube T.

J Anat. 2019 Jul;235(1):96-105. doi: 10.1111/joa.12990. Epub 2019 Apr 17.


Preeclampsia link to gestational hypoxia.

Tong W, Giussani DA.

J Dev Orig Health Dis. 2019 Jun;10(3):322-333. doi: 10.1017/S204017441900014X. Epub 2019 Apr 10.


Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.

Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE.

FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19.


Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth.

Garrud TAC, Giussani DA.

Trends Endocrinol Metab. 2019 Apr;30(4):258-269. doi: 10.1016/j.tem.2019.02.003. Epub 2019 Mar 5. Review.


Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.

Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE.

J Physiol. 2019 May;597(9):2391-2401. doi: 10.1113/JP277431. Epub 2019 Mar 24.


Intervention against hypertension in the next generation programmed by developmental hypoxia.

Brain KL, Allison BJ, Niu Y, Cross CM, Itani N, Kane AD, Herrera EA, Skeffington KL, Botting KJ, Giussani DA.

PLoS Biol. 2019 Jan 22;17(1):e2006552. doi: 10.1371/journal.pbio.2006552. eCollection 2019 Jan.


Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.

Niu Y, Kane AD, Lusby CM, Allison BJ, Chua YY, Kaandorp JJ, Nevin-Dolan R, Ashmore TJ, Blackmore HL, Derks JB, Ozanne SE, Giussani DA.

Hypertension. 2018 Oct;72(4):971-978. doi: 10.1161/HYPERTENSIONAHA.118.11363.


Improving pregnancy outcomes in humans through studies in sheep.

Morrison JL, Berry MJ, Botting KJ, Darby JRT, Frasch MG, Gatford KL, Giussani DA, Gray CL, Harding R, Herrera EA, Kemp MW, Lock MC, McMillen IC, Moss TJ, Musk GC, Oliver MH, Regnault TRH, Roberts CT, Soo JY, Tellam RL.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1123-R1153. doi: 10.1152/ajpregu.00391.2017. Epub 2018 Oct 16.


Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring.

Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE.

Mol Metab. 2018 Oct;16:35-44. doi: 10.1016/j.molmet.2018.06.009. Epub 2018 Jun 18.


Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.

Nuzzo AM, Camm EJ, Sferruzzi-Perri AN, Ashmore TJ, Yung HW, Cindrova-Davies T, Spiroski AM, Sutherland MR, Logan A, Austin-Williams S, Burton GJ, Rolfo A, Todros T, Murphy MP, Giussani DA.

Am J Pathol. 2018 Dec;188(12):2704-2716. doi: 10.1016/j.ajpath.2018.07.027. Epub 2018 Sep 22.


Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function.

Tay J, Masini G, McEniery CM, Giussani DA, Shaw CJ, Wilkinson IB, Bennett PR, Lees CC.

Am J Obstet Gynecol. 2019 Jan;220(1):96.e1-96.e8. doi: 10.1016/j.ajog.2018.09.017. Epub 2018 Sep 19.


Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.

Shaw CJ, Rivens I, Civale J, Botting KJ, Ter Haar G, Giussani DA, Lees CC.

Sci Rep. 2018 Sep 11;8(1):13631. doi: 10.1038/s41598-018-31914-4.


miRNA-210: a hypoxamiRyad of possibilities.

Cindrova-Davies T, Giussani DA.

J Physiol. 2018 Dec;596(23):5501-5502. doi: 10.1113/JP276591. Epub 2018 Jul 4. No abstract available.


Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood: the avian model.

Skeffington KL, Beck C, Itani N, Giussani DA.

J Dev Orig Health Dis. 2018 Aug;9(4):460-466. doi: 10.1017/S2040174418000247. Epub 2018 Apr 25.


Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet.

Loche E, Blackmore HL, Carpenter AA, Beeson JH, Pinnock A, Ashmore TJ, Aiken CE, de Almeida-Faria J, Schoonejans JM, Giussani DA, Fernandez-Twinn DS, Ozanne SE.

Cardiovasc Res. 2018 Aug 1;114(10):1372-1384. doi: 10.1093/cvr/cvy082.


Altered autonomic control of heart rate variability in the chronically hypoxic fetus.

Shaw CJ, Allison BJ, Itani N, Botting KJ, Niu Y, Lees CC, Giussani DA.

J Physiol. 2018 Dec;596(23):6105-6119. doi: 10.1113/JP275659. Epub 2018 Apr 29.


The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.

Reyes RV, Díaz M, Ebensperger G, Herrera EA, Quezada SA, Hernandez I, Sanhueza EM, Parer JT, Giussani DA, Llanos AJ.

J Physiol. 2018 Dec;596(23):5907-5923. doi: 10.1113/JP274340. Epub 2018 Mar 2.


Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo.

Mohammed R, Salinas CE, Giussani DA, Blanco CE, Cogolludo AL, Villamor E.

Physiol Rep. 2017 Nov;5(22). pii: e13501. doi: 10.14814/phy2.13501.


The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo.

Itani N, Salinas CE, Villena M, Skeffington KL, Beck C, Villamor E, Blanco CE, Giussani DA.

J Physiol. 2018 Aug;596(15):2991-3006. doi: 10.1113/JP274111. Epub 2017 Nov 15.


Influence of gestational diabetes on fetal autonomic nervous system: a study using phase-rectified signal-averaging analysis.

Lobmaier SM, Ortiz JU, Sewald M, Müller A, Schmidt G, Haller B, Oberhoffer R, Schneider KTM, Giussani DA, Wacker-Gussmann A.

Ultrasound Obstet Gynecol. 2018 Sep;52(3):347-351. doi: 10.1002/uog.18823. Epub 2018 Jul 26.


Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation.

McGillick EV, Orgeig S, Allison BJ, Brain KL, Niu Y, Itani N, Skeffington KL, Kane AD, Herrera EA, Giussani DA, Morrison JL.

J Physiol. 2017 Jul 1;595(13):4329-4350. doi: 10.1113/JP273842. Epub 2017 May 7.


At the heart of accelerated old matter.

Botting KJ, Giussani DA.

J Physiol. 2017 Feb 15;595(4):1009-1010. doi: 10.1113/JP273656. No abstract available.


Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo.

Itani N, Skeffington KL, Beck C, Giussani DA.

J Physiol. 2017 Mar 1;595(5):1563-1573. doi: 10.1113/JP273393. Epub 2016 Dec 11.


Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial.

Lobmaier SM, Mensing van Charante N, Ferrazzi E, Giussani DA, Shaw CJ, Müller A, Ortiz JU, Ostermayer E, Haller B, Prefumo F, Frusca T, Hecher K, Arabin B, Thilaganathan B, Papageorghiou AT, Bhide A, Martinelli P, Duvekot JJ, van Eyck J, Visser GH, Schmidt G, Ganzevoort W, Lees CC, Schneider KT; TRUFFLE investigators (see Acknowledgments).

Am J Obstet Gynecol. 2016 Nov;215(5):630.e1-630.e7. doi: 10.1016/j.ajog.2016.06.024. Epub 2016 Jun 23.


Chronic hypoxaemia as a molecular regulator of fetal lung development: implications for risk of respiratory complications at birth.

McGillick EV, Orgeig S, Giussani DA, Morrison JL.

Paediatr Respir Rev. 2017 Jan;21:3-10. doi: 10.1016/j.prrv.2016.08.011. Epub 2016 Aug 21. Review.


Labouring on decelerations: the fetal peripheral chemoreflex wins.

Giussani DA.

J Physiol. 2016 Sep 1;594(17):4699-700. doi: 10.1113/JP272339. No abstract available.


Noninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome: A preliminary in vivo study.

Shaw CJ, Civale J, Botting KJ, Niu Y, Ter Haar G, Rivens I, Giussani DA, Lees CC.

Sci Transl Med. 2016 Jul 13;8(347):347ra95. doi: 10.1126/scitranslmed.aaf2135.


Mind the gap: fetal physiology from bench to bedside.

Giussani DA.

Acta Obstet Gynecol Scand. 2016 Jun;95(6):617-20. doi: 10.1111/aogs.12926. No abstract available.


Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease.

Kane AD, Niu Y, Herrera EA, Morton AJ, Giussani DA.

Sci Rep. 2016 May 16;6:25979. doi: 10.1038/srep25979.


Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease.

Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA.

FASEB J. 2016 May;30(5):1968-75. doi: 10.1096/fj.201500057. Epub 2016 Mar 1.


Variations on fetal heart rate variability.

Shaw CJ, Lees CC, Giussani DA.

J Physiol. 2016 Mar 1;594(5):1279-80. doi: 10.1113/JP270717. No abstract available.


Fetal in vivo continuous cardiovascular function during chronic hypoxia.

Allison BJ, Brain KL, Niu Y, Kane AD, Herrera EA, Thakor AS, Botting KJ, Cross CM, Itani N, Skeffington KL, Beck C, Giussani DA.

J Physiol. 2016 Mar 1;594(5):1247-64. doi: 10.1113/JP271091.


Hypoxia, fetal and neonatal physiology: 100 years on from Sir Joseph Barcroft.

Giussani DA, Bennet L, Sferruzzi-Perri AN, Vaughan OR, Fowden AL.

J Physiol. 2016 Mar 1;594(5):1105-11. doi: 10.1113/JP272000. No abstract available.


Induction of controlled hypoxic pregnancy in large mammalian species.

Brain KL, Allison BJ, Niu Y, Cross CM, Itani N, Kane AD, Herrera EA, Giussani DA.

Physiol Rep. 2015 Dec;3(12). pii: e12614. doi: 10.14814/phy2.12614.


The fetal brain sparing response to hypoxia: physiological mechanisms.

Giussani DA.

J Physiol. 2016 Mar 1;594(5):1215-30. doi: 10.1113/JP271099. Epub 2016 Jan 6. Review.


Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo.

Itani N, Skeffington KL, Beck C, Niu Y, Giussani DA.

J Pineal Res. 2016 Jan;60(1):16-26. doi: 10.1111/jpi.12283. Epub 2015 Oct 26.


Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano.

Herrera EA, Rojas RT, Krause BJ, Ebensperger G, Reyes RV, Giussani DA, Parer JT, Llanos AJ.

J Physiol. 2016 Mar 1;594(5):1231-45. doi: 10.1113/JP271110. Epub 2015 Oct 1.


Developmental Expression and Glucocorticoid Control of the Leptin Receptor in Fetal Ovine Lung.

De Blasio MJ, Boije M, Vaughan OR, Bernstein BS, Davies KL, Plein A, Kempster SL, Smith GC, Charnock-Jones DS, Blache D, Wooding FB, Giussani DA, Fowden AL, Forhead AJ.

PLoS One. 2015 Aug 19;10(8):e0136115. doi: 10.1371/journal.pone.0136115. eCollection 2015.


Hypoxia, AMPK activation and uterine artery vasoreactivity.

Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG.

J Physiol. 2016 Mar 1;594(5):1357-69. doi: 10.1113/JP270995. Epub 2015 Jul 31.


Maternal Dexamethasone Treatment Alters Tissue and Circulating Components of the Renin-Angiotensin System in the Pregnant Ewe and Fetus.

Forhead AJ, Jellyman JK, De Blasio MJ, Johnson E, Giussani DA, Broughton Pipkin F, Fowden AL.

Endocrinology. 2015 Aug;156(8):3038-46. doi: 10.1210/en.2015-1197. Epub 2015 Jun 3.


Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.

Thakor AS, Allison BJ, Niu Y, Botting KJ, Serón-Ferré M, Herrera EA, Giussani DA.

J Pineal Res. 2015 Aug;59(1):80-90. doi: 10.1111/jpi.12242. Epub 2015 May 13.


Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight.

Blackmore HL, Niu Y, Fernandez-Twinn DS, Tarry-Adkins JL, Giussani DA, Ozanne SE.

Endocrinology. 2014 Oct;155(10):3970-80. doi: 10.1210/en.2014-1383. Epub 2014 Jul 22.


Heart disease link to fetal hypoxia and oxidative stress.

Giussani DA, Niu Y, Herrera EA, Richter HG, Camm EJ, Thakor AS, Kane AD, Hansell JA, Brain KL, Skeffington KL, Itani N, Wooding FB, Cross CM, Allison BJ.

Adv Exp Med Biol. 2014;814:77-87. doi: 10.1007/978-1-4939-1031-1_7. Review.


Developmental programming of cardiovascular disease by prenatal hypoxia.

Giussani DA, Davidge ST.

J Dev Orig Health Dis. 2013 Oct;4(5):328-37. doi: 10.1017/S204017441300010X.


High-altitude hypoxia and echocardiographic indices of pulmonary hypertension in male and female chickens at adulthood.

Salinas CE, Blanco CE, Villena M, Giussani DA.

Circ J. 2014;78(6):1459-64. Epub 2014 Apr 16.


Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery.

Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC.

J R Soc Interface. 2014 Mar 26;11(95):20140029. doi: 10.1098/rsif.2014.0029. Print 2014 Jun 6. Review.


Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat.

Kane AD, Camm EJ, Richter HG, Lusby C, Tijsseling D, Kaandorp JJ, Derks JB, Ozanne SE, Giussani DA.

Physiol Rep. 2013 Nov;1(6):e00156. doi: 10.1002/phy2.156. Epub 2013 Nov 13.


Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth.

Tarry-Adkins JL, Blackmore HL, Martin-Gronert MS, Fernandez-Twinn DS, McConnell JM, Hargreaves IP, Giussani DA, Ozanne SE.

Mol Metab. 2013 Sep 27;2(4):480-90. doi: 10.1016/j.molmet.2013.09.004. eCollection 2013.

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