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Items: 1 to 50 of 68

1.

The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence.

Seib KL, Haag AF, Oriente F, Fantappiè L, Borghi S, Semchenko EA, Schulz BL, Ferlicca F, Taddei AR, Giuliani MM, Pizza M, Delany I.

FASEB J. 2019 Aug 23:fj201900669R. doi: 10.1096/fj.201900669R. [Epub ahead of print]

PMID:
31442078
2.

Novel Multiplex Immunoassays for Quantification of IgG against Group B Streptococcus Capsular Polysaccharides in Human Sera.

Buffi G, Galletti B, Stella M, Proietti D, Balducci E, Romano MR, Mori E, Fabbrini M, Giuliani MM, Berti F, Margarit I.

mSphere. 2019 Aug 7;4(4). pii: e00273-19. doi: 10.1128/mSphere.00273-19.

3.

Meningococcal Antigen Typing System (MATS): A Tool to Estimate Global Coverage for 4CMenB, a Multicomponent Meningococcal B Vaccine.

Boccadifuoco G, Brunelli B, Mori E, Agnusdei M, Gianfaldoni C, Giuliani MM.

Methods Mol Biol. 2019;1969:205-215. doi: 10.1007/978-1-4939-9202-7_14.

PMID:
30877679
4.

Evaluation of strain coverage of the multicomponent meningococcal serogroup B vaccine (4CMenB) administered in infants according to different immunisation schedules.

Biolchi A, Tomei S, Santini L, Welsch JA, Toneatto D, Gaitatzis N, Bai X, Borrow R, Giuliani MM, Mori E, Pizza M.

Hum Vaccin Immunother. 2019;15(3):725-731. doi: 10.1080/21645515.2018.1537756. Epub 2019 Jan 2.

5.

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes.

Giuliani M, Bartolini E, Galli B, Santini L, Lo Surdo P, Buricchi F, Bruttini M, Benucci B, Pacchiani N, Alleri L, Donnarumma D, Pansegrau W, Peschiera I, Ferlenghi I, Cozzi R, Norais N, Giuliani MM, Maione D, Pizza M, Rappuoli R, Finco O, Masignani V.

Sci Rep. 2018 Feb 27;8(1):3700. doi: 10.1038/s41598-018-22057-7.

6.

Differences in gluten protein composition between old and modern durum wheat genotypes in relation to 20th century breeding in Italy.

De Santis MA, Giuliani MM, Giuzio L, De Vita P, Lovegrove A, Shewry PR, Flagella Z.

Eur J Agron. 2017 Jul;87:19-29. doi: 10.1016/j.eja.2017.04.003.

7.

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology.

Cariccio VL, Domina M, Benfatto S, Venza M, Venza I, Faleri A, Bruttini M, Bartolini E, Giuliani MM, Santini L, Brunelli B, Norais N, Borgogni E, Midiri A, Galbo R, Romeo L, Biondo C, Masignani V, Teti G, Felici F, Beninati C.

MAbs. 2016 May-Jun;8(4):741-50. doi: 10.1080/19420862.2016.1158371. Epub 2016 Mar 10.

8.

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.

9.

Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain, England.

Ladhani SN, Giuliani MM, Biolchi A, Pizza M, Beebeejaun K, Lucidarme J, Findlow J, Ramsay ME, Borrow R.

Emerg Infect Dis. 2016 Feb;22(2):309-11. doi: 10.3201/eid2202.150369.

10.

HexR Controls Glucose-Responsive Genes and Central Carbon Metabolism in Neisseria meningitidis.

Antunes A, Golfieri G, Ferlicca F, Giuliani MM, Scarlato V, Delany I.

J Bacteriol. 2015 Dec 7;198(4):644-54. doi: 10.1128/JB.00659-15.

11.

Meningococcal Antigen Typing System Development and Application to the Evaluation of Effectiveness of Meningococcal B Vaccine and Possible Use for Other Purposes.

Domnich A, Gasparini R, Amicizia D, Boccadifuoco G, Giuliani MM, Panatto D.

J Immunol Res. 2015;2015:353461. doi: 10.1155/2015/353461. Epub 2015 Aug 17. Review.

12.

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components.

Bertoldi I, Faleri A, Galli B, Lo Surdo P, Liguori A, Norais N, Santini L, Masignani V, Pizza M, Giuliani MM.

FASEB J. 2016 Jan;30(1):93-101. doi: 10.1096/fj.15-273813. Epub 2015 Aug 24.

PMID:
26304221
13.

Differential Expression of Durum Wheat Gluten Proteome under Water Stress during Grain Filling.

Giuliani MM, Palermo C, De Santis MA, Mentana A, Pompa M, Giuzio L, Masci S, Centonze D, Flagella Z.

J Agric Food Chem. 2015 Jul 29;63(29):6501-12. doi: 10.1021/acs.jafc.5b01635. Epub 2015 Jul 15.

PMID:
26138860
14.

Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.

Bottazzi B, Santini L, Savino S, Giuliani MM, Dueñas Díez AI, Mancuso G, Beninati C, Sironi M, Valentino S, Deban L, Garlanda C, Teti G, Pizza M, Rappuoli R, Mantovani A.

PLoS One. 2015 Mar 18;10(3):e0120807. doi: 10.1371/journal.pone.0120807. eCollection 2015.

15.

A large portion of meningococcal antigen typing system-negative meningococcal strains from spain is killed by sera from adolescents and infants immunized with 4CMenB.

Abad R, Biolchi A, Moschioni M, Giuliani MM, Pizza M, Vázquez JA.

Clin Vaccine Immunol. 2015 Apr;22(4):357-60. doi: 10.1128/CVI.00669-14. Epub 2015 Jan 28.

16.

Molecular and serological diversity of Neisseria meningitidis carrier strains isolated from Italian students aged 14 to 22 years.

Gasparini R, Comanducci M, Amicizia D, Ansaldi F, Canepa P, Orsi A, Icardi G, Rizzitelli E, De Angelis G, Bambini S, Moschioni M, Comandi S, Simmini I, Boccadifuoco G, Brunelli B, Giuliani MM, Pizza M, Panatto D.

J Clin Microbiol. 2014 Jun;52(6):1901-10. doi: 10.1128/JCM.03584-13. Epub 2014 Mar 19.

17.

Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage.

Frosi G, Biolchi A, Lo Sapio M, Rigat F, Gilchrist S, Lucidarme J, Findlow J, Borrow R, Pizza M, Giuliani MM, Medini D.

Vaccine. 2013 Oct 9;31(43):4968-74. doi: 10.1016/j.vaccine.2013.08.006. Epub 2013 Aug 14.

18.

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment.

Vogel U, Taha MK, Vazquez JA, Findlow J, Claus H, Stefanelli P, Caugant DA, Kriz P, Abad R, Bambini S, Carannante A, Deghmane AE, Fazio C, Frosch M, Frosi G, Gilchrist S, Giuliani MM, Hong E, Ledroit M, Lovaglio PG, Lucidarme J, Musilek M, Muzzi A, Oksnes J, Rigat F, Orlandi L, Stella M, Thompson D, Pizza M, Rappuoli R, Serruto D, Comanducci M, Boccadifuoco G, Donnelly JJ, Medini D, Borrow R.

Lancet Infect Dis. 2013 May;13(5):416-25. doi: 10.1016/S1473-3099(13)70006-9. Epub 2013 Feb 13.

PMID:
23414709
19.

Comparative analysis of gluten proteins in three durum wheat cultivars by a proteomic approach.

Pompa M, Giuliani MM, Palermo C, Agriesti F, Centonze D, Flagella Z.

J Agric Food Chem. 2013 Mar 20;61(11):2606-17. doi: 10.1021/jf304566d. Epub 2013 Mar 4.

PMID:
23414385
20.

Could the multicomponent meningococcal serogroup B vaccine (4CMenB) control Neisseria meningitidis capsular group X outbreaks in Africa?

Hong E, Giuliani MM, Deghmane AE, Comanducci M, Brunelli B, Dull P, Pizza M, Taha MK.

Vaccine. 2013 Feb 4;31(7):1113-6. doi: 10.1016/j.vaccine.2012.12.022. Epub 2012 Dec 20.

PMID:
23261039
21.

A combined approach to assess the potential coverage of a multicomponent protein-based vaccine.

Boccadifuoco G, Brunelli B, Pizza MG, Giuliani MM.

J Prev Med Hyg. 2012 Jun;53(2):56-60. Review.

PMID:
23240161
22.

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine.

Fagnocchi L, Biolchi A, Ferlicca F, Boccadifuoco G, Brunelli B, Brier S, Norais N, Chiarot E, Bensi G, Kroll JS, Pizza M, Donnelly J, Giuliani MM, Delany I.

Infect Immun. 2013 Feb;81(2):560-9. doi: 10.1128/IAI.01085-12. Epub 2012 Dec 10.

23.

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens.

Serruto D, Bottomley MJ, Ram S, Giuliani MM, Rappuoli R.

Vaccine. 2012 May 30;30 Suppl 2:B87-97. doi: 10.1016/j.vaccine.2012.01.033. Review.

24.

A new flow-cytometry-based opsonophagocytosis assay for the rapid measurement of functional antibody levels against Group B Streptococcus.

Fabbrini M, Sammicheli C, Margarit I, Maione D, Grandi G, Giuliani MM, Mori E, Nuti S.

J Immunol Methods. 2012 Apr 30;378(1-2):11-9. doi: 10.1016/j.jim.2012.01.011. Epub 2012 Jan 30.

25.

Rational design of a meningococcal antigen inducing broad protective immunity.

Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R.

Sci Transl Med. 2011 Jul 13;3(91):91ra62. doi: 10.1126/scitranslmed.3002234.

26.

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.

Seubert A, Calabro S, Santini L, Galli B, Genovese A, Valentini S, Aprea S, Colaprico A, D'Oro U, Giuliani MM, Pallaoro M, Pizza M, O'Hagan DT, Wack A, Rappuoli R, De Gregorio E.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11169-74. doi: 10.1073/pnas.1107941108. Epub 2011 Jun 20.

27.

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, Muzzi A, DiMarcello F, Marchi S, van der Ende A, Aricó B, Savino S, Scarselli M, Comanducci M, Rappuoli R, Giuliani MM, Pizza M.

Infect Immun. 2011 Feb;79(2):970-81. doi: 10.1128/IAI.00891-10. Epub 2010 Dec 13.

28.

Influence of sequence variability on bactericidal activity sera induced by Factor H binding protein variant 1.1.

Brunelli B, Del Tordello E, Palumbo E, Biolchi A, Bambini S, Comanducci M, Muzzi A, Pizza M, Rappuoli R, Donnelly JJ, Giuliani MM, Serruto D.

Vaccine. 2011 Jan 29;29(5):1072-81. doi: 10.1016/j.vaccine.2010.11.064. Epub 2010 Dec 3.

PMID:
21130753
29.

Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.

Donnelly J, Medini D, Boccadifuoco G, Biolchi A, Ward J, Frasch C, Moxon ER, Stella M, Comanducci M, Bambini S, Muzzi A, Andrews W, Chen J, Santos G, Santini L, Boucher P, Serruto D, Pizza M, Rappuoli R, Giuliani MM.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19490-5. doi: 10.1073/pnas.1013758107. Epub 2010 Oct 20.

30.

Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading.

Cox AD, St Michael F, Neelamegan D, Lacelle S, Cairns CM, Giuliani MM, Biolchi A, Hoe JC, Moxon ER, Richards JC.

Glycoconj J. 2010 Oct;27(7-9):643-8. doi: 10.1007/s10719-010-9309-y. Epub 2010 Oct 5.

PMID:
20922476
31.

Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus.

Giuliani MM, Biolchi A, Serruto D, Ferlicca F, Vienken K, Oster P, Rappuoli R, Pizza M, Donnelly J.

Vaccine. 2010 Jul 12;28(31):5023-30. doi: 10.1016/j.vaccine.2010.05.014. Epub 2010 May 21.

PMID:
20493284
32.

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.

Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Aricò B.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3770-5. doi: 10.1073/pnas.0915162107. Epub 2010 Feb 3.

33.

Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection.

Seib KL, Oriente F, Adu-Bobie J, Montanari P, Ferlicca F, Giuliani MM, Rappuoli R, Pizza M, Delany I.

Vaccine. 2010 Mar 11;28(12):2416-27. doi: 10.1016/j.vaccine.2009.12.082. Epub 2010 Jan 10.

PMID:
20067752
34.

The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression.

Fantappiè L, Metruccio MM, Seib KL, Oriente F, Cartocci E, Ferlicca F, Giuliani MM, Scarlato V, Delany I.

Infect Immun. 2009 May;77(5):1842-53. doi: 10.1128/IAI.01216-08. Epub 2009 Feb 17.

35.

Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis.

Scarselli M, Cantini F, Santini L, Veggi D, Dragonetti S, Donati C, Savino S, Giuliani MM, Comanducci M, Di Marcello F, Romagnoli G, Pizza M, Banci L, Rappuoli R.

J Mol Biol. 2009 Feb 13;386(1):97-108. doi: 10.1016/j.jmb.2008.12.005. Epub 2008 Dec 11.

PMID:
19100746
36.

Intranasal immunization of mice with recombinant Streptococcus gordonii expressing NadA of Neisseria meningitidis induces systemic bactericidal antibodies and local IgA.

Ciabattini A, Giomarelli B, Parigi R, Chiavolini D, Pettini E, Aricò B, Giuliani MM, Santini L, Medaglini D, Pozzi G.

Vaccine. 2008 Aug 5;26(33):4244-50. doi: 10.1016/j.vaccine.2008.05.049. Epub 2008 Jun 6.

PMID:
18582996
37.

Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.

Dunning Hotopp JC, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H.

Microbiology. 2006 Dec;152(Pt 12):3733-49.

PMID:
17159225
38.

A universal vaccine for serogroup B meningococcus.

Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. Epub 2006 Jul 6.

39.

Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles.

Ferrari G, Garaguso I, Adu-Bobie J, Doro F, Taddei AR, Biolchi A, Brunelli B, Giuliani MM, Pizza M, Norais N, Grandi G.

Proteomics. 2006 Mar;6(6):1856-66.

PMID:
16456881
40.

Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform.

Baudner BC, Verhoef JC, Giuliani MM, Peppoloni S, Rappuoli R, Del Giudice G, Junginger HE.

J Drug Target. 2005 Sep-Nov;13(8-9):489-98.

PMID:
16332574
41.

The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies.

Giuliani MM, Santini L, Brunelli B, Biolchi A, Aricò B, Di Marcello F, Cartocci E, Comanducci M, Masignani V, Lozzi L, Savino S, Scarselli M, Rappuoli R, Pizza M.

Infect Immun. 2005 Feb;73(2):1151-60.

42.

The impact of genomics on vaccine design.

Scarselli M, Giuliani MM, Adu-Bobie J, Pizza M, Rappuoli R.

Trends Biotechnol. 2005 Feb;23(2):84-91. Review.

PMID:
15661345
43.
44.

Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system.

Baudner BC, Morandi M, Giuliani MM, Verhoef JC, Junginger HE, Costantino P, Rappuoli R, Del Giudice G.

J Infect Dis. 2004 Mar 1;189(5):828-32. Epub 2004 Feb 18.

PMID:
14976599
45.

NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis.

Masignani V, Balducci E, Di Marcello F, Savino S, Serruto D, Veggi D, Bambini S, Scarselli M, Aricò B, Comanducci M, Adu-Bobie J, Giuliani MM, Rappuoli R, Pizza M.

Mol Microbiol. 2003 Nov;50(3):1055-67.

46.

The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines.

Baudner BC, Giuliani MM, Verhoef JC, Rappuoli R, Junginger HE, Giudice GD.

Vaccine. 2003 Sep 8;21(25-26):3837-44.

PMID:
12922117
47.

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870.

Masignani V, Comanducci M, Giuliani MM, Bambini S, Adu-Bobie J, Arico B, Brunelli B, Pieri A, Santini L, Savino S, Serruto D, Litt D, Kroll S, Welsch JA, Granoff DM, Rappuoli R, Pizza M.

J Exp Med. 2003 Mar 17;197(6):789-99.

48.

Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.

Baudner BC, Balland O, Giuliani MM, Von Hoegen P, Rappuoli R, Betbeder D, Del Giudice G.

Infect Immun. 2002 Sep;70(9):4785-90.

49.

Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays.

Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, Ratti G, Petracca R, Galli G, Agnusdei M, Giuliani MM, Santini L, Brunelli B, Tettelin H, Rappuoli R, Randazzo F, Grandi G.

Nat Biotechnol. 2002 Sep;20(9):914-21. Epub 2002 Aug 12.

PMID:
12172557
50.

NadA, a novel vaccine candidate of Neisseria meningitidis.

Comanducci M, Bambini S, Brunelli B, Adu-Bobie J, Aricò B, Capecchi B, Giuliani MM, Masignani V, Santini L, Savino S, Granoff DM, Caugant DA, Pizza M, Rappuoli R, Mora M.

J Exp Med. 2002 Jun 3;195(11):1445-54.

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