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Items: 1 to 50 of 160

1.

Evidence of a developmental origin of beta-cell heterogeneity using a dual lineage tracing technology.

Chen C, Shiota C, Agostinelli G, Ridley D, Jiang Y, Ma J, Prasadan K, Xiao X, Gittes GK.

Development. 2019 Jun 3. pii: dev.164913. doi: 10.1242/dev.164913. [Epub ahead of print]

PMID:
31160417
2.

Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.

Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z.

Theranostics. 2018 Nov 13;8(21):5960-5971. doi: 10.7150/thno.28960. eCollection 2018.

3.

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

Xiao X, Guo P, Shiota C, Zhang T, Coudriet GM, Fischbach S, Prasadan K, Fusco J, Ramachandran S, Witkowski P, Piganelli JD, Gittes GK.

Cell Stem Cell. 2018 Jan 4;22(1):78-90.e4. doi: 10.1016/j.stem.2017.11.020.

4.

Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.

Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F.

Sci Rep. 2017 Dec 13;7(1):17539. doi: 10.1038/s41598-017-17884-z.

5.

Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet.

Sheng Q, Xiao X, Prasadan K, Chen C, Ming Y, Fusco J, Gangopadhyay NN, Ricks D, Gittes GK.

Sci Rep. 2017 Nov 27;7(1):16348. doi: 10.1038/s41598-017-16485-0.

6.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

7.

Gcg CreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells.

Shiota C, Prasadan K, Guo P, Fusco J, Xiao X, Gittes GK.

Diabetologia. 2017 Dec;60(12):2399-2408. doi: 10.1007/s00125-017-4425-x. Epub 2017 Sep 7.

8.

SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.

Xiao X, Fischbach S, Zhang T, Chen C, Sheng Q, Zimmerman R, Patnaik S, Fusco J, Ming Y, Guo P, Shiota C, Prasadan K, Gangopadhyay N, Husain SZ, Dong H, Gittes GK.

Diabetes. 2017 Oct;66(10):2646-2658. doi: 10.2337/db17-0537. Epub 2017 Aug 3.

9.

Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.

Orabi AI, Wen L, Javed TA, Le T, Guo P, Sanker S, Ricks D, Boggs K, Eisses JF, Castro C, Xiao X, Prasadan K, Esni F, Gittes GK, Husain SZ.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):119-128. doi: 10.1016/j.jcmgh.2016.08.006.

10.

Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.

Xiao X, Chen C, Guo P, Zhang T, Fischbach S, Fusco J, Shiota C, Prasadan K, Dong H, Gittes GK.

J Biol Chem. 2017 Feb 24;292(8):3456-3465. doi: 10.1074/jbc.M116.770032. Epub 2017 Jan 5.

11.

Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.

Song Z, Fusco J, Zimmerman R, Fischbach S, Chen C, Ricks DM, Prasadan K, Shiota C, Xiao X, Gittes GK.

J Biol Chem. 2016 Oct 21;291(43):22630-22637. Epub 2016 Sep 1.

12.

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis.

Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP.

J Biol Chem. 2016 May 6;291(19):10184-200. doi: 10.1074/jbc.M115.688812. Epub 2016 Mar 11.

13.

PNA lectin for purifying mouse acinar cells from the inflamed pancreas.

Xiao X, Fischbach S, Fusco J, Zimmerman R, Song Z, Nebres P, Ricks DM, Prasadan K, Shiota C, Husain SZ, Gittes GK.

Sci Rep. 2016 Feb 17;6:21127. doi: 10.1038/srep21127.

14.

Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.

Xiao X, Fischbach S, Song Z, Gaffar I, Zimmerman R, Wiersch J, Prasadan K, Shiota C, Guo P, Ramachandran S, Witkowski P, Gittes GK.

Endocrinology. 2016 Apr;157(4):1348-56. doi: 10.1210/en.2015-1986. Epub 2016 Feb 12.

15.

Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.

J Biol Chem. 2016 Jan 15;291(3):1202. doi: 10.1074/jbc.A115.647933. No abstract available.

16.

Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis.

Gittes GK.

J Pathol. 2016 Apr;238(5):603-5. doi: 10.1002/path.4676. Epub 2016 Jan 13.

PMID:
26608971
17.

Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.

El-Gohary Y, Wiersch J, Tulachan S, Xiao X, Guo P, Rymer C, Fischbach S, Prasadan K, Shiota C, Gaffar I, Song Z, Galambos C, Esni F, Gittes GK.

Endocrinology. 2016 Jan;157(1):166-75. doi: 10.1210/en.2015-1175. Epub 2015 Oct 27.

18.

The Role of ARF6 in Biliary Atresia.

Ningappa M, So J, Glessner J, Ashokkumar C, Ranganathan S, Min J, Higgs BW, Sun Q, Haberman K, Schmitt L, Vilarinho S, Mistry PK, Vockley G, Dhawan A, Gittes GK, Hakonarson H, Jaffe R, Subramaniam S, Shin D, Sindhi R.

PLoS One. 2015 Sep 17;10(9):e0138381. doi: 10.1371/journal.pone.0138381. eCollection 2015.

19.

Defective parasympathetic innervation is associated with airway branching abnormalities in experimental CDH.

Rhodes J, Saxena D, Zhang G, Gittes GK, Potoka DA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L168-74. doi: 10.1152/ajplung.00299.2014. Epub 2015 May 1.

20.

Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation.

Xiao X, Gittes GK.

Stem Cells Transl Med. 2015 Jun;4(6):655-8. doi: 10.5966/sctm.2014-0248. Epub 2015 Apr 21. Review.

21.

Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.

J Biol Chem. 2015 May 1;290(18):11309-20. doi: 10.1074/jbc.M115.647933. Epub 2015 Mar 23. Erratum in: J Biol Chem. 2016 Jan 15;291(3):1202.

22.

Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes.

Xiao X, Guo P, Prasadan K, Shiota C, Peirish L, Fischbach S, Song Z, Gaffar I, Wiersch J, El-Gohary Y, Husain SZ, Gittes GK.

Nat Protoc. 2014 Dec;9(12):2719-24. doi: 10.1038/nprot.2014.183. Epub 2014 Oct 30.

23.

Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.

Criscimanna A, Coudriet GM, Gittes GK, Piganelli JD, Esni F.

Gastroenterology. 2014 Nov;147(5):1106-18.e11. doi: 10.1053/j.gastro.2014.08.008. Epub 2014 Aug 14.

PMID:
25128759
24.

Renal blood flow and oxygenation drive nephron progenitor differentiation.

Rymer C, Paredes J, Halt K, Schaefer C, Wiersch J, Zhang G, Potoka D, Vainio S, Gittes GK, Bates CM, Sims-Lucas S.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F337-45. doi: 10.1152/ajprenal.00208.2014. Epub 2014 Jun 11.

25.

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.

Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1211-20. doi: 10.1073/pnas.1321347111. Epub 2014 Mar 17.

26.

Pancreatic duct cells as a source of VEGF in mice.

Xiao X, Prasadan K, Guo P, El-Gohary Y, Fischbach S, Wiersch J, Gaffar I, Shiota C, Gittes GK.

Diabetologia. 2014 May;57(5):991-1000. doi: 10.1007/s00125-014-3179-y. Epub 2014 Feb 18.

27.

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ.

J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11.

28.

Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts.

Guo P, Xiao X, El-Gohary Y, Criscimanna A, Prasadan K, Rymer C, Shiota C, Wiersch J, Gaffar I, Esni F, Gittes GK.

Lab Invest. 2013 Nov;93(11):1241-53. doi: 10.1038/labinvest.2013.113. Epub 2013 Oct 7.

29.

α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets.

Shiota C, Prasadan K, Guo P, El-Gohary Y, Wiersch J, Xiao X, Esni F, Gittes GK.

Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1030-40. doi: 10.1152/ajpendo.00022.2013. Epub 2013 Aug 27.

30.

Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas.

Xiao X, Guo P, Shiota C, Prasadan K, El-Gohary Y, Wiersch J, Gaffar I, Gittes GK.

J Biol Chem. 2013 Aug 30;288(35):25297-308. doi: 10.1074/jbc.M113.484022. Epub 2013 Jul 18.

31.

PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis.

Criscimanna A, Duan LJ, Rhodes JA, Fendrich V, Wickline E, Hartman DJ, Monga SP, Lotze MT, Gittes GK, Fong GH, Esni F.

Cancer Res. 2013 Aug 1;73(15):4781-90. doi: 10.1158/0008-5472.CAN-13-0566. Epub 2013 Jun 7.

32.

No evidence for β cell neogenesis in murine adult pancreas.

Xiao X, Chen Z, Shiota C, Prasadan K, Guo P, El-Gohary Y, Paredes J, Welsh C, Wiersch J, Gittes GK.

J Clin Invest. 2013 May;123(5):2207-17. doi: 10.1172/JCI66323. Epub 2013 Apr 24.

33.

Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass.

Xiao X, Guo P, Chen Z, El-Gohary Y, Wiersch J, Gaffar I, Prasadan K, Shiota C, Gittes GK.

J Biol Chem. 2013 Mar 22;288(12):8636-46. doi: 10.1074/jbc.M112.422949. Epub 2013 Feb 1.

34.

High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

Mishra SK, Funair L, Cressley A, Gittes GK, Burns RC.

PLoS One. 2012;7(12):e52190. doi: 10.1371/journal.pone.0052190. Epub 2012 Dec 14.

35.

TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation.

Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, Welsh C, Shiota C, Gittes GK.

Diabetes. 2013 Apr;62(4):1217-26. doi: 10.2337/db12-1428. Epub 2012 Dec 17.

36.

A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning.

Guo P, Xiao X, El-Gohary Y, Paredes J, Prasadan K, Shiota C, Wiersch J, Welsh C, Gittes GK.

Bioengineered. 2013 Mar-Apr;4(2):103-6. doi: 10.4161/bioe.22293. Epub 2012 Mar 1.

37.

Three-dimensional analysis of the islet vasculature.

El-Gohary Y, Sims-Lucas S, Lath N, Tulachan S, Guo P, Xiao X, Welsh C, Paredes J, Wiersch J, Prasadan K, Shiota C, Gittes GK.

Anat Rec (Hoboken). 2012 Sep;295(9):1473-81. doi: 10.1002/ar.22530. Epub 2012 Jul 16.

38.

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ.

Gastroenterology. 2012 Sep;143(3):708-718.e5. doi: 10.1053/j.gastro.2012.05.053. Epub 2012 Jul 13.

39.

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.

Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25.

40.

Rapid and simplified purification of recombinant adeno-associated virus.

Guo P, El-Gohary Y, Prasadan K, Shiota C, Xiao X, Wiersch J, Paredes J, Tulachan S, Gittes GK.

J Virol Methods. 2012 Aug;183(2):139-46. doi: 10.1016/j.jviromet.2012.04.004. Epub 2012 Apr 26.

41.

Whole-mount imaging demonstrates hypervascularity of the pancreatic ducts and other pancreatic structures.

El-Gohary Y, Tulachan S, Branca M, Sims-Lucas S, Guo P, Prasadan K, Shiota C, Gittes GK.

Anat Rec (Hoboken). 2012 Mar;295(3):465-73. doi: 10.1002/ar.22420. Epub 2012 Jan 26.

42.

Defective pulmonary innervation and autonomic imbalance in congenital diaphragmatic hernia.

Lath NR, Galambos C, Rocha AB, Malek M, Gittes GK, Potoka DA.

Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L390-8. doi: 10.1152/ajplung.00275.2011. Epub 2011 Nov 23.

43.

Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice.

Criscimanna A, Speicher JA, Houshmand G, Shiota C, Prasadan K, Ji B, Logsdon CD, Gittes GK, Esni F.

Gastroenterology. 2011 Oct;141(4):1451-62, 1462.e1-6. doi: 10.1053/j.gastro.2011.07.003. Epub 2011 Jul 18.

44.

Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent.

Paredes J, Sims-Lucas S, Wang H, Lu W, Coley B, Gittes GK, Bates CM.

Am J Physiol Renal Physiol. 2011 May;300(5):F1262-5. doi: 10.1152/ajprenal.00720.2010. Epub 2011 Feb 16.

45.

The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas.

Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK.

Diabetes. 2011 Feb;60(2):548-54. doi: 10.2337/db09-0035.

46.

Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation.

Shah SR, Esni F, Jakub A, Paredes J, Lath N, Malek M, Potoka DA, Prasadan K, Mastroberardino PG, Shiota C, Guo P, Miller KA, Hackam DJ, Burns RC, Tulachan SS, Gittes GK.

Dev Biol. 2011 Jan 15;349(2):342-9. doi: 10.1016/j.ydbio.2010.10.033. Epub 2010 Nov 2.

47.

Impaired pancreatic development in Hif2-alpha deficient mice.

Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F.

Biochem Biophys Res Commun. 2010 Aug 27;399(3):440-5. doi: 10.1016/j.bbrc.2010.07.111. Epub 2010 Aug 3.

PMID:
20678473
48.

Congenital anomalies of the esophagus.

El-Gohary Y, Gittes GK, Tovar JA.

Semin Pediatr Surg. 2010 Aug;19(3):186-93. doi: 10.1053/j.sempedsurg.2010.03.009. Review.

PMID:
20610191
49.

Treatment of adolescent gynecomastia.

Laituri CA, Garey CL, Ostlie DJ, St Peter SD, Gittes GK, Snyder CL.

J Pediatr Surg. 2010 Mar;45(3):650-4. doi: 10.1016/j.jpedsurg.2009.11.016.

PMID:
20223338
50.

Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis.

Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ.

J Immunol. 2009 Jan 1;182(1):636-46.

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