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Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture.

Himuro M, Miyatsuka T, Suzuki L, Miura M, Katahira T, Goto H, Nishida Y, Sasaki S, Koike M, Shiota C, Gittes GK, Fujitani Y, Watada H.

J Endocr Soc. 2019 Aug 8;3(11):1979-1992. doi: 10.1210/js.2019-00075. eCollection 2019 Nov 1.


Prolactin Promotes Fibrosis and Pancreatic Cancer Progression.

Tandon M, Coudriet GM, Criscimanna A, Socorro M, Eliliwi M, Singhi AD, Cruz-Monserrate Z, Bailey P, Lotze MT, Zeh H, Hu J, Goffin V, Gittes GK, Biankin AV, Esni F.

Cancer Res. 2019 Oct 15;79(20):5316-5327. doi: 10.1158/0008-5472.CAN-18-3064. Epub 2019 Aug 8.


Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology.

Chen C, Shiota C, Agostinelli G, Ridley D, Jiang Y, Ma J, Prasadan K, Xiao X, Gittes GK.

Development. 2019 Jun 27;146(13). pii: dev164913. doi: 10.1242/dev.164913.


Simplified Purification of AAV and Delivery to the Pancreas by Intraductal Administration.

Guo P, Wiersch J, Xiao X, Gittes G.

Methods Mol Biol. 2019;1950:373-387. doi: 10.1007/978-1-4939-9139-6_22.


Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.

Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z.

Theranostics. 2018 Nov 13;8(21):5960-5971. doi: 10.7150/thno.28960. eCollection 2018.


Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

Xiao X, Guo P, Shiota C, Zhang T, Coudriet GM, Fischbach S, Prasadan K, Fusco J, Ramachandran S, Witkowski P, Piganelli JD, Gittes GK.

Cell Stem Cell. 2018 Jan 4;22(1):78-90.e4. doi: 10.1016/j.stem.2017.11.020.


Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.

Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F.

Sci Rep. 2017 Dec 13;7(1):17539. doi: 10.1038/s41598-017-17884-z.


Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet.

Sheng Q, Xiao X, Prasadan K, Chen C, Ming Y, Fusco J, Gangopadhyay NN, Ricks D, Gittes GK.

Sci Rep. 2017 Nov 27;7(1):16348. doi: 10.1038/s41598-017-16485-0.


Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.


Gcg CreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells.

Shiota C, Prasadan K, Guo P, Fusco J, Xiao X, Gittes GK.

Diabetologia. 2017 Dec;60(12):2399-2408. doi: 10.1007/s00125-017-4425-x. Epub 2017 Sep 7.


GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.

Fusco J, Xiao X, Prasadan K, Sheng Q, Chen C, Ming YC, Gittes G.

Sci Rep. 2017 Aug 22;7(1):9100. doi: 10.1038/s41598-017-09898-4.


SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.

Xiao X, Fischbach S, Zhang T, Chen C, Sheng Q, Zimmerman R, Patnaik S, Fusco J, Ming Y, Guo P, Shiota C, Prasadan K, Gangopadhyay N, Husain SZ, Dong H, Gittes GK.

Diabetes. 2017 Oct;66(10):2646-2658. doi: 10.2337/db17-0537. Epub 2017 Aug 3.


Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.

Orabi AI, Wen L, Javed TA, Le T, Guo P, Sanker S, Ricks D, Boggs K, Eisses JF, Castro C, Xiao X, Prasadan K, Esni F, Gittes GK, Husain SZ.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):119-128. doi: 10.1016/j.jcmgh.2016.08.006.


Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.

Xiao X, Chen C, Guo P, Zhang T, Fischbach S, Fusco J, Shiota C, Prasadan K, Dong H, Gittes GK.

J Biol Chem. 2017 Feb 24;292(8):3456-3465. doi: 10.1074/jbc.M116.770032. Epub 2017 Jan 5.


Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.

Song Z, Fusco J, Zimmerman R, Fischbach S, Chen C, Ricks DM, Prasadan K, Shiota C, Xiao X, Gittes GK.

J Biol Chem. 2016 Oct 21;291(43):22630-22637. Epub 2016 Sep 1.


Effect of Hypertriglyceridemia on Beta Cell Mass and Function in ApoC3 Transgenic Mice.

Liu YZ, Cheng X, Zhang T, Lee S, Yamauchi J, Xiao X, Gittes G, Qu S, Jiang CL, Dong HH.

J Biol Chem. 2016 Jul 8;291(28):14695-705. doi: 10.1074/jbc.M115.707885. Epub 2016 May 11.


A synopsis of factors regulating beta cell development and beta cell mass.

Prasadan K, Shiota C, Xiangwei X, Ricks D, Fusco J, Gittes G.

Cell Mol Life Sci. 2016 Oct;73(19):3623-37. doi: 10.1007/s00018-016-2231-0. Epub 2016 Apr 22. Review.


Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis.

Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP.

J Biol Chem. 2016 May 6;291(19):10184-200. doi: 10.1074/jbc.M115.688812. Epub 2016 Mar 11.


PNA lectin for purifying mouse acinar cells from the inflamed pancreas.

Xiao X, Fischbach S, Fusco J, Zimmerman R, Song Z, Nebres P, Ricks DM, Prasadan K, Shiota C, Husain SZ, Gittes GK.

Sci Rep. 2016 Feb 17;6:21127. doi: 10.1038/srep21127.


Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.

Xiao X, Fischbach S, Song Z, Gaffar I, Zimmerman R, Wiersch J, Prasadan K, Shiota C, Guo P, Ramachandran S, Witkowski P, Gittes GK.

Endocrinology. 2016 Apr;157(4):1348-56. doi: 10.1210/en.2015-1986. Epub 2016 Feb 12.


Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.

J Biol Chem. 2016 Jan 15;291(3):1202. doi: 10.1074/jbc.A115.647933. No abstract available.


FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH.

Endocrinology. 2016 Mar;157(3):1055-70. doi: 10.1210/en.2015-1852. Epub 2016 Jan 4.


Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis.

Gittes GK.

J Pathol. 2016 Apr;238(5):603-5. doi: 10.1002/path.4676. Epub 2016 Jan 13.


Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.

El-Gohary Y, Wiersch J, Tulachan S, Xiao X, Guo P, Rymer C, Fischbach S, Prasadan K, Shiota C, Gaffar I, Song Z, Galambos C, Esni F, Gittes GK.

Endocrinology. 2016 Jan;157(1):166-75. doi: 10.1210/en.2015-1175. Epub 2015 Oct 27.


The Role of ARF6 in Biliary Atresia.

Ningappa M, So J, Glessner J, Ashokkumar C, Ranganathan S, Min J, Higgs BW, Sun Q, Haberman K, Schmitt L, Vilarinho S, Mistry PK, Vockley G, Dhawan A, Gittes GK, Hakonarson H, Jaffe R, Subramaniam S, Shin D, Sindhi R.

PLoS One. 2015 Sep 17;10(9):e0138381. doi: 10.1371/journal.pone.0138381. eCollection 2015.


Defective parasympathetic innervation is associated with airway branching abnormalities in experimental CDH.

Rhodes J, Saxena D, Zhang G, Gittes GK, Potoka DA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L168-74. doi: 10.1152/ajplung.00299.2014. Epub 2015 May 1.


Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation.

Xiao X, Gittes GK.

Stem Cells Transl Med. 2015 Jun;4(6):655-8. doi: 10.5966/sctm.2014-0248. Epub 2015 Apr 21. Review.


Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.

J Biol Chem. 2015 May 1;290(18):11309-20. doi: 10.1074/jbc.M115.647933. Epub 2015 Mar 23. Erratum in: J Biol Chem. 2016 Jan 15;291(3):1202.


Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes.

Xiao X, Guo P, Prasadan K, Shiota C, Peirish L, Fischbach S, Song Z, Gaffar I, Wiersch J, El-Gohary Y, Husain SZ, Gittes GK.

Nat Protoc. 2014 Dec;9(12):2719-24. doi: 10.1038/nprot.2014.183. Epub 2014 Oct 30.


Barrier function of the coelomic epithelium in the developing pancreas.

Guo P, Preuett B, Krishna P, Xiao X, Shiota C, Wiersch J, Gaffar I, Tulachan S, El-Gohary Y, Song Z, Gittes G.

Mech Dev. 2014 Nov;134:67-79. doi: 10.1016/j.mod.2014.09.004. Epub 2014 Oct 5.


Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.

Criscimanna A, Coudriet GM, Gittes GK, Piganelli JD, Esni F.

Gastroenterology. 2014 Nov;147(5):1106-18.e11. doi: 10.1053/j.gastro.2014.08.008. Epub 2014 Aug 14.


Renal blood flow and oxygenation drive nephron progenitor differentiation.

Rymer C, Paredes J, Halt K, Schaefer C, Wiersch J, Zhang G, Potoka D, Vainio S, Gittes GK, Bates CM, Sims-Lucas S.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F337-45. doi: 10.1152/ajprenal.00208.2014. Epub 2014 Jun 11.


M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.

Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1211-20. doi: 10.1073/pnas.1321347111. Epub 2014 Mar 17.


Pancreatic duct cells as a source of VEGF in mice.

Xiao X, Prasadan K, Guo P, El-Gohary Y, Fischbach S, Wiersch J, Gaffar I, Shiota C, Gittes GK.

Diabetologia. 2014 May;57(5):991-1000. doi: 10.1007/s00125-014-3179-y. Epub 2014 Feb 18.


Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ.

J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11.


Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts.

Guo P, Xiao X, El-Gohary Y, Criscimanna A, Prasadan K, Rymer C, Shiota C, Wiersch J, Gaffar I, Esni F, Gittes GK.

Lab Invest. 2013 Nov;93(11):1241-53. doi: 10.1038/labinvest.2013.113. Epub 2013 Oct 7.


A smad signaling network regulates islet cell proliferation.

El-Gohary Y, Tulachan S, Wiersch J, Guo P, Welsh C, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G.

Diabetes. 2014 Jan;63(1):224-36. doi: 10.2337/db13-0432. Epub 2013 Oct 2.


α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets.

Shiota C, Prasadan K, Guo P, El-Gohary Y, Wiersch J, Xiao X, Esni F, Gittes GK.

Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1030-40. doi: 10.1152/ajpendo.00022.2013. Epub 2013 Aug 27.


Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas.

Xiao X, Guo P, Shiota C, Prasadan K, El-Gohary Y, Wiersch J, Gaffar I, Gittes GK.

J Biol Chem. 2013 Aug 30;288(35):25297-308. doi: 10.1074/jbc.M113.484022. Epub 2013 Jul 18.


Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme.

Sims-Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, Gittes G, Bates CM.

PLoS One. 2013 Jun 18;8(6):e65993. doi: 10.1371/journal.pone.0065993. Print 2013.


PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis.

Criscimanna A, Duan LJ, Rhodes JA, Fendrich V, Wickline E, Hartman DJ, Monga SP, Lotze MT, Gittes GK, Fong GH, Esni F.

Cancer Res. 2013 Aug 1;73(15):4781-90. doi: 10.1158/0008-5472.CAN-13-0566. Epub 2013 Jun 7.


No evidence for β cell neogenesis in murine adult pancreas.

Xiao X, Chen Z, Shiota C, Prasadan K, Guo P, El-Gohary Y, Paredes J, Welsh C, Wiersch J, Gittes GK.

J Clin Invest. 2013 May;123(5):2207-17. doi: 10.1172/JCI66323. Epub 2013 Apr 24.


Smad signaling pathways regulate pancreatic endocrine development.

El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G.

Dev Biol. 2013 Jun 15;378(2):83-93. doi: 10.1016/j.ydbio.2013.04.003. Epub 2013 Apr 17.


Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass.

Xiao X, Guo P, Chen Z, El-Gohary Y, Wiersch J, Gaffar I, Prasadan K, Shiota C, Gittes GK.

J Biol Chem. 2013 Mar 22;288(12):8636-46. doi: 10.1074/jbc.M112.422949. Epub 2013 Feb 1.


High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

Mishra SK, Funair L, Cressley A, Gittes GK, Burns RC.

PLoS One. 2012;7(12):e52190. doi: 10.1371/journal.pone.0052190. Epub 2012 Dec 14.


TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation.

Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, Welsh C, Shiota C, Gittes GK.

Diabetes. 2013 Apr;62(4):1217-26. doi: 10.2337/db12-1428. Epub 2012 Dec 17.


A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning.

Guo P, Xiao X, El-Gohary Y, Paredes J, Prasadan K, Shiota C, Wiersch J, Welsh C, Gittes GK.

Bioengineered. 2013 Mar-Apr;4(2):103-6. doi: 10.4161/bioe.22293. Epub 2012 Mar 1.


Three-dimensional analysis of the islet vasculature.

El-Gohary Y, Sims-Lucas S, Lath N, Tulachan S, Guo P, Xiao X, Welsh C, Paredes J, Wiersch J, Prasadan K, Shiota C, Gittes GK.

Anat Rec (Hoboken). 2012 Sep;295(9):1473-81. doi: 10.1002/ar.22530. Epub 2012 Jul 16.


Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ.

Gastroenterology. 2012 Sep;143(3):708-718.e5. doi: 10.1053/j.gastro.2012.05.053. Epub 2012 Jul 13.


Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.

Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25.

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